Motif ID: NFKB1_REL_RELA.p2

Z-value: 2.471


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_1034227300.944.3e-04Click!
RELchr2_+_611087750.811.6e-02Click!
RELAchr11_-_65430214-0.373.6e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51522953 4.434 NM_145888
KLK10
kallikrein-related peptidase 10
chr1_-_209825797 3.342 NM_000228
LAMB3
laminin, beta 3
chr1_-_209824641 3.189 NM_001017402
LAMB3
laminin, beta 3
chr12_-_58160823 2.887 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_+_46640748 2.871 NM_005727
TSPAN1
tetraspanin 1
chr6_+_30850693 2.788 DDR1
discoidin domain receptor tyrosine kinase 1
chr6_-_136847743 2.708 NM_001198614
NM_001198618
NM_001198619
MAP7


microtubule-associated protein 7


chr11_+_18287807 2.696 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr7_+_69064316 2.582 AUTS2
autism susceptibility candidate 2
chr20_+_43803539 2.511 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr6_-_136847078 2.508 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr19_-_4338750 2.460 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr1_-_209979388 2.430 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr6_-_136847609 2.392 MAP7
microtubule-associated protein 7
chr5_+_31639424 2.316 PDZD2
PDZ domain containing 2
chr2_-_74669005 2.296 RTKN
rhotekin
chr7_+_18548899 2.287 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr13_-_20806533 2.250 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr19_-_51456159 2.206 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr2_-_70781146 2.122 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
7.06 2.78e-02 GO:0002828 regulation of type 2 immune response
2.83 2.71e-02 GO:0002699 positive regulation of immune effector process
2.63 2.43e-02 GO:0051222 positive regulation of protein transport
2.27 2.44e-02 GO:0034762 regulation of transmembrane transport
2.23 2.06e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.80 4.09e-02 GO:0045597 positive regulation of cell differentiation
1.68 4.98e-02 GO:0051094 positive regulation of developmental process
1.64 3.15e-04 GO:0006955 immune response
1.64 1.78e-03 GO:0010628 positive regulation of gene expression
1.58 5.50e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.54 3.97e-04 GO:0042981 regulation of apoptosis
1.54 4.69e-02 GO:0002682 regulation of immune system process
1.53 3.59e-04 GO:0010941 regulation of cell death
1.53 3.92e-04 GO:0043067 regulation of programmed cell death
1.51 2.38e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.50 4.56e-02 GO:0048584 positive regulation of response to stimulus
1.48 4.37e-04 GO:0009893 positive regulation of metabolic process
1.45 2.63e-03 GO:0002376 immune system process
1.44 1.10e-08 GO:0048522 positive regulation of cellular process
1.44 6.04e-03 GO:0031325 positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
10.09 4.19e-03 GO:0033256 I-kappaB/NF-kappaB complex
1.32 2.68e-04 GO:0044459 plasma membrane part
1.18 1.33e-02 GO:0005886 plasma membrane
1.18 1.66e-02 GO:0071944 cell periphery
1.12 4.73e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.18 4.11e-07 GO:0005515 protein binding
1.08 4.97e-04 GO:0005488 binding