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Motif ID: NKX3-1.p2

Z-value: 1.129

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_-_153363544	2.303	NM_002964	S100A8	S100 calcium binding protein A8
chr8_-_15095791	1.890	NM_139167	SGCZ	sarcoglycan, zeta
chr7_+_86273219	1.871	NM_000840	GRM3	glutamate receptor, metabotropic 3
chr17_-_56492938	1.845		RNF43	ring finger protein 43
chr18_+_61554938	1.758	NM_001143818 NM_002575	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr7_-_41742666	1.671	NM_002192	INHBA	inhibin, beta A
chr6_-_136847078	1.663	NM_001198608 NM_001198609 NM_001198611	MAP7	microtubule-associated protein 7
chr17_-_7493389	1.313	NM_006942	SOX15	SRY (sex determining region Y)-box 15
chr10_+_118187381	1.261	NM_001011709	PNLIPRP3	pancreatic lipase-related protein 3
chr5_+_140261792	1.248	NM_018904 NM_031865	PCDHA13	protocadherin alpha 13
chr12_+_41831484	1.187	NM_013377	PDZRN4	PDZ domain containing ring finger 4
chrX_-_32430370	1.116	NM_004011 NM_004012	DMD	dystrophin
chr9_-_125941304	1.013		STRBP	spermatid perinuclear RNA binding protein
chr20_+_62795773	1.000		MYT1	myelin transcription factor 1
chr6_-_29012951	0.916	NM_030903	OR2W1	olfactory receptor, family 2, subfamily W, member 1
chr18_+_61420276	0.850	NM_001040147	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr6_+_134758840	0.838		LOC154092	uncharacterized LOC154092
chr20_+_9288446	0.818	NM_000933	PLCB4	phospholipase C, beta 4
chrX_+_105937067	0.776	NM_024539	RNF128	ring finger protein 128
chr5_+_140254930	0.740	NM_018903 NM_031864	PCDHA12	protocadherin alpha 12
chr1_+_84874033	0.718	NM_058248	DNASE2B	deoxyribonuclease II beta
chr3_-_197300193	0.700	NM_203315	BDH1	3-hydroxybutyrate dehydrogenase, type 1
chr2_+_234959345	0.682	NM_006944	SPP2	secreted phosphoprotein 2, 24kDa
chr4_+_88896838	0.667		SPP1	secreted phosphoprotein 1
chr11_-_108464344	0.651	NM_015065	EXPH5	exophilin 5
chr4_+_88896899	0.651		SPP1	secreted phosphoprotein 1
chrX_-_33229428	0.644	NM_004006	DMD	dystrophin
chr4_+_88896868	0.643		SPP1	secreted phosphoprotein 1
chr10_-_14816895	0.640	NM_031453	FAM107B	family with sequence similarity 107, member B
chr5_-_98262217	0.640	NM_001270	CHD1	chromodomain helicase DNA binding protein 1
chr2_+_228356287	0.637		AGFG1	ArfGAP with FG repeats 1
chr4_+_88896801	0.633	NM_000582 NM_001040058 NM_001040060 NM_001251829 NM_001251830	SPP1	secreted phosphoprotein 1
chr5_+_140186658	0.629	NM_018907 NM_031500	PCDHA4	protocadherin alpha 4
chr1_-_207205996	0.624	NM_001083924 NM_023938	C1orf116	chromosome 1 open reading frame 116
chr2_+_103378489	0.623	NM_144632	TMEM182	transmembrane protein 182
chr16_+_4845265	0.604	NM_001253793 NM_001253794	LOC440335	uncharacterized LOC440335
chr19_+_9296269	0.584	NM_175883	OR7D2	olfactory receptor, family 7, subfamily D, member 2
chr11_+_124120422	0.575	NM_001002905	OR8G1	olfactory receptor, family 8, subfamily G, member 1
chr9_-_23821842	0.560	NM_001171195	ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_+_115863004	0.553	NM_152829	TES	testis derived transcript (3 LIM domains)
chr10_-_116444374	0.547	NM_001003407 NM_001003408	ABLIM1	actin binding LIM protein 1
chr9_-_23821808	0.546		ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_+_71494460	0.542	NM_031889	ENAM	enamelin
chr10_-_98031154	0.533	NM_001114094 NM_013314	BLNK	B-cell linker
chr3_-_194188967	0.532	NM_024524	ATP13A3	ATPase type 13A3
chr4_-_153303663	0.531	NM_001013415	FBXW7	F-box and WD repeat domain containing 7
chr2_-_165551178	0.525		COBLL1	COBL-like 1
chr3_+_127641901	0.525	NM_207335	KBTBD12	kelch repeat and BTB (POZ) domain containing 12
chr6_-_136847609	0.517		MAP7	microtubule-associated protein 7
chr15_+_94899163	0.517	NM_001159644	MCTP2	multiple C2 domains, transmembrane 2
chr5_+_147258273	0.515	NM_054023	SCGB3A2	secretoglobin, family 3A, member 2
chrX_-_131261871	0.512	NM_194277	FRMD7	FERM domain containing 7
chr5_+_140235594	0.508	NM_018901 NM_031859 NM_031860	PCDHA10	protocadherin alpha 10
chr18_-_61329113	0.506	NM_006919	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr14_-_106610338	0.491		IGHV4-31 IGHG1	immunoglobulin heavy variable 4-31 immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_136788012	0.484	NM_001198615	MAP7	microtubule-associated protein 7
chr5_+_140247767	0.483	NM_018902 NM_031861	PCDHA11	protocadherin alpha 11
chr10_+_5488521	0.478	NM_005863	NET1	neuroepithelial cell transforming 1
chr12_+_20724797	0.473	NM_001244683	PDE3A	phosphodiesterase 3A, cGMP-inhibited
chr12_+_50869531	0.470		LARP4	La ribonucleoprotein domain family, member 4
chr3_+_142375738	0.469	NM_001172312	PLS1	plastin 1
chr2_+_207804277	0.467	NM_173077	CPO	carboxypeptidase O
chr18_+_61442611	0.465	NM_003784	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr2_+_17721806	0.458	NM_003385	VSNL1	visinin-like 1
chr10_-_118680978	0.457		KIAA1598	KIAA1598
chr6_-_51952368	0.448	NM_138694 NM_170724	PKHD1	polycystic kidney and hepatic disease 1 (autosomal recessive)
chr6_+_131958441	0.446	NM_005021	ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3
chr6_-_155777036	0.443	NM_015718	NOX3	NADPH oxidase 3
chr6_-_111888520	0.440	NM_001164283	TRAF3IP2	TRAF3 interacting protein 2
chr17_+_61086897	0.432	NM_025185	TANC2	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_+_10482677	0.431	NM_001172430	AMPD3	adenosine monophosphate deaminase 3
chr12_+_85430098	0.429	NM_001079910	LRRIQ1	leucine-rich repeats and IQ motif containing 1
chr2_+_102953716	0.421	NM_003856	IL1RL1	interleukin 1 receptor-like 1
chr1_+_160709038	0.408	NM_021181	SLAMF7	SLAM family member 7
chr13_+_42712177	0.406	NM_001204505 NM_001204506	DGKH	diacylglycerol kinase, eta
chr6_-_25874439	0.403	NM_001098486 NM_006632	SLC17A3	solute carrier family 17 (sodium phosphate), member 3
chr5_+_140207562	0.398	NM_018909 NM_031848 NM_031849	PCDHA6	protocadherin alpha 6
chr1_+_77333121	0.395		ST6GALNAC5	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr10_-_123353330	0.395	NM_001144913 NM_001144914	FGFR2	fibroblast growth factor receptor 2
chrX_+_107288199	0.394	NM_001170553 NM_182607	VSIG1	V-set and immunoglobulin domain containing 1
chr19_-_39264144	0.385	NM_002307	LGALS7 LGALS7B	lectin, galactoside-binding, soluble, 7 lectin, galactoside-binding, soluble, 7B
chr8_+_18248754	0.380	NM_000015	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr12_-_50595303	0.372	NM_001243775	LIMA1	LIM domain and actin binding 1
chrX_+_114827818	0.371	NM_001136025 NM_001172335	PLS3	plastin 3
chr3_-_196911001	0.371	NM_001204387 NM_001204388	DLG1	discs, large homolog 1 (Drosophila)
chr12_+_47610244	0.369		FAM113B	family with sequence similarity 113, member B
chr6_+_26365397	0.366	NM_001197247 NM_001197249 NM_007047 NM_001197248	BTN3A2	butyrophilin, subfamily 3, member A2
chr16_+_82068958	0.366		HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82068830	0.356	NM_002153	HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2
chr8_-_86253863	0.356	NM_001164830	CA1	carbonic anhydrase I
chr19_+_49078992	0.355	NM_004605	SULT2B1	sulfotransferase family, cytosolic, 2B, member 1
chr1_-_51887740	0.349	NM_001159969	EPS15	epidermal growth factor receptor pathway substrate 15
chr2_+_17721983	0.344		VSNL1	visinin-like 1
chr8_-_124749573	0.344	NM_001003954 NM_004306	ANXA13	annexin A13
chr2_-_165424993	0.344		GRB14	growth factor receptor-bound protein 14
chr18_+_72167021	0.343		CNDP2	CNDP dipeptidase 2 (metallopeptidase M20 family)
chr21_-_27253197	0.343		APP	amyloid beta (A4) precursor protein
chr5_+_36606667	0.342		SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_57529233	0.341	NM_001085458 NM_001085459 NM_001085460 NM_001085461 NM_001085462 NM_001085463 NM_001085464 NM_001085465 NM_001085466 NM_001085467 NM_001085468 NM_001085469 NM_001206883 NM_001206884 NM_001206885 NM_001206886 NM_001206887 NM_001206888 NM_001206889 NM_001206890 NM_001206891 NM_001331	CTNND1	catenin (cadherin-associated protein), delta 1
chr5_-_78281688	0.336	NM_198709	ARSB	arylsulfatase B
chr1_-_216978708	0.335	NM_001243514	ESRRG	estrogen-related receptor gamma
chr2_+_64681270	0.331	NM_014181	LGALSL	lectin, galactoside-binding-like
chr14_+_67831484	0.331		EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr12_+_56732658	0.314	NM_016584	IL23A	interleukin 23, alpha subunit p19
chr12_-_52604488	0.314	NM_001242696	LOC283403	uncharacterized LOC283403
chr4_-_103245468	0.308	NM_001135148	SLC39A8	solute carrier family 39 (zinc transporter), member 8
chr20_+_58713521	0.305		LOC284757	uncharacterized LOC284757
chr16_+_82068910	0.305		HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2
chr14_+_39703119	0.303	NM_054024	MIA2	melanoma inhibitory activity 2
chr1_+_158149736	0.302	NM_001766	CD1D	CD1d molecule
chr4_+_74301932	0.301	NM_001134	AFP	alpha-fetoprotein
chr14_-_75600111	0.299		TMED10	transmembrane emp24-like trafficking protein 10 (yeast)
chrX_-_77914824	0.297	NM_152694	ZCCHC5	zinc finger, CCHC domain containing 5
chr10_+_112344076	0.297		SMC3	structural maintenance of chromosomes 3
chr4_+_166131170	0.295	NM_001161521 NM_001161522	KLHL2	kelch-like 2, Mayven (Drosophila)
chr11_-_102651321	0.295	NM_002425	MMP10	matrix metallopeptidase 10 (stromelysin 2)
chrX_-_133792497	0.295	NM_021796	PLAC1	placenta-specific 1
chr15_-_62457481	0.292	NM_001007595	C2CD4B	C2 calcium-dependent domain containing 4B
chrX_+_115301957	0.287	NM_000686	AGTR2	angiotensin II receptor, type 2
chr6_+_14117486	0.286	NM_001251901	CD83	CD83 molecule
chr11_+_55578842	0.286	NM_001004738	OR5L1	olfactory receptor, family 5, subfamily L, member 1
chr17_-_29641094	0.284	NM_006495	EVI2B	ecotropic viral integration site 2B
chr6_-_138820578	0.284	NM_001144060	NHSL1	NHS-like 1
chrX_-_114252132	0.280	NM_000640	IL13RA2	interleukin 13 receptor, alpha 2
chr11_+_55594694	0.279	NM_001004739	OR5L2	olfactory receptor, family 5, subfamily L, member 2
chr17_-_64225496	0.276	NM_000042	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr20_+_30697291	0.275	NM_014742	TM9SF4	transmembrane 9 superfamily protein member 4
chrX_+_91090459	0.275	NM_001168360 NM_001168361 NM_001168362 NM_001168363	PCDH11X	protocadherin 11 X-linked
chr1_+_152784446	0.274	NM_178349	LCE1B	late cornified envelope 1B
chr13_-_86373328	0.272	NM_032229	SLITRK6	SLIT and NTRK-like family, member 6
chr17_+_7788094	0.272	NM_001005271	CHD3	chromodomain helicase DNA binding protein 3
chr10_+_116697914	0.270	NM_139169	TRUB1	TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr15_+_66694216	0.270		MAP2K1	mitogen-activated protein kinase kinase 1
chr19_-_42931500	0.270	NM_005357	LIPE	lipase, hormone-sensitive
chr17_+_9729380	0.269	NM_004246	GLP2R	glucagon-like peptide 2 receptor
chr12_+_47610051	0.269	NM_138371	FAM113B	family with sequence similarity 113, member B
chrX_-_2882288	0.269	NM_000047	ARSE	arylsulfatase E (chondrodysplasia punctata 1)
chr12_-_6055397	0.268	NM_020373	ANO2	anoctamin 2
chr7_+_48075107	0.266	NM_001100159	C7orf57	chromosome 7 open reading frame 57
chr10_-_99094427	0.263	NM_012083	FRAT2	frequently rearranged in advanced T-cell lymphomas 2
chr18_+_33234532	0.261	NM_020474	GALNT1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr14_-_23446431	0.260	NM_198086	AJUBA	ajuba LIM protein
chr4_-_123542165	0.259	NM_001207006 NM_021803	IL21	interleukin 21
chr8_+_101170231	0.257	NM_172218	SPAG1	sperm associated antigen 1
chr12_-_48963802	0.255	NM_002289	LALBA	lactalbumin, alpha-
chr13_-_75901897	0.254		TBC1D4	TBC1 domain family, member 4
chr11_+_12308446	0.253	NM_032867	MICALCL	MICAL C-terminal like
chr13_+_32313678	0.251	NM_001166058 NM_130806	RXFP2	relaxin/insulin-like family peptide receptor 2
chr2_-_142889269	0.251	NM_018557	LRP1B	low density lipoprotein receptor-related protein 1B
chrX_+_105412297	0.250	NM_001171020 NM_152423	MUM1L1	melanoma associated antigen (mutated) 1-like 1
chr5_+_166711842	0.244	NM_001122679	ODZ2	odz, odd Oz/ten-m homolog 2 (Drosophila)
chr8_+_26150731	0.242	NM_001177591	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr12_-_18243052	0.239	NM_024730	RERGL	RERG/RAS-like
chr1_+_84630374	0.236		PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr1_-_93342706	0.236	NM_001252271	FAM69A	family with sequence similarity 69, member A
chr5_+_140220811	0.236	NM_018911 NM_031856	PCDHA8	protocadherin alpha 8
chr19_-_44174497	0.235	NM_001005376 NM_001005377 NM_002659	PLAUR	plasminogen activator, urokinase receptor
chr10_-_116444112	0.234		ABLIM1	actin binding LIM protein 1
chr5_+_36606456	0.233	NM_001166696 NM_004172	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_116383323	0.229	NM_001111061	NHLH2	nescient helix loop helix 2
chr21_-_31538970	0.229	NM_012131	CLDN17	claudin 17
chr6_-_49604524	0.228	NM_000324	RHAG	Rh-associated glycoprotein
chr10_-_123353771	0.227	NM_001144916	FGFR2	fibroblast growth factor receptor 2
chr18_-_22930826	0.227
chr5_+_147691988	0.222	NM_032566	SPINK7	serine peptidase inhibitor, Kazal type 7 (putative)
chr14_-_35344852	0.218	NM_013448 NM_182648	BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr1_+_81771844	0.218		LPHN2	latrophilin 2
chr5_+_68800003	0.217	NM_001205255	OCLN	occludin
chr2_+_75059781	0.216	NM_000189	HK2	hexokinase 2
chr10_-_11574273	0.216	NM_001080491	USP6NL	USP6 N-terminal like
chr18_-_24442534	0.215	NM_004028	AQP4	aquaporin 4
chr4_+_78432905	0.212	NM_006419	CXCL13	chemokine (C-X-C motif) ligand 13
chr11_-_7818488	0.212	NM_153444	OR5P2	olfactory receptor, family 5, subfamily P, member 2
chr9_+_96233420	0.210		FAM120A	family with sequence similarity 120A
chr1_-_150738232	0.210		CTSS	cathepsin S
chr3_-_123339178	0.207		MYLK	myosin light chain kinase
chr1_+_167298382	0.207		POU2F1	POU class 2 homeobox 1
chr11_-_128894008	0.207	NM_014715	ARHGAP32	Rho GTPase activating protein 32
chr9_-_124922049	0.206	NM_014222	NDUFA8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chr21_-_36252872	0.205		RUNX1	runt-related transcription factor 1
chrX_-_131573638	0.205	NM_018388 NM_133486	MBNL3	muscleblind-like 3 (Drosophila)
chr4_+_69313166	0.205	NM_014058	TMPRSS11E	transmembrane protease, serine 11E
chr4_+_187148624	0.203	NM_000892	KLKB1	kallikrein B, plasma (Fletcher factor) 1
chr17_-_56494930	0.202	NM_017763	RNF43	ring finger protein 43
chr6_+_144185572	0.201	NM_001013623	C6orf94	chromosome 6 open reading frame 94
chr1_-_217250230	0.201	NM_001243507 NM_001243509	ESRRG	estrogen-related receptor gamma
chr6_-_119252887	0.200	NM_017696	MCM9	minichromosome maintenance complex component 9
chr9_-_124921981	0.200		NDUFA8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chrX_-_72434667	0.198	NM_021963	NAP1L2	nucleosome assembly protein 1-like 2
chr22_+_40322609	0.196		GRAP2	GRB2-related adaptor protein 2
chr11_-_30601919	0.196	NM_001584	MPPED2	metallophosphoesterase domain containing 2
chr2_+_234826042	0.195	NM_024080	TRPM8	transient receptor potential cation channel, subfamily M, member 8
chr1_+_186798031	0.195	NM_024420	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_-_39347258	0.194	NM_030772	GJA9-MYCBP GJA9	GJA9-MYCBP readthrough gap junction protein, alpha 9, 59kDa
chr9_+_125376947	0.193	NM_012364	OR1Q1	olfactory receptor, family 1, subfamily Q, member 1
chr17_-_16256708	0.193	NM_181716	CENPV	centromere protein V
chr11_+_128564130	0.193		FLI1	Friend leukemia virus integration 1
chr11_+_5474637	0.192	NM_001004754	OR51I2	olfactory receptor, family 51, subfamily I, member 2
chr2_+_120770606	0.189	NM_001184938	EPB41L5	erythrocyte membrane protein band 4.1 like 5
chr11_+_33363104	0.188		HIPK3	homeodomain interacting protein kinase 3

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
10.18	6.59e-04	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation
10.18	6.59e-04	GO:2000514	regulation of CD4-positive, alpha-beta T cell activation
7.21	3.97e-03	GO:0046637	regulation of alpha-beta T cell differentiation
21.62	8.95e-03	GO:0032693	negative regulation of interleukin-10 production
6.28	1.45e-02	GO:0046635	positive regulation of alpha-beta T cell activation
4.25	3.66e-02	GO:0045619	regulation of lymphocyte differentiation
4.92	4.86e-02	GO:0045621	positive regulation of lymphocyte differentiation

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.29	1.89e-03	GO:0005886	plasma membrane
1.27	3.70e-03	GO:0071944	cell periphery
1.42	7.29e-03	GO:0005576	extracellular region

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
3.48	2.04e-02	GO:0004867	serine-type endopeptidase inhibitor activity
1.44	3.44e-02	GO:0004872	receptor activity