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Motif ID: KLF12.p2

Z-value: 2.860

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_-_2018334	1.935		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018568	1.854		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018446	1.838		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_1665306	1.618		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665342	1.560		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_2017822	1.527		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_1665281	1.493		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_117070039	1.314	NM_001001522 NM_003186	TAGLN	transgelin
chr7_+_142552547	1.312	NM_004445	EPHB6	EPH receptor B6
chr1_+_159175048	1.227	NM_001122951	DARC	Duffy blood group, chemokine receptor
chr1_-_46598250	1.208	NM_003629 NM_001114172	PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr8_-_108510094	1.175	NM_001146 NM_001199859	ANGPT1	angiopoietin 1
chr3_-_87040246	1.132	NM_016206	VGLL3	vestigial like 3 (Drosophila)
chr17_+_1665233	1.129	NM_002615	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_2018703	1.072		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr10_+_20105344	1.063	NM_032812	PLXDC2	plexin domain containing 2
chr1_+_203274646	1.060	NM_006763	BTG2	BTG family, member 2
chr21_-_47604360	1.032	NM_001142854 NM_032261	C21orf56	chromosome 21 open reading frame 56
chr1_+_145438437	1.013	NM_006472	TXNIP	thioredoxin interacting protein
chr5_-_149535138	0.991		PDGFRB	platelet-derived growth factor receptor, beta polypeptide
chr1_-_168698412	0.988	NM_001937	DPT	dermatopontin
chr14_-_21994342	0.988		SALL2	sal-like 2 (Drosophila)
chr5_-_81046943	0.985	NM_012446	SSBP2	single-stranded DNA binding protein 2
chr6_-_46459710	0.962	NM_001251973	RCAN2	regulator of calcineurin 2
chr21_-_47604340	0.946		C21orf56	chromosome 21 open reading frame 56
chr5_-_81046858	0.940		SSBP2	single-stranded DNA binding protein 2
chr12_+_53817638	0.913	NM_001164690 NM_001164691 NM_020547	AMHR2	anti-Mullerian hormone receptor, type II
chr4_-_57522469	0.912	NM_001145459 NM_139211	HOPX	HOP homeobox
chr17_+_48172508	0.912	NM_001199900 NM_002611 NM_001199899	PDK2	pyruvate dehydrogenase kinase, isozyme 2
chr7_+_100199881	0.904	NM_002593	PCOLCE	procollagen C-endopeptidase enhancer
chr16_+_67312057	0.874	NM_001129727	PLEKHG4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr6_+_72596405	0.874		RIMS1	regulating synaptic membrane exocytosis 1
chr1_-_184006491	0.854		GLT25D2	glycosyltransferase 25 domain containing 2
chr1_+_215256559	0.839	NM_001017425 NM_014217	KCNK2	potassium channel, subfamily K, member 2
chr11_+_113930430	0.829	NM_006006	ZBTB16	zinc finger and BTB domain containing 16
chr8_-_48650683	0.828		CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr11_+_113930296	0.827		ZBTB16	zinc finger and BTB domain containing 16
chr19_-_18654280	0.816		FKBP8	FK506 binding protein 8, 38kDa
chr6_+_112408673	0.784	NM_001033564	C6orf225	chromosome 6 open reading frame 225
chr21_-_47604300	0.782		C21orf56	chromosome 21 open reading frame 56
chr12_+_79258448	0.764	NM_005639	SYT1	synaptotagmin I
chr15_+_74218811	0.760		LOXL1	lysyl oxidase-like 1
chr12_+_79258517	0.754		SYT1	synaptotagmin I
chr16_+_85646923	0.738	NM_014615	KIAA0182	KIAA0182
chr9_+_34652125	0.732	NM_001142784	IL11RA	interleukin 11 receptor, alpha
chr10_-_81205091	0.721	NM_153367	ZCCHC24	zinc finger, CCHC domain containing 24
chr20_+_34742656	0.710	NM_012156	EPB41L1	erythrocyte membrane protein band 4.1-like 1
chr7_+_94023872	0.697	NM_000089	COL1A2	collagen, type I, alpha 2
chr9_+_139871954	0.694	NM_000954	PTGDS	prostaglandin D2 synthase 21kDa (brain)
chr5_+_139060058	0.676		CXXC5	CXXC finger protein 5
chr6_+_52442104	0.667		FLJ37798	uncharacterized LOC401264
chr12_+_79258588	0.655		SYT1	synaptotagmin I
chr10_+_111969988	0.651	NM_001008541	MXI1	MAX interactor 1
chr5_+_139060186	0.643		CXXC5	CXXC finger protein 5
chr5_+_133842276	0.640
chr5_-_168727715	0.637	NM_003062	SLIT3	slit homolog 3 (Drosophila)
chr11_+_308106	0.624	NM_006435	IFITM2	interferon induced transmembrane protein 2 (1-8D)
chr17_+_78518742	0.621		RPTOR	regulatory associated protein of MTOR, complex 1
chr6_+_89790464	0.621		PNRC1	proline-rich nuclear receptor coactivator 1
chr17_+_38599651	0.613	NM_001552	IGFBP4	insulin-like growth factor binding protein 4
chr7_-_150946031	0.609		SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_+_164528914	0.608		PBX1	pre-B-cell leukemia homeobox 1
chr11_-_2019007	0.608		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr19_-_49371710	0.607	NM_001161354 NM_020904	PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr11_-_77899640	0.607	NM_001029859	KCTD21	potassium channel tetramerisation domain containing 21
chr3_-_121379757	0.606	NM_005335	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr6_+_89790412	0.602	NM_006813	PNRC1	proline-rich nuclear receptor coactivator 1
chr2_+_46769821	0.599	NM_012249	RHOQ	ras homolog gene family, member Q
chr1_+_170633312	0.598	NM_006902 NM_022716	PRRX1	paired related homeobox 1
chr3_-_121379701	0.598		HCLS1	hematopoietic cell-specific Lyn substrate 1
chr2_+_24272627	0.597		FKBP1B	FK506 binding protein 1B, 12.6 kDa
chr20_+_13976014	0.592	NM_080676	MACROD2	MACRO domain containing 2
chr2_-_220436010	0.588		OBSL1	obscurin-like 1
chr2_+_24272583	0.588	NM_004116 NM_054033	FKBP1B	FK506 binding protein 1B, 12.6 kDa
chr10_-_32636084	0.586	NM_025209	EPC1	enhancer of polycomb homolog 1 (Drosophila)
chr11_-_1771823	0.585	NM_001170820	IFITM10	interferon induced transmembrane protein 10
chr19_+_56158953	0.583	NM_013301	CCDC106	coiled-coil domain containing 106
chr14_-_34419957	0.582	NM_022073	EGLN3	egl nine homolog 3 (C. elegans)
chr19_-_51869579	0.581		ETFB	electron-transfer-flavoprotein, beta polypeptide
chr16_+_20911987	0.577	NM_001128301 NM_001128302	LYRM1	LYR motif containing 1
chr12_+_57482886	0.573		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr5_+_139060295	0.557		CXXC5	CXXC finger protein 5
chr11_-_1769086	0.556		IFITM10	interferon induced transmembrane protein 10
chr17_-_43045612	0.555	NM_006688	C1QL1	complement component 1, q subcomponent-like 1
chrX_+_135251454	0.553	NM_001159704	FHL1	four and a half LIM domains 1
chr9_-_95244750	0.550	NM_001193335 NM_017680	ASPN	asporin
chr17_-_5404304	0.544	NM_001162371	LOC728392	uncharacterized LOC728392
chr11_-_2019070	0.540		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr6_-_166796459	0.537	NM_016098	BRP44L	brain protein 44-like
chr14_-_103988829	0.536		CKB	creatine kinase, brain
chr19_+_45409003	0.533	NM_000041	APOE	apolipoprotein E
chr16_+_67312688	0.531		PLEKHG4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr7_-_27702357	0.530		HIBADH	3-hydroxyisobutyrate dehydrogenase
chr8_+_37654833	0.528		GPR124	G protein-coupled receptor 124
chr8_+_37654395	0.522	NM_032777	GPR124	G protein-coupled receptor 124
chr11_-_104916041	0.521	NM_001017534 NM_052889	CARD16	caspase recruitment domain family, member 16
chr19_-_18654376	0.519	NM_012181	FKBP8	FK506 binding protein 8, 38kDa
chr15_-_89456592	0.515	NM_001114614 NM_005928	MFGE8	milk fat globule-EGF factor 8 protein
chr1_+_6845381	0.515	NM_001195563 NM_001242701 NM_015215	CAMTA1	calmodulin binding transcription activator 1
chr4_-_175443791	0.514	NM_000860 NM_001145816	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)
chr20_+_35169897	0.512		MYL9	myosin, light chain 9, regulatory
chr20_+_35169876	0.505	NM_006097 NM_181526	MYL9	myosin, light chain 9, regulatory
chr5_-_124080773	0.499	NM_020747	ZNF608	zinc finger protein 608
chr7_-_150945731	0.497	NM_001003801	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr16_-_4562979	0.496		C16orf5	chromosome 16 open reading frame 5
chr10_-_32635842	0.494		EPC1	enhancer of polycomb homolog 1 (Drosophila)
chr14_-_23821423	0.494	NM_020372	SLC22A17	solute carrier family 22, member 17
chr5_+_137801166	0.493		EGR1	early growth response 1
chr2_-_224467049	0.493		SCG2	secretogranin II
chr8_+_37654406	0.491		GPR124	G protein-coupled receptor 124
chr9_+_101705710	0.490	NM_001855	COL15A1	collagen, type XV, alpha 1
chr17_+_61699786	0.486	NM_002401 NM_203351	MAP3K3	mitogen-activated protein kinase kinase kinase 3
chrX_+_135251795	0.486	NM_001167819	FHL1	four and a half LIM domains 1
chr10_-_64576074	0.483		EGR2	early growth response 2
chr9_-_95244634	0.482		ASPN	asporin
chr16_-_10275743	0.479	NM_001134408	GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr5_-_172198160	0.478	NM_004417	DUSP1	dual specificity phosphatase 1
chr11_-_102401430	0.476	NM_002423	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)
chr12_+_7167979	0.476	NM_001734 NM_201442	C1S	complement component 1, s subcomponent
chr5_-_92916924	0.474		FLJ42709	uncharacterized LOC441094
chr2_-_220083658	0.474		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr3_-_99833348	0.474	NM_001042459 NM_182909	FILIP1L	filamin A interacting protein 1-like
chr8_+_75736771	0.471	NM_015886	PI15	peptidase inhibitor 15
chr17_+_80332152	0.470	NM_018949	UTS2R	urotensin 2 receptor
chr6_+_72596699	0.467		RIMS1	regulating synaptic membrane exocytosis 1
chr6_-_152702329	0.464		SYNE1	spectrin repeat containing, nuclear envelope 1
chr8_+_1952875	0.463		KBTBD11	kelch repeat and BTB (POZ) domain containing 11
chr16_-_67977956	0.463	NM_000229	LCAT	lecithin-cholesterol acyltransferase
chr19_+_33697959	0.463		LRP3	low density lipoprotein receptor-related protein 3
chr11_+_47279467	0.462	NM_001130101 NM_005693	NR1H3	nuclear receptor subfamily 1, group H, member 3
chr1_-_38471170	0.462	NM_001243878 NM_004468	FHL3	four and a half LIM domains 3
chr4_-_175443601	0.461		HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)
chr19_+_50353942	0.461		PTOV1	prostate tumor overexpressed 1
chr4_-_159094163	0.459	NM_001031700 NM_001128424	FAM198B	family with sequence similarity 198, member B
chr7_+_28448970	0.455		LOC401317	uncharacterized LOC401317
chr13_-_67804432	0.454	NM_020403 NM_203487	PCDH9	protocadherin 9
chr15_-_82336880	0.451		MEX3B	mex-3 homolog B (C. elegans)
chr16_-_66952729	0.449	NM_001204744 NM_001204745 NM_001204746 NM_004062	CDH16	cadherin 16, KSP-cadherin
chr2_+_185463092	0.448	NM_194250	ZNF804A	zinc finger protein 804A
chr2_-_220083699	0.447	NM_005689	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr7_-_27702504	0.442	NM_152740	HIBADH	3-hydroxyisobutyrate dehydrogenase
chr9_-_130712866	0.442	NM_203305	FAM102A	family with sequence similarity 102, member A
chr5_+_145718586	0.438	NM_002700	POU4F3	POU class 4 homeobox 3
chr2_-_220436267	0.436	NM_001173408 NM_001173431 NM_015311	OBSL1	obscurin-like 1
chr5_-_19988293	0.436	NM_001167667 NM_004934	CDH18	cadherin 18, type 2
chr1_+_159173802	0.436	NM_002036	DARC	Duffy blood group, chemokine receptor
chrX_+_86772714	0.436	NM_019117 NM_057162	KLHL4	kelch-like 4 (Drosophila)
chr10_-_44144151	0.434	NM_001005368	ZNF32	zinc finger protein 32
chr1_+_183605207	0.433	NM_015149	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr3_+_29322802	0.433	NM_001003792 NM_001003793 NM_001177711 NM_001177712 NM_014483	RBMS3	RNA binding motif, single stranded interacting protein 3
chr15_+_74218962	0.431		LOXL1	lysyl oxidase-like 1
chrX_-_151999259	0.431	NM_004344	CETN2	centrin, EF-hand protein, 2
chrX_-_48828250	0.431	NM_004979	KCND1	potassium voltage-gated channel, Shal-related subfamily, member 1
chr9_+_139872014	0.429		PTGDS	prostaglandin D2 synthase 21kDa (brain)
chr5_+_119799898	0.428		PRR16	proline rich 16
chr20_+_34287231	0.428	NM_080748	ROMO1	reactive oxygen species modulator 1
chr16_+_28877586	0.427		SH2B1	SH2B adaptor protein 1
chr12_+_79258794	0.426		SYT1	synaptotagmin I
chr5_+_119800004	0.425	NM_016644	PRR16	proline rich 16
chr17_+_17942584	0.422	NM_024052	C17orf39	chromosome 17 open reading frame 39
chr12_-_124457099	0.422	NM_025140	CCDC92	coiled-coil domain containing 92
chr20_-_34241830	0.421	NM_003915	CPNE1	copine I
chr20_-_30310597	0.420	NM_001191 NM_138578	BCL2L1	BCL2-like 1
chr11_+_124609841	0.419		NRGN	neurogranin (protein kinase C substrate, RC3)
chr1_+_159141376	0.418	NM_021189 NM_001127173	CADM3	cell adhesion molecule 3
chr7_+_76026819	0.417	NM_007155	ZP3	zona pellucida glycoprotein 3 (sperm receptor)
chr19_-_14260728	0.417		LPHN1	latrophilin 1
chr8_-_93029864	0.411	NM_175636	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_+_111765725	0.410	NM_019903	ADD3	adducin 3 (gamma)
chr16_+_20911556	0.408	NM_020424	LYRM1	LYR motif containing 1
chr7_+_90338711	0.408	NM_012395	CDK14	cyclin-dependent kinase 14
chr21_-_40685545	0.407		BRWD1	bromodomain and WD repeat domain containing 1
chr3_+_38032260	0.406		VILL	villin-like
chr7_+_90339146	0.405		CDK14	cyclin-dependent kinase 14
chr14_+_24837225	0.404	NM_001198965 NM_004554	NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr19_-_45681454	0.404	NM_024108	TRAPPC6A	trafficking protein particle complex 6A
chr17_+_66244220	0.404
chr5_-_149535420	0.403	NM_002609	PDGFRB	platelet-derived growth factor receptor, beta polypeptide
chr14_-_25103365	0.403	NM_004131	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr2_-_225266710	0.400	NM_001122779 NM_024785	FAM124B	family with sequence similarity 124B
chrX_+_85517970	0.400	NM_001139515	DACH2	dachshund homolog 2 (Drosophila)
chr19_-_51869632	0.400	NM_001985	ETFB	electron-transfer-flavoprotein, beta polypeptide
chr21_-_48024985	0.399	NM_006272	S100B	S100 calcium binding protein B
chr1_-_76397975	0.395	NM_080868	ASB17	ankyrin repeat and SOCS box containing 17
chr9_-_130667571	0.395		LOC100131355 ST6GALNAC6	uncharacterized LOC100131355 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr11_-_64052123	0.394		BAD	BCL2-associated agonist of cell death
chr17_-_53809444	0.394	NM_001099640	TMEM100	transmembrane protein 100
chr14_+_75894508	0.392	NM_001135047	JDP2	Jun dimerization protein 2
chr15_+_74218786	0.391	NM_005576	LOXL1	lysyl oxidase-like 1
chr19_+_50380681	0.390	NM_001168222 NM_024682	TBC1D17	TBC1 domain family, member 17
chr14_-_103989112	0.389		CKB	creatine kinase, brain
chr1_+_61869699	0.388		NFIA	nuclear factor I/A
chr5_-_176936857	0.387	NM_024872	DOK3	docking protein 3
chr15_+_74218794	0.387		LOXL1	lysyl oxidase-like 1
chr3_+_49449753	0.386		TCTA	T-cell leukemia translocation altered gene
chr16_+_29690328	0.386	NM_014298	QPRT	quinolinate phosphoribosyltransferase
chr3_-_114478117	0.383	NM_001164344 NM_001164345	ZBTB20	zinc finger and BTB domain containing 20
chr3_+_9944295	0.382	NM_153483	IL17RE	interleukin 17 receptor E
chrX_-_118827322	0.382	NM_015129 NM_145799 NM_145800 NM_145802	SEPT6	septin 6
chr11_+_113931228	0.380	NM_001018011	ZBTB16	zinc finger and BTB domain containing 16

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.07	1.96e-06	GO:0009987	cellular process
1.21	9.56e-06	GO:0048731	system development
1.20	1.24e-05	GO:0048856	anatomical structure development
1.18	3.44e-05	GO:0007275	multicellular organismal development
1.22	6.81e-05	GO:0048519	negative regulation of biological process
1.17	9.35e-05	GO:0032502	developmental process
1.22	3.47e-04	GO:0048523	negative regulation of cellular process
1.28	3.56e-04	GO:0007399	nervous system development
1.10	4.08e-04	GO:0050794	regulation of cellular process
1.29	5.41e-04	GO:0035556	intracellular signal transduction
1.19	1.05e-03	GO:0048518	positive regulation of biological process
1.20	1.23e-03	GO:0048522	positive regulation of cellular process
1.09	1.35e-03	GO:0050789	regulation of biological process
1.09	2.55e-03	GO:0065007	biological regulation
1.24	4.14e-03	GO:0023051	regulation of signaling
1.25	5.26e-03	GO:0009966	regulation of signal transduction
1.30	9.88e-03	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.30	9.96e-03	GO:0032774	RNA biosynthetic process
1.37	1.18e-02	GO:0051254	positive regulation of RNA metabolic process
1.36	1.48e-02	GO:0010628	positive regulation of gene expression
1.38	1.60e-02	GO:0045893	positive regulation of transcription, DNA-dependent
1.14	1.99e-02	GO:0023052	signaling
1.25	2.12e-02	GO:0009893	positive regulation of metabolic process
1.47	2.26e-02	GO:0007264	small GTPase mediated signal transduction
1.28	2.92e-02	GO:0009605	response to external stimulus
1.33	3.00e-02	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.14	3.05e-02	GO:0007165	signal transduction
1.30	3.08e-02	GO:0006351	transcription, DNA-dependent
1.33	3.68e-02	GO:0016192	vesicle-mediated transport
1.16	3.68e-02	GO:0071842	cellular component organization at cellular level
1.25	3.99e-02	GO:0031325	positive regulation of cellular metabolic process
1.38	4.17e-02	GO:0051253	negative regulation of RNA metabolic process
1.31	4.80e-02	GO:0051173	positive regulation of nitrogen compound metabolic process
1.20	4.84e-02	GO:0048583	regulation of response to stimulus

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.09	4.95e-12	GO:0044424	intracellular part
1.08	5.39e-12	GO:0005622	intracellular
1.10	1.01e-07	GO:0005737	cytoplasm
1.09	1.47e-07	GO:0043229	intracellular organelle
1.09	1.62e-07	GO:0043226	organelle
1.13	4.37e-06	GO:0005634	nucleus
1.08	7.79e-05	GO:0043231	intracellular membrane-bounded organelle
1.08	9.40e-05	GO:0043227	membrane-bounded organelle
1.21	3.06e-04	GO:0005829	cytosol

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.14	3.63e-11	GO:0005515	protein binding
1.08	3.67e-10	GO:0005488	binding
1.32	3.59e-04	GO:0001071	nucleic acid binding transcription factor activity
1.32	3.59e-04	GO:0003700	sequence-specific DNA binding transcription factor activity
1.37	1.25e-03	GO:0043565	sequence-specific DNA binding
2.37	3.71e-03	GO:0003707	steroid hormone receptor activity
2.33	3.91e-03	GO:0004879	ligand-dependent nuclear receptor activity
1.37	5.17e-03	GO:0005198	structural molecule activity
1.28	6.31e-03	GO:0030528	transcription regulator activity