Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.059


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-3chr10_+_1012926890.521.8e-01Click!
NKX2-5chr5_-_1726620850.285.0e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_105845619 2.927 NM_000494
 COL17A1
collagen, type XVII, alpha 1
chr10_-_105845556 2.763 COL17A1
collagen, type XVII, alpha 1
chr3_-_151034514 1.986 NM_023915
 GPR87
G protein-coupled receptor 87
chr12_-_52886971 1.737 NM_005554
 KRT6A
keratin 6A
chr2_-_31352489 1.732 NM_001253827
 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr17_-_56494889 1.454 RNF43
ring finger protein 43
chr12_-_52914080 1.440 NM_000424
 KRT5
keratin 5
chr7_+_94297448 1.144 PEG10
paternally expressed 10
chr8_+_104831415 1.119 NM_014677
 RIMS2
regulating synaptic membrane exocytosis 2
chr9_+_12693385 1.076 NM_000550
 TYRP1
tyrosinase-related protein 1
chr1_+_156030965 1.067 NM_020387
 RAB25
RAB25, member RAS oncogene family
chr6_-_136847078 1.062 NM_001198608
NM_001198609
NM_001198611
 MAP7


microtubule-associated protein 7


chr20_+_62795773 1.051 MYT1
myelin transcription factor 1
chr10_-_123356158 0.987 NM_001144915
 FGFR2
fibroblast growth factor receptor 2
chr1_+_186798031 0.979 NM_024420
 PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr5_+_166711842 0.941 NM_001122679
 ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr2_-_161056573 0.878 NM_000888
 ITGB6
integrin, beta 6
chr1_-_183560010 0.771 NM_001127651
 NCF2
neutrophil cytosolic factor 2
chr1_+_35246789 0.768 NM_024009
 GJB3
gap junction protein, beta 3, 31kDa
chr12_-_28124915 0.761 NM_002820
NM_198965
 PTHLH

parathyroid hormone-like hormone


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.81 1.74e-02 GO:0006955 immune response
1.78 3.03e-02 GO:2000026 regulation of multicellular organismal development
1.76 1.09e-04 GO:0002376 immune system process
1.75 2.80e-02 GO:0006952 defense response
1.53 7.09e-04 GO:0030154 cell differentiation
1.49 1.30e-02 GO:0007166 cell surface receptor linked signaling pathway
1.48 3.23e-03 GO:0048869 cellular developmental process
1.48 1.56e-02 GO:0048513 organ development
1.47 6.61e-07 GO:0007275 multicellular organismal development
1.47 7.97e-05 GO:0048731 system development
1.45 6.20e-07 GO:0032502 developmental process
1.44 5.04e-05 GO:0048856 anatomical structure development
1.34 1.32e-02 GO:0007165 signal transduction
1.33 5.38e-06 GO:0032501 multicellular organismal process
1.33 5.46e-03 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.54 1.11e-02 GO:0031226 intrinsic to plasma membrane
1.53 1.60e-02 GO:0005887 integral to plasma membrane
1.48 1.60e-04 GO:0044459 plasma membrane part
1.39 2.18e-02 GO:0005576 extracellular region

Nothing significant found in function category.