Motif ID: HNF1A.p2

Z-value: 1.042


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1214162940.531.8e-01Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_74347461 0.968 NM_001133
 AFM
afamin
chr14_-_94854910 0.913 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_-_24383519 0.824 NM_001195610
 DCDC2
doublecortin domain containing 2
chr6_-_29012951 0.747 NM_030903
 OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr14_-_94855120 0.659 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_+_73553883 0.634 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr14_-_92333856 0.530 NM_001128596
 TC2N
tandem C2 domains, nuclear
chr8_-_17555158 0.530 NM_020749
 MTUS1
microtubule associated tumor suppressor 1
chr19_+_15052298 0.523 NM_012377
 OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr8_+_21911062 0.474 NM_001114137
 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr19_-_36303724 0.473 PRODH2
proline dehydrogenase (oxidase) 2
chr22_+_45098046 0.419 NM_181333
 PRR5
proline rich 5 (renal)
chr6_-_116381765 0.417 NM_002031
 FRK
fyn-related kinase
chr4_-_110723127 0.406 CFI
complement factor I
chr4_-_155511838 0.402 NM_000508
NM_021871
 FGA

fibrinogen alpha chain

chr16_-_66952729 0.391 NM_001204744
NM_001204745
NM_001204746
NM_004062
 CDH16



cadherin 16, KSP-cadherin



chr19_-_36303766 0.383 PRODH2
proline dehydrogenase (oxidase) 2
chrX_-_15683153 0.376 NM_020665
 TMEM27
transmembrane protein 27
chr17_+_1646129 0.368 NM_000934
NM_001165921
 SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr4_-_186733372 0.357 NM_003603
NM_001145670
 SORBS2

sorbin and SH3 domain containing 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
55.74 6.97e-03 GO:0034392 negative regulation of smooth muscle cell apoptosis
37.16 1.80e-03 GO:0034391 regulation of smooth muscle cell apoptosis
30.97 2.59e-04 GO:0009812 flavonoid metabolic process
25.34 9.22e-04 GO:0009698 phenylpropanoid metabolic process
24.77 1.45e-02 GO:0051918 negative regulation of fibrinolysis
20.27 3.69e-02 GO:0010660 regulation of muscle cell apoptosis
17.42 8.10e-03 GO:0015721 bile acid and bile salt transport
8.80 3.00e-11 GO:0006805 xenobiotic metabolic process
8.80 3.00e-11 GO:0071466 cellular response to xenobiotic stimulus
8.74 3.50e-11 GO:0009410 response to xenobiotic stimulus
5.60 7.99e-08 GO:0008202 steroid metabolic process
4.58 3.59e-02 GO:0006820 anion transport
4.45 4.72e-02 GO:0031016 pancreas development
3.79 4.42e-04 GO:0032787 monocarboxylic acid metabolic process
3.40 2.30e-04 GO:0071702 organic substance transport
2.87 6.49e-05 GO:0006082 organic acid metabolic process
2.67 1.23e-03 GO:0019752 carboxylic acid metabolic process
2.67 1.23e-03 GO:0043436 oxoacid metabolic process
2.61 1.94e-03 GO:0042180 cellular ketone metabolic process
2.33 2.36e-03 GO:0006629 lipid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
23.89 3.63e-02 GO:0005577 fibrinogen complex
9.61 2.85e-02 GO:0031526 brush border membrane
8.30 3.59e-03 GO:0031093 platelet alpha granule lumen
8.13 4.14e-03 GO:0034774 secretory granule lumen
7.81 5.45e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
7.51 7.08e-03 GO:0031983 vesicle lumen
7.43 2.72e-02 GO:0005903 brush border
6.85 1.30e-02 GO:0031091 platelet alpha granule
4.65 3.89e-04 GO:0016324 apical plasma membrane
4.39 1.84e-02 GO:0031225 anchored to membrane
3.70 5.35e-03 GO:0045177 apical part of cell
3.34 1.65e-02 GO:0005792 microsome
3.23 2.36e-02 GO:0042598 vesicular fraction
2.47 2.99e-04 GO:0005615 extracellular space
2.20 3.73e-02 GO:0005789 endoplasmic reticulum membrane
2.19 8.37e-04 GO:0044421 extracellular region part
1.78 4.00e-04 GO:0044459 plasma membrane part
1.73 3.37e-03 GO:0005576 extracellular region
1.34 1.65e-02 GO:0031224 intrinsic to membrane
1.29 3.69e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
20.27 8.64e-03 GO:0001972 retinoic acid binding
17.92 2.46e-07 GO:0015020 glucuronosyltransferase activity
7.60 3.58e-02 GO:0043498 cell surface binding
7.43 4.07e-02 GO:0015103 inorganic anion transmembrane transporter activity
6.97 1.72e-02 GO:0033293 monocarboxylic acid binding
5.20 2.52e-03 GO:0008194 UDP-glycosyltransferase activity
3.89 1.84e-02 GO:0016758 transferase activity, transferring hexosyl groups
3.20 3.83e-02 GO:0016757 transferase activity, transferring glycosyl groups
2.75 3.10e-02 GO:0030246 carbohydrate binding