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Motif ID: PITX1..3.p2

Z-value: 1.647

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_41158741	0.952	NM_005533	IFI35	interferon-induced protein 35
chr1_+_28832454	0.867	NM_001048199	RCC1	regulator of chromosome condensation 1
chrX_+_153448084	0.766	NM_000513 NM_001048181	OPN1MW OPN1MW2	opsin 1 (cone pigments), medium-wave-sensitive opsin 1 (cone pigments), medium-wave-sensitive 2
chrX_+_153485202	0.740	NM_000513 NM_001048181	OPN1MW OPN1MW2	opsin 1 (cone pigments), medium-wave-sensitive opsin 1 (cone pigments), medium-wave-sensitive 2
chr11_+_33363104	0.699		HIPK3	homeodomain interacting protein kinase 3
chr3_-_126327397	0.688	NM_001039783	TXNRD3NB	thioredoxin reductase 3 neighbor
chr1_-_153348057	0.646	NM_005621	S100A12	S100 calcium binding protein A12
chr16_+_72042486	0.636	NM_001361	DHODH	dihydroorotate dehydrogenase (quinone)
chr12_+_7023490	0.626	NM_001975	ENO2	enolase 2 (gamma, neuronal)
chr12_-_124068864	0.620
chr1_-_244006885	0.611	NM_001206729	AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr8_-_27941387	0.579	NM_001010906	C8orf80	chromosome 8 open reading frame 80
chr6_+_42018250	0.560	NM_138572	TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr17_-_81006406	0.554		B3GNTL1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chrX_-_2882288	0.538	NM_000047	ARSE	arylsulfatase E (chondrodysplasia punctata 1)
chr2_+_132285469	0.538	NM_138770	CCDC74A	coiled-coil domain containing 74A
chr1_+_247419273	0.537	NM_173858	VN1R5	vomeronasal 1 receptor 5 (gene/pseudogene)
chr1_-_16134192	0.522	NM_001089591	UQCRHL	ubiquinol-cytochrome c reductase hinge protein-like
chr19_+_7049349	0.518	NM_144614	MBD3L2	methyl-CpG binding domain protein 3-like 2
chr5_-_156486128	0.505		HAVCR1	hepatitis A virus cellular receptor 1
chr15_-_89764809	0.496	NM_000326	RLBP1	retinaldehyde binding protein 1
chr16_-_14788429	0.493	NM_003561	PLA2G10	phospholipase A2, group X
chr14_+_74058409	0.493	NM_152331	ACOT4	acyl-CoA thioesterase 4
chr12_-_121736110	0.489	NM_006549 NM_153499 NM_153500 NM_172214 NM_172215 NM_172216	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta
chr19_-_13068033	0.488	NM_052850	GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr1_+_24840800	0.487	NM_001251980 NM_001251982 NM_001251985	RCAN3	RCAN family member 3
chr12_+_47610051	0.487	NM_138371	FAM113B	family with sequence similarity 113, member B
chr9_-_116138340	0.483	NM_031219	HDHD3	haloacid dehalogenase-like hydrolase domain containing 3
chr7_+_134212343	0.471	NM_020299	AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)
chr16_+_21695749	0.464	NM_001161683	OTOA	otoancorin
chr19_+_6135650	0.459	NM_030924	ACSBG2	acyl-CoA synthetase bubblegum family member 2
chr19_-_23598867	0.454
chr6_+_42018264	0.453		TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr16_+_21689834	0.453	NM_144672	OTOA	otoancorin
chr1_+_114496498	0.450	NM_181358	HIPK1	homeodomain interacting protein kinase 1
chr19_-_23598839	0.450
chr7_-_99680358	0.448		ZNF3	zinc finger protein 3
chr19_+_15904760	0.442	NM_001004466	OR10H5	olfactory receptor, family 10, subfamily H, member 5
chr6_+_74104575	0.440		DDX43	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr16_+_3559893	0.433	NM_024793	CLUAP1	clusterin associated protein 1
chr4_+_1894508	0.428	NM_007331 NM_133330 NM_133331 NM_133335	WHSC1	Wolf-Hirschhorn syndrome candidate 1
chr1_-_7973286	0.424		UTS2	urotensin 2
chr9_-_117156684	0.417	NM_030767	AKNA	AT-hook transcription factor
chr15_+_45315301	0.417	NM_003104	SORD	sorbitol dehydrogenase
chr1_+_40859016	0.416	NM_001198979	SMAP2	small ArfGAP2
chrX_+_9431314	0.415	NM_001139466 NM_001139467 NM_001139468	TBL1X	transducin (beta)-like 1X-linked
chr19_-_38747171	0.413	NM_001243947 NM_033256	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr19_+_48964505	0.413	NM_170720	KCNJ14	potassium inwardly-rectifying channel, subfamily J, member 14
chr7_-_140302311	0.411	NM_015689	DENND2A	DENN/MADD domain containing 2A
chr19_-_15343194	0.411	NM_024794	EPHX3	epoxide hydrolase 3
chr15_+_24920540	0.406	NM_018958	C15orf2	chromosome 15 open reading frame 2
chr5_+_81601165	0.405	NM_001017971	ATP6AP1L	ATPase, H+ transporting, lysosomal accessory protein 1-like
chr1_+_40713572	0.405	NM_001008740	TMCO2	transmembrane and coiled-coil domains 2
chr6_-_26189303	0.405	NM_003539	HIST1H4D	histone cluster 1, H4d
chr1_-_161207879	0.405	NM_001077469 NM_001077470 NM_001077471 NM_001077472 NM_001077473 NM_001077474 NM_001077475 NM_001077476 NM_001077477 NM_001077478 NM_001077479 NM_001077480 NM_001077481 NM_001077482 NM_005122	NR1I3	nuclear receptor subfamily 1, group I, member 3
chr11_-_9225780	0.402		DENND5A	DENN/MADD domain containing 5A
chr19_+_18045904	0.399	NM_138442	CCDC124	coiled-coil domain containing 124
chrX_-_16730669	0.396	NM_175859 NM_019857	CTPS2	CTP synthase II
chr1_+_26504024	0.390		CNKSR1	connector enhancer of kinase suppressor of Ras 1
chr17_+_76210329	0.388		BIRC5	baculoviral IAP repeat containing 5
chr4_+_2627158	0.387	NM_003704	FAM193A	family with sequence similarity 193, member A
chr6_-_73935174	0.386	NM_001126063	KHDC1L	KH homology domain containing 1-like
chr19_-_2456954	0.384	NM_032737	LMNB2	lamin B2
chr6_+_109450506	0.378	NM_173830	CEP57L1	centrosomal protein 57kDa-like 1
chr1_-_150849147	0.378		ARNT	aryl hydrocarbon receptor nuclear translocator
chr6_-_31774725	0.367	NM_021177	LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr9_-_74675498	0.362	NM_001128618	C9orf57	chromosome 9 open reading frame 57
chr11_+_308106	0.362	NM_006435	IFITM2	interferon induced transmembrane protein 2 (1-8D)
chr2_-_171923482	0.361	NM_001136555	TLK1	tousled-like kinase 1
chr19_+_49458031	0.358	NM_004324 NM_138761 NM_138763 NM_138764	BAX	BCL2-associated X protein
chr19_-_39443326	0.356	NM_148169	FBXO17	F-box protein 17
chr19_+_49458129	0.355		BAX	BCL2-associated X protein
chr7_-_97619350	0.346	NM_006188	OCM2	oncomodulin 2
chr4_+_106631966	0.344	NM_001031720	GSTCD	glutathione S-transferase, C-terminal domain containing
chr11_+_60197061	0.338	NM_023945	MS4A5	membrane-spanning 4-domains, subfamily A, member 5
chr19_-_47735858	0.333	NM_001127240 NM_001127241 NM_001127242	BBC3	BCL2 binding component 3
chr1_+_11724148	0.329	NM_018438	FBXO6	F-box protein 6
chr19_-_46142643	0.328		EML2	echinoderm microtubule associated protein like 2
chr15_-_23115243	0.325		LOC283683	uncharacterized LOC283683
chrX_-_70326637	0.321	NM_001025265	CXorf65	chromosome X open reading frame 65
chr1_+_145487301	0.318		LIX1L	Lix1 homolog (mouse)-like
chr5_+_157184338	0.318
chr17_+_40703983	0.316	NM_000413	HSD17B1	hydroxysteroid (17-beta) dehydrogenase 1
chr1_+_234509213	0.316	NM_001206641 NM_001012985	C1orf31	chromosome 1 open reading frame 31
chr19_-_12792676	0.315		DHPS	deoxyhypusine synthase
chr15_-_90437616	0.314	NM_005829	AP3S2	adaptor-related protein complex 3, sigma 2 subunit
chr9_+_131217433	0.312	NM_153436	ODF2	outer dense fiber of sperm tails 2
chr19_-_12792577	0.312		DHPS	deoxyhypusine synthase
chr17_+_17380264	0.310	NM_018019	MED9	mediator complex subunit 9
chr8_+_11627144	0.308	NM_001135746 NM_001135747 NM_001135748 NM_145043	NEIL2	nei endonuclease VIII-like 2 (E. coli)
chr1_-_202896315	0.307		KLHL12	kelch-like 12 (Drosophila)
chr18_+_61370193	0.304	NM_080475	SERPINB11	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr8_-_38008332	0.304	NM_000349	STAR	steroidogenic acute regulatory protein
chr10_+_105005643	0.301	NM_001143909	LOC729020	rcRPE
chr22_-_42343079	0.300	NM_001002876 NM_024053	CENPM	centromere protein M
chr12_-_21757752	0.298	NM_021957	GYS2	glycogen synthase 2 (liver)
chr21_-_31859666	0.294	NM_181608	KRTAP19-2	keratin associated protein 19-2
chr22_-_17646176	0.294	NM_017829	CECR5	cat eye syndrome chromosome region, candidate 5
chr21_-_39493349	0.293	NM_005867	DSCR4	Down syndrome critical region gene 4
chr17_+_71229357	0.293		C17orf80	chromosome 17 open reading frame 80
chr16_+_12058963	0.292	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr2_+_75059781	0.291	NM_000189	HK2	hexokinase 2
chrX_-_129272014	0.291	NM_001130846	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1
chr17_-_6947241	0.290	NM_153357	SLC16A11	solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr18_+_3453771	0.290	NM_173211	TGIF1	TGFB-induced factor homeobox 1
chr1_-_27701302	0.289	NM_003665 NM_173452	FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
chrX_+_96138906	0.288	NM_013347	RPA4	replication protein A4, 30kDa
chr5_-_156485118	0.288		HAVCR1	hepatitis A virus cellular receptor 1
chr19_-_42931500	0.287	NM_005357	LIPE	lipase, hormone-sensitive
chr19_-_46142662	0.287	NM_012155	EML2	echinoderm microtubule associated protein like 2
chr19_+_17530841	0.282		FAM125A	family with sequence similarity 125, member A
chr11_+_68367824	0.280		PPP6R3	protein phosphatase 6, regulatory subunit 3
chr1_-_150849211	0.279	NM_001197325 NM_001668 NM_178427	ARNT	aryl hydrocarbon receptor nuclear translocator
chr19_-_12792698	0.278	NM_001930 NM_013406	DHPS	deoxyhypusine synthase
chr22_+_21128378	0.277	NM_000185	SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr20_+_51801821	0.276	NM_001193421	TSHZ2	teashirt zinc finger homeobox 2
chr22_-_42336222	0.273	NM_001110215	CENPM	centromere protein M
chr11_-_67211291	0.273	NM_001018070	CORO1B	coronin, actin binding protein, 1B
chr9_+_132388451	0.273		METTL11A	methyltransferase like 11A
chr5_+_54320083	0.272	NM_002104	GZMK	granzyme K (granzyme 3; tryptase II)
chr20_+_33462765	0.272	NM_001242393	ACSS2	acyl-CoA synthetase short-chain family member 2
chr1_+_3668961	0.271	NM_152492	CCDC27	coiled-coil domain containing 27
chrX_+_48620153	0.270	NM_001080489	GLOD5	glyoxalase domain containing 5
chr9_+_132388404	0.269	NM_014064	METTL11A	methyltransferase like 11A
chr11_-_62607627	0.267	NM_018093	WDR74	WD repeat domain 74
chr20_-_39928708	0.267	NM_015035	ZHX3	zinc fingers and homeoboxes 3
chr19_+_10812111	0.266	NM_031209	QTRT1	queuine tRNA-ribosyltransferase 1
chr12_-_49177876	0.265	NM_015270	ADCY6	adenylate cyclase 6
chr3_+_109128836	0.264	NM_001145553	FLJ25363	uncharacterized LOC401082
chr2_-_130902568	0.263	NM_207310	CCDC74B	coiled-coil domain containing 74B
chr19_+_14551080	0.262	NM_213560	PKN1	protein kinase N1
chr16_+_32752634	0.261		LOC100289574	hect domain and RLD 2 pseudogene
chr7_+_76054251	0.260	NM_001110354	ZP3	zona pellucida glycoprotein 3 (sperm receptor)
chr6_-_31763551	0.260	NM_006295	VARS	valyl-tRNA synthetase
chr15_-_70878943	0.259
chr2_+_204571197	0.259	NM_001243077 NM_001243078 NM_006139	CD28	CD28 molecule
chr10_-_99393851	0.258	NM_001098831	MORN4	MORN repeat containing 4
chr9_-_117160748	0.256		AKNA	AT-hook transcription factor
chr1_+_28832552	0.256		SNHG3	small nucleolar RNA host gene 3 (non-protein coding)
chr19_-_17932312	0.256	NM_005543	INSL3	insulin-like 3 (Leydig cell)
chr10_-_105452878	0.256		SH3PXD2A	SH3 and PX domains 2A
chr19_-_51893791	0.256	NM_001193623	LOC147646	uncharacterized LOC147646
chr16_-_25026650	0.256	NM_001006634 NM_018054	ARHGAP17	Rho GTPase activating protein 17
chr17_-_8113862	0.250	NM_004217	AURKB	aurora kinase B
chr16_-_32199406	0.248		LOC100289574	hect domain and RLD 2 pseudogene
chr5_-_156485969	0.248	NM_001173393	HAVCR1	hepatitis A virus cellular receptor 1
chr1_+_175036993	0.248	NM_022093	TNN	tenascin N
chr13_-_45992454	0.247		SLC25A30	solute carrier family 25, member 30
chr1_-_109203663	0.247	NM_001102592	HENMT1	HEN1 methyltransferase homolog 1 (Arabidopsis)
chr11_+_118955569	0.247	NM_000190	HMBS	hydroxymethylbilane synthase
chr12_-_31945174	0.246	NM_001013699	H3F3C	H3 histone, family 3C
chr4_-_159956332	0.246	NM_152543	C4orf45	chromosome 4 open reading frame 45
chr1_-_182359413	0.246		GLUL	glutamate-ammonia ligase
chr5_+_37379382	0.245		WDR70	WD repeat domain 70
chr19_+_14551052	0.243		PKN1	protein kinase N1
chr11_+_65101224	0.243	NM_006268	DPF2	D4, zinc and double PHD fingers family 2
chrX_+_2959511	0.243	NM_001201539	ARSF	arylsulfatase F
chr16_-_15833937	0.243		MYH11	myosin, heavy chain 11, smooth muscle
chr12_-_46357949	0.242
chr14_-_70826303	0.241		COX16	COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr14_-_35008781	0.240	NM_018453	EAPP	E2F-associated phosphoprotein
chr6_+_35995583	0.238		MAPK14	mitogen-activated protein kinase 14
chr22_+_39795745	0.237	NM_006116 NM_153497	TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1
chr19_+_6361558	0.236		CLPP	ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
chr13_-_21348081	0.235		N6AMT2	N-6 adenine-specific DNA methyltransferase 2 (putative)
chr1_+_151253977	0.235		ZNF687	zinc finger protein 687
chr6_+_31598366	0.234		PRRC2A	proline-rich coiled-coil 2A
chr16_-_1922079	0.234	NM_152764	C16orf73	chromosome 16 open reading frame 73
chr10_+_35535952	0.233	NM_181698	CCNY	cyclin Y
chr19_+_14551087	0.232		PKN1	protein kinase N1
chr19_+_7745706	0.230	NM_001042462	TRAPPC5	trafficking protein particle complex 5
chr9_-_116139148	0.230		HDHD3	haloacid dehalogenase-like hydrolase domain containing 3
chr17_-_56358161	0.230		MPO	myeloperoxidase
chr11_+_5641173	0.229	NM_001003827	TRIM34	tripartite motif containing 34
chr17_-_73761216	0.228	NM_000154	GALK1	galactokinase 1
chr11_-_68518944	0.225	NM_001039656 NM_004923	MTL5	metallothionein-like 5, testis-specific (tesmin)
chr16_-_1922161	0.224	NM_001163560	C16orf73	chromosome 16 open reading frame 73
chr6_-_109762373	0.223	NM_001111298 NM_173672	PPIL6	peptidylprolyl isomerase (cyclophilin)-like 6
chr10_+_126490353	0.223	NM_032182	FAM175B	family with sequence similarity 175, member B
chr19_-_13068008	0.222		GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr5_+_132406080	0.222		HSPA4	heat shock 70kDa protein 4
chr1_-_150849062	0.221		ARNT	aryl hydrocarbon receptor nuclear translocator
chr16_+_19078958	0.220		COQ7	coenzyme Q7 homolog, ubiquinone (yeast)
chr13_-_21348054	0.220	NM_174928	N6AMT2	N-6 adenine-specific DNA methyltransferase 2 (putative)
chr2_+_85843247	0.219		USP39	ubiquitin specific peptidase 39
chr13_+_41363546	0.218	NM_014252	SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr12_-_122296619	0.218	NM_002150	HPD	4-hydroxyphenylpyruvate dioxygenase
chr13_+_41363642	0.218		SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr1_+_24834083	0.217	NM_001251978	RCAN3	RCAN family member 3
chr1_-_713985	0.216		LOC100288069	general transcription factor IIi pseudogene
chr20_+_361272	0.216	NM_021158	TRIB3	tribbles homolog 3 (Drosophila)
chr7_+_76026819	0.215	NM_007155	ZP3	zona pellucida glycoprotein 3 (sperm receptor)
chr2_+_97001463	0.215	NM_015341	NCAPH	non-SMC condensin I complex, subunit H
chr17_-_5372235	0.214	NM_001199699 NM_020162	DHX33	DEAH (Asp-Glu-Ala-His) box polypeptide 33
chrX_+_35816458	0.214	NM_001099921	MAGEB16	melanoma antigen family B, 16
chr12_-_123706393	0.214	NM_022782	MPHOSPH9	M-phase phosphoprotein 9
chr17_-_56358266	0.213	NM_000250	MPO	myeloperoxidase
chr4_+_70861647	0.213	NM_001009181 NM_003154	STATH	statherin
chr6_-_31107110	0.212	NM_014069	PSORS1C2	psoriasis susceptibility 1 candidate 2
chr6_+_31430955	0.211		HCP5	HLA complex P5 (non-protein coding)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.18	1.12e-04	GO:0044238	primary metabolic process
1.76	1.37e-04	GO:0006396	RNA processing
1.16	1.53e-04	GO:0008152	metabolic process
1.99	1.78e-04	GO:0006397	mRNA processing
1.29	2.45e-04	GO:0034641	cellular nitrogen compound metabolic process
1.18	2.80e-04	GO:0044237	cellular metabolic process
1.32	3.60e-04	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28	4.40e-04	GO:0006807	nitrogen compound metabolic process
1.80	4.47e-04	GO:0016071	mRNA metabolic process
1.35	5.68e-04	GO:0090304	nucleic acid metabolic process
2.00	3.28e-03	GO:0008380	RNA splicing
1.65	1.73e-02	GO:0000278	mitotic cell cycle
1.18	1.82e-02	GO:0043170	macromolecule metabolic process
1.90	2.25e-02	GO:0006412	translation
1.33	2.51e-02	GO:0010467	gene expression
1.46	2.87e-02	GO:0007049	cell cycle
1.51	3.05e-02	GO:0043933	macromolecular complex subunit organization
1.52	3.26e-02	GO:0022402	cell cycle process
1.38	3.32e-02	GO:0009056	catabolic process
1.19	4.08e-02	GO:0044260	cellular macromolecule metabolic process
1.56	4.91e-02	GO:0022403	cell cycle phase
2.07	4.94e-02	GO:0000375	RNA splicing, via transesterification reactions

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.13	4.59e-11	GO:0044424	intracellular part
1.12	1.58e-09	GO:0005622	intracellular
1.13	1.03e-06	GO:0043229	intracellular organelle
1.22	1.05e-06	GO:0005634	nucleus
1.13	1.64e-06	GO:0043226	organelle
1.29	2.29e-06	GO:0032991	macromolecular complex
1.86	9.08e-06	GO:0030529	ribonucleoprotein complex
1.14	1.03e-05	GO:0043231	intracellular membrane-bounded organelle
1.14	1.30e-05	GO:0005737	cytoplasm
1.13	1.32e-05	GO:0043227	membrane-bounded organelle
1.38	2.37e-05	GO:0005829	cytosol
1.47	8.62e-05	GO:0005739	mitochondrion
1.34	2.37e-04	GO:0044428	nuclear part
5.31	6.43e-04	GO:0005689	U12-type spliceosomal complex
2.49	9.63e-04	GO:0005681	spliceosomal complex
1.32	7.14e-03	GO:0031981	nuclear lumen
1.13	3.94e-02	GO:0044444	cytoplasmic part
1.48	4.36e-02	GO:0031967	organelle envelope
1.25	4.38e-02	GO:0070013	intracellular organelle lumen
1.25	4.59e-02	GO:0043233	organelle lumen
1.34	4.67e-02	GO:0005654	nucleoplasm

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.54	2.08e-03	GO:0003723	RNA binding
1.07	2.51e-02	GO:0005488	binding
1.11	4.63e-02	GO:0005515	protein binding