Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.299


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7L2chr10_+_114710785-0.762.8e-02Click!
LEF1chr4_-_109087876-0.551.6e-01Click!
TCF7chr5_+_1334503530.492.1e-01Click!
TCF7L1chr2_+_853603730.206.3e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_127420690 2.149 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr8_+_32579350 1.128 NM_001159996
NRG1
neuregulin 1
chr1_-_242612757 1.066 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr15_+_43885251 1.044 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr2_+_47596447 0.992 EPCAM
epithelial cell adhesion molecule
chr19_-_51522953 0.942 NM_145888
KLK10
kallikrein-related peptidase 10
chr2_+_47596286 0.871 NM_002354
EPCAM
epithelial cell adhesion molecule
chr15_+_41136178 0.868 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr15_+_41136622 0.856 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr12_-_28124915 0.854 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr17_-_39507055 0.848 NM_004138
KRT33A
keratin 33A
chr6_-_11779279 0.834 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_-_177133950 0.812 NM_004319
NM_207108
ASTN1

astrotactin 1

chr1_-_177133818 0.809 ASTN1
astrotactin 1
chr5_+_66124603 0.647 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_-_75788079 0.633 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr2_+_204801453 0.630 NM_012092
ICOS
inducible T-cell co-stimulator
chr8_-_42234562 0.626 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr4_-_103265818 0.623 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr2_-_75788027 0.620 FAM176A
family with sequence similarity 176, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
5.40 4.02e-02 GO:0030282 bone mineralization
1.89 4.65e-04 GO:0006935 chemotaxis
1.89 4.65e-04 GO:0042330 taxis
1.66 6.91e-04 GO:0040011 locomotion
1.64 4.27e-02 GO:0032989 cellular component morphogenesis
1.60 4.44e-02 GO:0030182 neuron differentiation
1.51 2.66e-02 GO:0009605 response to external stimulus
1.47 1.13e-03 GO:0007399 nervous system development
1.30 7.25e-03 GO:0048731 system development
1.29 1.02e-03 GO:0007275 multicellular organismal development
1.27 1.60e-02 GO:0048856 anatomical structure development
1.24 1.71e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.38 4.27e-02 GO:0005887 integral to plasma membrane
1.33 2.14e-03 GO:0044459 plasma membrane part
1.19 3.56e-02 GO:0005886 plasma membrane
1.16 1.89e-02 GO:0016021 integral to membrane
1.16 2.50e-02 GO:0031224 intrinsic to membrane
1.15 1.17e-02 GO:0044425 membrane part
1.13 4.83e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
7.56 2.70e-02 GO:0045295 gamma-catenin binding
7.35 7.46e-03 GO:0005313 L-glutamate transmembrane transporter activity
7.35 7.46e-03 GO:0015172 acidic amino acid transmembrane transporter activity