Motif ID: PAX6.p2

Z-value: 0.562


Transcription factors associated with PAX6.p2:

Gene SymbolEntrez IDGene Name
PAX6 5080 paired box 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX6chr11_-_31839447-0.541.7e-01Click!


Activity profile for motif PAX6.p2.

activity profile for motif PAX6.p2


Sorted Z-values histogram for motif PAX6.p2

Sorted Z-values for motif PAX6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_77610610 0.929 SHROOM3
shroom family member 3
chr18_+_61420276 0.700 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr11_-_58343308 0.537 NM_004811
LPXN
leupaxin
chr11_+_117947785 0.500 TMPRSS4
transmembrane protease, serine 4
chr11_+_117947726 0.458 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr3_+_111717585 0.381 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr4_+_77356252 0.358 NM_020859
SHROOM3
shroom family member 3
chr12_-_71031174 0.351 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr5_+_140254930 0.325 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr6_-_42162693 0.239 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr1_-_6580068 0.219 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr5_-_142077508 0.202 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr20_+_9288446 0.190 NM_000933
PLCB4
phospholipase C, beta 4
chr1_+_186798031 0.161 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr5_-_94224601 0.155 MCTP1
multiple C2 domains, transmembrane 1
chrX_-_138914384 0.154 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr4_+_113970784 0.152 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr6_-_136788012 0.144 NM_001198615
MAP7
microtubule-associated protein 7
chr1_+_167298382 0.144 POU2F1
POU class 2 homeobox 1
chrX_-_106449543 0.142 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr8_+_124194873 0.135 FAM83A
family with sequence similarity 83, member A
chr4_-_174320616 0.128 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr6_-_134373618 0.122 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr20_-_1309809 0.101 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr1_-_87379808 0.098 SEP15
15 kDa selenoprotein
chr21_+_39644428 0.098 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr5_+_55147206 0.098 NM_001242637
NM_001242638
NM_139017
IL31RA


interleukin 31 receptor A


chr16_-_48266181 0.096 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr8_-_21771111 0.085 NM_003974
DOK2
docking protein 2, 56kDa
chr1_-_87379784 0.084 SEP15
15 kDa selenoprotein
chr2_-_133539627 0.083 NCKAP5
NCK-associated protein 5
chr6_-_46703429 0.082 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chrX_-_130423387 0.078 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr5_-_98262217 0.077 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr1_-_226926875 0.076 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr16_+_82068958 0.075 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_-_9694613 0.074 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr6_-_155777036 0.071 NM_015718
NOX3
NADPH oxidase 3
chr5_+_40909558 0.069 NM_000587
C7
complement component 7
chr19_+_7968820 0.068 MAP2K7
mitogen-activated protein kinase kinase 7
chr6_+_14117486 0.065 NM_001251901
CD83
CD83 molecule
chrX_+_49832214 0.064 NM_000084
CLCN5
chloride channel 5
chr16_+_82068910 0.063 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_+_62934030 0.063 NM_001142614
EHBP1
EH domain binding protein 1
chr1_-_12908141 0.062 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr5_-_141338626 0.061 NM_016580
PCDH12
protocadherin 12
chr4_+_88896801 0.060 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr7_+_155250705 0.059 NM_001427
EN2
engrailed homeobox 2
chr17_-_39023461 0.059 NM_000223
KRT12
keratin 12
chr3_-_194188967 0.057 NM_024524
ATP13A3
ATPase type 13A3
chr16_+_82068830 0.056 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr21_+_39628869 0.056 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_+_152126807 0.055 NM_001122741
ESR1
estrogen receptor 1
chr5_+_121465214 0.055 NM_207317
ZNF474
zinc finger protein 474
chr4_-_10686314 0.050 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr3_-_108248168 0.049 NM_014981
MYH15
myosin, heavy chain 15
chr1_+_209878135 0.047 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_-_39041436 0.046 NM_019010
KRT20
keratin 20
chr5_+_147691988 0.044 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr10_+_129845806 0.044 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr10_+_114043413 0.043 NM_058222
TECTB
tectorin beta
chr5_+_140174443 0.042 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr1_+_147374945 0.042 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr10_+_35894337 0.041 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr6_+_139349818 0.040 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr8_-_95487284 0.040 NM_001205262
NM_012415
RAD54B

RAD54 homolog B (S. cerevisiae)

chr4_+_70861647 0.040 NM_001009181
NM_003154
STATH

statherin

chr1_+_167298280 0.040 NM_001198783
POU2F1
POU class 2 homeobox 1
chr6_-_10412606 0.039 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr11_-_117747331 0.038 FXYD6
FXYD domain containing ion transport regulator 6
chr1_-_87380008 0.038 NM_004261
NM_203341
SEP15

15 kDa selenoprotein

chr8_-_87755880 0.037 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr12_+_21168629 0.036 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr2_-_163008913 0.035 NM_002054
GCG
glucagon
chr1_-_153044083 0.035 NM_001017418
SPRR2B
small proline-rich protein 2B
chr4_+_187148624 0.034 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr20_-_44144263 0.033 NM_006652
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr19_-_52133589 0.032 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr2_+_115822246 0.031 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr15_-_50405512 0.031 ATP8B4
ATPase, class I, type 8B, member 4
chr3_+_119500930 0.030 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr4_-_68749698 0.030 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr12_-_70093064 0.030 NM_032735
BEST3
bestrophin 3
chr12_-_80329234 0.029 NM_001143885
NM_001244990
PPP1R12A

protein phosphatase 1, regulatory subunit 12A

chr1_+_47533046 0.029 NM_178134
CYP4Z1
cytochrome P450, family 4, subfamily Z, polypeptide 1
chr1_+_160147200 0.028 NM_001001734
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chrX_+_148769902 0.028 NM_001011544
MAGEA11
melanoma antigen family A, 11
chr12_-_133215775 0.028 POLE
polymerase (DNA directed), epsilon
chr5_-_35048239 0.028 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr2_+_179184970 0.028 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr4_+_15429628 0.028 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr16_+_70147528 0.025 NM_017990
PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr16_+_72088507 0.024 NM_001126102
NM_005143
HP

haptoglobin

chr3_-_149051258 0.024 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr6_-_35480635 0.023 NM_003322
TULP1
tubby like protein 1
chr15_+_29213839 0.023 NM_001130414
NM_005503
APBA2

amyloid beta (A4) precursor protein-binding, family A, member 2

chr4_-_65275000 0.022 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr1_+_87380437 0.022 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr4_-_26491888 0.021 NM_000730
CCKAR
cholecystokinin A receptor
chr5_+_175223519 0.019 NM_006650
CPLX2
complexin 2
chr2_-_99871569 0.019 NM_175735
LYG2
lysozyme G-like 2
chr21_-_31588242 0.018 NM_199328
CLDN8
claudin 8
chrX_-_131573638 0.018 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr12_-_57504088 0.017 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_+_118175294 0.017 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr6_+_101846668 0.017 GRIK2
glutamate receptor, ionotropic, kainate 2
chr1_+_113236679 0.016 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr11_+_844445 0.016 NM_001025237
TSPAN4
tetraspanin 4
chr14_-_88737160 0.016 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr3_-_14583587 0.015 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr10_-_94257470 0.015 NM_001165946
IDE
insulin-degrading enzyme
chr1_+_84767288 0.015 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr10_-_82049178 0.015 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr2_-_162931051 0.015 NM_001935
DPP4
dipeptidyl-peptidase 4
chr3_+_108015392 0.015 HHLA2
HERV-H LTR-associating 2
chrX_+_144908927 0.014 NM_004709
CXorf1
chromosome X open reading frame 1
chr15_+_65337707 0.014 NM_178859
OSTBETA
organic solute transporter beta
chr17_+_58499854 0.014 NM_181707
C17orf64
chromosome 17 open reading frame 64
chr9_-_14779530 0.014 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr3_-_128186090 0.014 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr11_+_76883823 0.014 MYO7A
myosin VIIA
chr10_-_79628870 0.013 DLG5
discs, large homolog 5 (Drosophila)
chr8_+_7705401 0.013 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr4_+_71263598 0.012 NM_021225
PROL1
proline rich, lacrimal 1
chr22_+_40322609 0.011 GRAP2
GRB2-related adaptor protein 2
chr3_-_119379269 0.011 NM_022135
POPDC2
popeye domain containing 2
chr21_-_39870303 0.010 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr2_-_158182154 0.009 NM_020711
ERMN
ermin, ERM-like protein
chr3_+_119501556 0.009 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr19_-_54327428 0.009 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr19_-_14992166 0.008 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr9_-_140142165 0.008 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr12_-_2986299 0.008 NM_001243088
NM_001243089
NM_021953
NM_202002
NM_202003
FOXM1




forkhead box M1




chr7_-_26232148 0.008 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr20_+_4702499 0.007 NM_012409
PRND
prion protein 2 (dublet)
chr6_-_75994631 0.007 NM_001143958
NM_018247
TMEM30A

transmembrane protein 30A

chrX_+_50653734 0.006 NM_005448
BMP15
bone morphogenetic protein 15
chrX_-_15333726 0.005 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr8_-_59412695 0.005 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr11_+_59824054 0.005 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr8_-_7673137 0.005 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chrX_-_15332680 0.005 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr8_+_18079176 0.004 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr5_-_169724817 0.004 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr7_+_80267782 0.004 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr3_-_36781351 0.004 NM_033403
DCLK3
doublecortin-like kinase 3
chr3_+_136649316 0.004 NM_001190796
NCK1
NCK adaptor protein 1
chr7_+_45067232 0.004 NM_001029835
CCM2
cerebral cavernous malformation 2
chr1_-_211666258 0.003 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr5_-_169724734 0.003 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_+_158901336 0.003 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr10_+_118350470 0.003 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chrX_+_2670092 0.003 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr3_+_121286777 0.002 NM_001012659
ARGFX
arginine-fifty homeobox
chr6_-_76203256 0.002 NM_015687
FILIP1
filamin A interacting protein 1
chr11_+_71903172 0.001 NM_016729
FOLR1
folate receptor 1 (adult)
chr1_+_87380317 0.001 NM_001134492
NM_012262
HS2ST1

heparan sulfate 2-O-sulfotransferase 1

chr3_+_25470067 0.001 RARB
retinoic acid receptor, beta
chr4_+_71226477 0.001 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr5_+_152870083 0.000 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.90 4.01e-02 GO:0005576 extracellular region

Nothing significant found in function category.