Motif ID: PITX1..3.p2

Z-value: 1.647


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PITX1chr5_-_1343695710.753.3e-02Click!
PITX3chr10_-_104001229-0.571.4e-01Click!
PITX2chr4_-_111563278-0.344.1e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_41158741 0.952 NM_005533
 IFI35
interferon-induced protein 35
chr1_+_28832454 0.867 NM_001048199
 RCC1
regulator of chromosome condensation 1
chrX_+_153448084 0.766 NM_000513
NM_001048181
 OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chrX_+_153485202 0.740 NM_000513
NM_001048181
 OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr11_+_33363104 0.699 HIPK3
homeodomain interacting protein kinase 3
chr3_-_126327397 0.688 NM_001039783
 TXNRD3NB
thioredoxin reductase 3 neighbor
chr1_-_153348057 0.646 NM_005621
 S100A12
S100 calcium binding protein A12
chr16_+_72042486 0.636 NM_001361
 DHODH
dihydroorotate dehydrogenase (quinone)
chr12_+_7023490 0.626 NM_001975
 ENO2
enolase 2 (gamma, neuronal)
chr12_-_124068864 0.620


chr1_-_244006885 0.611 NM_001206729
 AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr8_-_27941387 0.579 NM_001010906
 C8orf80
chromosome 8 open reading frame 80
chr6_+_42018250 0.560 NM_138572
 TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr17_-_81006406 0.554 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chrX_-_2882288 0.538 NM_000047
 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr2_+_132285469 0.538 NM_138770
 CCDC74A
coiled-coil domain containing 74A
chr1_+_247419273 0.537 NM_173858
 VN1R5
vomeronasal 1 receptor 5 (gene/pseudogene)
chr1_-_16134192 0.522 NM_001089591
 UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr19_+_7049349 0.518 NM_144614
 MBD3L2
methyl-CpG binding domain protein 3-like 2
chr5_-_156486128 0.505 HAVCR1
hepatitis A virus cellular receptor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
2.07 4.94e-02 GO:0000375 RNA splicing, via transesterification reactions
2.00 3.28e-03 GO:0008380 RNA splicing
1.99 1.78e-04 GO:0006397 mRNA processing
1.90 2.25e-02 GO:0006412 translation
1.80 4.47e-04 GO:0016071 mRNA metabolic process
1.76 1.37e-04 GO:0006396 RNA processing
1.65 1.73e-02 GO:0000278 mitotic cell cycle
1.56 4.91e-02 GO:0022403 cell cycle phase
1.52 3.26e-02 GO:0022402 cell cycle process
1.51 3.05e-02 GO:0043933 macromolecular complex subunit organization
1.46 2.87e-02 GO:0007049 cell cycle
1.38 3.32e-02 GO:0009056 catabolic process
1.35 5.68e-04 GO:0090304 nucleic acid metabolic process
1.33 2.51e-02 GO:0010467 gene expression
1.32 3.60e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 2.45e-04 GO:0034641 cellular nitrogen compound metabolic process
1.28 4.40e-04 GO:0006807 nitrogen compound metabolic process
1.19 4.08e-02 GO:0044260 cellular macromolecule metabolic process
1.18 1.12e-04 GO:0044238 primary metabolic process
1.18 2.80e-04 GO:0044237 cellular metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
5.31 6.43e-04 GO:0005689 U12-type spliceosomal complex
2.49 9.63e-04 GO:0005681 spliceosomal complex
1.86 9.08e-06 GO:0030529 ribonucleoprotein complex
1.48 4.36e-02 GO:0031967 organelle envelope
1.47 8.62e-05 GO:0005739 mitochondrion
1.38 2.37e-05 GO:0005829 cytosol
1.34 2.37e-04 GO:0044428 nuclear part
1.34 4.67e-02 GO:0005654 nucleoplasm
1.32 7.14e-03 GO:0031981 nuclear lumen
1.29 2.29e-06 GO:0032991 macromolecular complex
1.25 4.38e-02 GO:0070013 intracellular organelle lumen
1.25 4.59e-02 GO:0043233 organelle lumen
1.22 1.05e-06 GO:0005634 nucleus
1.14 1.03e-05 GO:0043231 intracellular membrane-bounded organelle
1.14 1.30e-05 GO:0005737 cytoplasm
1.13 4.59e-11 GO:0044424 intracellular part
1.13 1.03e-06 GO:0043229 intracellular organelle
1.13 1.64e-06 GO:0043226 organelle
1.13 1.32e-05 GO:0043227 membrane-bounded organelle
1.13 3.94e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.54 2.08e-03 GO:0003723 RNA binding
1.11 4.63e-02 GO:0005515 protein binding
1.07 2.51e-02 GO:0005488 binding