Motif ID: IRF1,2,7.p3

Z-value: 3.456


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF1chr5_-_1318264260.724.5e-02Click!
IRF7chr11_-_6159200.591.3e-01Click!
IRF2chr4_-_1853956160.206.3e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_79086087 9.277 NM_006820
 IFI44L
interferon-induced protein 44-like
chr11_+_113931228 5.592 NM_001018011
 ZBTB16
zinc finger and BTB domain containing 16
chr4_-_138453628 3.361 NM_019035
 PCDH18
protocadherin 18
chr20_-_48099178 3.136 NM_004975
 KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr11_+_63304272 3.127 NM_004585
 RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr1_+_948846 3.000 NM_005101
 ISG15
ISG15 ubiquitin-like modifier
chr5_+_32710742 2.767 NM_001204376
 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr10_+_91152321 2.754 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr8_+_97657592 2.507 PGCP
plasma glutamate carboxypeptidase
chr1_+_221052845 2.336 HLX
H2.0-like homeobox
chr1_+_221052735 2.323 NM_021958
 HLX
H2.0-like homeobox
chr11_-_104916041 2.292 NM_001017534
NM_052889
 CARD16

caspase recruitment domain family, member 16

chr1_+_79115476 2.224 NM_006417
 IFI44
interferon-induced protein 44
chr7_-_122526781 2.148 NM_001009571
NM_001167940
NM_017954
 CADPS2


Ca++-dependent secretion activator 2


chr16_-_67970651 2.128 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr5_-_95158465 2.099 NM_001118890
NM_001243658
NM_001243659
NM_002064
 GLRX



glutaredoxin (thioltransferase)



chr13_-_43566301 2.094 NM_001002264
NM_033255
 EPSTI1

epithelial stromal interaction 1 (breast)

chr11_-_57335080 2.083 NM_004223
 UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_-_27998700 2.058 IFI6
interferon, alpha-inducible protein 6
chr11_+_5710816 2.055 NM_001199573
NM_006074
 TRIM22

tripartite motif containing 22


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 56 entries
enrichment   p-value GO term description
12.37 3.38e-02 GO:0045071 negative regulation of viral genome replication
12.37 3.38e-02 GO:0048525 negative regulation of viral reproduction
9.11 5.01e-18 GO:0034340 response to type I interferon
8.94 4.71e-17 GO:0060337 type I interferon-mediated signaling pathway
8.94 4.71e-17 GO:0071357 cellular response to type I interferon
8.58 1.46e-06 GO:0060338 regulation of type I interferon-mediated signaling pathway
7.70 3.37e-02 GO:0045069 regulation of viral genome replication
5.18 5.77e-15 GO:0009615 response to virus
4.87 5.33e-04 GO:0001959 regulation of cytokine-mediated signaling pathway
4.79 6.71e-04 GO:0060759 regulation of response to cytokine stimulus
4.54 4.40e-02 GO:0032479 regulation of type I interferon production
4.22 1.86e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.22 1.86e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
4.22 1.86e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.22 1.86e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.22 1.86e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.22 1.86e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
4.22 1.86e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.22 1.86e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.09 1.63e-10 GO:0019221 cytokine-mediated signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
8.91 6.54e-05 GO:0005839 proteasome core complex
3.77 1.98e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
19.80 2.99e-03 GO:0047023 androsterone dehydrogenase activity
14.85 1.94e-04 GO:0005132 interferon-alpha/beta receptor binding
8.49 1.62e-04 GO:0004298 threonine-type endopeptidase activity
8.49 1.62e-04 GO:0070003 threonine-type peptidase activity
2.55 7.45e-03 GO:0005125 cytokine activity
1.95 1.70e-02 GO:0008289 lipid binding
1.42 6.75e-03 GO:0008270 zinc ion binding