Motif ID: IKZF2.p2

Z-value: 1.800


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_2140150530.939.4e-04Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_57045235 5.911 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_189839132 5.627 COL3A1
collagen, type III, alpha 1
chr2_+_189839078 5.175 NM_000090
COL3A1
collagen, type III, alpha 1
chr1_+_159175048 5.084 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr13_-_38172862 5.009 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_-_57045214 4.890 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_189839113 4.401 COL3A1
collagen, type III, alpha 1
chr1_+_155853546 3.141 SYT11
synaptotagmin XI
chr12_-_91573264 2.963 NM_133503
DCN
decorin
chr17_-_66951381 2.661 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr7_+_93551015 2.625 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr12_-_91576579 2.593 DCN
decorin
chr2_-_238322770 2.588 COL6A3
collagen, type VI, alpha 3
chr2_-_238322840 2.446 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr1_+_163038564 2.419 NM_005613
RGS4
regulator of G-protein signaling 4
chr3_+_12392993 2.390 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr5_+_92918924 2.387 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_-_238322815 2.327 COL6A3
collagen, type VI, alpha 3
chr1_-_57045129 2.311 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_163038934 2.227 NM_001113381
RGS4
regulator of G-protein signaling 4
chr1_-_57044980 2.225 PPAP2B
phosphatidic acid phosphatase type 2B
chr7_+_94024201 2.196 COL1A2
collagen, type I, alpha 2
chrX_-_135863104 2.115 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_+_124317884 2.063 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr13_-_34250899 2.032 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_-_195310985 1.997 NM_001647
APOD
apolipoprotein D
chr17_-_67138013 1.915 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_+_157154579 1.873 NM_002852
PTX3
pentraxin 3, long
chr3_-_195310770 1.843 APOD
apolipoprotein D
chr3_+_69812620 1.785 NM_001184967
MITF
microphthalmia-associated transcription factor
chr8_+_17433941 1.746 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chrX_+_100333835 1.718 NM_021637
TMEM35
transmembrane protein 35
chr21_+_26934440 1.681 MIR155HG
MIR155 host gene (non-protein coding)
chr9_-_95244634 1.678 ASPN
asporin
chrX_-_135863033 1.578 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_-_92916924 1.543 FLJ42709
uncharacterized LOC441094
chr6_+_136172802 1.511 NM_018945
PDE7B
phosphodiesterase 7B
chr13_+_102104941 1.468 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_-_127963342 1.458 NM_001001665
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr4_+_124320664 1.451 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr5_-_111093792 1.444 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr2_-_145277879 1.421 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr2_-_200329810 1.413 NM_001172517
SATB2
SATB homeobox 2
chr5_+_140602914 1.406 NM_018934
PCDHB14
protocadherin beta 14
chr5_-_111091947 1.393 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_+_162602198 1.383 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr1_+_162602308 1.326 DDR2
discoidin domain receptor tyrosine kinase 2
chr17_-_53800074 1.293 NM_018286
TMEM100
transmembrane protein 100
chr10_+_69869249 1.283 NM_032578
MYPN
myopalladin
chr13_-_33780142 1.247 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr3_+_69915374 1.226 NM_198177
MITF
microphthalmia-associated transcription factor
chr12_-_15038724 1.201 NM_000900
NM_001190839
MGP

matrix Gla protein

chr2_-_163099877 1.193 NM_004460
FAP
fibroblast activation protein, alpha
chr11_+_65271145 1.185


chr5_+_140710203 1.176 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr15_-_55652777 1.156 CCPG1
cell cycle progression 1
chr5_+_43609261 1.085 NNT
nicotinamide nucleotide transhydrogenase
chr12_+_56075329 1.077 NM_152637
METTL7B
methyltransferase like 7B
chr1_+_79115476 1.073 NM_006417
IFI44
interferon-induced protein 44
chr8_-_108510094 1.054 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr14_+_52327384 1.042 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr2_-_190044330 1.031 NM_000393
COL5A2
collagen, type V, alpha 2
chrX_+_149613719 1.030 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr3_-_58563070 1.025 FAM107A
family with sequence similarity 107, member A
chr5_+_137203544 1.024 NM_001135940
NM_006790
MYOT

myotilin

chr3_-_112358510 1.019 CCDC80
coiled-coil domain containing 80
chr4_-_159093523 1.018 FAM198B
family with sequence similarity 198, member B
chr5_+_137203559 1.015 MYOT
myotilin
chr5_+_32711437 1.010 NM_000908
NM_001204375
NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

chr5_+_32710742 1.002 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr12_-_10605928 0.982 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr4_+_55095263 0.979 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr4_-_138453628 0.973 NM_019035
PCDH18
protocadherin 18
chr14_+_52327021 0.954 NM_001243773
NM_001243774
NM_053064
GNG2


guanine nucleotide binding protein (G protein), gamma 2


chrX_-_63005212 0.943 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr6_+_155411422 0.942 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr8_-_13372183 0.939 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr17_-_48262900 0.930 COL1A1
collagen, type I, alpha 1
chr20_-_34025955 0.921 NM_000557
GDF5
growth differentiation factor 5
chr7_+_142560512 0.915 EPHB6
EPH receptor B6
chr16_-_4896197 0.908 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr20_+_12989616 0.907 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr3_-_112358758 0.902 CCDC80
coiled-coil domain containing 80
chr3_+_69812961 0.881 NM_006722
MITF
microphthalmia-associated transcription factor
chr4_-_157892466 0.874 PDGFC
platelet derived growth factor C
chr1_-_79472360 0.868 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr5_-_158526698 0.859 NM_024007
EBF1
early B-cell factor 1
chr4_+_70916158 0.859 NM_002159
HTN1
histatin 1
chrX_-_135863502 0.855 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_-_157892545 0.851 NM_016205
PDGFC
platelet derived growth factor C
chr8_-_13134028 0.847 DLC1
deleted in liver cancer 1
chr18_-_52625278 0.835 NM_001143829
CCDC68
coiled-coil domain containing 68
chr4_-_138453564 0.835 PCDH18
protocadherin 18
chr4_-_157892054 0.833 PDGFC
platelet derived growth factor C
chr5_+_140718353 0.816 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr1_+_171060017 0.802 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr2_+_201473942 0.799 AOX1
aldehyde oxidase 1
chr17_-_8424217 0.795 MYH10
myosin, heavy chain 10, non-muscle
chr2_+_228678556 0.791 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr2_-_101767714 0.790 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr14_+_76071804 0.788 NM_001195283
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr5_-_121412805 0.778 NM_001178102
LOX
lysyl oxidase
chr14_-_73453651 0.775 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr5_-_147286064 0.773 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr12_+_60083125 0.773 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr11_-_70935807 0.770 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr3_-_112359251 0.767 CCDC80
coiled-coil domain containing 80
chr16_-_89349696 0.762 ANKRD11
ankyrin repeat domain 11
chrX_-_154250769 0.758 NM_000132
F8
coagulation factor VIII, procoagulant component
chr3_-_112359277 0.757 CCDC80
coiled-coil domain containing 80
chr1_-_153518265 0.756 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr7_-_23509631 0.751


chr1_-_157670280 0.750 NM_052939
FCRL3
Fc receptor-like 3
chr2_-_214015053 0.749 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr10_+_95848811 0.745 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr1_+_159141376 0.745 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr18_-_65182507 0.744 DSEL
dermatan sulfate epimerase-like
chr5_-_150537335 0.744 NM_001155
ANXA6
annexin A6
chr2_-_175462428 0.742 WIPF1
WAS/WASL interacting protein family, member 1
chr5_-_146833150 0.740 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr5_+_59784004 0.737 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_+_148447966 0.728 NM_032049
AGTR1
angiotensin II receptor, type 1
chr3_+_46619075 0.719 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr5_-_111312522 0.712 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr1_+_183774214 0.710 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr9_-_79520878 0.708 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr11_-_62472901 0.704


chr2_-_211179765 0.703 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr19_+_58152331 0.699 ZNF211
zinc finger protein 211
chr21_-_39288661 0.697 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr11_-_33890931 0.695 LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_201708648 0.691 NAV1
neuron navigator 1
chr5_-_75919051 0.683 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr3_+_29322802 0.680 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr11_+_126152979 0.675 NM_001039661
NM_148910
TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

chr7_+_134576187 0.673 CALD1
caldesmon 1
chr9_+_92219926 0.673 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr16_+_2807490 0.671


chr9_-_95186559 0.668 NM_005014
OMD
osteomodulin
chr8_-_72268720 0.666 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr12_-_91505215 0.666 LUM
lumican
chrX_-_135749436 0.657 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_-_175499275 0.655 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr10_+_90639900 0.651 NM_020799
STAMBPL1
STAM binding protein-like 1
chr2_-_175712276 0.646 NM_001206602
CHN1
chimerin (chimaerin) 1
chr10_-_14372807 0.641 NM_018027
FRMD4A
FERM domain containing 4A
chr3_-_58563490 0.640 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr10_+_70847817 0.639 NM_002727
SRGN
serglycin
chrX_-_99987072 0.637 NM_001129896
SYTL4
synaptotagmin-like 4
chr2_-_152146373 0.633 NM_004688
NMI
N-myc (and STAT) interactor
chr7_+_142552547 0.627 NM_004445
EPHB6
EPH receptor B6
chr6_+_31623688 0.616 APOM
apolipoprotein M
chr12_-_56236614 0.615 NM_002429
MMP19
matrix metallopeptidase 19
chr3_+_45927995 0.615 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr2_+_202671197 0.613 NM_139158
CDK15
cyclin-dependent kinase 15
chr12_-_91505541 0.611 NM_002345
LUM
lumican
chr10_+_91087601 0.611 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr5_+_140743755 0.609 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr6_+_31623668 0.608 NM_019101
APOM
apolipoprotein M
chr8_+_17396285 0.608 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr9_-_73483933 0.606 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chrX_+_80457559 0.605 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr12_+_103981050 0.604 NM_017564
STAB2
stabilin 2
chr4_-_39640461 0.600 NM_174921
C4orf34
chromosome 4 open reading frame 34
chrX_+_80457597 0.600 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr10_+_91092238 0.595 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_+_109204777 0.588 LIMS1
LIM and senescent cell antigen-like domains 1
chr4_+_74347461 0.584 NM_001133
AFM
afamin
chrX_+_80457302 0.579 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr2_+_152214105 0.576 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr13_-_44203608 0.575 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr7_+_104681378 0.571 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr12_-_47219734 0.570 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr5_-_138211054 0.569 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr10_+_70847857 0.568 SRGN
serglycin
chr4_-_159093717 0.568 NM_016613
FAM198B
family with sequence similarity 198, member B
chr5_+_304290 0.566 NM_001242412
NM_020731
AHRR

aryl-hydrocarbon receptor repressor

chr13_+_24144402 0.565 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr1_-_17307107 0.565 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr1_-_104238785 0.562 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chrX_+_73164162 0.561 JPX
JPX transcript, XIST activator (non-protein coding)
chr1_+_104159953 0.560 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr13_+_31287614 0.559 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr8_+_77593506 0.558 NM_024721
ZFHX4
zinc finger homeobox 4
chr8_+_97506141 0.558 SDC2
syndecan 2
chr4_+_55095433 0.558 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chrX_+_22050920 0.556 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr11_-_96076328 0.554 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr1_-_162838550 0.550 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr1_+_145727712 0.549 PDZK1
PDZ domain containing 1
chr3_-_187452669 0.544 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr7_-_137620651 0.544 CREB3L2
cAMP responsive element binding protein 3-like 2
chr20_-_58507172 0.538 NM_014258
SYCP2
synaptonemal complex protein 2
chr2_-_207082626 0.535 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr1_-_150780705 0.532 NM_000396
CTSK
cathepsin K
chr1_+_145727665 0.523 NM_001201325
NM_001201326
NM_002614
PDZK1


PDZ domain containing 1


chr1_+_104198301 0.522 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr13_+_76194569 0.522 NM_005358
LMO7
LIM domain 7
chr16_-_20911560 0.520 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr7_+_120628867 0.520 C7orf58
chromosome 7 open reading frame 58

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 1.26e-03 GO:0007155 cell adhesion
1.55 1.26e-03 GO:0022610 biological adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.24 1.43e-02 GO:0030055 cell-substrate junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.07 5.10e-04 GO:0005488 binding
1.11 1.04e-02 GO:0005515 protein binding