Motif ID: NFE2L2.p2

Z-value: 1.011


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L2chr2_-_178129294-0.629.9e-02Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_56075329 1.634 NM_152637
 METTL7B
methyltransferase like 7B
chr12_+_56075418 1.555 METTL7B
methyltransferase like 7B
chr5_-_75919051 0.665 NM_004101
 F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_+_223889253 0.657 NM_001146068
 CAPN2
calpain 2, (m/II) large subunit
chr16_+_53133063 0.628 CHD9
chromodomain helicase DNA binding protein 9
chr17_-_48264039 0.609 COL1A1
collagen, type I, alpha 1
chr1_-_162838550 0.601 NM_178550
 C1orf110
chromosome 1 open reading frame 110
chr7_+_93551015 0.539 NM_004126
 GNG11
guanine nucleotide binding protein (G protein), gamma 11
chrX_+_9431314 0.534 NM_001139466
NM_001139467
NM_001139468
 TBL1X


transducin (beta)-like 1X-linked


chr22_-_44708730 0.515 NM_001099294
 KIAA1644
KIAA1644
chr17_-_76921453 0.508 NM_003255
 TIMP2
TIMP metallopeptidase inhibitor 2
chr2_+_33359607 0.502 NM_000627
NM_001166264
NM_001166265
NM_001166266
 LTBP1



latent transforming growth factor beta binding protein 1



chr20_+_34742656 0.468 NM_012156
 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr7_+_23286277 0.465 NM_001005340
NM_002510
 GPNMB

glycoprotein (transmembrane) nmb

chr7_+_23286384 0.440 GPNMB
glycoprotein (transmembrane) nmb
chr22_+_22735202 0.437


chrX_+_30671602 0.420 GK
glycerol kinase
chr8_+_120428551 0.402 NM_002514
 NOV
nephroblastoma overexpressed gene
chr17_-_76921205 0.382 TIMP2
TIMP metallopeptidase inhibitor 2
chrX_+_149531439 0.375 NM_001177465
 MAMLD1
mastermind-like domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 59 entries
enrichment   p-value GO term description
6.67 6.40e-06 GO:0006521 regulation of cellular amino acid metabolic process
6.18 6.52e-06 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
6.18 6.52e-06 GO:0072395 signal transduction involved in cell cycle checkpoint
6.18 6.52e-06 GO:0072401 signal transduction involved in DNA integrity checkpoint
6.18 6.52e-06 GO:0072404 signal transduction involved in G1/S transition checkpoint
6.18 6.52e-06 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
6.18 6.52e-06 GO:0072422 signal transduction involved in DNA damage checkpoint
6.18 6.52e-06 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
6.18 6.52e-06 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
5.89 4.71e-06 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
5.89 1.39e-05 GO:0071158 positive regulation of cell cycle arrest
5.64 9.63e-06 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.63 2.85e-05 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.52 1.06e-04 GO:0033238 regulation of cellular amine metabolic process
5.46 2.19e-06 GO:0051351 positive regulation of ligase activity
5.44 6.43e-06 GO:0051443 positive regulation of ubiquitin-protein ligase activity
5.38 5.58e-05 GO:0051352 negative regulation of ligase activity
5.38 5.58e-05 GO:0051444 negative regulation of ubiquitin-protein ligase activity
5.20 3.59e-05 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.13 4.41e-05 GO:0031575 mitotic cell cycle G1/S transition checkpoint

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
6.73 2.15e-08 GO:0000502 proteasome complex
2.37 3.65e-02 GO:0016323 basolateral plasma membrane
1.73 1.04e-02 GO:0005626 insoluble fraction
1.70 1.22e-03 GO:0000267 cell fraction
1.69 2.90e-02 GO:0005624 membrane fraction

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
5.89 2.11e-03 GO:0003823 antigen binding
4.62 2.09e-02 GO:0005097 Rab GTPase activator activity