Motif ID: NR4A2.p2

Z-value: 2.320


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR4A2chr2_-_157189040-0.611.1e-01Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_43885251 6.019 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr12_-_52886971 4.577 NM_005554
KRT6A
keratin 6A
chr19_-_35992798 4.097 NM_001035516
DMKN
dermokine
chr1_+_46640748 4.039 NM_005727
TSPAN1
tetraspanin 1
chr20_+_58179601 3.491 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr17_+_48610045 3.358 NM_017957
EPN3
epsin 3
chr16_-_68269948 3.188 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr12_-_52867521 3.066 NM_173086
KRT6C
keratin 6C
chr3_-_151034514 2.912 NM_023915
GPR87
G protein-coupled receptor 87
chr10_-_123353771 2.505 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr12_-_28124915 2.446 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr1_-_242612757 2.372 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr17_+_48610077 2.312 EPN3
epsin 3
chr3_-_46718898 2.308 NM_182775
ALS2CL
ALS2 C-terminal like
chr6_-_13408368 2.250 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr17_-_56494889 2.162 RNF43
ring finger protein 43
chr4_-_15940362 2.040 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr10_-_123353330 2.032 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr12_-_52914080 1.972 NM_000424
KRT5
keratin 5
chr17_-_39675078 1.960 NM_002275
KRT15
keratin 15
chr2_-_110874142 1.916 NM_005434
MALL
mal, T-cell differentiation protein-like
chr6_-_2840683 1.883 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chrX_+_152954965 1.863 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr5_+_66124603 1.838 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_+_105153258 1.780 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr2_-_31637553 1.778 XDH
xanthine dehydrogenase
chr9_-_117150217 1.776 AKNA
AT-hook transcription factor
chr5_+_145316120 1.765 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr9_+_12693385 1.739 NM_000550
TYRP1
tyrosinase-related protein 1
chr5_+_167718485 1.680 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr20_+_43803539 1.679 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr12_-_54779482 1.668 ZNF385A
zinc finger protein 385A
chr8_-_127570710 1.626 NM_174911
FAM84B
family with sequence similarity 84, member B
chr17_+_9548853 1.584 NM_153210
USP43
ubiquitin specific peptidase 43
chr10_+_81107242 1.560 PPIF
peptidylprolyl isomerase F
chr15_-_83621350 1.541 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr8_+_86376130 1.533 NM_000067
CA2
carbonic anhydrase II
chr8_-_127570465 1.532 FAM84B
family with sequence similarity 84, member B
chr12_+_101188373 1.525 NM_178826
ANO4
anoctamin 4
chr20_-_1309809 1.519 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr1_+_233749917 1.515 KCNK1
potassium channel, subfamily K, member 1
chr2_-_110873638 1.511 MALL
mal, T-cell differentiation protein-like
chr11_+_130029699 1.501 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr19_-_11689765 1.499 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr2_-_31637598 1.484 NM_000379
XDH
xanthine dehydrogenase
chr12_-_86230158 1.482 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr1_+_236849753 1.459 NM_001103
ACTN2
actinin, alpha 2
chr1_-_153588789 1.444 NM_020672
S100A14
S100 calcium binding protein A14
chr1_+_233749749 1.412 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr11_+_130029663 1.409 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr17_-_39768939 1.408 NM_005557
KRT16
keratin 16
chr19_-_6433772 1.407 NM_173637
SLC25A41
solute carrier family 25, member 41
chr7_+_69063768 1.369 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr11_+_130029773 1.362 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr2_-_110873353 1.357 MALL
mal, T-cell differentiation protein-like
chr16_+_22825481 1.351 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_-_207205996 1.343 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr12_-_6484904 1.343 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr10_-_76995685 1.337 NM_144589
COMTD1
catechol-O-methyltransferase domain containing 1
chr2_-_161056573 1.335 NM_000888
ITGB6
integrin, beta 6
chr1_+_152881022 1.325 NM_005547
IVL
involucrin
chr5_+_80529138 1.304 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr16_+_57653649 1.299 GPR56
G protein-coupled receptor 56
chr17_-_56494930 1.274 NM_017763
RNF43
ring finger protein 43
chr8_-_125740378 1.273 MTSS1
metastasis suppressor 1
chr2_+_113885137 1.260 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr13_+_97928414 1.257 MBNL2
muscleblind-like 2 (Drosophila)
chr3_-_123339178 1.243 MYLK
myosin light chain kinase
chr11_-_118134986 1.239 MPZL2
myelin protein zero-like 2
chr16_+_68679198 1.230 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr12_+_20848288 1.224 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr15_+_78441737 1.223 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr5_-_176831385 1.216 F12
coagulation factor XII (Hageman factor)
chr11_-_119234628 1.208 USP2
ubiquitin specific peptidase 2
chr11_+_130029712 1.208 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr11_+_117947726 1.205 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr17_-_56358161 1.195 MPO
myeloperoxidase
chr16_+_57653909 1.191 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr9_+_93589704 1.183 NM_001174167
SYK
spleen tyrosine kinase
chr10_+_81107228 1.174 PPIF
peptidylprolyl isomerase F
chr7_-_139763520 1.169 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr9_-_125941304 1.162 STRBP
spermatid perinuclear RNA binding protein
chr11_+_117947785 1.152 TMPRSS4
transmembrane protease, serine 4
chr15_-_52030162 1.148 NM_153374
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr17_-_2614926 1.140 NM_015229
KIAA0664
KIAA0664
chr1_+_109792640 1.137 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr1_-_209824641 1.135 NM_001017402
LAMB3
laminin, beta 3
chr6_+_130758261 1.134 NM_052913
TMEM200A
transmembrane protein 200A
chr6_+_17282931 1.134 NM_153020
RBM24
RNA binding motif protein 24
chr2_-_46384 1.107 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr5_+_145317297 1.107 SH3RF2
SH3 domain containing ring finger 2
chr4_-_40517913 1.102 NM_019027
RBM47
RNA binding motif protein 47
chr19_-_11689591 1.095 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr10_-_116164222 1.094 AFAP1L2
actin filament associated protein 1-like 2
chr22_+_45072936 1.090 PRR5
proline rich 5 (renal)
chr12_-_52828105 1.084 NM_004693
KRT75
keratin 75
chr1_-_209825797 1.083 NM_000228
LAMB3
laminin, beta 3
chr12_-_6484389 1.082 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr20_+_1875825 1.081 NM_001040023
SIRPA
signal-regulatory protein alpha
chr6_-_136847078 1.072 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr5_-_149682447 1.066 NM_001012301
ARSI
arylsulfatase family, member I
chr14_-_94854910 1.064 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_-_23030141 1.064 NM_000361
THBD
thrombomodulin
chr8_-_125740650 1.060 NM_014751
MTSS1
metastasis suppressor 1
chr8_+_21911062 1.056 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr7_+_86273219 1.052 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr20_-_62130390 1.050 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr1_+_65210724 1.045 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr2_-_216878314 1.040 NM_018000
MREG
melanoregulin
chr15_+_78441678 1.033 NM_005530
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr8_-_131028674 1.031 FAM49B
family with sequence similarity 49, member B
chr3_+_142342265 1.024 NM_002670
PLS1
plastin 1
chr19_+_45394642 1.022 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr11_-_118134956 1.005 MPZL2
myelin protein zero-like 2
chr3_+_121774208 1.003 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr18_-_28681429 0.994 DSC2
desmocollin 2
chr2_+_113885145 0.988 IL1RN
interleukin 1 receptor antagonist
chr1_+_27668462 0.984 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr22_-_39639967 0.980 PDGFB
platelet-derived growth factor beta polypeptide
chr11_-_66139064 0.969 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr6_+_43737937 0.964 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr15_+_65204053 0.961 NM_182703
ANKDD1A
ankyrin repeat and death domain containing 1A
chr13_-_52585472 0.960 NM_000053
NM_001005918
NM_001243182
ATP7B


ATPase, Cu++ transporting, beta polypeptide


chr17_+_78075299 0.955 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr1_+_27668499 0.955 SYTL1
synaptotagmin-like 1
chr11_+_1860718 0.954 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr20_-_43883183 0.949 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr5_-_176831183 0.939 F12
coagulation factor XII (Hageman factor)
chr19_+_45394459 0.913 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr16_-_31147062 0.897 NM_002773
PRSS8
protease, serine, 8
chr1_+_32050510 0.893 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr15_+_45422130 0.892 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr11_+_62648340 0.892 NM_001013251
SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr20_+_9458460 0.889 PLCB4
phospholipase C, beta 4
chr3_-_123339423 0.888 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr19_+_35606731 0.885 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr7_+_141478241 0.884 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr1_-_209825673 0.881 NM_001127641
LAMB3
laminin, beta 3
chr1_+_32042122 0.879 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr20_+_58251715 0.875 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr4_+_41614911 0.875 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr3_+_142375738 0.873 NM_001172312
PLS1
plastin 1
chr10_+_81107259 0.872 PPIF
peptidylprolyl isomerase F
chr16_-_31146992 0.872 PRSS8
protease, serine, 8
chr12_-_16759531 0.866 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_+_21916858 0.858 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr8_-_42234562 0.857 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr2_-_161056762 0.855 ITGB6
integrin, beta 6
chr16_+_68679229 0.852 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr12_+_133067156 0.851 NM_001142641
FBRSL1
fibrosin-like 1
chr1_+_24649529 0.844 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr15_+_78441733 0.839 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr2_+_75061234 0.829 HK2
hexokinase 2
chr14_-_95942037 0.827 NM_152592
C14orf49
chromosome 14 open reading frame 49
chr17_-_7166263 0.821 NM_001185023
NM_001307
CLDN7

claudin 7

chr11_-_123756339 0.815 NM_001013743
TMEM225
transmembrane protein 225
chr13_+_97928196 0.815 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_116311330 0.815 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_238499317 0.814 RAB17
RAB17, member RAS oncogene family
chr17_-_46507599 0.814 SKAP1
src kinase associated phosphoprotein 1
chr7_+_73245192 0.813 NM_001305
CLDN4
claudin 4
chr14_-_23288912 0.807 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr4_+_81118639 0.806 NM_001099403
PRDM8
PR domain containing 8
chrX_-_133792497 0.804 NM_021796
PLAC1
placenta-specific 1
chr5_-_74162614 0.801 NM_015566
FAM169A
family with sequence similarity 169, member A
chr2_-_165551178 0.800 COBLL1
COBL-like 1
chr1_-_116311161 0.799 CASQ2
calsequestrin 2 (cardiac muscle)
chr17_+_37894161 0.794 NM_005310
GRB7
growth factor receptor-bound protein 7
chr12_-_52845862 0.793 NM_005555
KRT6B
keratin 6B
chrX_-_78623006 0.792 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr1_+_212738675 0.790 NM_001030287
ATF3
activating transcription factor 3
chr21_+_42540092 0.788 BACE2
beta-site APP-cleaving enzyme 2
chr15_+_40509628 0.785 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr3_+_189349215 0.783 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr8_-_144650998 0.778 C8orf73
chromosome 8 open reading frame 73
chr19_+_45394522 0.777 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr7_+_150782881 0.773 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr20_+_19870209 0.772 NM_018993
RIN2
Ras and Rab interactor 2
chr3_-_14166370 0.771 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr5_-_134914968 0.770 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr11_-_85430382 0.768 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_+_121513158 0.766 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr10_+_81107219 0.761 NM_005729
PPIF
peptidylprolyl isomerase F
chr8_-_15095791 0.761 NM_139167
SGCZ
sarcoglycan, zeta
chr22_+_45072687 0.761 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr17_+_73521744 0.753 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr7_-_139876718 0.749 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr19_-_51504799 0.749 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr4_+_140587086 0.742 MGST2
microsomal glutathione S-transferase 2
chr22_+_37309618 0.742 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr17_+_78075390 0.740 GAA
glucosidase, alpha; acid
chr17_-_56358118 0.739 MPO
myeloperoxidase
chr6_-_33547833 0.739 BAK1
BCL2-antagonist/killer 1
chr2_-_238499713 0.737 NM_022449
RAB17
RAB17, member RAS oncogene family
chr11_-_796175 0.732 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr1_+_154293568 0.718 NM_080429
AQP10
aquaporin 10
chr3_-_50649080 0.713 CISH
cytokine inducible SH2-containing protein
chr1_+_81771844 0.713 LPHN2
latrophilin 2
chr2_+_220094478 0.710 NM_018089
NM_001042410
ANKZF1

ankyrin repeat and zinc finger domain containing 1

chr17_+_37894212 0.706 GRB7
growth factor receptor-bound protein 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.60 1.18e-06 GO:0055085 transmembrane transport
1.09 1.23e-05 GO:0009987 cellular process
1.20 2.25e-03 GO:0051179 localization
1.25 8.24e-03 GO:0065008 regulation of biological quality
1.21 8.97e-03 GO:0006810 transport
1.27 1.38e-02 GO:0044281 small molecule metabolic process
1.41 1.45e-02 GO:0006811 ion transport
1.20 2.64e-02 GO:0051234 establishment of localization
1.17 2.79e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.02 6.34e-08 GO:0005743 mitochondrial inner membrane
1.45 1.71e-07 GO:0005739 mitochondrion
1.92 4.89e-07 GO:0019866 organelle inner membrane
1.74 5.43e-06 GO:0031966 mitochondrial membrane
1.58 6.71e-06 GO:0044429 mitochondrial part
1.71 7.58e-06 GO:0005740 mitochondrial envelope
1.52 5.17e-05 GO:0031975 envelope
1.52 8.72e-05 GO:0031967 organelle envelope
1.25 8.84e-04 GO:0044459 plasma membrane part
1.12 9.67e-03 GO:0044444 cytoplasmic part
1.37 1.74e-02 GO:0005626 insoluble fraction
1.08 1.79e-02 GO:0005737 cytoplasm
1.81 3.91e-02 GO:0016324 apical plasma membrane
1.30 3.92e-02 GO:0000267 cell fraction
1.68 4.59e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 1.58e-04 GO:0022857 transmembrane transporter activity
1.46 1.77e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.42 2.01e-04 GO:0022892 substrate-specific transporter activity
1.66 2.94e-03 GO:0022804 active transmembrane transporter activity
1.34 3.18e-03 GO:0005215 transporter activity
2.02 5.28e-03 GO:0008509 anion transmembrane transporter activity
1.43 6.41e-03 GO:0015075 ion transmembrane transporter activity
1.10 7.83e-03 GO:0005515 protein binding
1.87 1.11e-02 GO:0015077 monovalent inorganic cation transmembrane transporter activity
2.13 3.07e-02 GO:0046943 carboxylic acid transmembrane transporter activity
1.76 4.59e-02 GO:0015291 secondary active transmembrane transporter activity
2.09 4.61e-02 GO:0005342 organic acid transmembrane transporter activity