Motif ID: MZF1.p2

Z-value: 1.911


Transcription factors associated with MZF1.p2:

Gene SymbolEntrez IDGene Name
MZF1 7593 myeloid zinc finger 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MZF1chr19_-_59084735,
chr19_-_59084630
0.753.2e-02Click!


Activity profile for motif MZF1.p2.

activity profile for motif MZF1.p2


Sorted Z-values histogram for motif MZF1.p2

Sorted Z-values for motif MZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_57045129 3.141 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57045235 2.800 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr21_+_47401644 2.785 NM_001848
COL6A1
collagen, type VI, alpha 1
chr4_+_145567147 2.604 NM_022475
HHIP
hedgehog interacting protein
chrX_+_152760346 2.540 NM_001711
BGN
biglycan
chr1_-_72748147 2.510 NM_173808
NEGR1
neuronal growth regulator 1
chr1_-_72748491 2.418


chr1_-_57045214 2.310 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_92920592 2.238 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr5_+_92918924 2.201 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_+_82767492 2.143 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr7_-_150973819 1.956 NM_001003802
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_-_57044980 1.913 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_31608097 1.863 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr8_+_22457098 1.821 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr10_-_79397394 1.717 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_+_152760452 1.645 BGN
biglycan
chr1_+_164528586 1.598 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr10_-_79397290 1.579 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_-_79397204 1.553 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_+_66763868 1.467 NM_000044
AR
androgen receptor
chr5_-_111093251 1.466 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr14_-_61115906 1.465 NM_005982
SIX1
SIX homeobox 1
chr5_-_9546157 1.446 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr5_-_111092918 1.444 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr7_-_150974179 1.437 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr5_-_111093030 1.425 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr5_+_139028025 1.410 NM_016463
CXXC5
CXXC finger protein 5
chr5_-_92916924 1.386 FLJ42709
uncharacterized LOC441094
chr9_-_20622476 1.347 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr15_-_48937795 1.314 NM_000138
FBN1
fibrillin 1
chr8_+_97506020 1.293 SDC2
syndecan 2
chr2_-_200322699 1.288 NM_001172509
SATB2
SATB homeobox 2
chr13_+_88324777 1.282 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr5_+_139028483 1.274 CXXC5
CXXC finger protein 5
chr1_+_201617449 1.245 NM_020443
NAV1
neuron navigator 1
chr8_+_97506141 1.232 SDC2
syndecan 2
chr2_-_45236521 1.223 NM_016932
SIX2
SIX homeobox 2
chrX_-_107019001 1.210 NM_198057
TSC22D3
TSC22 domain family, member 3
chr10_-_79397470 1.193 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr14_-_53417808 1.135 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr2_+_48757292 1.128 NM_001198595
NM_006873
STON1

stonin 1

chr1_+_211432693 1.127 NM_001136223
NM_001136224
NM_001136225
RCOR3


REST corepressor 3


chr12_+_65672422 1.127 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr1_+_155829259 1.120 NM_152280
SYT11
synaptotagmin XI
chr20_+_33292117 1.109 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr5_+_95066628 1.083 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr5_-_172755195 1.070 STC2
stanniocalcin 2
chr12_-_91576805 1.062 NM_001920
DCN
decorin
chr12_+_65672682 1.038 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr9_-_20622433 1.030 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr5_-_81046858 1.028 SSBP2
single-stranded DNA binding protein 2
chr2_+_148778573 1.028 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr12_-_91576579 1.025 DCN
decorin
chr19_-_2015628 1.020 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr1_+_201617529 1.019 NAV1
neuron navigator 1
chr22_+_31003069 1.003 NM_000355
NM_001184726
TCN2

transcobalamin II

chr3_-_157823815 1.000 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr6_-_167275997 0.982 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_+_42700837 0.955 ZBTB47
zinc finger and BTB domain containing 47
chr7_+_100199881 0.954 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr2_-_145277568 0.952 ZEB2
zinc finger E-box binding homeobox 2
chr21_+_44073650 0.950 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr13_-_44361032 0.947 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr8_+_72756218 0.942 LOC100132891
uncharacterized LOC100132891
chr5_+_139027955 0.938 CXXC5
CXXC finger protein 5
chr8_+_72756335 0.932


chr5_-_127873734 0.930 NM_001999
FBN2
fibrillin 2
chr11_-_130184314 0.925 ZBTB44
zinc finger and BTB domain containing 44
chr17_-_48278874 0.921 COL1A1
collagen, type I, alpha 1
chr1_+_215256559 0.921 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr9_+_91606349 0.919 NM_005226
S1PR3
sphingosine-1-phosphate receptor 3
chr2_-_238322840 0.908 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_145275086 0.886 ZEB2
zinc finger E-box binding homeobox 2
chr10_-_79397546 0.885 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr6_-_167275657 0.884 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_236228476 0.881 NM_002508
NID1
nidogen 1
chr8_+_97505895 0.879 SDC2
syndecan 2
chr3_+_154797644 0.867 NM_007287
MME
membrane metallo-endopeptidase
chr19_-_31840118 0.865 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr11_-_73309090 0.853 NM_015159
FAM168A
family with sequence similarity 168, member A
chr11_-_2016743 0.849 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr2_-_68547018 0.849 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chr11_+_113930296 0.848 ZBTB16
zinc finger and BTB domain containing 16
chr3_-_18466759 0.834 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr8_-_60031545 0.834 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr19_+_50016606 0.831 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr8_-_116681253 0.824 TRPS1
trichorhinophalangeal syndrome I
chr15_-_82338459 0.823 MEX3B
mex-3 homolog B (C. elegans)
chr1_-_236228382 0.822 NID1
nidogen 1
chrX_-_107018889 0.819 TSC22D3
TSC22 domain family, member 3
chr11_+_113930430 0.815 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr16_+_55512801 0.798 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_+_211432855 0.796 RCOR3
REST corepressor 3
chr2_+_200323088 0.793


chr5_-_172756505 0.793 NM_003714
STC2
stanniocalcin 2
chr14_+_24838301 0.777 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr2_-_145090038 0.777 NM_001164629
GTDC1
glycosyltransferase-like domain containing 1
chr5_-_81046943 0.772 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr12_+_57522247 0.771 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr19_+_3366536 0.762 NM_001245002
NM_001245004
NM_005597
NFIC


nuclear factor I/C (CCAAT-binding transcription factor)


chr19_+_50016500 0.759 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_-_46115135 0.758 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr5_+_139027868 0.757 CXXC5
CXXC finger protein 5
chr19_+_35521591 0.750 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr17_-_48278987 0.745 NM_000088
COL1A1
collagen, type I, alpha 1
chr2_-_145090028 0.743 GTDC1
glycosyltransferase-like domain containing 1
chr5_+_139027907 0.743 CXXC5
CXXC finger protein 5
chr5_-_158526698 0.735 NM_024007
EBF1
early B-cell factor 1
chr18_-_25756946 0.731 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr17_-_19290471 0.729 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr1_+_89990396 0.720 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chr5_+_49962771 0.711 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr8_-_116681103 0.711 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr12_-_124457099 0.709 NM_025140
CCDC92
coiled-coil domain containing 92
chr1_-_1293907 0.707 NM_032348
MXRA8
matrix-remodelling associated 8
chr4_-_157892545 0.705 NM_016205
PDGFC
platelet derived growth factor C
chr7_-_23509631 0.700


chr8_-_11058847 0.694 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr5_-_168727715 0.692 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr5_-_121413906 0.688 LOX
lysyl oxidase
chr2_-_145277879 0.682 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chrX_+_54834775 0.678 NM_014599
MAGED2
melanoma antigen family D, 2
chr14_-_53417636 0.675 FERMT2
fermitin family member 2
chr22_+_45898690 0.675 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr3_-_187871816 0.675 LPP-AS2
LPP antisense RNA 2 (non-protein coding)
chr1_-_149889362 0.667 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr11_-_27743604 0.662 NM_170731
BDNF
brain-derived neurotrophic factor
chr7_+_44144002 0.658 AEBP1
AE binding protein 1
chr1_+_245133628 0.656 NM_001143943
EFCAB2
EF-hand calcium binding domain 2
chr5_-_121413967 0.645 LOX
lysyl oxidase
chr20_+_36531498 0.642 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr20_+_36531548 0.639 VSTM2L
V-set and transmembrane domain containing 2 like
chr8_-_141467810 0.637 TRAPPC9
trafficking protein particle complex 9
chr3_+_32280211 0.637 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr8_-_38325524 0.635 FGFR1
fibroblast growth factor receptor 1
chr2_+_27301434 0.635 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr3_+_110790460 0.634 NM_001243286
NM_015480
PVRL3

poliovirus receptor-related 3

chr2_+_8822112 0.634 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr12_+_6937570 0.631 NM_014262
LEPREL2
leprecan-like 2
chr8_-_141467853 0.628 NM_001160372
TRAPPC9
trafficking protein particle complex 9
chr2_+_217498205 0.627 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr17_+_38599651 0.624 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr1_+_211433285 0.622 NM_018254
RCOR3
REST corepressor 3
chr10_+_12391708 0.620 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr2_+_210288668 0.615 NM_001039538
MAP2
microtubule-associated protein 2
chr12_-_56101667 0.609 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr7_-_19157262 0.608 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr9_+_91605777 0.605 NM_001001938
NM_001142413
C9orf47

chromosome 9 open reading frame 47

chr2_+_217498082 0.604 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr16_+_69600110 0.600 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chrX_+_103031797 0.593 PLP1
proteolipid protein 1
chr5_-_111092865 0.593 C5orf13
chromosome 5 open reading frame 13
chr1_-_92351476 0.592 TGFBR3
transforming growth factor, beta receptor III
chr11_-_27721179 0.592 NM_170734
BDNF
brain-derived neurotrophic factor
chr7_-_38670950 0.591 AMPH
amphiphysin
chr7_-_137531585 0.587 NM_004717
DGKI
diacylglycerol kinase, iota
chr5_+_172484353 0.586 C5orf41
chromosome 5 open reading frame 41
chr7_-_38670988 0.583 NM_001635
NM_139316
AMPH

amphiphysin

chr8_+_97506071 0.582 SDC2
syndecan 2
chr19_+_56159400 0.581 CCDC106
coiled-coil domain containing 106
chr3_-_112359251 0.578 CCDC80
coiled-coil domain containing 80
chr16_+_69599869 0.577 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chrX_-_142722869 0.576 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr8_-_38325241 0.573 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr18_-_25757351 0.567 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr19_+_50016435 0.560 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_-_111782447 0.558 NM_001885
CRYAB
crystallin, alpha B
chr12_+_53443834 0.556 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr13_-_50699775 0.555 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr2_-_127864505 0.554 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chrX_-_62975005 0.552 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr5_-_172755418 0.551 STC2
stanniocalcin 2
chr4_-_157892466 0.550 PDGFC
platelet derived growth factor C
chr7_+_104654494 0.550 NM_018682
NM_182931
MLL5

myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)

chr12_-_56101465 0.549 ITGA7
integrin, alpha 7
chr1_-_3447974 0.547 MEGF6
multiple EGF-like-domains 6
chr17_-_76921076 0.546 TIMP2
TIMP metallopeptidase inhibitor 2
chr9_+_130922471 0.546 NM_024112
C9orf16
chromosome 9 open reading frame 16
chrX_-_62974987 0.545 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr19_+_3366575 0.545 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr10_+_83635069 0.543 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr16_+_50775960 0.542 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr1_-_86043932 0.539 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr12_-_53893195 0.533 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr8_-_72756384 0.532 MSC
musculin
chr2_-_238322815 0.531 COL6A3
collagen, type VI, alpha 3
chr21_-_28339405 0.526 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr15_-_37392322 0.524 MEIS2
Meis homeobox 2
chr14_-_77494621 0.523 IRF2BPL
interferon regulatory factor 2 binding protein-like
chr6_+_72596699 0.520 RIMS1
regulating synaptic membrane exocytosis 1
chr4_-_1166547 0.520 NM_012445
SPON2
spondin 2, extracellular matrix protein
chr9_+_2622099 0.518 VLDLR
very low density lipoprotein receptor
chr10_+_12391471 0.518 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr14_-_94595915 0.517 IFI27L2
interferon, alpha-inducible protein 27-like 2
chr4_-_1166364 0.517 SPON2
spondin 2, extracellular matrix protein
chr8_-_72756607 0.516 MSC
musculin
chr19_+_49977817 0.515 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr10_+_76586299 0.515 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr14_-_60097223 0.515 RTN1
reticulon 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.26e-23 GO:0009987 cellular process
1.14 8.84e-20 GO:0050789 regulation of biological process
1.14 1.08e-19 GO:0050794 regulation of cellular process
1.13 9.63e-19 GO:0065007 biological regulation
1.28 2.53e-17 GO:0048519 negative regulation of biological process
1.29 4.26e-17 GO:0048523 negative regulation of cellular process
1.25 6.66e-16 GO:0048518 positive regulation of biological process
1.34 4.23e-15 GO:0007399 nervous system development
1.25 1.54e-14 GO:0048522 positive regulation of cellular process
1.33 1.99e-14 GO:0009653 anatomical structure morphogenesis
1.20 6.60e-14 GO:0071840 cellular component organization or biogenesis
1.42 7.30e-14 GO:0022008 neurogenesis
1.20 2.08e-13 GO:0016043 cellular component organization
1.42 9.63e-13 GO:0048699 generation of neurons
1.29 5.14e-12 GO:0023051 regulation of signaling
1.18 5.31e-12 GO:0032502 developmental process
1.25 1.90e-11 GO:0048869 cellular developmental process
1.53 2.36e-11 GO:0000904 cell morphogenesis involved in differentiation
1.25 2.90e-11 GO:0030154 cell differentiation
1.41 3.29e-11 GO:0051128 regulation of cellular component organization
1.46 7.17e-11 GO:0032989 cellular component morphogenesis
1.18 8.94e-11 GO:0007275 multicellular organismal development
1.20 9.84e-11 GO:0048731 system development
1.17 1.21e-10 GO:0031323 regulation of cellular metabolic process
1.17 1.65e-10 GO:0023052 signaling
1.46 3.03e-10 GO:0000902 cell morphogenesis
1.43 3.20e-10 GO:0030182 neuron differentiation
1.18 3.81e-10 GO:0048856 anatomical structure development
1.18 4.58e-10 GO:0060255 regulation of macromolecule metabolic process
1.14 5.36e-10 GO:0043170 macromolecule metabolic process
1.15 1.15e-09 GO:0044260 cellular macromolecule metabolic process
1.17 1.54e-09 GO:0080090 regulation of primary metabolic process
1.20 1.75e-09 GO:0071842 cellular component organization at cellular level
1.20 1.88e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.35 3.48e-09 GO:0048468 cell development
1.28 4.20e-09 GO:0009966 regulation of signal transduction
1.15 1.24e-08 GO:0019222 regulation of metabolic process
1.23 1.50e-08 GO:0048583 regulation of response to stimulus
1.16 1.97e-08 GO:0007165 signal transduction
1.30 2.19e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.33 2.51e-08 GO:0009892 negative regulation of metabolic process
1.50 2.51e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.47 2.86e-08 GO:0031175 neuron projection development
1.33 2.91e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.48 4.73e-08 GO:0048812 neuron projection morphogenesis
1.33 5.21e-08 GO:0010605 negative regulation of macromolecule metabolic process
1.28 6.14e-08 GO:0009893 positive regulation of metabolic process
1.33 1.11e-07 GO:0031324 negative regulation of cellular metabolic process
1.49 1.19e-07 GO:0007409 axonogenesis
1.41 1.67e-07 GO:0048666 neuron development
1.14 2.25e-07 GO:0051716 cellular response to stimulus
1.31 2.38e-07 GO:0032879 regulation of localization
1.39 2.58e-07 GO:0030030 cell projection organization
1.28 3.67e-07 GO:0031325 positive regulation of cellular metabolic process
1.10 4.86e-07 GO:0044238 primary metabolic process
1.09 6.66e-07 GO:0008152 metabolic process
1.43 6.69e-07 GO:0032990 cell part morphogenesis
1.43 8.50e-07 GO:0048858 cell projection morphogenesis
1.10 1.90e-06 GO:0044237 cellular metabolic process
1.36 3.13e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.27 4.34e-06 GO:0051246 regulation of protein metabolic process
1.37 4.76e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.25 4.77e-06 GO:0051239 regulation of multicellular organismal process
1.27 5.78e-06 GO:0010646 regulation of cell communication
1.36 5.99e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.37 6.32e-06 GO:0010629 negative regulation of gene expression
1.34 7.90e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.34 8.15e-06 GO:0009890 negative regulation of biosynthetic process
1.41 9.43e-06 GO:0072358 cardiovascular system development
1.41 9.43e-06 GO:0072359 circulatory system development
1.36 1.17e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.43 1.44e-05 GO:0008285 negative regulation of cell proliferation
1.16 1.65e-05 GO:0031326 regulation of cellular biosynthetic process
1.16 1.70e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.51 1.76e-05 GO:0051130 positive regulation of cellular component organization
1.37 2.19e-05 GO:0051253 negative regulation of RNA metabolic process
1.38 2.25e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.27 2.38e-05 GO:0032268 regulation of cellular protein metabolic process
1.16 2.59e-05 GO:0009889 regulation of biosynthetic process
1.33 3.02e-05 GO:0010628 positive regulation of gene expression
1.16 3.72e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 3.80e-05 GO:0065008 regulation of biological quality
1.16 4.27e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.17 4.51e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.47 5.32e-05 GO:0007411 axon guidance
1.13 8.99e-05 GO:0051179 localization
1.37 9.00e-05 GO:0007417 central nervous system development
1.33 1.01e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.51 1.08e-04 GO:0001568 blood vessel development
1.26 1.12e-04 GO:0009605 response to external stimulus
1.33 1.18e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.31 1.25e-04 GO:0019220 regulation of phosphate metabolic process
1.31 1.25e-04 GO:0051174 regulation of phosphorus metabolic process
1.29 1.39e-04 GO:0031399 regulation of protein modification process
1.30 1.42e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.54 1.65e-04 GO:0051129 negative regulation of cellular component organization
1.48 2.01e-04 GO:0001944 vasculature development
1.31 2.07e-04 GO:0042325 regulation of phosphorylation
1.27 2.09e-04 GO:0006351 transcription, DNA-dependent
1.31 2.66e-04 GO:0045595 regulation of cell differentiation
1.26 2.79e-04 GO:0050793 regulation of developmental process
1.31 2.85e-04 GO:0051254 positive regulation of RNA metabolic process
1.27 3.35e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.28 4.43e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.14 4.43e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 4.69e-04 GO:0001932 regulation of protein phosphorylation
1.13 4.88e-04 GO:0006807 nitrogen compound metabolic process
1.30 5.51e-04 GO:0009790 embryo development
1.15 5.83e-04 GO:0010468 regulation of gene expression
1.41 5.83e-04 GO:0016568 chromatin modification
1.18 6.21e-04 GO:0006464 protein modification process
1.39 6.54e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.28 6.84e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 7.34e-04 GO:0009891 positive regulation of biosynthetic process
1.16 8.00e-04 GO:0042221 response to chemical stimulus
1.25 8.67e-04 GO:0042127 regulation of cell proliferation
1.15 9.99e-04 GO:0051252 regulation of RNA metabolic process
1.20 1.23e-03 GO:0065009 regulation of molecular function
1.36 1.45e-03 GO:0023057 negative regulation of signaling
1.28 1.50e-03 GO:0051049 regulation of transport
1.45 1.86e-03 GO:0035295 tube development
1.16 1.95e-03 GO:0043412 macromolecule modification
1.27 2.14e-03 GO:2000026 regulation of multicellular organismal development
1.29 2.18e-03 GO:0009719 response to endogenous stimulus
1.49 2.43e-03 GO:0006897 endocytosis
1.49 2.43e-03 GO:0010324 membrane invagination
1.27 2.64e-03 GO:0016192 vesicle-mediated transport
1.12 2.80e-03 GO:0034641 cellular nitrogen compound metabolic process
1.15 2.81e-03 GO:0090304 nucleic acid metabolic process
1.35 3.01e-03 GO:0010648 negative regulation of cell communication
1.20 3.41e-03 GO:0035556 intracellular signal transduction
1.16 3.50e-03 GO:0048513 organ development
1.43 3.66e-03 GO:0051270 regulation of cellular component movement
1.38 3.75e-03 GO:0007420 brain development
1.32 3.89e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.30 4.01e-03 GO:0009725 response to hormone stimulus
1.49 4.78e-03 GO:0048514 blood vessel morphogenesis
1.17 5.14e-03 GO:0009059 macromolecule biosynthetic process
1.36 5.75e-03 GO:0009968 negative regulation of signal transduction
1.17 5.90e-03 GO:0034645 cellular macromolecule biosynthetic process
1.17 6.21e-03 GO:0006996 organelle organization
1.15 7.21e-03 GO:0006355 regulation of transcription, DNA-dependent
1.37 8.01e-03 GO:0043009 chordate embryonic development
1.50 8.29e-03 GO:0044087 regulation of cellular component biogenesis
1.34 9.22e-03 GO:0040008 regulation of growth
1.31 1.03e-02 GO:0051338 regulation of transferase activity
1.36 1.09e-02 GO:0009792 embryo development ending in birth or egg hatching
1.22 1.20e-02 GO:0006793 phosphorus metabolic process
1.22 1.20e-02 GO:0006796 phosphate metabolic process
1.16 1.20e-02 GO:0007166 cell surface receptor linked signaling pathway
1.42 1.23e-02 GO:0061061 muscle structure development
1.39 1.23e-02 GO:0060284 regulation of cell development
1.12 1.25e-02 GO:0006810 transport
1.23 1.33e-02 GO:0008219 cell death
1.43 1.34e-02 GO:0030334 regulation of cell migration
1.28 1.36e-02 GO:0009887 organ morphogenesis
1.33 1.43e-02 GO:0061024 membrane organization
1.70 1.47e-02 GO:0003007 heart morphogenesis
1.31 1.53e-02 GO:0043549 regulation of kinase activity
1.42 1.53e-02 GO:2000145 regulation of cell motility
1.12 1.55e-02 GO:0019538 protein metabolic process
1.23 1.59e-02 GO:0016265 death
1.32 1.60e-02 GO:0016044 cellular membrane organization
1.13 1.84e-02 GO:0044267 cellular protein metabolic process
1.75 1.85e-02 GO:0030100 regulation of endocytosis
1.35 2.07e-02 GO:0090066 regulation of anatomical structure size
1.21 2.12e-02 GO:0022607 cellular component assembly
1.20 2.27e-02 GO:0010941 regulation of cell death
1.12 2.35e-02 GO:0051234 establishment of localization
1.56 2.43e-02 GO:0001655 urogenital system development
1.60 2.43e-02 GO:0010959 regulation of metal ion transport
1.30 2.47e-02 GO:0006935 chemotaxis
1.30 2.47e-02 GO:0042330 taxis
1.31 2.69e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.21 2.71e-02 GO:0042981 regulation of apoptosis
1.40 2.83e-02 GO:0048545 response to steroid hormone stimulus
1.79 2.87e-02 GO:0010563 negative regulation of phosphorus metabolic process
1.79 2.87e-02 GO:0045936 negative regulation of phosphate metabolic process
1.48 3.22e-02 GO:0007517 muscle organ development
1.63 3.30e-02 GO:0072001 renal system development
1.44 3.32e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.54 3.39e-02 GO:0034330 cell junction organization
1.36 3.58e-02 GO:0044057 regulation of system process
1.19 3.64e-02 GO:0044085 cellular component biogenesis
1.20 3.65e-02 GO:0043067 regulation of programmed cell death
1.30 3.96e-02 GO:0045859 regulation of protein kinase activity
2.24 4.77e-02 GO:0060688 regulation of morphogenesis of a branching structure

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 3.36e-18 GO:0044424 intracellular part
1.07 3.25e-17 GO:0005622 intracellular
1.10 1.89e-15 GO:0005737 cytoplasm
1.08 8.13e-13 GO:0043226 organelle
1.08 1.65e-12 GO:0043229 intracellular organelle
1.09 7.86e-12 GO:0043227 membrane-bounded organelle
1.09 1.01e-11 GO:0043231 intracellular membrane-bounded organelle
1.25 9.70e-11 GO:0031981 nuclear lumen
1.12 1.27e-10 GO:0005634 nucleus
1.22 3.22e-10 GO:0044428 nuclear part
1.40 1.53e-08 GO:0030054 cell junction
1.32 2.33e-07 GO:0031982 vesicle
1.18 2.49e-07 GO:0043233 organelle lumen
1.32 5.39e-07 GO:0031410 cytoplasmic vesicle
1.18 5.52e-07 GO:0031974 membrane-enclosed lumen
1.32 1.07e-06 GO:0031988 membrane-bounded vesicle
1.44 1.11e-06 GO:0043005 neuron projection
1.62 1.29e-06 GO:0030135 coated vesicle
1.18 1.43e-06 GO:0070013 intracellular organelle lumen
1.15 1.52e-06 GO:0043234 protein complex
1.29 2.04e-06 GO:0042995 cell projection
1.16 2.51e-06 GO:0043228 non-membrane-bounded organelle
1.16 2.51e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.87 2.53e-06 GO:0005925 focal adhesion
1.32 2.76e-06 GO:0016023 cytoplasmic membrane-bounded vesicle
1.82 3.42e-06 GO:0030055 cell-substrate junction
1.84 3.93e-06 GO:0005924 cell-substrate adherens junction
1.36 4.08e-06 GO:0005694 chromosome
1.55 5.48e-06 GO:0016323 basolateral plasma membrane
1.23 6.02e-06 GO:0005654 nucleoplasm
1.68 7.18e-06 GO:0005912 adherens junction
1.42 7.26e-06 GO:0045202 synapse
1.10 7.41e-06 GO:0044446 intracellular organelle part
1.09 8.80e-06 GO:0044422 organelle part
1.63 1.90e-05 GO:0070161 anchoring junction
1.16 2.21e-05 GO:0044459 plasma membrane part
1.63 2.38e-05 GO:0030136 clathrin-coated vesicle
1.17 4.26e-05 GO:0005829 cytosol
1.44 4.41e-05 GO:0044433 cytoplasmic vesicle part
1.60 5.24e-05 GO:0044454 nuclear chromosome part
1.53 5.44e-05 GO:0000228 nuclear chromosome
1.41 6.06e-05 GO:0048471 perinuclear region of cytoplasm
1.02 3.09e-04 GO:0005623 cell
1.02 3.67e-04 GO:0044464 cell part
1.08 3.90e-04 GO:0044444 cytoplasmic part
1.78 3.98e-04 GO:0008021 synaptic vesicle
2.10 5.09e-04 GO:0000792 heterochromatin
1.53 5.12e-04 GO:0031252 cell leading edge
1.33 6.20e-04 GO:0044427 chromosomal part
1.78 8.51e-04 GO:0000790 nuclear chromatin
1.11 8.70e-04 GO:0032991 macromolecular complex
1.42 1.42e-03 GO:0030659 cytoplasmic vesicle membrane
1.39 2.59e-03 GO:0044456 synapse part
1.40 3.72e-03 GO:0012506 vesicle membrane
1.49 3.86e-03 GO:0030424 axon
1.61 4.54e-03 GO:0030662 coated vesicle membrane
1.28 9.50e-03 GO:0005730 nucleolus
2.16 1.75e-02 GO:0005720 nuclear heterochromatin
1.92 1.79e-02 GO:0030672 synaptic vesicle membrane
1.31 2.10e-02 GO:0009986 cell surface
1.39 2.43e-02 GO:0000785 chromatin
1.65 2.51e-02 GO:0030665 clathrin coated vesicle membrane
1.43 2.68e-02 GO:0030425 dendrite
1.56 2.70e-02 GO:0044420 extracellular matrix part
1.72 4.30e-02 GO:0030427 site of polarized growth
1.73 4.76e-02 GO:0030426 growth cone

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 3.98e-36 GO:0005515 protein binding
1.08 7.96e-21 GO:0005488 binding
1.40 1.01e-09 GO:0043565 sequence-specific DNA binding
1.28 9.96e-07 GO:0030528 transcription regulator activity
1.28 1.72e-06 GO:0001071 nucleic acid binding transcription factor activity
1.28 1.72e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 2.31e-06 GO:0019904 protein domain specific binding
1.31 5.79e-06 GO:0019899 enzyme binding
1.69 1.66e-05 GO:0003714 transcription corepressor activity
1.57 8.84e-05 GO:0003682 chromatin binding
1.39 2.28e-04 GO:0000988 protein binding transcription factor activity
1.39 2.28e-04 GO:0000989 transcription factor binding transcription factor activity
1.44 2.69e-04 GO:0008134 transcription factor binding
1.39 3.21e-04 GO:0003712 transcription cofactor activity
1.32 5.41e-04 GO:0008092 cytoskeletal protein binding
1.42 3.03e-03 GO:0032403 protein complex binding
1.45 1.15e-02 GO:0000975 regulatory region DNA binding
1.45 1.15e-02 GO:0001067 regulatory region nucleic acid binding
1.45 1.15e-02 GO:0044212 transcription regulatory region DNA binding
1.45 1.86e-02 GO:0010843 promoter binding