Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.299


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7L2chr10_+_114710785-0.762.8e-02Click!
LEF1chr4_-_109087876-0.551.6e-01Click!
TCF7chr5_+_1334503530.492.1e-01Click!
TCF7L1chr2_+_853603730.206.3e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_127420690 2.149 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr8_+_32579350 1.128 NM_001159996
NRG1
neuregulin 1
chr1_-_242612757 1.066 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr15_+_43885251 1.044 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr2_+_47596447 0.992 EPCAM
epithelial cell adhesion molecule
chr19_-_51522953 0.942 NM_145888
KLK10
kallikrein-related peptidase 10
chr2_+_47596286 0.871 NM_002354
EPCAM
epithelial cell adhesion molecule
chr15_+_41136178 0.868 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr15_+_41136622 0.856 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr12_-_28124915 0.854 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr17_-_39507055 0.848 NM_004138
KRT33A
keratin 33A
chr6_-_11779279 0.834 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_-_177133950 0.812 NM_004319
NM_207108
ASTN1

astrotactin 1

chr1_-_177133818 0.809 ASTN1
astrotactin 1
chr5_+_66124603 0.647 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_-_75788079 0.633 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr2_+_204801453 0.630 NM_012092
ICOS
inducible T-cell co-stimulator
chr8_-_42234562 0.626 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr4_-_103265818 0.623 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr2_-_75788027 0.620 FAM176A
family with sequence similarity 176, member A
chr17_-_56494889 0.617 RNF43
ring finger protein 43
chr3_+_132757216 0.617 TMEM108
transmembrane protein 108
chr14_-_35344450 0.617 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_-_43424324 0.609 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr3_+_189349215 0.608 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr15_+_90744506 0.597 NM_198925
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr7_+_73245192 0.596 NM_001305
CLDN4
claudin 4
chr10_-_123356158 0.590 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr2_-_38525527 0.577 ATL2
atlastin GTPase 2
chr13_+_26042965 0.575 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr5_-_157002739 0.567 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr1_-_43424536 0.561 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr13_-_99910548 0.558 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr5_-_16936290 0.557 MYO10
myosin X
chr12_+_78225068 0.541 NM_014903
NAV3
neuron navigator 3
chr1_-_53793743 0.537 NM_001018054
NM_004631
NM_017522
NM_033300
LRP8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr5_+_140254930 0.533 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr17_-_39093671 0.529 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr5_+_140220811 0.529 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr4_-_103266396 0.527 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr5_-_16936371 0.516 NM_012334
MYO10
myosin X
chr10_-_88717319 0.504 NM_024756
MMRN2
multimerin 2
chr13_+_26042917 0.499 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr2_-_46384 0.488 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr2_-_9143742 0.479 NM_138799
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr1_+_156254069 0.478 NM_032323
TMEM79
transmembrane protein 79
chr5_-_16738346 0.476 MYO10
myosin X
chr6_-_2840683 0.476 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr17_-_56494930 0.474 NM_017763
RNF43
ring finger protein 43
chr1_+_160160284 0.470 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr6_+_96025343 0.466 NM_024641
MANEA
mannosidase, endo-alpha
chr8_-_16859540 0.465 NM_019851
FGF20
fibroblast growth factor 20
chr1_-_54303933 0.458 TMEM48
transmembrane protein 48
chr8_-_145047639 0.453 NM_201378
PLEC
plectin
chr18_+_11751470 0.448 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr14_-_35344852 0.443 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr1_+_13911966 0.431 NM_001006624
NM_001006625
PDPN

podoplanin

chr13_-_25496913 0.421 CENPJ
centromere protein J
chrX_-_117119282 0.419 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr4_-_103266286 0.416 NM_022154
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr6_+_37137882 0.410 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr18_+_59992519 0.404 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr17_+_30813928 0.399 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_-_53793583 0.397 LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr1_+_2036154 0.395 NM_001033582
PRKCZ
protein kinase C, zeta
chr14_-_21572374 0.391


chr10_-_123353771 0.380 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr10_+_7745325 0.380 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_87908551 0.379 NM_022337
RAB38
RAB38, member RAS oncogene family
chr5_+_36606667 0.378 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_24007822 0.375 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr15_+_94841429 0.372 NM_001159643
NM_018349
MCTP2

multiple C2 domains, transmembrane 2

chr17_+_38171613 0.371 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr1_-_6479880 0.368 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr3_-_167813058 0.367 GOLIM4
golgi integral membrane protein 4
chr3_-_123339178 0.366 MYLK
myosin light chain kinase
chr10_+_27444296 0.366 MASTL
microtubule associated serine/threonine kinase-like
chr1_+_153330329 0.365 NM_002965
S100A9
S100 calcium binding protein A9
chr8_-_139926235 0.363 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr1_+_207039153 0.352 NM_018724
IL20
interleukin 20
chr3_+_39371196 0.349 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr1_-_183559463 0.348 NCF2
neutrophil cytosolic factor 2
chr8_+_80523304 0.347 STMN2
stathmin-like 2
chr10_-_116392099 0.346 ABLIM1
actin binding LIM protein 1
chr5_+_140235594 0.346 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr1_+_172502291 0.344 NM_016227
C1orf9
chromosome 1 open reading frame 9
chr17_-_61518174 0.343 NM_001017917
CYB561
cytochrome b-561
chr1_-_183559669 0.342 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr3_-_123339423 0.342 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr1_-_54304107 0.341 NM_001168551
NM_018087
TMEM48

transmembrane protein 48

chr6_+_83073954 0.336 NM_001166392
TPBG
trophoblast glycoprotein
chr19_+_46733008 0.334 NM_198541
IGFL1
IGF-like family member 1
chr2_-_165478357 0.326 NM_004490
GRB14
growth factor receptor-bound protein 14
chr14_-_35344080 0.326 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr2_-_231989755 0.325 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr16_-_18812691 0.324 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr12_-_48963802 0.324 NM_002289
LALBA
lactalbumin, alpha-
chr3_-_79817058 0.324 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_-_29527477 0.322 UBD
ubiquitin D
chr21_+_39628663 0.321 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr19_+_11071583 0.314 NM_001128844
NM_003072
SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

chr2_-_165424993 0.313 GRB14
growth factor receptor-bound protein 14
chr8_-_15095791 0.311 NM_139167
SGCZ
sarcoglycan, zeta
chr7_+_20370324 0.311 ITGB8
integrin, beta 8
chr14_-_35344526 0.310 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr5_+_36606456 0.310 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr6_-_29527701 0.304 NM_006398
UBD
ubiquitin D
chr15_+_89631625 0.304 ABHD2
abhydrolase domain containing 2
chr6_-_138893666 0.301 NM_020464
NHSL1
NHS-like 1
chr1_-_109935869 0.297 NM_001205228
SORT1
sortilin 1
chr10_+_71561643 0.294 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr8_-_87081850 0.291 NM_033126
PSKH2
protein serine kinase H2
chr20_+_42965625 0.291 NM_178491
R3HDML
R3H domain containing-like
chr20_-_13971256 0.288 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chrX_+_49832214 0.288 NM_000084
CLCN5
chloride channel 5
chr10_+_7745341 0.287 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_67072881 0.283 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr14_-_35344490 0.282 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_-_115053677 0.282 TRIM33
tripartite motif containing 33
chr17_+_19990334 0.282 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr1_+_9648931 0.282 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr17_-_39646115 0.280 NM_003771
KRT36
keratin 36
chr7_-_158611301 0.278 ESYT2
extended synaptotagmin-like protein 2
chr19_-_17375522 0.277 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr6_-_136788012 0.277 NM_001198615
MAP7
microtubule-associated protein 7
chr10_-_5541401 0.276 NM_017422
CALML5
calmodulin-like 5
chr8_+_80523339 0.275 STMN2
stathmin-like 2
chr12_+_19282402 0.274 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr4_-_139163222 0.273 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr2_+_105471745 0.272 NM_006236
POU3F3
POU class 3 homeobox 3
chr2_-_208031570 0.271 KLF7
Kruppel-like factor 7 (ubiquitous)
chr19_-_6720585 0.269 NM_000064
C3
complement component 3
chr1_-_28503454 0.267 NM_000952
NM_001164723
PTAFR

platelet-activating factor receptor

chr18_+_55888799 0.266 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_-_132515290 0.265 NM_004878
PTGES
prostaglandin E synthase
chr17_+_36861398 0.265 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr12_+_53491417 0.263 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr2_-_100722259 0.263 AFF3
AF4/FMR2 family, member 3
chr10_+_27444263 0.263 MASTL
microtubule associated serine/threonine kinase-like
chr20_+_58630965 0.262 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr21_+_39628869 0.261 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr15_+_43985083 0.261 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr20_-_56284945 0.260 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr10_+_54074037 0.259 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr8_+_124194751 0.259 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr6_-_79787887 0.259 PHIP
pleckstrin homology domain interacting protein
chr8_-_29206321 0.259 NM_057158
DUSP4
dual specificity phosphatase 4
chr15_+_89631731 0.259 ABHD2
abhydrolase domain containing 2
chr11_-_30601919 0.258 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr9_-_117150217 0.258 AKNA
AT-hook transcription factor
chr3_+_132757170 0.257 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr17_+_59529778 0.256 TBX4
T-box 4
chr19_+_13134782 0.255 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_+_1151578 0.255 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr17_+_57232859 0.254 NM_018304
PRR11
proline rich 11
chr10_+_7745354 0.254 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr18_+_55888838 0.254 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_-_123353330 0.253 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr7_-_148725764 0.251 NM_004911
PDIA4
protein disulfide isomerase family A, member 4
chr17_+_72428228 0.251 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chrX_-_110655384 0.249 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr2_+_69240137 0.248 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr19_+_35606731 0.247 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr18_+_11689135 0.246 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr22_+_29313376 0.246 NM_032173
ZNRF3
zinc and ring finger 3
chr8_+_29952971 0.246 LEPROTL1
leptin receptor overlapping transcript-like 1
chr15_+_75074714 0.245 CSK
c-src tyrosine kinase
chr1_+_179965756 0.244 CEP350
centrosomal protein 350kDa
chr1_+_955468 0.242 NM_198576
AGRN
agrin
chr10_-_116164514 0.242 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr15_+_65822738 0.242 NM_016395
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr6_-_138189313 0.242


chr7_+_26191732 0.241 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chrX_-_32173585 0.239 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr2_+_26568900 0.239 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr10_-_73848766 0.239 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr9_-_27005649 0.237 NM_022901
LRRC19
leucine rich repeat containing 19
chr1_+_82266081 0.237 NM_012302
LPHN2
latrophilin 2
chr1_-_85358851 0.236 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr17_+_18684579 0.234 NM_016078
FAM18B1
family with sequence similarity 18, member B1
chr7_-_16505292 0.234 NM_015464
SOSTDC1
sclerostin domain containing 1
chr20_-_43977023 0.234 NM_002999
SDC4
syndecan 4
chr8_-_119964059 0.231 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr17_+_57233100 0.230 PRR11
proline rich 11
chr11_+_44117098 0.230 NM_001178083
NM_207122
EXT2

exostosin 2

chr15_+_66694216 0.230 MAP2K1
mitogen-activated protein kinase kinase 1
chr12_+_69979447 0.230 NM_001198842
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chrX_-_103268231 0.229 NM_001002916
H2BFWT
H2B histone family, member W, testis-specific
chr2_+_171571800 0.229 NM_001003845
SP5
Sp5 transcription factor
chr2_+_26568991 0.225 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr15_+_65822842 0.225 PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr17_-_56160564 0.225


chr8_+_80523376 0.223 STMN2
stathmin-like 2
chr17_+_37618249 0.223 CDK12
cyclin-dependent kinase 12
chr4_-_79860369 0.222 NM_001040202
PAQR3
progestin and adipoQ receptor family member III
chr17_+_56315786 0.222 NM_001160102
NM_006151
LPO

lactoperoxidase

chr15_+_32907690 0.222 NM_014783
NM_199357
ARHGAP11A

Rho GTPase activating protein 11A

chr6_-_108279212 0.222 SEC63
SEC63 homolog (S. cerevisiae)
chr1_+_955609 0.221 AGRN
agrin
chr13_-_99630243 0.221 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.89 4.65e-04 GO:0006935 chemotaxis
1.89 4.65e-04 GO:0042330 taxis
1.66 6.91e-04 GO:0040011 locomotion
1.29 1.02e-03 GO:0007275 multicellular organismal development
1.47 1.13e-03 GO:0007399 nervous system development
1.30 7.25e-03 GO:0048731 system development
1.27 1.60e-02 GO:0048856 anatomical structure development
1.24 1.71e-02 GO:0032502 developmental process
1.51 2.66e-02 GO:0009605 response to external stimulus
5.40 4.02e-02 GO:0030282 bone mineralization
1.64 4.27e-02 GO:0032989 cellular component morphogenesis
1.60 4.44e-02 GO:0030182 neuron differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 2.14e-03 GO:0044459 plasma membrane part
1.13 4.83e-03 GO:0016020 membrane
1.15 1.17e-02 GO:0044425 membrane part
1.16 1.89e-02 GO:0016021 integral to membrane
1.16 2.50e-02 GO:0031224 intrinsic to membrane
1.19 3.56e-02 GO:0005886 plasma membrane
1.38 4.27e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.35 7.46e-03 GO:0005313 L-glutamate transmembrane transporter activity
7.35 7.46e-03 GO:0015172 acidic amino acid transmembrane transporter activity
7.56 2.70e-02 GO:0045295 gamma-catenin binding