Motif ID: NKX2-2,8.p2

Z-value: 1.019


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-2chr20_-_214946630.482.3e-01Click!
NKX2-8chr14_-_370517850.275.2e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_215178884 1.963 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr13_+_102104941 1.912 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr1_+_163038395 1.823 NM_001102445
RGS4
regulator of G-protein signaling 4
chr12_-_91573264 1.572 NM_133503
DCN
decorin
chr5_+_71502700 1.441 MAP1B
microtubule-associated protein 1B
chr4_-_156787377 1.232 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chrX_+_66788682 1.193 NM_001011645
AR
androgen receptor
chr3_+_157154579 1.017 NM_002852
PTX3
pentraxin 3, long
chr5_+_156820161 0.945 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr3_-_100712248 0.935 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr4_+_113739203 0.923 NM_001127493
ANK2
ankyrin 2, neuronal
chr17_-_66951381 0.864 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr11_+_65266642 0.819


chr2_+_152214105 0.790 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_-_112359251 0.745 CCDC80
coiled-coil domain containing 80
chr17_-_67138013 0.739 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_+_145487301 0.673 LIX1L
Lix1 homolog (mouse)-like
chr1_+_104159953 0.669 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr1_+_162602198 0.662 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chrX_-_70474402 0.630 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr5_-_150521200 0.629 NM_001193544
ANXA6
annexin A6
chr3_-_112359277 0.621 CCDC80
coiled-coil domain containing 80
chr11_+_65271145 0.572


chr9_-_20622476 0.567 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr8_-_122653493 0.534 NM_005328
HAS2
hyaluronan synthase 2
chr10_+_124670216 0.518 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr3_-_114790221 0.508 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_114214102 0.492 ANK2
ankyrin 2, neuronal
chr9_-_21482311 0.491 NM_176891
IFNE
interferon, epsilon
chr2_-_216300444 0.464 FN1
fibronectin 1
chr1_-_144997110 0.444 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr6_-_152702329 0.434 SYNE1
spectrin repeat containing, nuclear envelope 1
chr10_+_63808968 0.416 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr9_-_20622433 0.414 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_170533536 0.397 NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr9_+_120466607 0.396 TLR4
toll-like receptor 4
chr3_-_15839674 0.386 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr7_+_104681378 0.385 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr20_+_17674319 0.383 NM_001159495
BANF2
barrier to autointegration factor 2
chr6_+_73076431 0.376 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr9_+_96846710 0.374 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chrX_+_22050920 0.373 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr12_-_102591547 0.367 NM_002674
PMCH
pro-melanin-concentrating hormone
chr1_-_163113129 0.357 RGS5
regulator of G-protein signaling 5
chr3_-_112359863 0.356 CCDC80
coiled-coil domain containing 80
chr9_+_120466625 0.351 TLR4
toll-like receptor 4
chr5_+_140792507 0.348 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr3_-_151058439 0.347 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr22_+_42086546 0.339 NM_001142964
C22orf46
chromosome 22 open reading frame 46
chr6_-_152702450 0.338 SYNE1
spectrin repeat containing, nuclear envelope 1
chr8_-_120651019 0.331 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr14_+_21467413 0.330 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr17_+_3377346 0.329 NM_001128085
ASPA
aspartoacylase
chr3_-_112359547 0.329 CCDC80
coiled-coil domain containing 80
chr4_-_138453628 0.327 NM_019035
PCDH18
protocadherin 18
chr14_-_73360792 0.322 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr11_+_65266980 0.321


chr2_-_190044330 0.320 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_-_112359565 0.319 CCDC80
coiled-coil domain containing 80
chr3_-_112358510 0.317 CCDC80
coiled-coil domain containing 80
chr4_-_138453564 0.303 PCDH18
protocadherin 18
chr6_+_155411422 0.302 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr19_-_51845377 0.301 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr3_-_112359660 0.301 CCDC80
coiled-coil domain containing 80
chr5_+_140729723 0.299 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr4_+_100495972 0.297 MTTP
microsomal triglyceride transfer protein
chr2_-_145275086 0.295 ZEB2
zinc finger E-box binding homeobox 2
chr5_-_139937677 0.290 NM_001035235
SRA1
steroid receptor RNA activator 1
chr2_-_224467049 0.288 SCG2
secretogranin II
chr15_-_55652777 0.288 CCPG1
cell cycle progression 1
chrX_+_85517970 0.282 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr2_+_79347487 0.278 NM_002909
REG1A
regenerating islet-derived 1 alpha
chr1_+_145663156 0.277 RNF115
ring finger protein 115
chr9_+_79056581 0.273 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr6_+_28249313 0.273 NM_001184743
NM_032507
PGBD1

piggyBac transposable element derived 1

chr18_-_65182507 0.269 DSEL
dermatan sulfate epimerase-like
chr1_-_232651227 0.265 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr5_-_78281076 0.261 ARSB
arylsulfatase B
chr8_-_12973752 0.258 NM_001164271
DLC1
deleted in liver cancer 1
chr5_-_78281556 0.254 ARSB
arylsulfatase B
chr4_+_36283243 0.253 NM_001136536
DTHD1
death domain containing 1
chr2_-_158300517 0.252 NM_004288
CYTIP
cytohesin 1 interacting protein
chr10_-_27529263 0.252 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr3_+_69985750 0.250 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr7_-_14025826 0.249 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_+_92918924 0.248 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr18_-_3011944 0.247 NM_014646
LPIN2
lipin 2
chr8_+_22210311 0.246 PIWIL2
piwi-like 2 (Drosophila)
chr9_+_127119114 0.244


chrX_+_47092264 0.242 NM_004651
USP11
ubiquitin specific peptidase 11
chr5_+_161277391 0.239 NM_001127647
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_-_31648140 0.239 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr12_-_90049818 0.235 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr22_-_24092951 0.230 NM_021916
ZNF70
zinc finger protein 70
chr16_+_21695749 0.230 NM_001161683
OTOA
otoancorin
chrX_-_70473979 0.229 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr2_-_192711651 0.225 SDPR
serum deprivation response
chr12_+_109826523 0.224 NM_001101421
MYO1H
myosin IH
chrX_-_70473941 0.223 ZMYM3
zinc finger, MYM-type 3
chr10_-_93392744 0.223 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr2_-_145277879 0.222 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr3_-_9920633 0.218 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr2_-_224467095 0.218 SCG2
secretogranin II
chr13_-_107220444 0.217 NM_018011
ARGLU1
arginine and glutamate rich 1
chr5_+_139505519 0.216 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr17_+_1665281 0.213 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr16_+_69680959 0.212 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr9_+_66553254 0.210 MGC21881
uncharacterized locus MGC21881
chr1_+_104292439 0.210 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr2_-_40739570 0.206 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_104198301 0.206 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr2_-_202563353 0.205 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chrX_-_40036581 0.204 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr3_+_152017193 0.203 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr19_+_14551052 0.201 PKN1
protein kinase N1
chr9_-_14086901 0.199 NFIB
nuclear factor I/B
chr14_-_100841656 0.198 WARS
tryptophanyl-tRNA synthetase
chr6_-_138820580 0.198


chr5_+_140602914 0.198 NM_018934
PCDHB14
protocadherin beta 14
chr11_+_12960793 0.197 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr5_+_54455945 0.197 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr8_-_93115453 0.195 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr7_+_120702818 0.193 C7orf58
chromosome 7 open reading frame 58
chr3_-_186262114 0.189 NM_017541
CRYGS
crystallin, gamma S
chr13_-_61989654 0.189 NM_022843
PCDH20
protocadherin 20
chr20_-_34117447 0.189 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr10_-_7682741 0.188 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr12_-_120315074 0.187 NM_001206999
NM_007174
CIT

citron (rho-interacting, serine/threonine kinase 21)

chr3_-_112358758 0.187 CCDC80
coiled-coil domain containing 80
chr1_+_178310605 0.186 NM_004841
RASAL2
RAS protein activator like 2
chr18_+_6834431 0.185 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr14_-_88460008 0.185 NM_001201402
GALC
galactosylceramidase
chr1_+_43312302 0.185 ZNF691
zinc finger protein 691
chr17_-_72357957 0.184 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr4_-_170077807 0.184 SH3RF1
SH3 domain containing ring finger 1
chr3_+_38035077 0.183 NM_015873
VILL
villin-like
chr17_+_18647325 0.183 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chr8_-_133772808 0.182 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr1_+_171481164 0.182 PRRC2C
proline-rich coiled-coil 2C
chr2_-_175712276 0.180 NM_001206602
CHN1
chimerin (chimaerin) 1
chr10_+_70482210 0.180 CCAR1
cell division cycle and apoptosis regulator 1
chr16_+_86600856 0.178 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr2_+_33661392 0.178 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr8_+_17822093 0.178 PCM1
pericentriolar material 1
chr3_-_51996855 0.176 NM_033010
PCBP4
poly(rC) binding protein 4
chr11_-_26743545 0.173 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr12_+_60083125 0.172 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr20_+_30102261 0.172 HM13
histocompatibility (minor) 13
chr5_-_58652671 0.172 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_49582800 0.171 NM_006009
TUBA1A
tubulin, alpha 1a
chr6_-_100442098 0.171 NM_001040179
NM_032503
MCHR2

melanin-concentrating hormone receptor 2

chr9_+_125132823 0.167 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr8_+_68864589 0.166 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr8_+_17829848 0.166 PCM1
pericentriolar material 1
chr5_+_76382458 0.166 LOC728723
uncharacterized LOC728723
chr20_+_56964162 0.165 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr1_+_202431870 0.164 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr8_+_17396285 0.163 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr7_-_44228880 0.163 NM_000162
GCK
glucokinase (hexokinase 4)
chr5_+_108083522 0.163 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr9_-_95244750 0.163 NM_001193335
NM_017680
ASPN

asporin

chr21_-_31864274 0.162 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr5_-_160112266 0.161 ATP10B
ATPase, class V, type 10B
chr6_+_144612872 0.161 NM_007124
UTRN
utrophin
chr10_+_88985204 0.161 NM_001099338
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chrX_-_15333726 0.160 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr4_-_57547845 0.160 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr11_+_120973374 0.159 NM_005422
TECTA
tectorin alpha
chr19_-_1401474 0.159 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr17_-_67240955 0.158 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr1_+_203596222 0.157 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr12_+_18891040 0.156 NM_033328
CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr17_+_1665233 0.155 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr5_+_55062712 0.155 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chrX_-_19817907 0.152 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr16_-_4854748 0.152 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr7_-_138794393 0.152 NM_020119
NM_024625
ZC3HAV1

zinc finger CCCH-type, antiviral 1

chr1_-_150780705 0.150 NM_000396
CTSK
cathepsin K
chr12_-_71551564 0.150 TSPAN8
tetraspanin 8
chr9_+_112887780 0.150 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr4_-_177241488 0.149


chr3_+_119013216 0.149 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr14_+_65877309 0.149 NM_004480
NM_178155
NM_178156
FUT8


fucosyltransferase 8 (alpha (1,6) fucosyltransferase)


chr12_-_10588543 0.148 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr9_-_73029539 0.148 NM_001206
KLF9
Kruppel-like factor 9
chr3_-_71592707 0.148 NM_001244816
FOXP1
forkhead box P1
chr2_+_170366211 0.147 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr5_+_95066628 0.145 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr20_-_3765747 0.143 CENPB
centromere protein B, 80kDa
chr13_+_24144402 0.140 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr10_+_225932 0.140 NM_001202467
NM_001202468
ZMYND11

zinc finger, MYND-type containing 11

chr11_+_120195837 0.139 NM_001198670
NM_001198671
NM_001198672
NM_001198673
NM_001198674
NM_001198675
NM_174926
TMEM136






transmembrane protein 136






chr4_+_166299942 0.139 NM_001873
CPE
carboxypeptidase E
chr14_-_60097314 0.139 RTN1
reticulon 1
chr15_-_60690115 0.139 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr3_-_42917191 0.138 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_-_29641068 0.137 EVI2B
ecotropic viral integration site 2B
chr3_-_112359443 0.137 CCDC80
coiled-coil domain containing 80
chr5_+_140800536 0.137 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr10_-_65028825 0.137 NM_004241
JMJD1C
jumonji domain containing 1C

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 1.65e-02 GO:0065007 biological regulation

Nothing significant found in compartment category.

Nothing significant found in function category.