Motif ID: HNF4A_NR2F1,2.p2

Z-value: 2.793


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR2F2chr15_+_96876568-0.977.0e-05Click!
NR2F1chr5_+_92918924-0.902.6e-03Click!
HNF4Achr20_+_430300050.866.6e-03Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_43885251 7.766 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr2_+_95940220 3.772 PROM2
prominin 2
chr15_+_43985083 3.719 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr2_+_95940195 3.597 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr19_+_751108 3.379 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr4_-_53617781 3.121 NM_001242690
NM_024534
ERVMER34-1

endogenous retrovirus group MER34, member 1

chr1_+_44064509 2.944 PTPRF
protein tyrosine phosphatase, receptor type, F
chr2_-_238499317 2.883 RAB17
RAB17, member RAS oncogene family
chr6_+_125475334 2.845 NM_001003395
TPD52L1
tumor protein D52-like 1
chr12_-_54779482 2.707 ZNF385A
zinc finger protein 385A
chr2_-_238499713 2.616 NM_022449
RAB17
RAB17, member RAS oncogene family
chr14_-_94855120 2.573 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr4_-_10023094 2.533 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr6_+_150464156 2.464 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr3_-_189840225 2.388 NM_001134418
LEPREL1
leprecan-like 1
chr14_-_92333856 2.388 NM_001128596
TC2N
tandem C2 domains, nuclear
chr1_+_156030965 2.284 NM_020387
RAB25
RAB25, member RAS oncogene family
chr8_+_21916858 2.267 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr19_-_6720585 2.189 NM_000064
C3
complement component 3
chr16_+_3115312 2.154 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr16_+_67233013 2.123 NM_024712
ELMO3
engulfment and cell motility 3
chr11_-_118134986 2.015 MPZL2
myelin protein zero-like 2
chr11_+_72929302 2.005 NM_002564
NM_176072
P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr19_-_16045669 1.978 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr14_+_39735871 1.977 CTAGE5
CTAGE family, member 5
chr18_+_61442611 1.958 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr7_-_143105897 1.952 NM_005232
EPHA1
EPH receptor A1
chr20_-_43883183 1.950 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr1_+_44398991 1.911 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr8_+_95653272 1.894 ESRP1
epithelial splicing regulatory protein 1
chr6_-_13408368 1.879 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr18_-_47376156 1.821 MYO5B
myosin VB
chr18_+_29027731 1.798 NM_001944
DSG3
desmoglein 3
chr11_+_72929392 1.786 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr16_+_57653909 1.781 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr7_+_86274076 1.769 GRM3
glutamate receptor, metabotropic 3
chr14_-_94854910 1.757 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_156785938 1.748 NM_001161443
SH2D2A
SH2 domain containing 2A
chr14_+_21525980 1.746 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr12_-_6484904 1.728 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr6_-_11779279 1.683 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr11_-_118135197 1.673 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr1_+_153003677 1.666 NM_003125
SPRR1B
small proline-rich protein 1B
chr1_+_26872306 1.649 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_+_48255223 1.648 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr1_+_26856240 1.637 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_-_118134956 1.628 MPZL2
myelin protein zero-like 2
chr1_+_153330329 1.615 NM_002965
S100A9
S100 calcium binding protein A9
chr1_+_26872342 1.602 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_-_70780621 1.548 TGFA
transforming growth factor, alpha
chr16_+_3014216 1.546 NM_001253725
NM_001253726
NM_024507
NM_172229
KREMEN2



kringle containing transmembrane protein 2



chr8_+_21916685 1.537 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr8_-_57232653 1.512 SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr15_+_40532034 1.485 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr12_-_28124915 1.479 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr16_-_84273303 1.476 NM_172347
KCNG4
potassium voltage-gated channel, subfamily G, member 4
chr19_-_4342718 1.462 STAP2
signal transducing adaptor family member 2
chr17_+_73717556 1.455 ITGB4
integrin, beta 4
chrX_+_48916515 1.407 NM_001163322
NM_033626
NM_001163321
NM_001163323
CCDC120



coiled-coil domain containing 120



chr1_+_200860619 1.392 NM_018265
C1orf106
chromosome 1 open reading frame 106
chr4_-_53617565 1.391 ERVMER34-1
endogenous retrovirus group MER34, member 1
chr20_+_62795773 1.388 MYT1
myelin transcription factor 1
chr7_+_86273867 1.382 GRM3
glutamate receptor, metabotropic 3
chr2_+_47596286 1.369 NM_002354
EPCAM
epithelial cell adhesion molecule
chr19_-_1174257 1.367 SBNO2
strawberry notch homolog 2 (Drosophila)
chr2_-_74667553 1.365 NM_001015056
NM_033046
RTKN

rhotekin

chr1_+_26856259 1.352 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr7_+_86273951 1.342 GRM3
glutamate receptor, metabotropic 3
chr2_+_27719702 1.332 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr1_+_205473768 1.324 CDK18
cyclin-dependent kinase 18
chr1_+_26856252 1.257 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr20_+_58630965 1.253 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr5_+_131409484 1.228 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr2_-_165477818 1.222 GRB14
growth factor receptor-bound protein 14
chr1_-_21059132 1.220 NM_001103160
NM_001103161
SH2D5

SH2 domain containing 5

chr16_+_57673206 1.201 NM_001145774
GPR56
G protein-coupled receptor 56
chr1_+_155100304 1.194 NM_004428
NM_182685
EFNA1

ephrin-A1

chr17_+_73717596 1.194 ITGB4
integrin, beta 4
chr19_+_45394522 1.185 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_110163667 1.170 AMPD2
adenosine monophosphate deaminase 2
chr6_+_30856462 1.167 NM_001202521
NM_001202522
NM_013994
DDR1


discoidin domain receptor tyrosine kinase 1


chr7_-_139763520 1.164 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr22_+_45072936 1.164 PRR5
proline rich 5 (renal)
chr21_-_42218587 1.152 DSCAM
Down syndrome cell adhesion molecule
chr3_-_119396220 1.151 NM_005694
COX17
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr2_+_26568900 1.146 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr19_+_14142261 1.140 NM_004843
IL27RA
interleukin 27 receptor, alpha
chr11_+_45943171 1.132 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr19_+_39279849 1.132 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chrX_+_16804531 1.131 NM_001168683
NM_018360
TXLNG

taxilin gamma

chrX_+_138612894 1.129 NM_000133
F9
coagulation factor IX
chr1_-_16539103 1.128 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr11_-_17035948 1.127 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr1_+_101702304 1.112 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr1_+_13910251 1.110 NM_006474
NM_198389
PDPN

podoplanin

chr1_+_65613211 1.106 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr17_-_8027396 1.105 NM_001165967
NM_032580
HES7

hairy and enhancer of split 7 (Drosophila)

chr12_+_132413776 1.098 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr10_-_116444374 1.095 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr6_+_30851860 1.087 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_+_20915440 1.082 NM_001785
CDA
cytidine deaminase
chr19_-_1174263 1.080 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr19_+_45394642 1.079 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_152486977 1.076 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr1_+_158149736 1.064 NM_001766
CD1D
CD1d molecule
chr16_+_69139466 1.056 NM_001199280
HAS3
hyaluronan synthase 3
chr2_+_219187975 1.042 PNKD
paroxysmal nonkinesigenic dyskinesia
chr17_-_47841517 1.041 NM_030802
FAM117A
family with sequence similarity 117, member A
chr14_+_61788398 1.039 NM_006255
PRKCH
protein kinase C, eta
chr11_+_394238 1.037 PKP3
plakophilin 3
chr11_-_102668822 1.022 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr12_+_105153258 1.021 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_+_53497273 1.005 NM_003578
SOAT2
sterol O-acyltransferase 2
chr2_-_31637553 1.003 XDH
xanthine dehydrogenase
chr11_+_706607 1.002 EPS8L2
EPS8-like 2
chr19_+_5823817 1.001 NM_004558
NRTN
neurturin
chr11_-_85437457 0.978 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr11_-_123525300 0.975 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr6_+_33172418 0.973 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr19_-_1174201 0.970


chr22_+_45072687 0.970 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr2_-_31361591 0.968 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr4_+_48018775 0.955 NM_207330
NIPAL1
NIPA-like domain containing 1
chr1_+_158150678 0.946 CD1D
CD1d molecule
chr17_-_47841468 0.946 FAM117A
family with sequence similarity 117, member A
chr22_-_51021255 0.944 CHKB
choline kinase beta
chr12_+_101188373 0.942 NM_178826
ANO4
anoctamin 4
chr2_+_113931565 0.934 PSD4
pleckstrin and Sec7 domain containing 4
chr11_-_102668892 0.919 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr1_+_6052357 0.918 NM_001199861
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr17_+_7812703 0.917 CHD3
chromodomain helicase DNA binding protein 3
chr9_-_117554809 0.912 NM_001204344
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr2_-_31637598 0.904 NM_000379
XDH
xanthine dehydrogenase
chr17_+_37894212 0.903 GRB7
growth factor receptor-bound protein 7
chr17_+_73717515 0.900 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr10_+_102732285 0.897 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr14_-_24777160 0.896 CIDEB
cell death-inducing DFFA-like effector b
chr17_+_1646290 0.885 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr17_+_37896219 0.883 NM_001242443
GRB7
growth factor receptor-bound protein 7
chr17_+_1646129 0.878 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr19_+_6464259 0.876 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr4_-_120243257 0.876 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr19_-_633474 0.874 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr8_+_22436641 0.870 PDLIM2
PDZ and LIM domain 2 (mystique)
chr9_-_117156684 0.868 NM_030767
AKNA
AT-hook transcription factor
chr6_-_31550065 0.868 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr1_+_35220647 0.864 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr13_-_42535066 0.862 KIAA0564
KIAA0564
chr10_-_116392099 0.861 ABLIM1
actin binding LIM protein 1
chr17_-_39942937 0.849 NM_002230
NM_021991
JUP

junction plakoglobin

chr20_+_43803539 0.849 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr14_-_24777153 0.845 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777184 0.842 CIDEB
cell death-inducing DFFA-like effector b
chr12_+_132414041 0.842 PUS1
pseudouridylate synthase 1
chr14_-_21572789 0.839 NM_001102454
ZNF219
zinc finger protein 219
chr15_-_79237353 0.837 NM_004390
CTSH
cathepsin H
chr6_-_136788012 0.830 NM_001198615
MAP7
microtubule-associated protein 7
chr1_-_27286875 0.822 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr1_-_24126891 0.822 NM_000403
GALE
UDP-galactose-4-epimerase
chr1_+_55007927 0.820 ACOT11
acyl-CoA thioesterase 11
chr1_-_160068261 0.818 IGSF8
immunoglobulin superfamily, member 8
chr22_+_38035683 0.818 NM_018957
SH3BP1
SH3-domain binding protein 1
chr19_-_633526 0.815 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr22_-_51021337 0.813 NM_005198
CHKB
CHKB-CPT1B
choline kinase beta
CHKB-CPT1B readthrough (non-protein coding)
chr20_-_1309809 0.812 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr1_+_196857143 0.812 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr1_-_43751238 0.807 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr17_-_56492938 0.803 RNF43
ring finger protein 43
chr6_+_30850693 0.794 DDR1
discoidin domain receptor tyrosine kinase 1
chr19_+_45394569 0.794 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr19_-_1111972 0.790 SBNO2
strawberry notch homolog 2 (Drosophila)
chr5_+_65892139 0.790 NM_001164664
NM_198828
MAST4

microtubule associated serine/threonine kinase family member 4

chr11_+_63137260 0.790 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr19_-_11689591 0.788 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr3_+_111717585 0.782 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr4_-_103266396 0.782 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr8_-_127570710 0.781 NM_174911
FAM84B
family with sequence similarity 84, member B
chr6_-_3272349 0.780 SLC22A23
solute carrier family 22, member 23
chr3_+_52812438 0.779 NM_001166434
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr10_-_71906409 0.774 TYSND1
trypsin domain containing 1
chr19_-_11689765 0.771 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr8_-_142238672 0.770 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr19_-_633563 0.766 NM_005035
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr11_+_59522905 0.765 STX3
syntaxin 3
chr16_+_3115611 0.765 NM_001012635
IL32
interleukin 32
chr3_+_36421944 0.759 NM_003149
STAC
SH3 and cysteine rich domain
chr11_-_66488712 0.759 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr19_-_44143943 0.757 NM_145296
CADM4
cell adhesion molecule 4
chr22_+_21321446 0.755 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr11_-_85425790 0.755 NM_032379
SYTL2
synaptotagmin-like 2
chr9_-_117568292 0.754 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr19_-_15590203 0.752 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr9_-_117111278 0.750 AKNA
AT-hook transcription factor
chr2_+_206547131 0.749 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr14_+_75745480 0.747 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr6_+_29691116 0.744 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr4_+_140587086 0.742 MGST2
microsomal glutathione S-transferase 2
chrX_-_133792497 0.742 NM_021796
PLAC1
placenta-specific 1
chr6_+_43737937 0.732 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr7_+_142982039 0.729 NM_001242773
NM_001242774
NM_001242775
NM_001242776
NM_001242777
NM_153345
TMEM139





transmembrane protein 139






Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.08e-05 GO:0009987 cellular process
1.28 1.12e-02 GO:0044281 small molecule metabolic process
1.25 1.78e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 6.89e-05 GO:0000267 cell fraction
1.51 2.18e-04 GO:0044429 mitochondrial part
1.14 2.43e-04 GO:0044444 cytoplasmic part
1.45 5.06e-04 GO:0005624 membrane fraction
1.10 5.29e-04 GO:0005737 cytoplasm
1.44 5.41e-04 GO:0005626 insoluble fraction
1.23 4.63e-03 GO:0044459 plasma membrane part
1.43 5.29e-03 GO:0031967 organelle envelope
1.53 7.60e-03 GO:0005740 mitochondrial envelope
1.42 8.29e-03 GO:0031975 envelope
1.29 1.69e-02 GO:0031226 intrinsic to plasma membrane
1.51 1.97e-02 GO:0031966 mitochondrial membrane
1.29 2.05e-02 GO:0005887 integral to plasma membrane
1.22 2.17e-02 GO:0031090 organelle membrane
1.28 2.94e-02 GO:0005739 mitochondrion
3.81 3.64e-02 GO:0030057 desmosome
1.65 4.03e-02 GO:0005759 mitochondrial matrix
1.09 4.60e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.62 2.38e-02 GO:0070330 aromatase activity