Motif ID: NKX3-1.p2

Z-value: 1.129


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_235404010.098.3e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_153363544 2.303 NM_002964
 S100A8
S100 calcium binding protein A8
chr8_-_15095791 1.890 NM_139167
 SGCZ
sarcoglycan, zeta
chr7_+_86273219 1.871 NM_000840
 GRM3
glutamate receptor, metabotropic 3
chr17_-_56492938 1.845 RNF43
ring finger protein 43
chr18_+_61554938 1.758 NM_001143818
NM_002575
 SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr7_-_41742666 1.671 NM_002192
 INHBA
inhibin, beta A
chr6_-_136847078 1.663 NM_001198608
NM_001198609
NM_001198611
 MAP7


microtubule-associated protein 7


chr17_-_7493389 1.313 NM_006942
 SOX15
SRY (sex determining region Y)-box 15
chr10_+_118187381 1.261 NM_001011709
 PNLIPRP3
pancreatic lipase-related protein 3
chr5_+_140261792 1.248 NM_018904
NM_031865
 PCDHA13

protocadherin alpha 13

chr12_+_41831484 1.187 NM_013377
 PDZRN4
PDZ domain containing ring finger 4
chrX_-_32430370 1.116 NM_004011
NM_004012
 DMD

dystrophin

chr9_-_125941304 1.013 STRBP
spermatid perinuclear RNA binding protein
chr20_+_62795773 1.000 MYT1
myelin transcription factor 1
chr6_-_29012951 0.916 NM_030903
 OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr18_+_61420276 0.850 NM_001040147
 SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr6_+_134758840 0.838 LOC154092
uncharacterized LOC154092
chr20_+_9288446 0.818 NM_000933
 PLCB4
phospholipase C, beta 4
chrX_+_105937067 0.776 NM_024539
 RNF128
ring finger protein 128
chr5_+_140254930 0.740 NM_018903
NM_031864
 PCDHA12

protocadherin alpha 12


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
21.62 8.95e-03 GO:0032693 negative regulation of interleukin-10 production
10.18 6.59e-04 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
10.18 6.59e-04 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
7.21 3.97e-03 GO:0046637 regulation of alpha-beta T cell differentiation
6.28 1.45e-02 GO:0046635 positive regulation of alpha-beta T cell activation
4.92 4.86e-02 GO:0045621 positive regulation of lymphocyte differentiation
4.25 3.66e-02 GO:0045619 regulation of lymphocyte differentiation

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.42 7.29e-03 GO:0005576 extracellular region
1.29 1.89e-03 GO:0005886 plasma membrane
1.27 3.70e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
3.48 2.04e-02 GO:0004867 serine-type endopeptidase inhibitor activity
1.44 3.44e-02 GO:0004872 receptor activity