Motif ID: PAX2.p2

Z-value: 0.859


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_102505337-0.049.2e-01Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_91572328 1.121 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr7_+_149571029 0.966 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr20_+_33146500 0.929 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr8_+_97506478 0.830 SDC2
syndecan 2
chr10_-_93392857 0.825 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr10_-_93392744 0.809 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr9_+_120466625 0.806 TLR4
toll-like receptor 4
chr12_-_91573264 0.751 NM_133503
DCN
decorin
chr1_+_183605207 0.690 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chrX_-_106960028 0.674 TSC22D3
TSC22 domain family, member 3
chr1_+_163038934 0.670 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_-_63328663 0.656 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr2_+_33172368 0.634 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr5_+_71502700 0.623 MAP1B
microtubule-associated protein 1B
chrX_+_30671602 0.610 GK
glycerol kinase
chr9_+_120466453 0.588 NM_138554
TLR4
toll-like receptor 4
chrX_+_30671456 0.568 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr5_-_75919051 0.563 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr3_-_151987332 0.556 LOC401093
uncharacterized LOC401093
chrX_-_106960268 0.543 NM_004089
TSC22D3
TSC22 domain family, member 3
chr8_-_13134028 0.517 DLC1
deleted in liver cancer 1
chr5_-_126366068 0.516 MARCH3
membrane-associated ring finger (C3HC4) 3
chr15_+_44084039 0.505 NM_001018108
NM_001199875
NM_001199876
SERF2


small EDRK-rich factor 2


chr6_-_46293404 0.496 RCAN2
regulator of calcineurin 2
chr5_-_150537335 0.489 NM_001155
ANXA6
annexin A6
chr13_-_33859835 0.489 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr20_-_48099178 0.487 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr1_+_77747602 0.465 NM_174858
AK5
adenylate kinase 5
chr1_+_215178884 0.461 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr5_-_92916924 0.460 FLJ42709
uncharacterized LOC441094
chr5_-_150537261 0.451 ANXA6
annexin A6
chr5_-_150537306 0.439 ANXA6
annexin A6
chr22_+_35777051 0.438 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr3_-_9920471 0.438 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr1_+_11866240 0.435 CLCN6
chloride channel 6
chr7_-_149570763 0.430 LOC401431
uncharacterized LOC401431
chr8_-_27472298 0.425 NM_001831
CLU
clusterin
chr1_+_11866206 0.422 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr19_+_14544216 0.421 PKN1
protein kinase N1
chr15_+_33010174 0.418 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr22_+_35777087 0.409 HMOX1
heme oxygenase (decycling) 1
chr15_+_43809805 0.394 NM_002373
MAP1A
microtubule-associated protein 1A
chr20_+_44519590 0.391 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr13_+_102104941 0.391 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_+_46926049 0.388 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr12_+_56109832 0.387 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 readthrough
biogenesis of lysosomal organelles complex-1, subunit 1
chr19_+_14544100 0.387 NM_002741
PKN1
protein kinase N1
chr19_+_49458151 0.384 BAX
BCL2-associated X protein
chr5_+_172483285 0.384 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr5_-_172198160 0.381 NM_004417
DUSP1
dual specificity phosphatase 1
chr12_+_90103470 0.375 LOC338758
uncharacterized LOC338758
chr6_-_46293628 0.375 NM_005822
RCAN2
regulator of calcineurin 2
chr12_+_12764844 0.374 CREBL2
cAMP responsive element binding protein-like 2
chr5_-_137368682 0.372 FAM13B
family with sequence similarity 13, member B
chr6_-_84937313 0.364 NM_014895
KIAA1009
KIAA1009
chr1_+_246887591 0.362 SCCPDH
saccharopine dehydrogenase (putative)
chr14_+_96505566 0.360 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chr19_+_49458031 0.360 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr9_-_97401588 0.357 FBP1
fructose-1,6-bisphosphatase 1
chr12_-_63328857 0.356 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr19_+_49458129 0.355 BAX
BCL2-associated X protein
chr5_+_156820161 0.355 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr7_-_27196163 0.355 NM_006896
HOXA7
homeobox A7
chr17_-_48262900 0.349 COL1A1
collagen, type I, alpha 1
chr5_-_132299263 0.348 NM_014423
AFF4
AF4/FMR2 family, member 4
chr18_+_9136742 0.348 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr12_+_90102639 0.348 LOC338758
uncharacterized LOC338758
chr1_-_155210887 0.345 GBA
glucosidase, beta, acid
chr22_-_36903033 0.342 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr5_-_137368778 0.339 NM_001101800
NM_001101801
NM_016603
FAM13B


family with sequence similarity 13, member B


chr21_+_47545896 0.337 COL6A2
collagen, type VI, alpha 2
chr9_+_120466607 0.337 TLR4
toll-like receptor 4
chr1_-_241520467 0.336 NM_002924
RGS7
regulator of G-protein signaling 7
chr16_-_4897265 0.336 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr20_+_33292117 0.328 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr1_-_212873306 0.324 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr17_+_61851512 0.315


chr18_-_70534809 0.314 NM_001201465
NM_138966
NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

chr22_+_35695872 0.314 TOM1
target of myb1 (chicken)
chr5_-_132299248 0.314 AFF4
AF4/FMR2 family, member 4
chr5_+_133706869 0.313 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B
chr12_-_46384317 0.311 SCAF11
SR-related CTD-associated factor 11
chr22_-_36903086 0.311 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr3_-_33260706 0.307 NM_015551
SUSD5
sushi domain containing 5
chrX_-_100872926 0.305 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr12_+_65672422 0.304 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr1_-_155211049 0.302 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr11_+_65479685 0.302 KAT5
K(lysine) acetyltransferase 5
chr10_+_76586299 0.301 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr19_-_48018317 0.297 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr8_-_27472188 0.296 CLU
clusterin
chr1_-_241520384 0.295 RGS7
regulator of G-protein signaling 7
chrX_-_107019001 0.293 NM_198057
TSC22D3
TSC22 domain family, member 3
chr1_+_210111575 0.290 SYT14
synaptotagmin XIV
chr12_+_65672682 0.288 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr3_-_48594209 0.288 NM_004567
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr2_+_46926323 0.286 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr5_-_139944045 0.282 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr11_-_27742224 0.281 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr2_-_216300444 0.280 FN1
fibronectin 1
chr5_-_150138081 0.280 NM_001135644
DCTN4
dynactin 4 (p62)
chrX_+_30671537 0.279 GK
glycerol kinase
chr17_+_47074749 0.278 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr10_-_3827205 0.277 KLF6
Kruppel-like factor 6
chr15_+_44084493 0.275 SERF2
small EDRK-rich factor 2
chr1_+_36690038 0.273 THRAP3
thyroid hormone receptor associated protein 3
chr16_-_31161381 0.273 NM_173502
PRSS36
protease, serine, 36
chr13_+_48878025 0.272 RB1
retinoblastoma 1
chrX_+_102883891 0.271 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr14_-_88459459 0.270 GALC
galactosylceramidase
chr11_-_82782883 0.270 NM_014488
RAB30
RAB30, member RAS oncogene family
chr12_+_12764755 0.268 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr1_-_212873104 0.266 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr15_+_44084517 0.265 NM_001199878
SERF2-C15ORF63
SERF2
SERF2-C15orf63 readthrough
small EDRK-rich factor 2
chr17_-_7218665 0.265 GPS2
G protein pathway suppressor 2
chr11_+_67776016 0.264 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr12_+_16035287 0.264 NM_007178
STRAP
serine/threonine kinase receptor associated protein
chr17_+_78194090 0.262 NM_001166347
NM_001166348
NM_001166349
NM_173626
SLC26A11



solute carrier family 26, member 11



chr4_-_119273874 0.262 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr10_-_64576074 0.261 EGR2
early growth response 2
chr17_-_67138013 0.259 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_+_30524485 0.259 NM_001077497
NM_025263
PRR3

proline rich 3

chrX_+_102883647 0.256 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr10_-_64576123 0.255 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr19_+_16435734 0.254 KLF2
Kruppel-like factor 2 (lung)
chr14_+_61447949 0.253 SLC38A6
solute carrier family 38, member 6
chr19_-_36545646 0.253 NM_152658
THAP8
THAP domain containing 8
chr5_-_180688095 0.252 NM_032765
TRIM52
tripartite motif containing 52
chr17_+_14204326 0.251 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr5_+_149340287 0.250 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr6_+_151646634 0.247 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr9_-_110252045 0.247 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr14_-_88459469 0.246 NM_000153
NM_001201401
GALC

galactosylceramidase

chr5_+_149340437 0.246 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr20_+_44520021 0.245 CTSA
cathepsin A
chr5_+_67586466 0.244 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chrX_+_149531439 0.244 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr11_+_65479472 0.243 NM_001206833
NM_006388
NM_182709
NM_182710
KAT5



K(lysine) acetyltransferase 5



chr2_+_74781846 0.243 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr8_+_17434700 0.241 PDGFRL
platelet-derived growth factor receptor-like
chr8_+_42128797 0.240 NM_001190720
NM_001242778
NM_001556
IKBKB


inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta


chrX_-_15872921 0.240 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chrX_-_34675366 0.240 NM_031442
TMEM47
transmembrane protein 47
chr3_+_44903376 0.239 NM_144638
TMEM42
transmembrane protein 42
chr19_-_3047632 0.237 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr13_+_48877950 0.236 RB1
retinoblastoma 1
chrX_+_10124984 0.236 NM_001830
CLCN4
chloride channel 4
chr8_-_13372183 0.236 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr2_+_54342409 0.236 NM_138448
ACYP2
acylphosphatase 2, muscle type
chr3_+_158519877 0.235 MFSD1
major facilitator superfamily domain containing 1
chr11_+_108093558 0.233 NM_000051
ATM
ataxia telangiectasia mutated
chr16_-_88923233 0.232 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr19_-_36909463 0.232 NM_133466
ZFP82
zinc finger protein 82 homolog (mouse)
chr7_+_150065330 0.232 REPIN1
replication initiator 1
chr21_-_34100210 0.231 SYNJ1
synaptojanin 1
chr3_+_12330336 0.230 NM_138711
PPARG
peroxisome proliferator-activated receptor gamma
chr20_-_57425957 0.230 GNAS-AS1
GNAS antisense RNA 1 (non-protein coding)
chr11_+_64781584 0.229 NM_001199745
NM_001667
ARL2-SNX15
ARL2

ARL2-SNX15 readthrough
ADP-ribosylation factor-like 2

chr14_+_53019865 0.229 NM_001099652
GPR137C
G protein-coupled receptor 137C
chr14_+_74486049 0.226 NM_025057
C14orf45
chromosome 14 open reading frame 45
chrX_-_15872882 0.226 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_78470593 0.224 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_-_197686837 0.223 NM_032263
IQCG
IQ motif containing G
chr20_+_33299315 0.223 TP53INP2
tumor protein p53 inducible nuclear protein 2
chrX_-_15872905 0.222


chrX_-_15872938 0.222 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_86666089 0.221 FZD4
frizzled family receptor 4
chr3_-_112280759 0.221 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr3_+_158519888 0.221 MFSD1
major facilitator superfamily domain containing 1
chr12_-_65153182 0.221 GNS
glucosamine (N-acetyl)-6-sulfatase
chr1_+_155853546 0.220 SYT11
synaptotagmin XI
chrX_-_15872871 0.220 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr10_+_105036783 0.220 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chrX_-_15873094 0.219 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr3_+_158519911 0.219 MFSD1
major facilitator superfamily domain containing 1
chr1_-_31845818 0.219 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr6_+_112408673 0.218 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr5_-_19988293 0.218 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr9_-_115652961 0.217 NM_033051
SLC46A2
solute carrier family 46, member 2
chr1_-_212873197 0.217 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr17_-_37886729 0.216 MIEN1
migration and invasion enhancer 1
chr17_+_30677187 0.215 ZNF207
zinc finger protein 207
chr20_+_44519924 0.215 CTSA
cathepsin A
chr11_+_58346636 0.214 ZFP91-CNTF
ZFP91
ZFP91-CNTF readthrough
zinc finger protein 91 homolog (mouse)
chr1_-_150602047 0.214 ENSA
endosulfine alpha
chr6_+_30524662 0.214 PRR3
proline rich 3
chr5_-_121413967 0.214 LOX
lysyl oxidase
chr19_-_48018163 0.214 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr17_-_78194085 0.214 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr13_+_48877887 0.213 RB1
retinoblastoma 1
chr5_-_159797618 0.213 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr13_-_50699775 0.213 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_174843523 0.212 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr22_-_32341298 0.212 NM_015372
C22orf24
chromosome 22 open reading frame 24
chr22_-_20850075 0.210 NM_032775
KLHL22
kelch-like 22 (Drosophila)
chr22_+_38142255 0.209 TRIOBP
TRIO and F-actin binding protein
chr22_+_38142230 0.209 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr3_-_141944441 0.206 NM_001039547
GK5
glycerol kinase 5 (putative)
chr5_-_121413906 0.206 LOX
lysyl oxidase
chr8_+_42128851 0.206 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.04e-05 GO:0009987 cellular process
1.24 1.80e-04 GO:0006810 transport
1.24 1.97e-04 GO:0051234 establishment of localization
1.51 2.40e-04 GO:0046907 intracellular transport
1.41 3.84e-04 GO:0051649 establishment of localization in cell
1.37 1.18e-03 GO:0051641 cellular localization
1.47 2.81e-03 GO:0016192 vesicle-mediated transport
2.19 1.59e-02 GO:0016197 endosome transport
1.12 3.48e-02 GO:0044237 cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 8.61e-16 GO:0005622 intracellular
1.12 5.61e-15 GO:0044424 intracellular part
1.15 6.00e-11 GO:0005737 cytoplasm
1.18 1.80e-08 GO:0044444 cytoplasmic part
1.13 3.41e-08 GO:0043227 membrane-bounded organelle
1.11 4.64e-08 GO:0043226 organelle
1.13 5.57e-08 GO:0043231 intracellular membrane-bounded organelle
1.11 5.74e-08 GO:0043229 intracellular organelle
1.29 3.54e-05 GO:0005829 cytosol
1.15 5.89e-05 GO:0005634 nucleus
1.04 1.85e-03 GO:0044464 cell part
1.04 1.93e-03 GO:0005623 cell
1.12 1.32e-02 GO:0044422 organelle part
1.18 2.18e-02 GO:0043234 protein complex
1.90 2.38e-02 GO:0005769 early endosome
1.16 2.60e-02 GO:0032991 macromolecular complex
1.49 2.65e-02 GO:0005768 endosome
1.11 3.43e-02 GO:0044446 intracellular organelle part
1.83 3.86e-02 GO:0044437 vacuolar part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 1.37e-13 GO:0005515 protein binding
1.10 2.33e-10 GO:0005488 binding
1.60 5.47e-03 GO:0000988 protein binding transcription factor activity
1.60 5.47e-03 GO:0000989 transcription factor binding transcription factor activity
1.59 8.98e-03 GO:0003712 transcription cofactor activity