Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.059


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-3chr10_+_1012926890.521.8e-01Click!
NKX2-5chr5_-_1726620850.285.0e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_105845619 2.927 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr10_-_105845556 2.763 COL17A1
collagen, type XVII, alpha 1
chr3_-_151034514 1.986 NM_023915
GPR87
G protein-coupled receptor 87
chr12_-_52886971 1.737 NM_005554
KRT6A
keratin 6A
chr2_-_31352489 1.732 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr17_-_56494889 1.454 RNF43
ring finger protein 43
chr12_-_52914080 1.440 NM_000424
KRT5
keratin 5
chr7_+_94297448 1.144 PEG10
paternally expressed 10
chr8_+_104831415 1.119 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr9_+_12693385 1.076 NM_000550
TYRP1
tyrosinase-related protein 1
chr1_+_156030965 1.067 NM_020387
RAB25
RAB25, member RAS oncogene family
chr6_-_136847078 1.062 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr20_+_62795773 1.051 MYT1
myelin transcription factor 1
chr10_-_123356158 0.987 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr1_+_186798031 0.979 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr5_+_166711842 0.941 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr2_-_161056573 0.878 NM_000888
ITGB6
integrin, beta 6
chr1_-_183560010 0.771 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr1_+_35246789 0.768 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr12_-_28124915 0.761 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr12_+_41831484 0.761 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chrX_+_105937067 0.741 NM_024539
RNF128
ring finger protein 128
chr9_-_124984018 0.740 NM_001242335
LHX6
LIM homeobox 6
chr18_-_53089722 0.705 NM_001243233
TCF4
transcription factor 4
chr12_-_6484904 0.696 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr2_-_165424993 0.693 GRB14
growth factor receptor-bound protein 14
chr9_-_23826062 0.654 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_41742666 0.624 NM_002192
INHBA
inhibin, beta A
chr11_-_16497917 0.622 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr2_-_216003068 0.616 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_+_41086189 0.599 NM_001843
NM_175038
CNTN1

contactin 1

chr19_+_45409003 0.598 NM_000041
APOE
apolipoprotein E
chr13_-_86373328 0.594 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr4_+_77356252 0.587 NM_020859
SHROOM3
shroom family member 3
chr2_+_171571800 0.576 NM_001003845
SP5
Sp5 transcription factor
chr1_-_150738232 0.567 CTSS
cathepsin S
chr5_+_52776479 0.565 FST
follistatin
chr4_+_69313166 0.546 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr1_+_81771844 0.507 LPHN2
latrophilin 2
chr7_-_27205148 0.504 NM_152739
HOXA9
homeobox A9
chr5_+_140186658 0.494 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr8_-_110620220 0.481 SYBU
syntabulin (syntaxin-interacting)
chr8_-_17579729 0.465 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr3_-_79817058 0.456 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chrX_-_32173585 0.455 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr1_-_217250230 0.451 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chrX_-_24690740 0.448 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr7_-_27205123 0.447 HOXA9
homeobox A9
chr4_-_153273683 0.445 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr17_+_39382878 0.441 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr12_+_29376596 0.433 NM_018099
FAR2
fatty acyl CoA reductase 2
chr5_+_140247767 0.427 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr8_-_110655418 0.423 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr10_+_24755459 0.411 KIAA1217
KIAA1217
chr18_-_52988916 0.410 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr6_-_13408368 0.410 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr9_-_95166827 0.409 NM_014057
NM_033014
OGN

osteoglycin

chr6_-_11779279 0.408 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr10_-_5446781 0.403 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr11_-_104972147 0.398 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr3_+_189507448 0.392 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr11_-_104905849 0.391 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr1_-_116383692 0.386 NM_005599
NHLH2
nescient helix loop helix 2
chr6_+_121756744 0.381 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_42384326 0.378 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr10_-_98031154 0.374 NM_001114094
NM_013314
BLNK

B-cell linker

chr1_+_153003677 0.364 NM_003125
SPRR1B
small proline-rich protein 1B
chr17_-_9694613 0.358 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr12_-_6484389 0.351 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_-_16760935 0.336 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr1_+_156254069 0.332 NM_032323
TMEM79
transmembrane protein 79
chrX_+_102965836 0.332 NM_182541
TMEM31
transmembrane protein 31
chr1_-_226926875 0.328 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr2_-_31361591 0.327 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr8_+_107738239 0.326 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr11_+_20620945 0.317 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr12_+_8975149 0.315 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr1_+_86889768 0.315 NM_006536
CLCA2
chloride channel accessory 2
chr20_+_9198036 0.314 NM_182797
PLCB4
phospholipase C, beta 4
chr13_+_97928414 0.308 MBNL2
muscleblind-like 2 (Drosophila)
chr11_-_16424391 0.302 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr8_-_17580024 0.298 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr12_-_6745087 0.298 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr3_+_127641901 0.296 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr15_+_94899163 0.290 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr18_-_53071225 0.289 NM_001243232
TCF4
transcription factor 4
chr3_-_52090090 0.289 NM_001947
DUSP7
dual specificity phosphatase 7
chr4_-_123542165 0.287 NM_001207006
NM_021803
IL21

interleukin 21

chr6_+_130758261 0.287 NM_052913
TMEM200A
transmembrane protein 200A
chr12_-_24103842 0.285 SOX5
SRY (sex determining region Y)-box 5
chr6_-_29012951 0.284 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chrX_-_133792497 0.284 NM_021796
PLAC1
placenta-specific 1
chr5_+_68710938 0.282 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr6_+_134758840 0.281 LOC154092
uncharacterized LOC154092
chr1_+_209878135 0.279 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr11_-_85437457 0.274 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr11_+_34642587 0.271 NM_001206615
NM_012153
EHF

ets homologous factor

chr7_+_129015483 0.264 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_84768333 0.261 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr4_+_71494460 0.258 NM_031889
ENAM
enamelin
chr1_-_23886284 0.258 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr1_+_50569581 0.257 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr8_-_86290333 0.255 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr18_-_53303129 0.254 NM_001243226
TCF4
transcription factor 4
chr13_+_78109808 0.253 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr12_-_31479084 0.253 FAM60A
family with sequence similarity 60, member A
chr6_-_136847609 0.250 MAP7
microtubule-associated protein 7
chr4_+_140587086 0.247 MGST2
microsomal glutathione S-transferase 2
chr18_+_29027731 0.246 NM_001944
DSG3
desmoglein 3
chr7_-_83824216 0.246 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr11_+_117947785 0.245 TMPRSS4
transmembrane protease, serine 4
chr12_+_105153258 0.241 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr20_+_9288446 0.241 NM_000933
PLCB4
phospholipase C, beta 4
chr2_-_69098502 0.237 NM_014482
BMP10
bone morphogenetic protein 10
chr11_+_12308446 0.237 NM_032867
MICALCL
MICAL C-terminal like
chr12_-_123201319 0.232 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr1_-_153044083 0.230 NM_001017418
SPRR2B
small proline-rich protein 2B
chr4_-_77328457 0.230 NM_001042784
CCDC158
coiled-coil domain containing 158
chr10_+_49609641 0.227 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr11_-_124190092 0.225 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr17_-_41836132 0.224 NM_025237
SOST
sclerostin
chr8_-_125579395 0.224 MTSS1
metastasis suppressor 1
chr6_-_33754712 0.224 NM_001143944
LEMD2
LEM domain containing 2
chr7_-_37024664 0.218 NM_001039459
ELMO1
engulfment and cell motility 1
chr7_+_115863004 0.218 NM_152829
TES
testis derived transcript (3 LIM domains)
chr4_-_87281374 0.212 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr14_+_39703119 0.209 NM_054024
MIA2
melanoma inhibitory activity 2
chr1_+_100316530 0.207 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr22_-_45608346 0.207 NM_015264
KIAA0930
KIAA0930
chr1_+_196621007 0.206 NM_000186
NM_001014975
CFH

complement factor H

chr11_-_120008801 0.204 TRIM29
tripartite motif containing 29
chr4_-_87374282 0.203 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr15_-_90349819 0.202 ANPEP
alanyl (membrane) aminopeptidase
chrX_-_128788913 0.201 NM_017413
APLN
apelin
chr1_+_50574589 0.198 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chrX_-_114252132 0.197 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr12_-_6484557 0.197 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr5_-_1882764 0.196 NM_016358
IRX4
iroquois homeobox 4
chr8_-_7287651 0.196 NM_018661
DEFB103B
defensin, beta 103B
chr14_+_92788924 0.195 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr1_-_183559669 0.195 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr5_+_140235594 0.195 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr12_+_28410132 0.194 NM_018318
CCDC91
coiled-coil domain containing 91
chr1_-_222763081 0.193 NM_001201536
NM_005681
NM_139352
TAF1A


TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa


chr2_-_99871569 0.193 NM_175735
LYG2
lysozyme G-like 2
chr6_-_155777036 0.193 NM_015718
NOX3
NADPH oxidase 3
chr12_-_123187842 0.192 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr5_+_147582338 0.190 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chrX_-_21776158 0.190 NM_014332
SMPX
small muscle protein, X-linked
chr4_+_78432905 0.189 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr5_+_140207562 0.189 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr5_+_40909617 0.188 C7
complement component 7
chrX_-_15683153 0.188 NM_020665
TMEM27
transmembrane protein 27
chr13_-_103719195 0.188 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chrX_-_15288172 0.188 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr4_+_30721865 0.187 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr11_-_112034671 0.186 NM_001243211
NM_001562
IL18

interleukin 18 (interferon-gamma-inducing factor)

chrX_-_15333726 0.185 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr5_+_40909558 0.185 NM_000587
C7
complement component 7
chr4_+_30722191 0.185 PCDH7
protocadherin 7
chr11_+_6866882 0.183 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr2_+_207804277 0.183 NM_173077
CPO
carboxypeptidase O
chr1_+_28261503 0.182 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr7_+_129984629 0.182 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr11_-_83393436 0.182 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr12_-_31479120 0.181 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr3_-_57234279 0.181 NM_003865
HESX1
HESX homeobox 1
chr5_+_55149149 0.180 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr11_-_120008738 0.179 TRIM29
tripartite motif containing 29
chr2_+_162272892 0.179 TBR1
T-box, brain, 1
chr6_+_27777713 0.177 NM_003536
HIST1H3H
histone cluster 1, H3h
chr8_+_7738908 0.176 NM_018661
DEFB103B
defensin, beta 103B
chrX_-_131573638 0.176 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr3_-_126327397 0.175 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr1_+_160370363 0.173 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr17_-_39093671 0.173 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_29624249 0.172 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr11_+_34642651 0.171 EHF
ets homologous factor
chr4_+_94750041 0.171 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr22_-_17747520 0.169 CECR3
cat eye syndrome chromosome region, candidate 3 (non-protein coding)
chr9_-_19786886 0.167 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr4_+_169013687 0.166 NM_007193
ANXA10
annexin A10
chr17_+_37894212 0.166 GRB7
growth factor receptor-bound protein 7
chr8_-_20040612 0.166 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr8_+_21900389 0.166 NM_003867
FGF17
fibroblast growth factor 17
chr2_+_33738941 0.165 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_71148063 0.164 PTPRR
protein tyrosine phosphatase, receptor type, R
chr2_+_90211704 0.164


chrX_-_117119282 0.163 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr4_-_111563278 0.161 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr17_+_74553845 0.159 LOC100507246
uncharacterized LOC100507246
chr2_-_190927321 0.159 NM_005259
MSTN
myostatin
chr17_-_46622274 0.158 NM_002145
HOXB2
homeobox B2
chr13_-_75901897 0.158 TBC1D4
TBC1 domain family, member 4
chr1_+_151032866 0.158 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_-_124989755 0.157 NM_001242334
LHX6
LIM homeobox 6
chr7_-_107880492 0.157 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr7_+_114066554 0.156 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr5_+_147258273 0.156 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr5_+_34687663 0.155 NM_001145523
RAI14
retinoic acid induced 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 6.20e-07 GO:0032502 developmental process
1.47 6.61e-07 GO:0007275 multicellular organismal development
1.33 5.38e-06 GO:0032501 multicellular organismal process
1.44 5.04e-05 GO:0048856 anatomical structure development
1.47 7.97e-05 GO:0048731 system development
1.76 1.09e-04 GO:0002376 immune system process
1.53 7.09e-04 GO:0030154 cell differentiation
1.48 3.23e-03 GO:0048869 cellular developmental process
1.33 5.46e-03 GO:0023052 signaling
1.49 1.30e-02 GO:0007166 cell surface receptor linked signaling pathway
1.34 1.32e-02 GO:0007165 signal transduction
1.48 1.56e-02 GO:0048513 organ development
1.81 1.74e-02 GO:0006955 immune response
1.75 2.80e-02 GO:0006952 defense response
1.78 3.03e-02 GO:2000026 regulation of multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 1.60e-04 GO:0044459 plasma membrane part
1.54 1.11e-02 GO:0031226 intrinsic to plasma membrane
1.53 1.60e-02 GO:0005887 integral to plasma membrane
1.39 2.18e-02 GO:0005576 extracellular region

Nothing significant found in function category.