Motif ID: MSX1,2.p2

Z-value: 0.782


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX1chr4_+_48613710.649.1e-02Click!
MSX2chr5_+_174151531-0.502.0e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_238322840 1.734 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_238322815 1.719 COL6A3
collagen, type VI, alpha 3
chr2_-_238322770 1.597 COL6A3
collagen, type VI, alpha 3
chr13_+_102104941 1.356 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr9_+_120466607 1.167 TLR4
toll-like receptor 4
chr11_+_15133969 1.014 NM_001031853
INSC
inscuteable homolog (Drosophila)
chr3_+_69812620 0.781 NM_001184967
MITF
microphthalmia-associated transcription factor
chr3_+_69812961 0.752 NM_006722
MITF
microphthalmia-associated transcription factor
chr9_+_120466625 0.575 TLR4
toll-like receptor 4
chr2_-_192711923 0.560 NM_004657
SDPR
serum deprivation response
chr4_-_156787377 0.511 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chrX_+_16964730 0.445 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr2_-_192711651 0.435 SDPR
serum deprivation response
chr17_-_66951381 0.399 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chrX_+_66788682 0.391 NM_001011645
AR
androgen receptor
chr2_-_145277879 0.385 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr7_-_14025826 0.384 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_+_59784004 0.378 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr17_-_19651586 0.366 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr10_+_124320180 0.352 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr5_+_140810181 0.322 PCDHGA12
protocadherin gamma subfamily A, 12
chr4_-_159092509 0.302 FAM198B
family with sequence similarity 198, member B
chr1_-_241799101 0.299 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr12_+_71833518 0.279 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr3_-_151102536 0.277 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr11_-_27681195 0.269 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr5_+_140810126 0.268 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr1_+_78470593 0.266 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr12_+_32654976 0.252 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_+_12392993 0.250 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr5_+_140529619 0.245 NM_018939
PCDHB6
protocadherin beta 6
chr9_-_21482311 0.244 NM_176891
IFNE
interferon, epsilon
chr17_-_15168590 0.244 NM_000304
PMP22
peripheral myelin protein 22
chr3_-_195310985 0.240 NM_001647
APOD
apolipoprotein D
chrX_-_135863033 0.226 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr3_+_45067750 0.222 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr14_+_101295409 0.218 MEG3
maternally expressed 3 (non-protein coding)
chrX_-_62975005 0.213 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr7_+_120629444 0.198 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr5_-_160279045 0.198 NM_025153
ATP10B
ATPase, class V, type 10B
chr2_-_175499275 0.193 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr5_+_15500288 0.184 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr1_+_153190059 0.183 NM_001195571
PRR9
proline rich 9
chr6_+_16129321 0.180 MYLIP
myosin regulatory light chain interacting protein
chr9_-_116840551 0.179 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_-_86043932 0.175 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr6_+_16129285 0.165 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr12_-_105627182 0.159 NM_001251905
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr4_+_71062241 0.157 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr11_-_40315663 0.157 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr20_+_123230 0.157 NM_030931
DEFB126
defensin, beta 126
chr1_-_104239071 0.156 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chrX_-_19688991 0.153 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr19_-_14169970 0.151 NM_001145028
PALM3
paralemmin 3
chr3_-_149095458 0.151 TM4SF1
transmembrane 4 L six family member 1
chr2_+_65216482 0.143 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr19_+_50016500 0.141 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_+_18474078 0.140 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr7_-_23509972 0.139 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr3_-_149095517 0.138 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr1_+_104198140 0.133 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr5_+_139876504 0.131 ANKHD1
ankyrin repeat and KH domain containing 1
chr5_+_140718353 0.130 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr17_-_78450247 0.128 NM_002522
NPTX1
neuronal pentraxin I
chr9_-_116840460 0.127 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_+_131240370 0.126 NM_001048209
NTM
neurotrimin
chr4_+_113970784 0.125 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr20_+_43850009 0.121 NM_003008
SEMG2
semenogelin II
chr1_+_145487301 0.120 LIX1L
Lix1 homolog (mouse)-like
chr3_+_69915374 0.120 NM_198177
MITF
microphthalmia-associated transcription factor
chr7_-_135613197 0.118 LUZP6
leucine zipper protein 6
chr3_+_9944295 0.113 NM_153483
IL17RE
interleukin 17 receptor E
chr2_-_163099877 0.111 NM_004460
FAP
fibroblast activation protein, alpha
chr9_+_111624545 0.111 NM_006687
ACTL7A
actin-like 7A
chr3_+_9944511 0.110 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr1_-_150978879 0.110 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr17_-_42908178 0.109 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr12_-_53171104 0.108 NM_015848
KRT76
keratin 76
chr5_+_126859157 0.108 PRRC1
proline-rich coiled-coil 1
chr12_+_51318743 0.107 METTL7A
methyltransferase like 7A
chrX_-_62974987 0.102 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr19_-_7698569 0.101 NM_174895
PCP2
Purkinje cell protein 2
chr14_-_105259937 0.099 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr2_-_105467912 0.097 LOC100506421
uncharacterized LOC100506421
chr7_-_108142934 0.097 PNPLA8
patatin-like phospholipase domain containing 8
chr19_+_49376488 0.092 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr3_-_71180061 0.092 NM_001244815
FOXP1
forkhead box P1
chr5_-_59783885 0.090 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_138210992 0.090 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr11_+_117070039 0.089 NM_001001522
NM_003186
TAGLN

transgelin

chr6_+_87969619 0.086 ZNF292
zinc finger protein 292
chr3_-_149095333 0.085 TM4SF1
transmembrane 4 L six family member 1
chrX_-_135863104 0.085 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_+_140734767 0.085 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr20_-_34543280 0.083 NM_016558
SCAND1
SCAN domain containing 1
chr5_+_43602738 0.083 NM_012343
NNT
nicotinamide nucleotide transhydrogenase
chr5_-_138211054 0.083 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr14_-_73453651 0.083 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr17_-_15554809 0.082 TRIM16
tripartite motif containing 16
chr15_-_43594452 0.082 NM_052955
TGM7
transglutaminase 7
chr2_-_175462428 0.081 WIPF1
WAS/WASL interacting protein family, member 1
chr3_+_187943192 0.080 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr15_+_91769329 0.080 SV2B
synaptic vesicle glycoprotein 2B
chr9_-_116840604 0.079 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_-_149095413 0.078 TM4SF1
transmembrane 4 L six family member 1
chr1_+_201751757 0.077 NAV1
neuron navigator 1
chr7_+_90338711 0.076 NM_012395
CDK14
cyclin-dependent kinase 14
chr3_-_99833348 0.076 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr12_-_13248581 0.074 NM_001206843
NM_001206845
NM_031289
NM_153823
GSG1



germ cell associated 1



chr1_-_19217384 0.073 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr3_+_183894736 0.073 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr3_+_8543539 0.071 LMCD1
LIM and cysteine-rich domains 1
chr2_+_61389628 0.071 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr5_+_140749830 0.071 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr22_+_35462125 0.071 NM_001008494
ISX
intestine-specific homeobox
chr20_-_45976626 0.070 ZMYND8
zinc finger, MYND-type containing 8
chr2_+_113825546 0.070 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr17_+_65936590 0.069 BPTF
bromodomain PHD finger transcription factor
chr17_-_9929567 0.069 NM_001130831
GAS7
growth arrest-specific 7
chr1_-_149900143 0.069 NM_005850
SF3B4
splicing factor 3b, subunit 4, 49kDa
chrX_-_19988381 0.069 NM_198279
CXorf23
chromosome X open reading frame 23
chr4_+_106473776 0.068 NM_001242729
NM_017700
ARHGEF38

Rho guanine nucleotide exchange factor (GEF) 38

chr11_-_71746966 0.067


chr5_+_140809957 0.066 PCDHGA12
protocadherin gamma subfamily A, 12
chr15_+_99645152 0.066 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr16_-_73092533 0.066 NM_001164766
ZFHX3
zinc finger homeobox 3
chr12_+_1017011 0.065 WNK1
WNK lysine deficient protein kinase 1
chr9_+_134305476 0.065 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr12_+_54891539 0.065 NCKAP1L
NCK-associated protein 1-like
chr6_+_147527102 0.064 STXBP5
syntaxin binding protein 5 (tomosyn)
chr10_-_13749622 0.064 FRMD4A
FERM domain containing 4A
chr12_-_71551564 0.063 TSPAN8
tetraspanin 8
chr8_-_27115897 0.062 NM_030795
STMN4
stathmin-like 4
chr18_+_3594056 0.062 FLJ35776
uncharacterized LOC649446
chr9_-_116840673 0.061 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr7_+_77469446 0.060 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr16_+_53479685 0.060 RBL2
retinoblastoma-like 2 (p130)
chr12_-_52585686 0.058 NM_001081492
NM_182507
KRT80

keratin 80

chr12_+_54891522 0.057 NCKAP1L
NCK-associated protein 1-like
chr9_-_116840545 0.056 AMBP
alpha-1-microglobulin/bikunin precursor
chr8_-_93075190 0.056 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_132937819 0.056 NM_001037126
NM_021807
EXOC4

exocyst complex component 4

chr11_-_85397215 0.056 NM_152723
CCDC89
coiled-coil domain containing 89
chr1_+_153232178 0.054 NM_000427
LOR
loricrin
chr4_-_70725792 0.054 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr6_+_163984574 0.053 QKI
QKI, KH domain containing, RNA binding
chr1_+_207277577 0.051 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr7_+_27282163 0.051 NM_001989
EVX1
even-skipped homeobox 1
chr21_-_19775958 0.050 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr20_+_18122867 0.049 NM_020536
CSRP2BP
CSRP2 binding protein
chr17_+_33448597 0.049 NM_017559
FNDC8
fibronectin type III domain containing 8
chrX_+_16668280 0.049 NM_004057
S100G
S100 calcium binding protein G
chr14_+_78870092 0.048 NM_004796
NRXN3
neurexin 3
chr6_-_32977312 0.048 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr10_+_35484829 0.048 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr20_+_32150139 0.048 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr5_-_179044835 0.048 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr3_+_46616044 0.047 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr16_-_46655262 0.047 SHCBP1
SHC SH2-domain binding protein 1
chr3_+_25470067 0.046 RARB
retinoic acid receptor, beta
chr3_+_186383770 0.045 NM_000412
HRG
histidine-rich glycoprotein
chr17_+_48821106 0.044 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr3_-_15798057 0.044 NM_001195099
ANKRD28
ankyrin repeat domain 28
chr5_+_138211084 0.044 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr3_+_99833773 0.044 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr1_+_104292278 0.043 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr17_+_4854383 0.042 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr4_-_54457723 0.040 NM_001126328
LNX1
ligand of numb-protein X 1
chr5_-_13944588 0.038 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr6_+_64231626 0.038 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_99717463 0.038 NM_001190415
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_+_169780880 0.038 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr8_-_27115935 0.037 STMN4
stathmin-like 4
chr12_+_54891491 0.037 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr10_-_74714479 0.037 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr6_-_56507585 0.037 NM_001723
NM_015548
DST

dystonin

chr6_-_154677868 0.036 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr9_-_34662629 0.036 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chrX_-_153602928 0.035 FLNA
filamin A, alpha
chr3_-_114790221 0.035 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_31769826 0.035 NM_016505
ZCCHC17
zinc finger, CCHC domain containing 17
chr14_-_24683035 0.035 NM_014169
CHMP4A
charged multivesicular body protein 4A
chr7_+_91924291 0.035


chr1_-_201915715 0.034 NM_012134
LMOD1
leiomodin 1 (smooth muscle)
chr1_+_84647342 0.034 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_-_56618178 0.033 NM_001198713
SEPT4
septin 4
chr3_-_97754147 0.033 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chrX_-_153602998 0.033 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr9_+_1050367 0.033 DMRT2
doublesex and mab-3 related transcription factor 2
chr11_-_101000457 0.032 NM_000926
PGR
progesterone receptor
chrX_+_54947228 0.032 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr2_-_211018294 0.032 C2orf67
chromosome 2 open reading frame 67
chr12_-_21654484 0.032 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr1_+_196788860 0.032 NM_002113
CFHR1
complement factor H-related 1
chr1_+_3541587 0.032 TPRG1L
tumor protein p63 regulated 1-like
chr5_+_73109342 0.031 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr6_-_31681845 0.030


chr2_-_162929928 0.029 DPP4
dipeptidyl-peptidase 4
chr11_-_55703875 0.029 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr1_+_15764934 0.029 NM_007272
CTRC
chymotrypsin C (caldecrin)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.99 1.10e-02 GO:0007399 nervous system development

Nothing significant found in compartment category.

Nothing significant found in function category.