Motif ID: NKX6-1,2.p2

Z-value: 0.303


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-1chr4_-_85419386-0.472.4e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_238322815 0.298 COL6A3
collagen, type VI, alpha 3
chr2_-_238322840 0.296 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chrX_+_85517970 0.277 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr1_+_79086087 0.264 NM_006820
IFI44L
interferon-induced protein 44-like
chr5_+_95066628 0.218 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr6_+_72922513 0.199 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr14_-_60097531 0.182 NM_206852
RTN1
reticulon 1
chr14_-_60097314 0.176 RTN1
reticulon 1
chr13_-_33760215 0.162 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr13_-_38172862 0.157 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_+_155853546 0.152 SYT11
synaptotagmin XI
chr20_-_18477811 0.150 NM_006606
RBBP9
retinoblastoma binding protein 9
chr14_-_61115906 0.147 NM_005982
SIX1
SIX homeobox 1
chr4_-_138453628 0.146 NM_019035
PCDH18
protocadherin 18
chr2_-_188419049 0.145 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_188419185 0.141 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_+_210444364 0.137 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr10_+_31610063 0.137 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr6_-_46293628 0.137 NM_005822
RCAN2
regulator of calcineurin 2
chr3_+_12392993 0.132 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr5_-_111091947 0.132 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr12_-_91573264 0.130 NM_133503
DCN
decorin
chr12_+_32654976 0.127 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr6_+_136172802 0.126 NM_018945
PDE7B
phosphodiesterase 7B
chr8_+_79428335 0.125 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr8_-_82395401 0.121 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_-_54199876 0.118 NM_147193
GLIS1
GLIS family zinc finger 1
chr4_+_74347461 0.117 NM_001133
AFM
afamin
chr2_+_210444154 0.107 MAP2
microtubule-associated protein 2
chrX_+_80457302 0.107 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_+_210501595 0.106 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr14_+_101295409 0.100 MEG3
maternally expressed 3 (non-protein coding)
chr5_+_67586466 0.094 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_+_140729723 0.094 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr5_-_58295758 0.092 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_-_103087106 0.091 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr2_+_33359607 0.090 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr4_+_70894129 0.090 NM_000200
HTN3
histatin 3
chr3_+_45927995 0.090 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr13_+_24144402 0.088 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr10_-_70066594 0.085 PBLD
phenazine biosynthesis-like protein domain containing
chr20_-_45927496 0.084 ZMYND8
zinc finger, MYND-type containing 8
chr1_+_114522029 0.084 NM_020190
OLFML3
olfactomedin-like 3
chr2_-_175712276 0.083 NM_001206602
CHN1
chimerin (chimaerin) 1
chr3_-_114790221 0.082 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_148447966 0.081 NM_032049
AGTR1
angiotensin II receptor, type 1
chr18_-_3011944 0.081 NM_014646
LPIN2
lipin 2
chr3_-_151102536 0.080 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr4_-_138453564 0.079 PCDH18
protocadherin 18
chr9_-_73736513 0.079 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr4_+_55095263 0.076 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr4_+_166299942 0.074 NM_001873
CPE
carboxypeptidase E
chr12_-_46357949 0.073


chr19_-_9092017 0.073 NM_024690
MUC16
mucin 16, cell surface associated
chr11_-_102401430 0.072 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr1_-_57045235 0.071 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr10_-_14372807 0.070 NM_018027
FRMD4A
FERM domain containing 4A
chr3_-_58563070 0.069 FAM107A
family with sequence similarity 107, member A
chr19_-_23598867 0.067


chr1_-_92351613 0.067 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr19_-_3029611 0.066 NM_001144762
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chrX_+_66788682 0.066 NM_001011645
AR
androgen receptor
chr3_-_105421044 0.064 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr1_+_104097321 0.064 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr1_+_104159953 0.063 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr6_+_114178516 0.063 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr2_-_65593763 0.063 SPRED2
sprouty-related, EVH1 domain containing 2
chr13_-_44203608 0.062 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr9_+_34652125 0.062 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr7_+_150065330 0.059 REPIN1
replication initiator 1
chr3_-_9920633 0.059 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr20_-_34025955 0.058 NM_000557
GDF5
growth differentiation factor 5
chr19_-_23598839 0.057


chr17_+_78356710 0.057 RNF213
ring finger protein 213
chr5_+_140739589 0.057 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr6_+_25962978 0.056 NM_006355
TRIM38
tripartite motif containing 38
chr2_+_102770401 0.056 NM_000877
IL1R1
interleukin 1 receptor, type I
chr1_+_201617529 0.054 NAV1
neuron navigator 1
chr20_+_11898536 0.054 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr11_-_27681195 0.053 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr1_+_179560747 0.053 NM_001199091
NM_001199085
NM_173533
TDRD5


tudor domain containing 5


chr1_+_145477018 0.053 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr18_+_72922725 0.052 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr12_-_91505541 0.052 NM_002345
LUM
lumican
chr2_-_144994905 0.052 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr12_-_10573041 0.051 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chrX_+_80457597 0.051 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr7_+_64601439 0.051 INTS4L1
integrator complex subunit 4-like 1
chr7_-_92855780 0.050 NM_001039372
HEPACAM2
HEPACAM family member 2
chr20_+_57022460 0.049 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr12_-_91505215 0.047 LUM
lumican
chrX_+_10124984 0.047 NM_001830
CLCN4
chloride channel 4
chrX_+_47441650 0.047 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr7_+_23286384 0.046 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_79115476 0.046 NM_006417
IFI44
interferon-induced protein 44
chr7_+_28725597 0.045 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr8_-_23712297 0.044 NM_003155
STC1
stanniocalcin 1
chr5_+_59784004 0.042 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr2_-_202563353 0.042 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr21_-_35884503 0.041 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr2_+_108994366 0.041 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr3_-_58563490 0.041 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr5_+_140800536 0.041 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr16_-_11375094 0.041 NM_002761
PRM1
protamine 1
chr15_+_93443559 0.040 CHD2
chromodomain helicase DNA binding protein 2
chr4_+_62362838 0.039 NM_015236
LPHN3
latrophilin 3
chr18_+_66465316 0.039 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr3_-_64211111 0.039 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr6_-_87804773 0.039 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr16_+_15596122 0.039 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr9_+_82186846 0.039 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr7_+_7606549 0.038 NM_019005
MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chrX_-_19988381 0.038 NM_198279
CXorf23
chromosome X open reading frame 23
chr12_-_53558276 0.038 NM_001244706
CSAD
cysteine sulfinic acid decarboxylase
chr9_-_73483933 0.037 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr12_-_58135853 0.037 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_-_110155672 0.037 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr6_+_35226685 0.037 ZNF76
zinc finger protein 76
chr5_+_76382458 0.037 LOC728723
uncharacterized LOC728723
chrX_+_153533408 0.037 NM_001145934
TKTL1
transketolase-like 1
chr5_+_118965253 0.036 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chrX_-_100872926 0.036 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr4_-_140201339 0.036 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr3_-_151987332 0.036 LOC401093
uncharacterized LOC401093
chr6_+_39760138 0.036


chr3_+_149192367 0.035 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr16_+_67311412 0.035 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr4_-_17806820 0.035 DCAF16
DDB1 and CUL4 associated factor 16
chr4_+_169418167 0.035 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr6_+_79787548 0.035 PHIP
pleckstrin homology domain interacting protein
chr16_-_3627353 0.035 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr8_+_24298442 0.035 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr9_-_123812535 0.035 NM_001735
C5
complement component 5
chr3_+_180320955 0.034 TTC14
tetratricopeptide repeat domain 14
chr5_-_147162264 0.034 JAKMIP2
janus kinase and microtubule interacting protein 2
chrX_+_102840412 0.034 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr3_-_138048727 0.033 NM_178130
NME9
NME gene family member 9
chrX_+_47441802 0.033 TIMP1
TIMP metallopeptidase inhibitor 1
chr7_-_137028533 0.033 NM_002825
PTN
pleiotrophin
chr4_+_77227178 0.033 NM_003943
STBD1
starch binding domain 1
chr17_-_67240955 0.032 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr12_+_60083125 0.032 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr1_+_59775749 0.032 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr11_+_103907307 0.031 NM_001001711
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr12_+_7023490 0.031 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr22_-_36562224 0.031 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr7_-_137686814 0.031 NM_001253775
NM_194071
CREB3L2

cAMP responsive element binding protein 3-like 2

chr1_+_196621007 0.031 NM_000186
NM_001014975
CFH

complement factor H

chr4_+_74606222 0.031 NM_000584
IL8
interleukin 8
chr17_+_3379295 0.030 NM_000049
ASPA
aspartoacylase
chr10_+_74870209 0.030 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr11_-_55703875 0.030 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr2_+_24807345 0.030 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr6_+_41020939 0.030 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr1_+_104198301 0.030 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr4_-_186732047 0.030 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr7_+_23286277 0.030 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr18_+_43306917 0.029 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr2_+_109204777 0.029 LIMS1
LIM and senescent cell antigen-like domains 1
chr7_-_14025826 0.029 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_-_33041266 0.029 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr7_+_23286420 0.029 GPNMB
glycoprotein (transmembrane) nmb
chr11_+_17332454 0.029


chr2_+_204801453 0.029 NM_012092
ICOS
inducible T-cell co-stimulator
chr20_+_20037289 0.029 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr5_-_147162175 0.029 JAKMIP2
janus kinase and microtubule interacting protein 2
chr3_-_39234071 0.029 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr1_-_57044980 0.029 PPAP2B
phosphatidic acid phosphatase type 2B
chr19_-_49220213 0.029 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr7_+_23286390 0.029 GPNMB
glycoprotein (transmembrane) nmb
chr17_+_48821106 0.029 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr12_+_8332789 0.029 FAM66C
family with sequence similarity 66, member C
chr1_-_150849043 0.029 ARNT
aryl hydrocarbon receptor nuclear translocator
chr12_-_53600999 0.029 NM_000889
ITGB7
integrin, beta 7
chr12_-_53601051 0.028 ITGB7
integrin, beta 7
chr7_-_50772997 0.028 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr2_-_178483677 0.028 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr12_-_81991959 0.028 NM_001220477
NM_001220478
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr4_-_159093523 0.028 FAM198B
family with sequence similarity 198, member B
chr8_-_13372183 0.028 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr19_-_48759141 0.028 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr5_+_140749830 0.028 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr6_+_144612872 0.027 NM_007124
UTRN
utrophin
chr4_-_186733372 0.027 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr20_+_23345020 0.027 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr20_-_48099178 0.027 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr4_-_170077807 0.027 SH3RF1
SH3 domain containing ring finger 1
chr18_-_65182507 0.027 DSEL
dermatan sulfate epimerase-like
chr2_-_166060552 0.027 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr20_-_20036685 0.027 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr5_+_67588395 0.027 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr19_+_15852200 0.027 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr2_-_217559497 0.027 IGFBP5
insulin-like growth factor binding protein 5
chr8_-_143999255 0.026 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr17_-_67311773 0.026 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr7_-_107880492 0.026 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr10_+_63808968 0.026 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr2_+_109204904 0.026 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_71294229 0.026 NM_001244814
FOXP1
forkhead box P1
chr7_+_132937819 0.026 NM_001037126
NM_021807
EXOC4

exocyst complex component 4


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 5.57e-04 GO:0007275 multicellular organismal development
1.40 8.36e-04 GO:0048856 anatomical structure development
1.43 1.00e-03 GO:0048731 system development
1.53 2.08e-03 GO:0048513 organ development
1.34 2.19e-03 GO:0032502 developmental process
2.89 3.72e-03 GO:0007517 muscle organ development
2.38 2.90e-02 GO:0061061 muscle structure development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
21.24 4.96e-02 GO:0004556 alpha-amylase activity
21.24 4.96e-02 GO:0016160 amylase activity