Motif ID: KLF4.p3

Z-value: 0.409


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_110252045-0.502.1e-01Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_33285493 0.392 NM_005453
 ZBTB22
zinc finger and BTB domain containing 22
chr6_-_33285718 0.346 NM_001145338
 ZBTB22
zinc finger and BTB domain containing 22
chr18_+_11981552 0.308 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr9_+_130922471 0.306 NM_024112
 C9orf16
chromosome 9 open reading frame 16
chr2_+_30369868 0.300 YPEL5
yippee-like 5 (Drosophila)
chrY_-_1521733 0.297 NM_001173474
NM_004192
 ASMTL

acetylserotonin O-methyltransferase-like

chrY_-_1522648 0.289 NM_001173473
 ASMTL
acetylserotonin O-methyltransferase-like
chrX_-_1572648 0.286 NM_001173473
 ASMTL
acetylserotonin O-methyltransferase-like
chrX_-_1571733 0.273 NM_001173474
NM_004192
 ASMTL

acetylserotonin O-methyltransferase-like

chr18_+_11981421 0.266 NM_014214
 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr1_-_11714738 0.252 NM_012168
 FBXO2
F-box protein 2
chr18_+_11981457 0.243 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr19_+_8455265 0.239 RAB11B
RAB11B, member RAS oncogene family
chr14_-_99947080 0.233 SETD3
SET domain containing 3
chr16_+_3074027 0.231 NM_001142350
NM_024339
 THOC6

THO complex 6 homolog (Drosophila)

chr1_-_1850704 0.230 NM_178545
 TMEM52
transmembrane protein 52
chr2_+_30369800 0.227 YPEL5
yippee-like 5 (Drosophila)
chr19_+_8455243 0.224 RAB11B
RAB11B, member RAS oncogene family
chrX_-_134232663 0.208 LINC00087
long intergenic non-protein coding RNA 87
chr19_+_33166312 0.205 NM_207391
 RGS9BP
regulator of G protein signaling 9 binding protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 129 entries
enrichment   p-value GO term description
1.66 2.12e-04 GO:0031098 stress-activated protein kinase signaling cascade
1.65 2.92e-02 GO:0000209 protein polyubiquitination
1.65 2.92e-02 GO:0045787 positive regulation of cell cycle
1.64 3.10e-02 GO:0007254 JNK cascade
1.63 3.28e-02 GO:0008629 induction of apoptosis by intracellular signals
1.60 1.22e-03 GO:0007265 Ras protein signal transduction
1.51 1.38e-02 GO:0008286 insulin receptor signaling pathway
1.50 9.07e-03 GO:0006184 GTP catabolic process
1.49 5.92e-03 GO:0046039 GTP metabolic process
1.44 4.59e-08 GO:0007264 small GTPase mediated signal transduction
1.43 1.02e-02 GO:0043408 regulation of MAPKKK cascade
1.42 3.38e-02 GO:0032869 cellular response to insulin stimulus
1.40 3.83e-03 GO:0000165 MAPKKK cascade
1.39 1.24e-03 GO:0071900 regulation of protein serine/threonine kinase activity
1.39 1.92e-02 GO:0071375 cellular response to peptide hormone stimulus
1.38 1.31e-04 GO:0012502 induction of programmed cell death
1.37 1.83e-04 GO:0006917 induction of apoptosis
1.37 4.74e-02 GO:0032868 response to insulin stimulus
1.33 2.46e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.33 2.56e-05 GO:0043068 positive regulation of programmed cell death

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.95 6.92e-04 GO:0008287 protein serine/threonine phosphatase complex
1.44 1.49e-03 GO:0031252 cell leading edge
1.26 1.90e-19 GO:0005829 cytosol
1.24 4.06e-04 GO:0015630 microtubule cytoskeleton
1.23 8.25e-09 GO:0005654 nucleoplasm
1.21 5.63e-10 GO:0031981 nuclear lumen
1.20 4.06e-12 GO:0044428 nuclear part
1.19 8.59e-11 GO:0070013 intracellular organelle lumen
1.18 2.60e-10 GO:0043233 organelle lumen
1.18 5.36e-10 GO:0031974 membrane-enclosed lumen
1.17 6.63e-04 GO:0005739 mitochondrion
1.16 5.68e-24 GO:0005634 nucleus
1.15 6.78e-42 GO:0005737 cytoplasm
1.14 1.04e-22 GO:0044444 cytoplasmic part
1.13 1.07e-15 GO:0044446 intracellular organelle part
1.12 1.13e-55 GO:0044424 intracellular part
1.12 2.27e-36 GO:0043226 organelle
1.12 7.35e-34 GO:0043227 membrane-bounded organelle
1.12 8.56e-34 GO:0043231 intracellular membrane-bounded organelle
1.12 2.11e-14 GO:0044422 organelle part

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.41 3.09e-03 GO:0003924 GTPase activity
1.41 4.54e-02 GO:0004721 phosphoprotein phosphatase activity
1.33 3.77e-02 GO:0016791 phosphatase activity
1.32 7.94e-09 GO:0019899 enzyme binding
1.29 1.73e-02 GO:0042578 phosphoric ester hydrolase activity
1.28 2.30e-02 GO:0005525 GTP binding
1.27 3.06e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.27 3.97e-03 GO:0030695 GTPase regulator activity
1.26 2.61e-03 GO:0008092 cytoskeletal protein binding
1.25 2.96e-02 GO:0019904 protein domain specific binding
1.24 5.25e-05 GO:0016301 kinase activity
1.24 3.01e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.24 2.21e-03 GO:0004672 protein kinase activity
1.21 1.51e-10 GO:0035639 purine ribonucleoside triphosphate binding
1.21 2.26e-10 GO:0017076 purine nucleotide binding
1.21 2.86e-10 GO:0032553 ribonucleotide binding
1.21 2.86e-10 GO:0032555 purine ribonucleotide binding
1.21 5.32e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.19 1.26e-10 GO:0000166 nucleotide binding
1.19 7.45e-07 GO:0030554 adenyl nucleotide binding