Motif ID: LHX3,4.p2

Z-value: 0.734


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX3chr9_-_1390948860.403.3e-01Click!
LHX4chr1_+_180199432-0.176.9e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_155853546 2.024 SYT11
synaptotagmin XI
chr5_+_71502700 1.280 MAP1B
microtubule-associated protein 1B
chr13_+_102104941 0.963 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr8_+_17396285 0.958 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr5_-_111093792 0.819 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr3_+_69812961 0.781 NM_006722
MITF
microphthalmia-associated transcription factor
chr8_-_108510094 0.766 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr14_-_61115906 0.688 NM_005982
SIX1
SIX homeobox 1
chr5_+_156696351 0.672 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr20_-_18477811 0.670 NM_006606
RBBP9
retinoblastoma binding protein 9
chr3_-_195310770 0.641 APOD
apolipoprotein D
chr3_-_195310985 0.625 NM_001647
APOD
apolipoprotein D
chr20_-_34025955 0.621 NM_000557
GDF5
growth differentiation factor 5
chr7_-_92777657 0.591 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr1_+_163038395 0.535 NM_001102445
RGS4
regulator of G-protein signaling 4
chr2_-_200325200 0.521 SATB2
SATB homeobox 2
chr12_-_91576805 0.497 NM_001920
DCN
decorin
chr5_+_59784004 0.497 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr2_-_175462428 0.492 WIPF1
WAS/WASL interacting protein family, member 1
chr7_-_14025826 0.491 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_-_232651227 0.489 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr16_-_4896197 0.469 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_+_145487301 0.446 LIX1L
Lix1 homolog (mouse)-like
chr14_+_101295409 0.443 MEG3
maternally expressed 3 (non-protein coding)
chr4_-_57547845 0.426 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr4_+_77953942 0.422 SEPT11
septin 11
chr5_+_67586466 0.422 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_-_54653317 0.382 NM_001127322
CBX5
chromobox homolog 5
chr5_-_88119604 0.377 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr5_+_67588395 0.375 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_-_54653369 0.365 NM_001127321
CBX5
chromobox homolog 5
chr8_+_70378858 0.351 NM_001128204
NM_015170
SULF1

sulfatase 1

chr12_-_91572328 0.321 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr3_+_12329332 0.319 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr9_-_14086901 0.313 NFIB
nuclear factor I/B
chr20_+_5987897 0.309 NM_001127458
CRLS1
cardiolipin synthase 1
chr5_+_115898218 0.309


chr11_-_27742224 0.306 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr6_+_114178516 0.306 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr7_+_90338711 0.305 NM_012395
CDK14
cyclin-dependent kinase 14
chr2_-_207082626 0.305 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr1_-_57045235 0.304 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_121554866 0.303 NM_005270
GLI2
GLI family zinc finger 2
chr16_+_86612114 0.303 NM_005250
FOXL1
forkhead box L1
chr6_+_73076431 0.301 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr7_+_90339146 0.299 CDK14
cyclin-dependent kinase 14
chr2_-_158300517 0.299 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_102531673 0.298 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr16_+_2809933 0.297


chr13_-_34250899 0.292 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_+_151985828 0.268 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr11_+_89392464 0.267 NM_153696
FOLH1B
folate hydrolase 1B
chr1_-_151414641 0.264 NM_207171
POGZ
pogo transposable element with ZNF domain
chr9_+_111624545 0.260 NM_006687
ACTL7A
actin-like 7A
chr6_+_132873829 0.258 NM_053278
TAAR8
trace amine associated receptor 8
chr2_+_210444364 0.257 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr10_+_69869249 0.253 NM_032578
MYPN
myopalladin
chr5_-_95158365 0.248 GLRX
glutaredoxin (thioltransferase)
chr1_-_57045214 0.247 PPAP2B
phosphatidic acid phosphatase type 2B
chr14_+_29236171 0.245 NM_005249
FOXG1
forkhead box G1
chr5_+_140792507 0.244 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr7_-_14029641 0.241 NM_001163147
NM_004956
ETV1

ets variant 1

chr2_-_175712276 0.240 NM_001206602
CHN1
chimerin (chimaerin) 1
chr6_-_87804773 0.240 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr5_-_124080773 0.234 NM_020747
ZNF608
zinc finger protein 608
chrX_-_154250769 0.233 NM_000132
F8
coagulation factor VIII, procoagulant component
chr7_+_23286384 0.228 GPNMB
glycoprotein (transmembrane) nmb
chr20_+_57022460 0.228 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr10_-_21786186 0.226 C10orf114
chromosome 10 open reading frame 114
chr10_-_74283693 0.225 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr3_+_45927995 0.223 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr12_+_54422193 0.219 NM_004503
HOXC6
homeobox C6
chr7_+_23286386 0.216 GPNMB
glycoprotein (transmembrane) nmb
chr16_-_66583587 0.215 TK2
thymidine kinase 2, mitochondrial
chr2_+_201170603 0.213 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr10_-_21186530 0.209 NM_006393
NEBL
nebulette
chr5_-_59783885 0.206 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_115572414 0.205 NM_000549
TSHB
thyroid stimulating hormone, beta
chr10_+_63808968 0.200 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr7_+_23286390 0.199 GPNMB
glycoprotein (transmembrane) nmb
chr4_+_160188997 0.195 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr12_-_95945226 0.192 NM_032147
USP44
ubiquitin specific peptidase 44
chr1_+_163041694 0.192 NM_001113380
RGS4
regulator of G-protein signaling 4
chr12_-_91576579 0.191 DCN
decorin
chr10_+_17270257 0.191 NM_003380
VIM
vimentin
chr3_+_141043054 0.188 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr12_+_18414473 0.188 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr14_+_62164339 0.187 NM_001243084
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr1_+_59775749 0.187 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr17_+_37784750 0.185 NM_001242464
NM_181505
PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B

chrX_+_57618268 0.184 NM_007157
ZXDB
zinc finger, X-linked, duplicated B
chr15_+_93443559 0.183 CHD2
chromodomain helicase DNA binding protein 2
chr5_-_160112266 0.179 ATP10B
ATPase, class V, type 10B
chrX_+_85517970 0.176 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr6_+_144612872 0.172 NM_007124
UTRN
utrophin
chr20_-_45927496 0.169 ZMYND8
zinc finger, MYND-type containing 8
chr1_-_149900143 0.168 NM_005850
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr5_+_95066628 0.166 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr4_+_123091757 0.166 NM_015312
KIAA1109
KIAA1109
chr2_+_201473942 0.166 AOX1
aldehyde oxidase 1
chr10_-_50732142 0.165 NM_170753
PGBD3
piggyBac transposable element derived 3
chr5_+_141348450 0.165 NM_004290
NM_183398
NM_183400
RNF14


ring finger protein 14


chr8_+_105352050 0.165 NM_030788
TM7SF4
transmembrane 7 superfamily member 4
chr20_-_20036685 0.164 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr2_+_152214105 0.163 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_104198140 0.162 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr5_+_140729723 0.162 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr10_+_17270469 0.161 VIM
vimentin
chr8_-_7212868 0.161 FAM66B
family with sequence similarity 66, member B
chr13_-_38172862 0.160 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr12_-_7656285 0.159 NM_004244
NM_203416
CD163

CD163 molecule

chr3_+_69915374 0.159 NM_198177
MITF
microphthalmia-associated transcription factor
chr12_-_53601051 0.157 ITGB7
integrin, beta 7
chr2_+_109204777 0.157 LIMS1
LIM and senescent cell antigen-like domains 1
chr22_+_44395090 0.156 NM_001003828
PARVB
parvin, beta
chr12_-_53994783 0.156 NM_001130059
ATF7
activating transcription factor 7
chrX_+_7137471 0.155 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr20_-_52199635 0.155 NM_006526
ZNF217
zinc finger protein 217
chr4_-_170077807 0.154 SH3RF1
SH3 domain containing ring finger 1
chr11_-_88781039 0.153 NM_001143831
GRM5
glutamate receptor, metabotropic 5
chr3_-_17741511 0.153 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr1_-_205325915 0.153 NM_018203
KLHDC8A
kelch domain containing 8A
chr9_-_99540327 0.152 NM_014930
ZNF510
zinc finger protein 510
chr9_+_118916069 0.152 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr12_-_52946734 0.151 NM_033448
KRT71
keratin 71
chr1_+_244216506 0.150 NM_006352
ZNF238
zinc finger protein 238
chr8_-_38326351 0.150 NM_001174063
NM_001174064
NM_015850
NM_023105
NM_023106
NM_023110
FGFR1





fibroblast growth factor receptor 1





chr10_-_21786205 0.149 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr9_-_85882093 0.147 NM_001244962
FRMD3
FERM domain containing 3
chr3_-_99833348 0.145 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr5_-_168271852 0.144


chr10_+_124320180 0.144 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr11_-_58611979 0.143 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr3_-_64211111 0.142 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_-_15332680 0.140 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr2_-_99279935 0.139 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_61869699 0.139 NFIA
nuclear factor I/A
chr20_+_17674319 0.138 NM_001159495
BANF2
barrier to autointegration factor 2
chr1_+_244214576 0.138 ZNF238
zinc finger protein 238
chr14_-_106926393 0.137 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr13_-_60587298 0.137 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr3_-_105421044 0.136 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr17_+_39240412 0.136 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr6_-_169654047 0.136 NM_003247
THBS2
thrombospondin 2
chr17_-_40833840 0.136 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr14_+_75898836 0.136 NM_001135049
JDP2
Jun dimerization protein 2
chr8_-_62602285 0.135 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chrX_-_13835012 0.134 GPM6B
glycoprotein M6B
chr1_+_203764802 0.134 ZC3H11A
zinc finger CCCH-type containing 11A
chr1_-_144997110 0.133 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr6_+_136172802 0.129 NM_018945
PDE7B
phosphodiesterase 7B
chr6_-_13295817 0.129 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr6_+_47749774 0.128 NM_181744
OPN5
opsin 5
chr5_-_156485969 0.128 NM_001173393
HAVCR1
hepatitis A virus cellular receptor 1
chr5_-_95158465 0.128 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr11_-_124973204 0.128 NM_001080546
TMEM218
transmembrane protein 218
chr7_+_23286420 0.127 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_183774214 0.127 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr18_+_72201669 0.126 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr14_-_74025643 0.125 NM_001220484
NM_203309
HEATR4

HEAT repeat containing 4

chr7_-_64023454 0.124 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr6_+_72926462 0.124 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr17_-_39623476 0.123 NM_002278
KRT32
keratin 32
chr19_-_44008984 0.120 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr2_+_88047603 0.120 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr5_-_156486128 0.119 HAVCR1
hepatitis A virus cellular receptor 1
chr5_+_140771482 0.118 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr6_+_155538096 0.117 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr2_-_200329810 0.117 NM_001172517
SATB2
SATB homeobox 2
chr4_+_39063851 0.116 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr3_+_69812620 0.115 NM_001184967
MITF
microphthalmia-associated transcription factor
chr15_+_100173182 0.115 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr5_+_179132676 0.115 CANX
calnexin
chr4_+_169418167 0.114 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr11_-_59633942 0.114 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr9_+_79093256 0.113 NM_001097635
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr13_+_53602829 0.112 NM_006418
OLFM4
olfactomedin 4
chr12_-_53600999 0.112 NM_000889
ITGB7
integrin, beta 7
chr5_+_140529619 0.111 NM_018939
PCDHB6
protocadherin beta 6
chr6_-_24877453 0.111 NM_015864
FAM65B
family with sequence similarity 65, member B
chr17_-_66951381 0.110 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_-_157221362 0.110 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr2_-_190044330 0.109 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_+_54348683 0.108 NM_173860
HOXC12
homeobox C12
chr10_+_94594469 0.106 NM_001013848
EXOC6
exocyst complex component 6
chr3_-_112359443 0.105 CCDC80
coiled-coil domain containing 80
chr20_-_39928708 0.105 NM_015035
ZHX3
zinc fingers and homeoboxes 3
chr7_+_23286277 0.104 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr16_+_53133063 0.103 CHD9
chromodomain helicase DNA binding protein 9
chr2_+_161993465 0.103 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr7_+_77469446 0.103 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr10_+_126630691 0.102 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr11_+_60552820 0.102 NM_206893
MS4A10
membrane-spanning 4-domains, subfamily A, member 10
chr3_-_18480203 0.102 NM_001131010
SATB1
SATB homeobox 1
chr13_-_24007822 0.101 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_-_93692898 0.101 NM_000313
PROS1
protein S (alpha)
chr2_-_200213802 0.101 SATB2
SATB homeobox 2
chr1_+_202509241 0.100 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr1_+_104292278 0.099 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr13_-_60325073 0.098



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 4.20e-05 GO:0065007 biological regulation
1.23 3.26e-04 GO:0050789 regulation of biological process
1.21 4.61e-03 GO:0050794 regulation of cellular process
2.85 1.64e-02 GO:0007517 muscle organ development
1.49 2.56e-02 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.53 1.90e-04 GO:0005576 extracellular region

Nothing significant found in function category.