• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: NHLH1,2.p2

Z-value: 1.624

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_-_137531585	2.597	NM_004717	DGKI	diacylglycerol kinase, iota
chrX_+_16964730	2.586	NM_001080975 NM_004726	REPS2	RALBP1 associated Eps domain containing 2
chr8_+_97506141	2.246		SDC2	syndecan 2
chr1_-_57045129	2.213		PPAP2B	phosphatidic acid phosphatase type 2B
chr8_+_97506071	2.206		SDC2	syndecan 2
chr8_+_97506020	2.117		SDC2	syndecan 2
chr8_+_97506478	2.088		SDC2	syndecan 2
chr11_+_113930430	1.992	NM_006006	ZBTB16	zinc finger and BTB domain containing 16
chr1_+_89990396	1.922	NM_001134476	LRRC8B	leucine rich repeat containing 8 family, member B
chr19_+_18111923	1.774	NM_001025604	ARRDC2	arrestin domain containing 2
chr2_+_109745996	1.772	NM_001099289	SH3RF3	SH3 domain containing ring finger 3
chr11_-_35547144	1.766	NM_001001991 NM_015430	PAMR1	peptidase domain containing associated with muscle regeneration 1
chr2_-_230579198	1.756	NM_139072	DNER	delta/notch-like EGF repeat containing
chr2_-_230135954	1.683	NM_001100818 NM_017933	PID1	phosphotyrosine interaction domain containing 1
chr8_+_104383785	1.682	NM_138455	CTHRC1	collagen triple helix repeat containing 1
chr8_+_104383701	1.638		CTHRC1	collagen triple helix repeat containing 1
chr9_-_97401588	1.614		FBP1	fructose-1,6-bisphosphatase 1
chr15_-_48937795	1.592	NM_000138	FBN1	fibrillin 1
chr1_-_57044980	1.564		PPAP2B	phosphatidic acid phosphatase type 2B
chr1_-_57045214	1.560		PPAP2B	phosphatidic acid phosphatase type 2B
chrX_-_154114431	1.553	NM_019863	F8	coagulation factor VIII, procoagulant component
chr5_+_92920592	1.539		NR2F1 NR2F2	nuclear receptor subfamily 2, group F, member 1 nuclear receptor subfamily 2, group F, member 2
chr16_+_53133063	1.532		CHD9	chromodomain helicase DNA binding protein 9
chr9_-_97401746	1.489		FBP1	fructose-1,6-bisphosphatase 1
chr6_+_124125068	1.407	NM_001040214 NM_153355	NKAIN2	Na+/K+ transporting ATPase interacting 2
chr5_+_156693051	1.402	NM_001037333 NM_001037332	CYFIP2	cytoplasmic FMR1 interacting protein 2
chr19_+_12863406	1.374	NM_017682	BEST2	bestrophin 2
chr12_+_90102639	1.349		LOC338758	uncharacterized LOC338758
chr5_-_19988293	1.301	NM_001167667 NM_004934	CDH18	cadherin 18, type 2
chr19_+_35521591	1.293	NM_001037 NM_199037	SCN1B	sodium channel, voltage-gated, type I, beta
chr14_-_52535711	1.290		NID2	nidogen 2 (osteonidogen)
chr14_-_52535765	1.272		NID2	nidogen 2 (osteonidogen)
chr9_-_97401833	1.263	NM_000507	FBP1	fructose-1,6-bisphosphatase 1
chr14_-_52535737	1.258		NID2	nidogen 2 (osteonidogen)
chr11_+_113930296	1.256		ZBTB16	zinc finger and BTB domain containing 16
chr20_+_34894190	1.222		DLGAP4	discs, large (Drosophila) homolog-associated protein 4
chr6_-_46459010	1.214	NM_001251974	RCAN2	regulator of calcineurin 2
chr5_-_180688095	1.198	NM_032765	TRIM52	tripartite motif containing 52
chr12_-_29936685	1.195	NM_001193451	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr2_+_56411123	1.140	NM_001080433	CCDC85A	coiled-coil domain containing 85A
chr22_+_21738039	1.135	NM_001128635	RIMBP3B	RIMS binding protein 3B
chr1_-_92351613	1.131	NM_001195683 NM_003243	TGFBR3	transforming growth factor, beta receptor III
chr10_-_81205091	1.123	NM_153367	ZCCHC24	zinc finger, CCHC domain containing 24
chr7_-_131241321	1.093	NM_001018111 NM_005397	PODXL	podocalyxin-like
chr5_+_67511578	1.063	NM_181523	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_-_61115906	1.023	NM_005982	SIX1	SIX homeobox 1
chr5_-_69881965	1.020		SMA4	glucuronidase, beta pseudogene
chr2_+_148778573	1.015	NM_018328	MBD5	methyl-CpG binding domain protein 5
chr3_-_195306274	1.014		APOD	apolipoprotein D
chr14_-_89020888	0.999	NM_007039	PTPN21	protein tyrosine phosphatase, non-receptor type 21
chr6_-_139695739	0.991		CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr12_+_53443834	0.989	NM_170754	TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr6_-_139695784	0.960	NM_006079	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr11_+_46299554	0.955		CREB3L1	cAMP responsive element binding protein 3-like 1
chr2_+_233498206	0.954	NM_025202	EFHD1	EF-hand domain family, member D1
chr13_-_44361032	0.942	NM_001242863 NM_017993	ENOX1	ecto-NOX disulfide-thiol exchanger 1
chr21_+_27011588	0.937	NM_021219	JAM2	junctional adhesion molecule 2
chr6_-_154831788	0.913		CNKSR3	CNKSR family member 3
chr1_-_72748491	0.908
chr6_-_154831652	0.901		CNKSR3	CNKSR family member 3
chr2_-_19558371	0.899	NM_145260	OSR1	odd-skipped related 1 (Drosophila)
chr22_-_21905372	0.891	NM_001128635	RIMBP3B	RIMS binding protein 3B
chr7_+_17338182	0.890	NM_001621	AHR	aryl hydrocarbon receptor
chr11_-_70672644	0.876		SHANK2	SH3 and multiple ankyrin repeat domains 2
chr3_-_73673978	0.869	NM_015009	PDZRN3	PDZ domain containing ring finger 3
chr12_-_56101667	0.862	NM_001144996 NM_002206	ITGA7	integrin, alpha 7
chr8_+_17014006	0.860		ZDHHC2	zinc finger, DHHC-type containing 2
chr11_-_74022609	0.858	NM_182904	P4HA3	prolyl 4-hydroxylase, alpha polypeptide III
chr6_+_72596699	0.857		RIMS1	regulating synaptic membrane exocytosis 1
chr5_+_69696805	0.857		SMA4	glucuronidase, beta pseudogene
chr7_+_100199881	0.852	NM_002593	PCOLCE	procollagen C-endopeptidase enhancer
chr9_+_37650996	0.840	NM_014907	FRMPD1	FERM and PDZ domain containing 1
chr6_-_139695349	0.839	NM_001168389 NM_001168388	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr6_-_154831704	0.838	NM_173515	CNKSR3	CNKSR family member 3
chr3_+_8543508	0.837	NM_014583	LMCD1	LIM and cysteine-rich domains 1
chrX_-_107018889	0.827		TSC22D3	TSC22 domain family, member 3
chr5_-_172756505	0.827	NM_003714	STC2	stanniocalcin 2
chr7_+_44788453	0.812	NM_031449	ZMIZ2	zinc finger, MIZ-type containing 2
chr12_-_56101465	0.806		ITGA7	integrin, alpha 7
chr3_+_32280154	0.804	NM_178868	CMTM8	CKLF-like MARVEL transmembrane domain containing 8
chr3_+_32280211	0.802		CMTM8	CKLF-like MARVEL transmembrane domain containing 8
chr12_-_63328663	0.789	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_+_56075329	0.786	NM_152637	METTL7B	methyltransferase like 7B
chr5_-_136834887	0.786	NM_004598	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr12_+_56075418	0.780		METTL7B	methyltransferase like 7B
chr5_+_176237435	0.779	NM_133369	UNC5A	unc-5 homolog A (C. elegans)
chr1_-_72748147	0.776	NM_173808	NEGR1	neuronal growth regulator 1
chr5_-_158526428	0.770		EBF1	early B-cell factor 1
chr12_-_15038724	0.767	NM_000900 NM_001190839	MGP	matrix Gla protein
chrX_+_51927918	0.753	NM_001098800 NM_001242362 NM_030801 NM_177535 NM_177537	MAGED4 MAGED4B	melanoma antigen family D, 4 melanoma antigen family D, 4B
chr1_+_77747727	0.753		AK5	adenylate kinase 5
chr2_+_46926323	0.752	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr6_+_72596405	0.742		RIMS1	regulating synaptic membrane exocytosis 1
chr10_-_79397204	0.741		KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr8_+_72756218	0.738		LOC100132891	uncharacterized LOC100132891
chr8_+_72756335	0.733
chr6_-_167040659	0.731		RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr21_+_47401644	0.727	NM_001848	COL6A1	collagen, type VI, alpha 1
chr1_-_236228476	0.722	NM_002508	NID1	nidogen 1
chrX_-_51812249	0.713	NM_001098800 NM_001242362 NM_030801 NM_177535 NM_177537	MAGED4 MAGED4B	melanoma antigen family D, 4 melanoma antigen family D, 4B
chr1_-_236228382	0.705		NID1	nidogen 1
chr17_-_73761216	0.704	NM_000154	GALK1	galactokinase 1
chr6_-_167040700	0.702	NM_021135	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr17_-_66596736	0.691		FAM20A	family with sequence similarity 20, member A
chr1_+_210406194	0.688	NM_019605	SERTAD4	SERTA domain containing 4
chr4_-_2420252	0.687	NM_001172656 NM_001172657 NM_001172658 NM_020972	ZFYVE28	zinc finger, FYVE domain containing 28
chr12_+_90103470	0.681		LOC338758	uncharacterized LOC338758
chr14_-_52535945	0.675	NM_007361	NID2	nidogen 2 (osteonidogen)
chr9_-_104357202	0.671	NM_147180	PPP3R2	protein phosphatase 3, regulatory subunit B, beta
chr1_-_236228374	0.670		NID1	nidogen 1
chrX_-_19140581	0.670	NM_001079858 NM_001079859 NM_001079860 NM_001184833 NM_001184834 NM_001184835 NM_001184836 NM_001184837 NM_005756	GPR64	G protein-coupled receptor 64
chr2_-_233352530	0.664	NM_004826	ECEL1	endothelin converting enzyme-like 1
chr4_-_39640461	0.655	NM_174921	C4orf34	chromosome 4 open reading frame 34
chr12_-_96184346	0.650		NTN4	netrin 4
chr9_+_108006990	0.649		SLC44A1	solute carrier family 44, member 1
chr12_-_63328857	0.644		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr5_+_71403040	0.642	NM_005909	MAP1B	microtubule-associated protein 1B
chr17_-_15165860	0.642		PMP22	peripheral myelin protein 22
chr17_-_8702438	0.640	NM_152599	MFSD6L	major facilitator superfamily domain containing 6-like
chr5_+_67511601	0.640		PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_-_44070008	0.638	NM_001099282 NM_001099283 NM_001099284	ZNF239	zinc finger protein 239
chr1_-_85930610	0.638		DDAH1	dimethylarginine dimethylaminohydrolase 1
chr5_-_172198160	0.630	NM_004417	DUSP1	dual specificity phosphatase 1
chr14_+_74003817	0.628	NM_001037161	ACOT1	acyl-CoA thioesterase 1
chr1_-_16939687	0.627	NM_017940	NBPF1	neuroblastoma breakpoint family, member 1
chr3_-_45267068	0.623		TMEM158	transmembrane protein 158 (gene/pseudogene)
chr8_+_97505895	0.616		SDC2	syndecan 2
chr5_+_137774632	0.616	NM_016606	REEP2	receptor accessory protein 2
chrX_+_152760346	0.613	NM_001711	BGN	biglycan
chr1_-_92351476	0.613		TGFBR3	transforming growth factor, beta receptor III
chr11_-_70507911	0.610	NM_133266	SHANK2	SH3 and multiple ankyrin repeat domains 2
chr2_+_33359607	0.609	NM_000627 NM_001166264 NM_001166265 NM_001166266	LTBP1	latent transforming growth factor beta binding protein 1
chrX_+_152760452	0.606		BGN	biglycan
chr17_-_78194085	0.605	NM_000199	SGSH	N-sulfoglucosamine sulfohydrolase
chr8_+_97505876	0.604	NM_002998	SDC2	syndecan 2
chrX_-_106959597	0.603	NM_001015881	TSC22D3	TSC22 domain family, member 3
chr12_-_96184510	0.600	NM_021229	NTN4	netrin 4
chrX_+_149531439	0.600	NM_001177465	MAMLD1	mastermind-like domain containing 1
chr1_+_22351984	0.596		LINC00339	long intergenic non-protein coding RNA 339
chrX_+_80457597	0.595		SH3BGRL	SH3 domain binding glutamic acid-rich protein like
chr3_+_69788562	0.590	NM_198159	MITF	microphthalmia-associated transcription factor
chr5_+_95066628	0.587	NM_014899	RHOBTB3	Rho-related BTB domain containing 3
chr15_-_78369825	0.583	NM_015079 NM_144572	TBC1D2B	TBC1 domain family, member 2B
chr6_+_42750465	0.583		FLJ38717	FLJ38717 protein
chr12_-_124457099	0.582	NM_025140	CCDC92	coiled-coil domain containing 92
chr9_+_79074067	0.575	NM_001097633 NM_001490	GCNT1	glucosaminyl (N-acetyl) transferase 1, core 2
chr2_+_238395863	0.574	NM_001042467 NM_024101	MLPH	melanophilin
chr16_+_30406711	0.573	NM_152652	ZNF48	zinc finger protein 48
chr1_-_33647626	0.571	NM_018207	TRIM62	tripartite motif containing 62
chr1_-_57045235	0.568	NM_003713	PPAP2B	phosphatidic acid phosphatase type 2B
chr1_+_78354199	0.562	NM_001172309 NM_144573	NEXN	nexilin (F actin binding protein)
chr4_+_145567147	0.561	NM_022475	HHIP	hedgehog interacting protein
chr5_+_95067511	0.561
chr4_-_57976550	0.559	NM_001253835 NM_001553	IGFBP7	insulin-like growth factor binding protein 7
chr1_+_159175048	0.559	NM_001122951	DARC	Duffy blood group, chemokine receptor
chr1_-_17338266	0.559	NM_001141973 NM_001141974 NM_022089	ATP13A2	ATPase type 13A2
chr20_-_39995497	0.559	NM_052846	EMILIN3	elastin microfibril interfacer 3
chr19_-_46285746	0.557		DMPK	dystrophia myotonica-protein kinase
chr8_+_42995640	0.554		HGSNAT	heparan-alpha-glucosaminide N-acetyltransferase
chr1_-_47133982	0.553		ATPAF1	ATP synthase mitochondrial F1 complex assembly factor 1
chr17_-_66596934	0.552	NM_001243746 NM_017565	FAM20A	family with sequence similarity 20, member A
chr22_-_44708730	0.552	NM_001099294	KIAA1644	KIAA1644
chr10_-_62703822	0.546	NM_001242359 NM_014836	RHOBTB1	Rho-related BTB domain containing 1
chr2_+_191745791	0.546		GLS	glutaminase
chr8_+_37654833	0.545		GPR124	G protein-coupled receptor 124
chr11_-_6341708	0.538	NM_145040	PRKCDBP	protein kinase C, delta binding protein
chr10_+_31608097	0.535	NM_001174093 NM_001174095 NM_001174096 NM_030751	ZEB1	zinc finger E-box binding homeobox 1
chr20_-_57582303	0.534	NM_001336	CTSZ	cathepsin Z
chr4_-_1107313	0.533	NM_001131034 NM_001193318 NM_194439	RNF212	ring finger protein 212
chr11_-_694842	0.531		DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)
chrX_-_99665270	0.530	NM_001105243 NM_001184880 NM_020766	PCDH19	protocadherin 19
chr2_+_241938254	0.527	NM_001080437	SNED1	sushi, nidogen and EGF-like domains 1
chr1_-_85930733	0.522	NM_012137	DDAH1	dimethylarginine dimethylaminohydrolase 1
chr13_+_102104941	0.521	NM_004791	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
chr17_-_66453561	0.520	NM_017983	WIPI1	WD repeat domain, phosphoinositide interacting 1
chr1_-_212873104	0.520		BATF3	basic leucine zipper transcription factor, ATF-like 3
chr10_+_72972268	0.518	NM_001244889 NM_170744	UNC5B	unc-5 homolog B (C. elegans)
chr2_-_202316227	0.517	NM_015049	TRAK2	trafficking protein, kinesin binding 2
chr14_+_38678594	0.517		SSTR1	somatostatin receptor 1
chr1_-_84464728	0.514	NM_024686	TTLL7	tubulin tyrosine ligase-like family, member 7
chr9_-_35689799	0.510		TPM2	tropomyosin 2 (beta)
chr12_+_79258588	0.510		SYT1	synaptotagmin I
chrX_-_39956655	0.509	NM_001123385 NM_017745	BCOR	BCL6 corepressor
chr10_+_31610063	0.507	NM_001128128 NM_001174094	ZEB1	zinc finger E-box binding homeobox 1
chr21_+_27011766	0.504		JAM2	junctional adhesion molecule 2
chr16_-_3355374	0.503	NM_033208	TIGD7	tigger transposable element derived 7
chr12_+_79258517	0.500		SYT1	synaptotagmin I
chr4_-_185747051	0.499		ACSL1	acyl-CoA synthetase long-chain family member 1
chr22_-_41634055	0.498		CHADL	chondroadherin-like
chr16_+_89642111	0.495	NM_014427 NM_153636	CPNE7	copine VII
chr1_+_155829259	0.495	NM_152280	SYT11	synaptotagmin XI
chr16_+_2802683	0.494		SRRM2	serine/arginine repetitive matrix 2
chr8_-_91657898	0.494	NM_001008495 NM_001146273	TMEM64	transmembrane protein 64
chr1_+_2518464	0.493		FAM213B	family with sequence similarity 213, member B
chr1_-_212873306	0.493	NM_018664	BATF3	basic leucine zipper transcription factor, ATF-like 3
chr8_+_37654757	0.491		GPR124	G protein-coupled receptor 124
chr19_+_18118921	0.490	NM_015683	ARRDC2	arrestin domain containing 2
chr12_+_79258794	0.490		SYT1	synaptotagmin I
chr19_+_36359346	0.489	NM_001024807 NM_005166	APLP1	amyloid beta (A4) precursor-like protein 1
chr19_+_4304590	0.489	NM_024333	FSD1	fibronectin type III and SPRY domain containing 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.45	6.40e-07	GO:0051128	regulation of cellular component organization
1.31	7.01e-06	GO:0007399	nervous system development
1.07	1.21e-05	GO:0009987	cellular process
1.48	2.59e-05	GO:0009725	response to hormone stimulus
1.44	5.65e-05	GO:0009719	response to endogenous stimulus
1.38	5.67e-05	GO:0050793	regulation of developmental process
1.21	1.95e-04	GO:0048519	negative regulation of biological process
1.36	2.02e-04	GO:0048468	cell development
1.22	2.79e-04	GO:0048523	negative regulation of cellular process
1.40	9.48e-04	GO:0045595	regulation of cell differentiation
1.35	1.24e-03	GO:0048699	generation of neurons
1.28	1.32e-03	GO:0051239	regulation of multicellular organismal process
1.37	1.43e-03	GO:2000026	regulation of multicellular organismal development
1.33	1.89e-03	GO:0022008	neurogenesis
1.10	1.97e-03	GO:0050794	regulation of cellular process
1.58	2.66e-03	GO:0022603	regulation of anatomical structure morphogenesis
1.35	5.50e-03	GO:0016192	vesicle-mediated transport
1.38	6.96e-03	GO:0007167	enzyme linked receptor protein signaling pathway
1.09	9.06e-03	GO:0050789	regulation of biological process
1.43	9.50e-03	GO:0031175	neuron projection development
1.56	1.16e-02	GO:0040012	regulation of locomotion
1.52	1.18e-02	GO:0071495	cellular response to endogenous stimulus
1.08	1.27e-02	GO:0065007	biological regulation
1.53	1.30e-02	GO:0060284	regulation of cell development
1.53	1.36e-02	GO:0032870	cellular response to hormone stimulus
1.19	1.66e-02	GO:0030154	cell differentiation
1.19	1.75e-02	GO:0048869	cellular developmental process
1.41	1.85e-02	GO:0000904	cell morphogenesis involved in differentiation
1.82	3.18e-02	GO:0010975	regulation of neuron projection development
1.13	3.18e-02	GO:0032502	developmental process
1.56	3.25e-02	GO:2000145	regulation of cell motility
1.37	3.28e-02	GO:0048666	neuron development
1.50	3.45e-02	GO:0051093	negative regulation of developmental process
1.56	3.61e-02	GO:0030334	regulation of cell migration
1.21	3.70e-02	GO:0023051	regulation of signaling

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.13	3.14e-13	GO:0005737	cytoplasm
1.08	2.06e-11	GO:0044424	intracellular part
1.08	9.57e-10	GO:0005622	intracellular
1.12	1.65e-05	GO:0044444	cytoplasmic part
1.07	2.35e-04	GO:0043226	organelle
1.07	3.12e-04	GO:0043229	intracellular organelle
1.71	7.95e-03	GO:0005912	adherens junction
1.28	9.90e-03	GO:0042995	cell projection
1.06	1.35e-02	GO:0043227	membrane-bounded organelle
1.06	1.36e-02	GO:0043231	intracellular membrane-bounded organelle
1.39	4.24e-02	GO:0043005	neuron projection
1.27	4.56e-02	GO:0031982	vesicle

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.12	6.00e-08	GO:0005515	protein binding
1.06	9.33e-05	GO:0005488	binding