Motif ID: IKZF1.p2

Z-value: 1.485


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_503482550.811.5e-02Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_41136178 2.766 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr12_-_58160823 2.420 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr19_-_51456159 2.144 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr2_+_47596286 2.041 NM_002354
EPCAM
epithelial cell adhesion molecule
chr19_-_10697907 1.945 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_+_26856259 1.859 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_26856252 1.623 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_209979388 1.604 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr19_+_38755097 1.563 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_38755422 1.540 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr2_-_113594325 1.513 NM_000576
IL1B
interleukin 1, beta
chr1_+_26856240 1.468 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_+_62649160 1.452 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr19_+_54371170 1.389 MYADM
myeloid-associated differentiation marker
chr1_+_183155173 1.375 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr11_+_18287807 1.344 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr16_-_68269948 1.323 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr20_+_44637539 1.309 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr17_-_7493389 1.303 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr11_-_18270167 1.279 NM_001199744
NM_001127380
NM_030754
SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr1_-_209825673 1.271 NM_001127641
LAMB3
laminin, beta 3
chr1_+_92495484 1.240 NM_173567
EPHX4
epoxide hydrolase 4
chr8_-_125740650 1.235 NM_014751
MTSS1
metastasis suppressor 1
chr12_+_41086189 1.200 NM_001843
NM_175038
CNTN1

contactin 1

chr1_-_209825797 1.182 NM_000228
LAMB3
laminin, beta 3
chr2_-_165424993 1.180 GRB14
growth factor receptor-bound protein 14
chr1_+_35247838 1.176 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr8_+_124194751 1.170 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr1_+_32042122 1.144 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr19_+_35739282 1.140 LSR
lipolysis stimulated lipoprotein receptor
chr1_+_32042085 1.133 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr3_-_69435223 1.124 FRMD4B
FERM domain containing 4B
chr11_+_10482677 1.122 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr8_+_95653340 1.114 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr2_+_17721806 1.081 NM_003385
VSNL1
visinin-like 1
chr1_+_32042125 1.074 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_15250578 1.069 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr19_-_36001336 1.064 NM_001126059
DMKN
dermokine
chr2_+_17721983 1.060 VSNL1
visinin-like 1
chr19_+_38755238 1.054 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr3_-_69435429 1.037 NM_015123
FRMD4B
FERM domain containing 4B
chr19_+_45312294 1.013 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr1_+_209848659 0.998 NM_015714
G0S2
G0/G1switch 2
chr8_+_95653399 0.985 ESRP1
epithelial splicing regulatory protein 1
chr17_-_27401216 0.965 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr17_-_27401590 0.947 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr1_+_1981902 0.938 NM_002744
PRKCZ
protein kinase C, zeta
chr1_+_117452359 0.936 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr1_+_32043745 0.932 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr8_+_95653272 0.928 ESRP1
epithelial splicing regulatory protein 1
chr1_-_28520379 0.922 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr7_+_148036528 0.911 CNTNAP2
contactin associated protein-like 2
chr12_-_52867521 0.911 NM_173086
KRT6C
keratin 6C
chr18_-_28681885 0.908 NM_004949
NM_024422
DSC2

desmocollin 2

chr8_+_101170510 0.890 NM_003114
SPAG1
sperm associated antigen 1
chr9_-_33447527 0.866 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr14_+_65171243 0.863 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr2_+_95940195 0.859 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr5_+_140186658 0.855 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr1_-_201368434 0.848 LAD1
ladinin 1
chr2_+_102608305 0.819 NM_004633
IL1R2
interleukin 1 receptor, type II
chr2_+_95940220 0.816 PROM2
prominin 2
chr5_+_66124603 0.815 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_-_56881901 0.804 NM_013267
GLS2
glutaminase 2 (liver, mitochondrial)
chr14_+_65171149 0.802 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr19_+_54371125 0.795 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr1_-_153588789 0.782 NM_020672
S100A14
S100 calcium binding protein A14
chr17_-_39646115 0.774 NM_003771
KRT36
keratin 36
chr11_+_130029699 0.771 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr13_+_25254548 0.763 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr14_+_96671015 0.750 NM_000623
BDKRB2
bradykinin receptor B2
chr12_-_53298765 0.747 NM_002273
KRT8
keratin 8
chr1_-_160990862 0.737 F11R
F11 receptor
chr2_-_238499317 0.716 RAB17
RAB17, member RAS oncogene family
chr15_-_73661141 0.684 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr11_+_130029663 0.679 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr1_+_234040547 0.662 NM_173508
SLC35F3
solute carrier family 35, member F3
chr2_-_238499713 0.658 NM_022449
RAB17
RAB17, member RAS oncogene family
chr6_+_126070895 0.620 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr6_+_125474800 0.592 NM_001003396
NM_001003397
NM_003287
TPD52L1


tumor protein D52-like 1


chr6_+_18155535 0.585 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr1_+_155099935 0.579 EFNA1
ephrin-A1
chr17_+_57297827 0.574 NM_001165993
NM_001165994
NM_182569
GDPD1


glycerophosphodiester phosphodiesterase domain containing 1


chr9_+_130911731 0.570 NM_005564
LCN2
lipocalin 2
chr5_+_176794312 0.565 RGS14
regulator of G-protein signaling 14
chr3_+_50192420 0.563 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chrX_-_31284946 0.552 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr13_+_37005966 0.552 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr17_+_48610045 0.551 NM_017957
EPN3
epsin 3
chr14_-_24036939 0.545 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr12_-_322612 0.527 NM_003044
NM_001122847
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr9_+_131644780 0.523 NM_001127244
LRRC8A
leucine rich repeat containing 8 family, member A
chr17_-_3599487 0.516 NM_001204519
NM_001204520
NM_002561
NM_175080
P2RX5-TAX1BP3
P2RX5



P2RX5-TAX1BP3 readthrough
purinergic receptor P2X, ligand-gated ion channel, 5



chr19_+_45843997 0.515 NM_177417
KLC3
kinesin light chain 3
chr2_+_163200582 0.499 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr5_-_35938736 0.496 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr4_-_36245893 0.495 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_-_20256942 0.491 NM_182762
MACC1
metastasis associated in colon cancer 1
chr20_+_58630965 0.488 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr15_+_40545348 0.488 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_60691911 0.484 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr19_-_11688508 0.483 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr19_+_10381516 0.480 NM_000201
ICAM1
intercellular adhesion molecule 1
chr8_-_57232700 0.477 SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr13_-_52980628 0.473 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr16_-_87903028 0.463 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr11_+_6866882 0.462 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr1_+_205473768 0.459 CDK18
cyclin-dependent kinase 18
chr6_+_150464156 0.457 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr20_-_23030141 0.455 NM_000361
THBD
thrombomodulin
chr19_+_10381763 0.453 ICAM1
intercellular adhesion molecule 1
chr6_-_13486986 0.453 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr9_+_115913227 0.452 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr19_-_51504799 0.450 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr9_+_115913266 0.449 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr1_-_201368617 0.448 NM_005558
LAD1
ladinin 1
chr2_+_163200623 0.447 GCA
grancalcin, EF-hand calcium binding protein
chr9_+_22446783 0.447 NM_022160
DMRTA1
DMRT-like family A1
chr4_-_40631846 0.446 NM_001098634
RBM47
RNA binding motif protein 47
chr18_+_55714457 0.445 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_160370363 0.444 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr11_-_66488712 0.443 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr16_-_2031179 0.441 NM_172167
NM_172168
NOXO1

NADPH oxidase organizer 1

chrY_-_21154560 0.426 NM_013230
CD24
CD24P4
CD24 molecule
CD24 molecule pseudogene 4
chrX_+_102470003 0.419 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr10_-_120925157 0.419 NM_213649
SFXN4
sideroflexin 4
chr6_-_47009992 0.416 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr1_-_117210301 0.414 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr1_-_201368716 0.411 LAD1
ladinin 1
chr3_-_12800739 0.411 NM_018306
TMEM40
transmembrane protein 40
chr11_-_118016134 0.411 NM_001142349
SCN4B
sodium channel, voltage-gated, type IV, beta
chr15_+_59730272 0.411 NM_152450
FAM81A
family with sequence similarity 81, member A
chr8_-_145669796 0.410 NM_013432
TONSL
tonsoku-like, DNA repair protein
chr8_+_124084936 0.410 WDR67
WD repeat domain 67
chr17_-_39768939 0.408 NM_005557
KRT16
keratin 16
chr11_+_62648340 0.407 NM_001013251
SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr13_-_52980234 0.405 THSD1
thrombospondin, type I, domain containing 1
chr7_-_16505292 0.403 NM_015464
SOSTDC1
sclerostin domain containing 1
chr10_-_131762017 0.400 NM_001005463
EBF3
early B-cell factor 3
chr11_+_130029712 0.398 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr19_+_54371150 0.394 MYADM
myeloid-associated differentiation marker
chr8_+_124084898 0.394 NM_001145088
NM_145647
WDR67

WD repeat domain 67

chr14_-_24037266 0.389 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr19_+_39138349 0.387 ACTN4
actinin, alpha 4
chr6_-_13487772 0.386 NM_001242629
NM_018988
GFOD1

glucose-fructose oxidoreductase domain containing 1

chr6_+_80340971 0.377 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr14_-_24732344 0.375 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr6_+_125475334 0.373 NM_001003395
TPD52L1
tumor protein D52-like 1
chr5_+_36606667 0.371 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_15939949 0.369 FGFBP1
fibroblast growth factor binding protein 1
chr11_-_85430382 0.366 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr17_+_7342688 0.365 NM_004112
FGF11
fibroblast growth factor 11
chr3_+_142442855 0.363


chr15_+_66679107 0.358 NM_002755
MAP2K1
mitogen-activated protein kinase kinase 1
chr16_+_27325269 0.357 IL4R
interleukin 4 receptor
chr15_+_66694216 0.357 MAP2K1
mitogen-activated protein kinase kinase 1
chr1_+_24649529 0.350 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr2_-_142889269 0.348 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr17_-_41322211 0.346 BRCA1
breast cancer 1, early onset
chr18_+_12254317 0.345 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr8_-_66754276 0.344 PDE7A
phosphodiesterase 7A
chr16_+_27325244 0.343 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr7_+_26191732 0.342 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr16_+_30194730 0.342 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr14_-_21572374 0.341


chr15_+_42120155 0.340 NM_001114632
NM_001198588
NM_005090
JMJD7
JMJD7-PLA2G4B

jumonji domain containing 7
JMJD7-PLA2G4B readthrough

chr9_+_12693385 0.338 NM_000550
TYRP1
tyrosinase-related protein 1
chr6_+_126070738 0.337 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr1_-_116311330 0.336 CASQ2
calsequestrin 2 (cardiac muscle)
chr16_-_71264557 0.335 NM_032821
NM_017558
HYDIN

hydrocephalus inducing homolog (mouse)

chr11_+_117947726 0.334 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr17_+_48610077 0.334 EPN3
epsin 3
chr7_+_89783688 0.330 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr14_+_39703119 0.329 NM_054024
MIA2
melanoma inhibitory activity 2
chr1_-_85462622 0.328 NM_153259
MCOLN2
mucolipin 2
chr2_+_206547131 0.324 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr20_+_35201854 0.322 NM_001199513
NM_001199514
TGIF2

TGFB-induced factor homeobox 2

chr2_+_96931988 0.322 CIAO1
cytosolic iron-sulfur protein assembly 1
chr1_-_26680620 0.322 NM_001039775
AIM1L
absent in melanoma 1-like
chr4_-_153456152 0.320 NM_033632
FBXW7
F-box and WD repeat domain containing 7
chr1_+_100326765 0.320 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr1_+_209602164 0.317 NM_001104548
MIR205HG
MIR205 host gene (non-protein coding)
chr4_+_81256873 0.315 NM_001206997
NM_152770
C4orf22

chromosome 4 open reading frame 22

chr2_+_97426571 0.314 NM_020184
CNNM4
cyclin M4
chr6_+_132859426 0.311 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr16_-_11680146 0.310 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr1_+_110577219 0.309 NM_033088
FAM40A
family with sequence similarity 40, member A
chr1_-_54303933 0.307 TMEM48
transmembrane protein 48
chr15_-_52587851 0.306 NM_018728
MYO5C
myosin VC
chr16_+_23690234 0.305 PLK1
polo-like kinase 1
chr16_-_23652477 0.304 NM_024675
PALB2
partner and localizer of BRCA2
chr19_-_43098980 0.303 NM_001816
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr10_+_103911932 0.302 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr20_-_1309809 0.301 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr11_+_1860232 0.301 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr2_+_16080559 0.300 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr18_-_19284622 0.298 ABHD3
abhydrolase domain containing 3
chr5_+_72861567 0.296 NM_032175
UTP15
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
chr21_-_31538970 0.289 NM_012131
CLDN17
claudin 17
chr11_+_119039415 0.288 NM_024618
NM_170722
NLRX1

NLR family member X1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.12 1.51e-09 GO:0009987 cellular process
1.12 3.53e-03 GO:0065007 biological regulation
1.20 1.38e-02 GO:0023052 signaling
1.18 3.46e-02 GO:0051716 cellular response to stimulus
1.12 3.81e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.90e-03 GO:0044459 plasma membrane part
1.26 4.78e-03 GO:0070013 intracellular organelle lumen
1.26 5.17e-03 GO:0031974 membrane-enclosed lumen
1.25 6.64e-03 GO:0043233 organelle lumen
1.56 1.55e-02 GO:0005730 nucleolus
1.28 1.60e-02 GO:0031981 nuclear lumen
1.25 1.94e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 2.11e-02 GO:0005515 protein binding
3.75 4.88e-02 GO:0030551 cyclic nucleotide binding