Motif ID: KLF12.p2

Z-value: 2.860


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_747079130.591.2e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_2018334 1.935 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018568 1.854 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018446 1.838 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_1665306 1.618 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665342 1.560 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_2017822 1.527 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_1665281 1.493 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_117070039 1.314 NM_001001522
NM_003186
 TAGLN

transgelin

chr7_+_142552547 1.312 NM_004445
 EPHB6
EPH receptor B6
chr1_+_159175048 1.227 NM_001122951
 DARC
Duffy blood group, chemokine receptor
chr1_-_46598250 1.208 NM_003629
NM_001114172
 PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr8_-_108510094 1.175 NM_001146
NM_001199859
 ANGPT1

angiopoietin 1

chr3_-_87040246 1.132 NM_016206
 VGLL3
vestigial like 3 (Drosophila)
chr17_+_1665233 1.129 NM_002615
 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_2018703 1.072 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr10_+_20105344 1.063 NM_032812
 PLXDC2
plexin domain containing 2
chr1_+_203274646 1.060 NM_006763
 BTG2
BTG family, member 2
chr21_-_47604360 1.032 NM_001142854
NM_032261
 C21orf56

chromosome 21 open reading frame 56

chr1_+_145438437 1.013 NM_006472
 TXNIP
thioredoxin interacting protein
chr5_-_149535138 0.991 PDGFRB
platelet-derived growth factor receptor, beta polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
1.47 2.26e-02 GO:0007264 small GTPase mediated signal transduction
1.38 1.60e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.38 4.17e-02 GO:0051253 negative regulation of RNA metabolic process
1.37 1.18e-02 GO:0051254 positive regulation of RNA metabolic process
1.36 1.48e-02 GO:0010628 positive regulation of gene expression
1.33 3.00e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 3.68e-02 GO:0016192 vesicle-mediated transport
1.31 4.80e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.30 9.88e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.30 9.96e-03 GO:0032774 RNA biosynthetic process
1.30 3.08e-02 GO:0006351 transcription, DNA-dependent
1.29 5.41e-04 GO:0035556 intracellular signal transduction
1.28 3.56e-04 GO:0007399 nervous system development
1.28 2.92e-02 GO:0009605 response to external stimulus
1.25 5.26e-03 GO:0009966 regulation of signal transduction
1.25 2.12e-02 GO:0009893 positive regulation of metabolic process
1.25 3.99e-02 GO:0031325 positive regulation of cellular metabolic process
1.24 4.14e-03 GO:0023051 regulation of signaling
1.22 6.81e-05 GO:0048519 negative regulation of biological process
1.22 3.47e-04 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.21 3.06e-04 GO:0005829 cytosol
1.13 4.37e-06 GO:0005634 nucleus
1.10 1.01e-07 GO:0005737 cytoplasm
1.09 4.95e-12 GO:0044424 intracellular part
1.09 1.47e-07 GO:0043229 intracellular organelle
1.09 1.62e-07 GO:0043226 organelle
1.08 5.39e-12 GO:0005622 intracellular
1.08 7.79e-05 GO:0043231 intracellular membrane-bounded organelle
1.08 9.40e-05 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.37 3.71e-03 GO:0003707 steroid hormone receptor activity
2.33 3.91e-03 GO:0004879 ligand-dependent nuclear receptor activity
1.37 1.25e-03 GO:0043565 sequence-specific DNA binding
1.37 5.17e-03 GO:0005198 structural molecule activity
1.32 3.59e-04 GO:0001071 nucleic acid binding transcription factor activity
1.32 3.59e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.28 6.31e-03 GO:0030528 transcription regulator activity
1.14 3.63e-11 GO:0005515 protein binding
1.08 3.67e-10 GO:0005488 binding