Motif ID: NR6A1.p2

Z-value: 0.357


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR6A1chr9_-_1275333970.541.6e-01Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_6720585 0.506 NM_000064
C3
complement component 3
chr15_+_101420004 0.431 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr11_-_108464344 0.318 NM_015065
EXPH5
exophilin 5
chr15_+_101420032 0.283 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr7_+_26403944 0.280 NM_001199838
SNX10
sorting nexin 10
chr9_-_38069082 0.113 SHB
Src homology 2 domain containing adaptor protein B
chr2_+_18059923 0.105 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr6_+_129204285 0.098 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr17_-_29624249 0.097 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr6_+_84743250 0.074 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr1_-_158656487 0.070 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr1_+_33231260 0.068 KIAA1522
KIAA1522
chr11_+_36317724 0.067 NM_001160167
PRR5L
proline rich 5 like
chr17_-_27402626 0.067 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr1_+_19923457 0.063 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr11_+_111789658 0.062 C11orf52
chromosome 11 open reading frame 52
chr19_+_10196972 0.060 C19orf66
chromosome 19 open reading frame 66
chr12_+_109273856 0.056 NM_001917
DAO
D-amino-acid oxidase
chr22_+_23229959 0.054 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr9_-_38069207 0.053 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr10_+_81107259 0.053 PPIF
peptidylprolyl isomerase F
chr6_-_133035180 0.052 NM_004666
VNN1
vanin 1
chr1_+_117452359 0.050 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr9_-_130679210 0.047 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr6_-_33547833 0.046 BAK1
BCL2-antagonist/killer 1
chr20_-_30000640 0.043 NM_001171832
DEFB121
defensin, beta 121
chr4_+_41614725 0.043 LIMCH1
LIM and calponin homology domains 1
chr12_+_7169192 0.042


chr5_+_63802427 0.042 NM_001029875
RGS7BP
regulator of G-protein signaling 7 binding protein
chr11_+_111789600 0.040 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr16_+_776957 0.040 NM_032304
HAGHL
hydroxyacylglutathione hydrolase-like
chr12_-_6484389 0.039 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr2_-_31361591 0.038 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr1_+_40420837 0.035 MFSD2A
major facilitator superfamily domain containing 2A
chr13_-_42535066 0.035 KIAA0564
KIAA0564
chr12_+_108956293 0.035 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr10_+_123754141 0.034 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_935469 0.032 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr11_+_66188474 0.032 NM_178864
NPAS4
neuronal PAS domain protein 4
chr21_+_42688660 0.031 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chr1_+_197886499 0.031 NM_020204
LHX9
LIM homeobox 9
chr4_-_90758126 0.031 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr21_+_33765411 0.030 C21orf119
chromosome 21 open reading frame 119
chr12_-_110252600 0.029 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr5_-_42175355 0.029


chr19_+_10197023 0.028 C19orf66
chromosome 19 open reading frame 66
chr14_-_106967528 0.026 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_+_40420802 0.026 MFSD2A
major facilitator superfamily domain containing 2A
chrX_+_48916515 0.025 NM_001163322
NM_033626
NM_001163321
NM_001163323
CCDC120



coiled-coil domain containing 120



chrX_-_44402088 0.025 NM_173794
FUNDC1
FUN14 domain containing 1
chr2_+_191002485 0.024 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr1_+_26503973 0.024 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr10_+_81107242 0.024 PPIF
peptidylprolyl isomerase F
chr1_+_212738675 0.024 NM_001030287
ATF3
activating transcription factor 3
chr3_+_46619075 0.024 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr3_-_139396773 0.023 NM_001200047
NM_178177
NMNAT3

nicotinamide nucleotide adenylyltransferase 3

chr2_+_33701678 0.023 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr9_-_21166609 0.022 NM_002175
IFNA21
interferon, alpha 21
chr3_-_14989857 0.021 LOC100505641
uncharacterized LOC100505641
chr4_-_48014960 0.020 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr9_+_35792405 0.020 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr12_+_100897137 0.020 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr7_+_37960418 0.019 EPDR1
ependymin related protein 1 (zebrafish)
chr19_-_7796977 0.019 NM_001244856
NM_198492
CLEC4G

C-type lectin domain family 4, member G

chrX_+_8432870 0.019 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr1_+_113236679 0.019 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr4_-_159956332 0.019 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr12_+_116997185 0.019 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr1_-_160617042 0.019 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr10_-_126107493 0.019 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr1_-_211666258 0.018 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr9_-_21217303 0.018 NM_002173
IFNA16
interferon, alpha 16
chr1_+_63063186 0.018 NM_014495
ANGPTL3
angiopoietin-like 3
chr11_-_111957417 0.018 NM_012459
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr8_-_93115453 0.018 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr7_-_150038689 0.017 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr7_-_97601564 0.017 MGC72080
MGC72080 pseudogene
chr1_-_11042093 0.015 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr7_+_37960162 0.015 NM_001242946
NM_017549
EPDR1

ependymin related protein 1 (zebrafish)

chr19_-_15083729 0.015 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr19_-_43709692 0.015 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chrX_-_153095332 0.014 PDZD4
PDZ domain containing 4
chr1_-_40236926 0.014 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr16_+_56995761 0.014 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr8_+_142432006 0.014 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr6_-_30899926 0.014 NM_205854
SFTA2
surfactant associated 2
chr19_+_41699076 0.013 NM_030622
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr13_+_23755059 0.013 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chrX_+_17653412 0.012 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr1_-_16134192 0.012 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr8_-_145690737 0.012 NM_032687
NM_001129888
CYHR1

cysteine/histidine-rich 1

chr6_+_31973358 0.012 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr19_+_41620336 0.011 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chrX_-_104465349 0.011 NM_031274
TEX13A
testis expressed 13A
chr14_+_93118793 0.011 RIN3
Ras and Rab interactor 3
chrX_-_138724851 0.011 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr1_-_153538305 0.011 NM_005978
S100A2
S100 calcium binding protein A2
chr16_+_31366519 0.010 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr2_-_25564745 0.010 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr8_-_53626991 0.010 NM_001083617
NM_014781
RB1CC1

RB1-inducible coiled-coil 1

chr7_+_73868111 0.010 NM_001199207
NM_005685
NM_016328
GTF2IRD1


GTF2I repeat domain containing 1


chr3_-_128294928 0.009 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr12_-_16760935 0.009 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr6_+_42982221 0.009 NM_001242872
KLHDC3
kelch domain containing 3
chr11_+_65192284 0.009 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr3_+_133464883 0.008 NM_001063
TF
transferrin
chr3_+_133465098 0.008 TF
transferrin
chr10_-_126107454 0.008 OAT
ornithine aminotransferase
chr19_-_16738986 0.008 NM_004831
MED26
mediator complex subunit 26
chr9_-_21228132 0.008 NM_021268
IFNA17
interferon, alpha 17
chr12_-_10562142 0.008 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr11_+_66314373 0.008 NM_001104
ACTN3
actinin, alpha 3
chr12_-_7261788 0.008 NM_016546
C1RL
complement component 1, r subcomponent-like
chr11_+_111957611 0.007 SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr8_+_144349564 0.007 NM_138465
GLI4
GLI family zinc finger 4
chr7_+_73868236 0.007 GTF2IRD1
GTF2I repeat domain containing 1
chr6_-_43484503 0.007 YIPF3
Yip1 domain family, member 3
chr3_+_133465204 0.007 TF
transferrin
chr3_+_14716605 0.006 NM_001184957
NM_001184958
NM_032137
C3orf20


chromosome 3 open reading frame 20


chr7_+_56032065 0.006 NM_001202469
NM_001483
GBAS

glioblastoma amplified sequence

chr20_+_57264186 0.006 NM_001204872
NM_001204873
NPEPL1

aminopeptidase-like 1

chr21_-_43916298 0.006 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr20_-_7921068 0.006 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr14_+_93118576 0.006 RIN3
Ras and Rab interactor 3
chr19_-_5846465 0.006 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr2_+_26568900 0.006 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr14_-_58893867 0.006 TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr6_+_43028181 0.006 NM_201522
KLC4
kinesin light chain 4
chrY_-_1460901 0.006 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr20_+_18794369 0.006 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr10_-_63212924 0.006 TMEM26
transmembrane protein 26
chr2_-_211090146 0.005 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr6_-_132910824 0.005 NM_003967
TAAR5
trace amine associated receptor 5
chr19_+_8953268 0.005 NM_145208
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr2_-_31361364 0.005


chr7_+_26438186 0.005 LOC441204
uncharacterized LOC441204
chr1_+_93300359 0.005 RPL5
ribosomal protein L5
chr14_-_106641585 0.005 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_60458228 0.005 NM_001048249
C5orf43
chromosome 5 open reading frame 43
chr14_-_106733392 0.004 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr19_-_53770917 0.004 NM_173857
VN1R4
vomeronasal 1 receptor 4
chr15_-_41166336 0.004 NM_133639
RHOV
ras homolog gene family, member V
chr6_-_43484701 0.004 NM_015388
YIPF3
Yip1 domain family, member 3
chr1_+_153606457 0.004 NM_001206612
NM_001244664
NM_015607
CHTOP


chromatin target of PRMT1


chr5_+_175308843 0.004 CPLX2
complexin 2
chr11_-_5462782 0.004 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr14_-_106453162 0.004 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_-_125651494 0.004 NM_198148
CPXM2
carboxypeptidase X (M14 family), member 2
chr18_+_33767420 0.004 NM_017947
MOCOS
molybdenum cofactor sulfurase
chr11_+_111957533 0.003 NM_003002
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr14_-_47120940 0.003 NM_080746
RPL10L
ribosomal protein L10-like
chr14_-_106452693 0.003 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_21207141 0.003 NM_002171
IFNA10
interferon, alpha 10
chr1_+_153606550 0.002 CHTOP
chromatin target of PRMT1
chr5_-_156536185 0.002 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr17_-_62009620 0.002 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr6_-_32339648 0.002 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr1_+_6684924 0.002 NM_001195753
THAP3
THAP domain containing, apoptosis associated protein 3
chr3_-_138478184 0.002 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr2_-_200715842 0.002 FONG
uncharacterized LOC348751
chr1_+_45274153 0.002 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr3_+_46411632 0.001 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr1_+_40997232 0.001 NM_152373
ZNF684
zinc finger protein 684
chr14_+_105391154 0.001 PLD4
phospholipase D family, member 4
chr8_-_145701717 0.001 NM_003923
FOXH1
forkhead box H1
chr5_-_41213513 0.001 NM_000065
C6
complement component 6
chr22_-_24059502 0.001 GUSBP11
glucuronidase, beta pseudogene 11
chr20_-_43024303 0.001


chr21_-_37914897 0.001 NM_001146078
CLDN14
claudin 14
chr17_+_12692779 0.001 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chrX_+_47229981 0.000 NM_003446
ZNF157
zinc finger protein 157
chr8_+_11188494 0.000 NM_054028
SLC35G5
solute carrier family 35, member G5
chr11_+_30344645 0.000 NM_152316
C11orf46
chromosome 11 open reading frame 46
chr1_+_219347123 0.000 NM_138794
LYPLAL1
lysophospholipase-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.27 6.28e-03 GO:0006955 immune response
2.55 1.89e-02 GO:0002376 immune system process
19.73 2.90e-02 GO:0007006 mitochondrial membrane organization
123.27 4.13e-02 GO:0001969 regulation of activation of membrane attack complex
123.27 4.13e-02 GO:0001970 positive regulation of activation of membrane attack complex
123.27 4.13e-02 GO:0045917 positive regulation of complement activation
123.27 4.13e-02 GO:2000259 positive regulation of protein activation cascade
8.51 4.75e-02 GO:0002443 leukocyte mediated immunity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
33.62 1.12e-02 GO:0005744 mitochondrial inner membrane presequence translocase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
21.58 4.33e-06 GO:0003823 antigen binding