Motif ID: NKX3-2.p2

Z-value: 1.420


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13546037-0.383.5e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17721983 3.405 VSNL1
visinin-like 1
chr2_-_70781146 2.595 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr5_+_52776479 2.113 FST
follistatin
chr2_+_17721806 2.068 NM_003385
VSNL1
visinin-like 1
chr5_+_52776263 1.991 NM_006350
NM_013409
FST

follistatin

chr5_+_52776408 1.985 FST
follistatin
chr10_-_123353771 1.905 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr2_-_70780621 1.815 TGFA
transforming growth factor, alpha
chr7_+_26403944 1.780 NM_001199838
SNX10
sorting nexin 10
chr11_-_120008801 1.545 TRIM29
tripartite motif containing 29
chr11_-_120008738 1.527 TRIM29
tripartite motif containing 29
chr19_-_6720585 1.460 NM_000064
C3
complement component 3
chr1_+_86889768 1.453 NM_006536
CLCA2
chloride channel accessory 2
chr12_+_4382882 1.364 NM_001759
CCND2
cyclin D2
chr16_+_57406398 1.316 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr1_-_153363544 1.303 NM_002964
S100A8
S100 calcium binding protein A8
chr11_-_120008219 1.279 TRIM29
tripartite motif containing 29
chr10_+_82173574 1.220 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr7_+_26331493 1.202 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr15_+_41136622 1.199 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr7_+_26331611 1.147 SNX10
sorting nexin 10
chr10_-_5446781 1.142 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr2_-_161056573 1.132 NM_000888
ITGB6
integrin, beta 6
chr12_-_58160823 1.131 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_+_35247838 1.081 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr16_-_31146992 1.048 PRSS8
protease, serine, 8
chr12_-_52914080 1.022 NM_000424
KRT5
keratin 5
chr8_+_102504836 1.002 GRHL2
grainyhead-like 2 (Drosophila)
chr2_-_113594325 0.999 NM_000576
IL1B
interleukin 1, beta
chr16_-_31147062 0.996 NM_002773
PRSS8
protease, serine, 8
chr1_-_160990862 0.954 F11R
F11 receptor
chr1_-_160990971 0.953 NM_016946
F11R
F11 receptor
chr8_+_102504661 0.947 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr15_+_40509628 0.914 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr8_+_120220554 0.904 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr15_-_74726258 0.886 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr12_-_6484904 0.864 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr11_-_120008848 0.862 NM_012101
TRIM29
tripartite motif containing 29
chr6_-_136788012 0.843 NM_001198615
MAP7
microtubule-associated protein 7
chr6_-_30712294 0.839 NM_003897
IER3
immediate early response 3
chr1_+_35246789 0.826 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr1_+_46646199 0.818 TSPAN1
tetraspanin 1
chr3_+_50192420 0.799 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr7_+_18126543 0.796 NM_001204144
HDAC9
histone deacetylase 9
chrX_+_105937067 0.796 NM_024539
RNF128
ring finger protein 128
chr5_-_60140041 0.777 NM_001104558
NM_024930
ELOVL7

ELOVL fatty acid elongase 7

chr8_-_42397048 0.772 NM_006749
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr6_+_54711568 0.766 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr4_+_77356252 0.766 NM_020859
SHROOM3
shroom family member 3
chrX_-_32173585 0.760 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr11_+_10482677 0.758 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr1_+_26856252 0.754 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr5_+_66124603 0.752 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr9_-_33447527 0.745 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr4_-_84255999 0.732 HPSE
heparanase
chr10_+_47746919 0.728 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr1_-_221915426 0.721 DUSP10
dual specificity phosphatase 10
chr16_+_68679198 0.713 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr8_+_123793988 0.701 ZHX2
zinc fingers and homeoboxes 2
chr20_-_22564893 0.697 FOXA2
forkhead box A2
chr3_-_190040192 0.696 NM_021101
CLDN1
claudin 1
chr1_+_153330329 0.689 NM_002965
S100A9
S100 calcium binding protein A9
chr8_+_123794043 0.683 ZHX2
zinc fingers and homeoboxes 2
chr18_+_61254533 0.680 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_+_26856240 0.674 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr18_-_28742744 0.674 NM_004948
NM_024421
DSC1

desmocollin 1

chr8_+_123793894 0.665 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr2_-_69098502 0.664 NM_014482
BMP10
bone morphogenetic protein 10
chr12_-_52886971 0.662 NM_005554
KRT6A
keratin 6A
chr12_-_53298765 0.662 NM_002273
KRT8
keratin 8
chr1_-_159915382 0.659 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr1_+_43735664 0.656 NM_144626
TMEM125
transmembrane protein 125
chr10_+_24755459 0.653 KIAA1217
KIAA1217
chr15_-_83621350 0.638 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr16_+_68679229 0.635 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr6_+_80340971 0.631 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr10_-_116286661 0.622 NM_006720
ABLIM1
actin binding LIM protein 1
chr17_-_76128487 0.607 NM_007267
TMC6
transmembrane channel-like 6
chr2_-_161056762 0.604 ITGB6
integrin, beta 6
chr11_-_118134986 0.599 MPZL2
myelin protein zero-like 2
chr12_+_41831484 0.596 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr3_+_136676706 0.593 NM_144717
IL20RB
interleukin 20 receptor beta
chr12_-_123201319 0.588 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr12_-_52845862 0.585 NM_005555
KRT6B
keratin 6B
chr15_+_40531236 0.584 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_107682628 0.582 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr4_-_84256012 0.565 NM_001098540
HPSE
heparanase
chr1_-_24469571 0.552 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr12_-_123187842 0.552 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr5_+_68710938 0.552 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr2_+_102979096 0.549 NM_003855
IL18R1
interleukin 18 receptor 1
chr1_+_158150678 0.547 CD1D
CD1d molecule
chr6_+_90276556 0.545 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr3_-_182880463 0.545 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr16_+_82068830 0.544 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr19_+_7702020 0.538 STXBP2
syntaxin binding protein 2
chr8_-_57233240 0.532 NM_138969
SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr16_-_72206023 0.531 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr12_+_107712151 0.531 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr3_+_121774208 0.530 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr12_+_57984914 0.528 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr1_+_82266081 0.528 NM_012302
LPHN2
latrophilin 2
chr10_-_98031154 0.526 NM_001114094
NM_013314
BLNK

B-cell linker

chr12_+_104850762 0.526 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_+_156119734 0.519 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr12_+_104850784 0.518 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_-_217262946 0.516 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr10_+_82167584 0.510 NM_001243779
C10orf58
chromosome 10 open reading frame 58
chr3_-_46718898 0.505 NM_182775
ALS2CL
ALS2 C-terminal like
chr2_+_173292306 0.505 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr6_+_125475334 0.498 NM_001003395
TPD52L1
tumor protein D52-like 1
chr1_-_209825673 0.493 NM_001127641
LAMB3
laminin, beta 3
chr11_+_18287807 0.492 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr4_-_110723127 0.492 CFI
complement factor I
chrX_-_15683153 0.490 NM_020665
TMEM27
transmembrane protein 27
chr12_-_8815266 0.486 MFAP5
microfibrillar associated protein 5
chr5_+_131409484 0.485 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr12_+_83080621 0.484 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr12_+_107974633 0.479 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr1_+_151483861 0.478 NM_020770
CGN
cingulin
chr4_-_84256304 0.471 NM_001166498
NM_006665
HPSE

heparanase

chr8_-_66701175 0.471 NM_002603
PDE7A
phosphodiesterase 7A
chr12_-_8815479 0.469 MFAP5
microfibrillar associated protein 5
chr17_-_47841468 0.467 FAM117A
family with sequence similarity 117, member A
chrX_-_117119282 0.464 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr12_+_57984992 0.463 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr3_+_50192847 0.462 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr10_-_123353330 0.462 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr4_-_84255895 0.461 NM_001199830
HPSE
heparanase
chr11_-_18270167 0.455 NM_001199744
NM_001127380
NM_030754
SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr10_+_82213892 0.452 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr12_+_70759974 0.444 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr11_-_118135197 0.444 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr22_-_37584254 0.444 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr4_-_110723334 0.440 NM_000204
CFI
complement factor I
chr14_+_68086633 0.438 ARG2
arginase, type II
chr17_-_47841517 0.438 NM_030802
FAM117A
family with sequence similarity 117, member A
chr1_+_26872342 0.433 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_+_82214066 0.433 TSPAN14
tetraspanin 14
chr16_+_69139466 0.432 NM_001199280
HAS3
hyaluronan synthase 3
chr6_-_41715078 0.426 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr8_+_95653272 0.425 ESRP1
epithelial splicing regulatory protein 1
chr1_+_60280462 0.422 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr1_+_234040547 0.420 NM_173508
SLC35F3
solute carrier family 35, member F3
chr2_-_237416091 0.417 NM_024726
IQCA1
IQ motif containing with AAA domain 1
chr1_+_26872306 0.417 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_+_7348362 0.414 NM_000747
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr16_+_68771192 0.414 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr4_-_10041833 0.414 NM_001001290
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr12_+_41086189 0.412 NM_001843
NM_175038
CNTN1

contactin 1

chr11_+_10477480 0.411 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr12_-_6745087 0.409 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr12_-_71031174 0.409 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr16_+_68771304 0.408 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr8_+_24772454 0.408 NM_001105541
NEFM
neurofilament, medium polypeptide
chr14_-_21567069 0.408 NM_001101672
ZNF219
zinc finger protein 219
chr3_+_122044010 0.407 NM_005213
CSTA
cystatin A (stefin A)
chr2_+_191045588 0.406 NM_001042519
NM_032321
C2orf88

chromosome 2 open reading frame 88

chr1_+_160370363 0.405 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr1_-_209979388 0.405 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr6_-_143832770 0.402 NM_032020
FUCA2
fucosidase, alpha-L- 2, plasma
chr17_-_46655544 0.402 NM_024015
HOXB4
homeobox B4
chr10_-_103874661 0.400 NM_003893
LDB1
LIM domain binding 1
chr20_-_22565050 0.394 NM_021784
FOXA2
forkhead box A2
chr1_-_221915393 0.393 DUSP10
dual specificity phosphatase 10
chr2_-_192015733 0.390 STAT4
signal transducer and activator of transcription 4
chr1_-_221915458 0.388 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr10_+_82214071 0.386 TSPAN14
tetraspanin 14
chr6_-_111894897 0.385 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chrX_-_128788913 0.383 NM_017413
APLN
apelin
chr11_-_64727608 0.383 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr10_-_88717319 0.381 NM_024756
MMRN2
multimerin 2
chr5_-_139726173 0.380 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr12_-_54778456 0.378 NM_015481
ZNF385A
zinc finger protein 385A
chr3_-_171177851 0.378 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr2_+_85811530 0.378 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr11_-_118134956 0.378 MPZL2
myelin protein zero-like 2
chr10_+_71390002 0.378 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr6_+_50681256 0.376 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr1_-_21059132 0.376 NM_001103160
NM_001103161
SH2D5

SH2 domain containing 5

chr2_+_68961912 0.375 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr3_-_191048324 0.375 NM_198152
UTS2D
urotensin 2 domain containing
chr11_+_34642587 0.374 NM_001206615
NM_012153
EHF

ets homologous factor

chr10_+_82214074 0.373 TSPAN14
tetraspanin 14
chr6_-_86352564 0.373 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr14_-_54421269 0.373 NM_130851
BMP4
bone morphogenetic protein 4
chr4_+_144257982 0.373 NM_002039
NM_207123
GAB1

GRB2-associated binding protein 1

chr1_+_152974222 0.372 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chrX_-_31284946 0.371 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr12_+_13043955 0.371 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr1_+_206730497 0.370 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr13_-_103719195 0.370 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr1_-_153029987 0.368 NM_005988
SPRR2A
small proline-rich protein 2A
chr7_+_18548899 0.367 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr5_+_140345746 0.366 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr11_+_1861431 0.365 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr16_+_68771214 0.360 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr15_+_40532034 0.360 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr12_+_56732658 0.359 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr3_-_143567163 0.358 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 3.69e-05 GO:0009987 cellular process
1.20 1.13e-04 GO:0023052 signaling
1.20 6.84e-04 GO:0007165 signal transduction
1.20 9.61e-04 GO:0048856 anatomical structure development
1.25 3.04e-03 GO:0030154 cell differentiation
1.25 4.13e-03 GO:0048869 cellular developmental process
1.17 7.11e-03 GO:0032502 developmental process
1.32 1.24e-02 GO:0002376 immune system process
1.20 1.34e-02 GO:0048731 system development
1.17 3.42e-02 GO:0007275 multicellular organismal development
1.19 4.47e-02 GO:0048518 positive regulation of biological process
1.27 4.77e-02 GO:0007399 nervous system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 2.16e-03 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 2.79e-07 GO:0005515 protein binding