Motif ID: IRF1,2,7.p3

Z-value: 3.456


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF1chr5_-_1318264260.724.5e-02Click!
IRF7chr11_-_6159200.591.3e-01Click!
IRF2chr4_-_1853956160.206.3e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_79086087 9.277 NM_006820
IFI44L
interferon-induced protein 44-like
chr11_+_113931228 5.592 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr4_-_138453628 3.361 NM_019035
PCDH18
protocadherin 18
chr20_-_48099178 3.136 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr11_+_63304272 3.127 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr1_+_948846 3.000 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr5_+_32710742 2.767 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr10_+_91152321 2.754 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr8_+_97657592 2.507 PGCP
plasma glutamate carboxypeptidase
chr1_+_221052845 2.336 HLX
H2.0-like homeobox
chr1_+_221052735 2.323 NM_021958
HLX
H2.0-like homeobox
chr11_-_104916041 2.292 NM_001017534
NM_052889
CARD16

caspase recruitment domain family, member 16

chr1_+_79115476 2.224 NM_006417
IFI44
interferon-induced protein 44
chr7_-_122526781 2.148 NM_001009571
NM_001167940
NM_017954
CADPS2


Ca++-dependent secretion activator 2


chr16_-_67970651 2.128 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr5_-_95158465 2.099 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr13_-_43566301 2.094 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr11_-_57335080 2.083 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_-_27998700 2.058 IFI6
interferon, alpha-inducible protein 6
chr11_+_5710816 2.055 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr9_-_123812535 2.037 NM_001735
C5
complement component 5
chr1_-_27998719 2.007 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr9_+_90112754 2.004 NM_004938
DAPK1
death-associated protein kinase 1
chrX_+_80457559 1.980 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr6_+_26440699 1.979 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr5_-_95158365 1.898 GLRX
glutaredoxin (thioltransferase)
chr1_-_27998658 1.889 IFI6
interferon, alpha-inducible protein 6
chr16_-_67970734 1.889 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr3_-_114343052 1.877 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_114478117 1.865 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr10_+_91092238 1.860 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr4_+_8951476 1.859 NM_001040071
LOC650293
seven transmembrane helix receptor
chr9_-_97402530 1.834 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr6_+_32821924 1.807 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr9_-_21305311 1.801 NM_002169
IFNA5
interferon, alpha 5
chr10_+_91087601 1.730 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr7_-_92777657 1.721 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chrX_+_80457597 1.681 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr22_+_18632841 1.677 USP18
ubiquitin specific peptidase 18
chr1_+_221053000 1.674 HLX
H2.0-like homeobox
chr7_-_122526410 1.657 CADPS2
Ca++-dependent secretion activator 2
chr9_-_95298251 1.656 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr22_+_18632704 1.636 NM_017414
USP18
ubiquitin specific peptidase 18
chrX_+_80457302 1.588 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chrX_+_66788682 1.576 NM_001011645
AR
androgen receptor
chr4_+_186990308 1.531 NM_003265
TLR3
toll-like receptor 3
chr3_-_49851356 1.528 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr12_-_15374290 1.468 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr3_-_49851217 1.452 UBA7
ubiquitin-like modifier activating enzyme 7
chr12_+_94542239 1.450 NM_005761
PLXNC1
plexin C1
chr3_+_187086167 1.374 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr7_+_154720154 1.346 LOC100132707
uncharacterized LOC100132707
chr11_-_102826433 1.321 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr7_+_142552547 1.276 NM_004445
EPHB6
EPH receptor B6
chr5_+_131746579 1.248 C5orf56
chromosome 5 open reading frame 56
chr6_+_26402464 1.246 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr19_+_10196757 1.234 NM_018381
C19orf66
chromosome 19 open reading frame 66
chr3_+_154797910 1.232 NM_007288
MME
membrane metallo-endopeptidase
chr1_+_27668499 1.228 SYTL1
synaptotagmin-like 1
chr19_+_10196972 1.224 C19orf66
chromosome 19 open reading frame 66
chr1_+_27668462 1.218 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr6_+_72922513 1.196 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr17_+_25958257 1.190 LGALS9
lectin, galactoside-binding, soluble, 9
chr10_+_91061705 1.183 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chrX_+_102883647 1.175 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr19_-_49371710 1.169 NM_001161354
NM_020904
PLEKHA4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

chr17_+_25958245 1.157 LGALS9
lectin, galactoside-binding, soluble, 9
chr19_+_44669214 1.149 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr3_+_51977286 1.132 PARP3
poly (ADP-ribose) polymerase family, member 3
chr5_+_156696351 1.126 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr22_-_29075708 1.121 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr19_-_17516383 1.102 NM_004335
BST2
bone marrow stromal cell antigen 2
chr17_+_6659356 1.094 XAF1
XIAP associated factor 1
chr4_-_138453564 1.077 PCDH18
protocadherin 18
chr3_+_51976274 1.075 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr17_+_6659155 1.073 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr18_-_65182507 1.066 DSEL
dermatan sulfate epimerase-like
chrX_+_102883891 1.061 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr3_+_11178778 1.020 NM_001098213
HRH1
histamine receptor H1
chr3_+_154798078 0.998 NM_007289
MME
membrane metallo-endopeptidase
chr4_+_142557722 0.994 NM_000585
NM_172175
IL15

interleukin 15

chr8_-_93029864 0.993 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_161068150 0.988 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr17_-_53800074 0.985 NM_018286
TMEM100
transmembrane protein 100
chr4_-_156874993 0.978 NM_001334
CTSO
cathepsin O
chr6_+_31913852 0.976 CFB
complement factor B
chr17_-_40264687 0.976 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr11_+_58390145 0.970 NM_000614
CNTF
ciliary neurotrophic factor
chrX_+_110366304 0.951 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr2_-_152146133 0.945 NMI
N-myc (and STAT) interactor
chr6_+_31913763 0.941 CFB
complement factor B
chr11_-_104972147 0.940 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr4_+_41614725 0.925 LIMCH1
LIM and calponin homology domains 1
chr6_+_25963398 0.920 TRIM38
tripartite motif containing 38
chr11_+_114167168 0.915 NNMT
nicotinamide N-methyltransferase
chr11_+_114167197 0.914 NNMT
nicotinamide N-methyltransferase
chr1_-_149908759 0.911 NM_001145862
MTMR11
myotubularin related protein 11
chr22_-_36635552 0.891 APOL2
apolipoprotein L, 2
chr6_+_31913708 0.878 NM_001710
CFB
complement factor B
chr5_-_111093251 0.876 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr3_-_122283423 0.872 NM_001146103
NM_031458
PARP9

poly (ADP-ribose) polymerase family, member 9

chr4_-_100242487 0.865 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr19_+_10197023 0.850 C19orf66
chromosome 19 open reading frame 66
chr6_-_138820580 0.845


chr9_+_131684561 0.844 NM_001100877
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chrX_+_100333835 0.843 NM_021637
TMEM35
transmembrane protein 35
chr1_-_149908721 0.838 MTMR11
myotubularin related protein 11
chr9_-_97402556 0.824 FBP1
fructose-1,6-bisphosphatase 1
chr2_-_152146373 0.819 NM_004688
NMI
N-myc (and STAT) interactor
chr14_-_60097223 0.818 RTN1
reticulon 1
chr13_+_31309644 0.814 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr17_-_67138013 0.812 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr15_+_74287132 0.811 PML
promyelocytic leukemia
chr13_-_34250899 0.802 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_-_28390506 0.800 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr6_-_32811773 0.789 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr13_+_102104941 0.786 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr19_-_47735858 0.783 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr22_-_36556781 0.777 NM_145640
APOL3
apolipoprotein L, 3
chr12_+_26348488 0.762 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_+_174843523 0.759 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr11_+_65266642 0.755


chr11_-_57335756 0.753 NM_198183
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr12_-_4758175 0.752 AKAP3
A kinase (PRKA) anchor protein 3
chr20_+_388963 0.749 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr13_-_44203608 0.741 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr2_-_101767714 0.731 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr3_-_28390280 0.730 AZI2
5-azacytidine induced 2
chr20_+_388693 0.727 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr9_-_21202201 0.725 NM_021057
IFNA7
interferon, alpha 7
chr3_-_100712248 0.724 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_-_89530890 0.719 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr19_+_17516502 0.717 LOC100507535
uncharacterized LOC100507535
chr19_+_9486991 0.711 NM_001172651
ZNF177
zinc finger protein 177
chr13_+_31309690 0.709 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr3_-_145968819 0.704 PLSCR4
phospholipid scramblase 4
chrX_+_103031753 0.703 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr6_-_32812189 0.699 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr12_+_26348268 0.698 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr22_+_36649172 0.692 APOL1
apolipoprotein L, 1
chr17_-_15586192 0.690 NM_006470
TRIM16
tripartite motif containing 16
chr2_+_61389628 0.689 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr7_+_93551015 0.686 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr20_+_389346 0.685 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_163041694 0.683 NM_001113380
RGS4
regulator of G-protein signaling 4
chr5_+_75699003 0.683 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr19_+_30863318 0.678 NM_014717
ZNF536
zinc finger protein 536
chr17_-_66951381 0.667 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chrX_-_39956655 0.662 NM_001123385
NM_017745
BCOR

BCL6 corepressor

chr10_+_92980322 0.653 NM_032373
PCGF5
polycomb group ring finger 5
chr11_+_65266462 0.652 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr1_+_229440128 0.651 NM_006542
SPHAR
S-phase response (cyclin related)
chr15_+_74287107 0.650 PML
promyelocytic leukemia
chr8_+_97506020 0.649 SDC2
syndecan 2
chr17_+_4643318 0.647 NM_001136046
NM_032265
ZMYND15

zinc finger, MYND-type containing 15

chr11_-_320775 0.647 NM_021034
IFITM3
interferon induced transmembrane protein 3
chr19_-_6442004 0.638 SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr5_-_158526428 0.632 EBF1
early B-cell factor 1
chr9_-_21217303 0.628 NM_002173
IFNA16
interferon, alpha 16
chr3_+_48507621 0.627 TREX1
three prime repair exonuclease 1
chr16_+_56666533 0.624 NM_176870
MT1M
metallothionein 1M
chr17_+_46908371 0.617 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr22_-_32651317 0.617 NM_014227
SLC5A4
solute carrier family 5 (low affinity glucose cotransporter), member 4
chr10_+_115439632 0.606 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr22_+_36649116 0.605 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr6_-_110736748 0.599 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr11_-_320925 0.599 IFITM3
interferon induced transmembrane protein 3
chrX_+_56755666 0.598 LOC550643
uncharacterized LOC550643
chr4_+_52917440 0.597 NM_145263
SPATA18
spermatogenesis associated 18 homolog (rat)
chr5_+_140739589 0.592 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr6_-_56258891 0.588 COL21A1
collagen, type XXI, alpha 1
chr10_+_115439425 0.587 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr3_+_122399665 0.575 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr18_+_61575203 0.575 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr3_+_48507209 0.568 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr1_-_182558344 0.567 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr16_+_66968365 0.563 CES2
carboxylesterase 2
chr9_-_21077804 0.562 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr9_+_120466607 0.562 TLR4
toll-like receptor 4
chr16_+_66968360 0.562 CES2
carboxylesterase 2
chr3_-_187452669 0.561 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr6_+_126240369 0.561 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr10_+_63808968 0.554 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_+_18343794 0.552 NM_001142307
NM_005316
GTF2H1

general transcription factor IIH, polypeptide 1, 62kDa

chrX_+_54947228 0.549 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr4_-_8073711 0.547 ABLIM2
actin binding LIM protein family, member 2
chr16_-_21289637 0.540 CRYM
crystallin, mu
chr16_+_55515468 0.538 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr7_-_124430742 0.538 NM_001024603
LOC154872
uncharacterized LOC154872
chr6_+_155411422 0.535 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr9_-_73483933 0.533 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr12_-_11002051 0.531 NM_001098538
NM_007244
PRR4

proline rich 4 (lacrimal)

chr10_+_70847817 0.523 NM_002727
SRGN
serglycin
chr11_+_1874199 0.520 NM_002339
LSP1
lymphocyte-specific protein 1
chr9_-_115818967 0.519 NM_003408
ZFP37
zinc finger protein 37 homolog (mouse)
chr1_-_163172863 0.518 NM_003617
RGS5
regulator of G-protein signaling 5
chr1_-_146644045 0.517 NM_005399
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr6_+_136172802 0.516 NM_018945
PDE7B
phosphodiesterase 7B
chr1_+_162602308 0.515 DDR2
discoidin domain receptor tyrosine kinase 2
chr16_+_66968390 0.514 CES2
carboxylesterase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.11 5.01e-18 GO:0034340 response to type I interferon
8.94 4.71e-17 GO:0060337 type I interferon-mediated signaling pathway
8.94 4.71e-17 GO:0071357 cellular response to type I interferon
5.18 5.77e-15 GO:0009615 response to virus
3.29 2.87e-12 GO:0045087 innate immune response
2.41 1.24e-10 GO:0006955 immune response
4.09 1.63e-10 GO:0019221 cytokine-mediated signaling pathway
2.93 8.59e-10 GO:0051707 response to other organism
3.69 4.81e-09 GO:0071345 cellular response to cytokine stimulus
2.20 2.65e-08 GO:0006952 defense response
1.94 2.77e-08 GO:0002376 immune system process
3.08 5.38e-08 GO:0034097 response to cytokine stimulus
2.53 9.08e-08 GO:0009607 response to biotic stimulus
2.08 1.87e-07 GO:0051704 multi-organism process
8.58 1.46e-06 GO:0060338 regulation of type I interferon-mediated signaling pathway
1.55 3.28e-04 GO:0048583 regulation of response to stimulus
4.87 5.33e-04 GO:0001959 regulation of cytokine-mediated signaling pathway
4.79 6.71e-04 GO:0060759 regulation of response to cytokine stimulus
1.95 8.32e-04 GO:0002682 regulation of immune system process
1.46 8.36e-04 GO:0006950 response to stress
2.43 1.12e-03 GO:0031347 regulation of defense response
3.91 2.45e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
1.76 2.87e-03 GO:0070887 cellular response to chemical stimulus
3.52 3.26e-03 GO:0042770 signal transduction in response to DNA damage
1.59 3.59e-03 GO:0009966 regulation of signal transduction
2.23 3.75e-03 GO:0032270 positive regulation of cellular protein metabolic process
2.12 4.90e-03 GO:0050776 regulation of immune response
2.18 4.91e-03 GO:0051247 positive regulation of protein metabolic process
1.79 5.25e-03 GO:0044093 positive regulation of molecular function
3.86 6.03e-03 GO:2000045 regulation of G1/S transition of mitotic cell cycle
1.90 6.20e-03 GO:0071310 cellular response to organic substance
2.02 6.43e-03 GO:0080134 regulation of response to stress
2.81 9.40e-03 GO:0045088 regulation of innate immune response
4.08 1.30e-02 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
3.81 1.48e-02 GO:0031575 mitotic cell cycle G1/S transition checkpoint
3.81 1.48e-02 GO:0071779 G1/S transition checkpoint
1.28 1.68e-02 GO:0051716 cellular response to stimulus
1.81 1.85e-02 GO:0043085 positive regulation of catalytic activity
4.22 1.86e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.22 1.86e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
4.22 1.86e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.22 1.86e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.22 1.86e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.22 1.86e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
4.22 1.86e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.22 1.86e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
1.49 2.60e-02 GO:0023051 regulation of signaling
1.20 3.08e-02 GO:0050896 response to stimulus
4.02 3.23e-02 GO:0071158 positive regulation of cell cycle arrest
7.70 3.37e-02 GO:0045069 regulation of viral genome replication
12.37 3.38e-02 GO:0045071 negative regulation of viral genome replication
12.37 3.38e-02 GO:0048525 negative regulation of viral reproduction
2.13 3.51e-02 GO:0044419 interspecies interaction between organisms
1.58 3.57e-02 GO:0050790 regulation of catalytic activity
4.54 4.40e-02 GO:0032479 regulation of type I interferon production
2.22 4.60e-02 GO:0031401 positive regulation of protein modification process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.91 6.54e-05 GO:0005839 proteasome core complex
3.77 1.98e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.49 1.62e-04 GO:0004298 threonine-type endopeptidase activity
8.49 1.62e-04 GO:0070003 threonine-type peptidase activity
14.85 1.94e-04 GO:0005132 interferon-alpha/beta receptor binding
19.80 2.99e-03 GO:0047023 androsterone dehydrogenase activity
1.42 6.75e-03 GO:0008270 zinc ion binding
2.55 7.45e-03 GO:0005125 cytokine activity
1.95 1.70e-02 GO:0008289 lipid binding