Motif ID: POU3F1..4.p2

Z-value: 0.510


Transcription factors associated with POU3F1..4.p2:

Gene SymbolEntrez IDGene Name
POU3F1 5453 POU class 3 homeobox 1
POU3F2 5454 POU class 3 homeobox 2
POU3F3 5455 POU class 3 homeobox 3
POU3F4 5456 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU3F4chrX_+_827632680.551.6e-01Click!
POU3F3chr2_+_1054717450.472.4e-01Click!
POU3F1chr1_-_385124460.078.7e-01Click!
POU3F2chr6_+_99282597-0.068.8e-01Click!


Activity profile for motif POU3F1..4.p2.

activity profile for motif POU3F1..4.p2


Sorted Z-values histogram for motif POU3F1..4.p2

Sorted Z-values for motif POU3F1..4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F1..4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_61554938 0.799 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_-_242612757 0.649 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr6_-_136788012 0.434 NM_001198615
MAP7
microtubule-associated protein 7
chr18_+_61442611 0.381 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_+_186798031 0.373 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr8_+_104831415 0.363 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr7_-_20256942 0.342 NM_182762
MACC1
metastasis associated in colon cancer 1
chr8_-_17579729 0.317 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr12_-_52867521 0.285 NM_173086
KRT6C
keratin 6C
chrX_+_102585113 0.280 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr2_+_68961912 0.268 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr2_-_113594325 0.254 NM_000576
IL1B
interleukin 1, beta
chr8_-_15095791 0.244 NM_139167
SGCZ
sarcoglycan, zeta
chrX_+_65384078 0.238 NM_001130860
NM_014799
HEPH

hephaestin

chr6_+_121756744 0.229 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_+_152956563 0.221 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr3_+_122044010 0.218 NM_005213
CSTA
cystatin A (stefin A)
chr5_+_140213968 0.217 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr16_+_4845265 0.207 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr16_+_68679198 0.193 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr7_+_26403944 0.184 NM_001199838
SNX10
sorting nexin 10
chr20_+_9458460 0.182 PLCB4
phospholipase C, beta 4
chr6_+_47624222 0.182 NM_153839
GPR111
G protein-coupled receptor 111
chr4_+_100737980 0.177 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr5_+_55149149 0.170 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr5_+_68788118 0.168 NM_002538
OCLN
occludin
chr6_+_43738394 0.163 VEGFA
vascular endothelial growth factor A
chrX_-_33229428 0.158 NM_004006
DMD
dystrophin
chr15_+_43885251 0.156 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chrX_+_105937067 0.155 NM_024539
RNF128
ring finger protein 128
chr6_+_24357130 0.153 NM_181337
KAAG1
kidney associated antigen 1
chr18_+_61254533 0.148 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr4_+_88896868 0.147 SPP1
secreted phosphoprotein 1
chr3_+_136676706 0.145 NM_144717
IL20RB
interleukin 20 receptor beta
chr1_-_204329043 0.144 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr2_-_160472960 0.143 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr2_-_31352489 0.141 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr4_+_88896838 0.137 SPP1
secreted phosphoprotein 1
chr18_-_52969714 0.135 NM_001243236
TCF4
transcription factor 4
chr1_+_47264669 0.134 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr2_+_191014971 0.133 NM_001042520
C2orf88
chromosome 2 open reading frame 88
chr2_-_113542970 0.133 NM_000575
IL1A
interleukin 1, alpha
chr12_-_71031174 0.127 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr8_-_17555158 0.126 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr14_-_94855120 0.126 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr5_+_147258273 0.121 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr18_+_61575203 0.121 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr10_-_116286661 0.121 NM_006720
ABLIM1
actin binding LIM protein 1
chr5_+_86676620 0.120


chr13_+_43355685 0.117 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr20_+_58296264 0.116 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr3_+_148583042 0.115 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr9_+_117904096 0.115 NM_017418
DEC1
deleted in esophageal cancer 1
chrX_-_32430370 0.115 NM_004011
NM_004012
DMD

dystrophin

chr12_+_21168629 0.114 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr3_-_46718898 0.114 NM_182775
ALS2CL
ALS2 C-terminal like
chr8_+_1993157 0.113 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr11_+_6866882 0.112 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr15_+_40509628 0.111 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr1_+_95285900 0.110 NM_001114106
SLC44A3
solute carrier family 44, member 3
chr8_-_66701175 0.108 NM_002603
PDE7A
phosphodiesterase 7A
chr6_-_33041266 0.105 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr3_+_121613170 0.103 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr1_+_28261503 0.102 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr12_+_57984992 0.101 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr18_-_47376156 0.099 MYO5B
myosin VB
chr12_+_41831484 0.099 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr10_-_69425356 0.098 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr13_+_97874540 0.097 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr12_-_105322056 0.097 NM_032148
SLC41A2
solute carrier family 41, member 2
chr8_-_20040612 0.096 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr4_-_80994309 0.095 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr10_-_113933517 0.092 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr1_-_156399183 0.092 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr17_-_39646115 0.092 NM_003771
KRT36
keratin 36
chr7_-_83278478 0.091 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr13_+_97874704 0.091 MBNL2
muscleblind-like 2 (Drosophila)
chr9_+_131684561 0.090 NM_001100877
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr1_+_244515936 0.090 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr2_+_166428845 0.089 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr18_-_53068755 0.089 TCF4
transcription factor 4
chr10_+_105127709 0.088 NM_006951
TAF5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
chr12_+_8975149 0.087 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr4_-_87028805 0.085 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr4_-_100242487 0.085 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr11_-_85469043 0.083 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr14_+_21510384 0.083 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr6_+_144185572 0.080 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chrX_-_117107700 0.079 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr17_-_7493389 0.079 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr3_-_151034514 0.078 NM_023915
GPR87
G protein-coupled receptor 87
chr11_+_63753827 0.077 OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr5_+_40909617 0.077 C7
complement component 7
chr4_-_123377471 0.075 NM_000586
IL2
interleukin 2
chr4_+_88896801 0.074 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr14_-_61748510 0.074 NM_001017970
TMEM30B
transmembrane protein 30B
chr4_-_100485173 0.073 NM_001134665
NM_001134666
RG9MTD2

RNA (guanine-9-) methyltransferase domain containing 2

chr6_-_25832268 0.072 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr2_-_113810439 0.071 NM_014438
NM_173178
IL36B

interleukin 36, beta

chr1_-_110933635 0.071 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr5_+_40909558 0.070 NM_000587
C7
complement component 7
chr21_+_42733916 0.070 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr9_-_19786886 0.069 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr21_-_39956823 0.069 NM_001243429
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr21_+_43619798 0.069 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr5_+_147582338 0.068 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr2_+_166095911 0.067 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr9_-_104147261 0.066 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chrX_-_52386015 0.066 NM_001079538
XAGE2B
XAGE2
X antigen family, member 2B
X antigen family, member 2
chr6_+_147829784 0.066 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr6_-_132967141 0.065 NM_138327
TAAR1
trace amine associated receptor 1
chr8_-_124749573 0.065 NM_001003954
NM_004306
ANXA13

annexin A13

chr8_-_124544376 0.064 NM_148177
FBXO32
F-box protein 32
chr11_-_118123001 0.064 NM_198275
MPZL3
myelin protein zero-like 3
chrX_+_22291029 0.064 NM_152577
ZNF645
zinc finger protein 645
chr18_-_3845295 0.062 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr21_+_30452872 0.058 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr12_+_80603232 0.058 NM_173591
OTOGL
otogelin-like
chr8_+_75736771 0.058 NM_015886
PI15
peptidase inhibitor 15
chr17_-_9694613 0.057 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr7_+_141463896 0.057 NM_016943
TAS2R3
taste receptor, type 2, member 3
chr13_-_25746304 0.057 FAM123A
family with sequence similarity 123A
chr12_-_16759733 0.056 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_19082227 0.056 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr7_+_106505696 0.054 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_183580960 0.054 NM_018981
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr5_+_54398473 0.054 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr11_-_67205151 0.053 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chrX_+_99899162 0.053 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr11_+_63137260 0.052 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr4_-_100273831 0.052 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr4_+_140586921 0.052 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chr7_+_130126035 0.051 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr7_+_128580725 0.051 NM_001098627
IRF5
interferon regulatory factor 5
chr9_-_32526164 0.051 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr13_+_109248499 0.051 NM_015011
MYO16
myosin XVI
chr7_-_16505292 0.051 NM_015464
SOSTDC1
sclerostin domain containing 1
chr4_-_153303663 0.050 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chrX_+_129139163 0.050 NM_021946
BCORL1
BCL6 corepressor-like 1
chr4_-_72649734 0.049 NM_000583
GC
group-specific component (vitamin D binding protein)
chr1_+_171060017 0.049 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr6_+_31543340 0.047 NM_000594
TNF
tumor necrosis factor
chr9_+_12693385 0.047 NM_000550
TYRP1
tyrosinase-related protein 1
chr13_-_78492906 0.047 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr17_-_2996289 0.046 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr12_+_12224401 0.046 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr2_-_190927321 0.046 NM_005259
MSTN
myostatin
chr18_+_55888838 0.045 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_1418179 0.044 NM_175721
NM_175722
TPO

thyroid peroxidase

chr19_+_4229494 0.044 NM_005755
EBI3
Epstein-Barr virus induced 3
chr8_-_110620220 0.044 SYBU
syntabulin (syntaxin-interacting)
chr3_+_97887543 0.044 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr2_+_189156603 0.043 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr17_+_40439564 0.042 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr14_+_24782312 0.042 NM_181657
LTB4R
leukotriene B4 receptor
chr6_+_90604185 0.042 NM_032602
GJA10
gap junction protein, alpha 10, 62kDa
chr9_+_35042222 0.042 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr1_-_26197743 0.041 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr6_+_18155535 0.041 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr4_+_76481257 0.041 NM_001206981
NM_178497
C4orf26

chromosome 4 open reading frame 26

chr5_+_34684611 0.041 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr19_-_54804172 0.040 NM_001172654
NM_006865
LILRA3

LILRA6
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr4_+_187148624 0.040 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr13_-_78493902 0.040 NM_001201397
EDNRB
endothelin receptor type B
chr9_+_96233420 0.039 FAM120A
family with sequence similarity 120A
chr11_+_113775517 0.039 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr10_-_116286570 0.039 ABLIM1
actin binding LIM protein 1
chr17_+_28268622 0.039 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr5_-_78281688 0.038 NM_198709
ARSB
arylsulfatase B
chrX_+_134654546 0.038 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr1_+_182419255 0.038 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr14_+_23305792 0.038 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr7_-_124405680 0.038 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr7_-_16921596 0.037 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr3_-_193272587 0.037 NM_032279
ATP13A4
ATPase type 13A4
chr12_-_9268475 0.037 A2M
alpha-2-macroglobulin
chr6_+_29364331 0.037 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr11_+_10477480 0.036 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr11_-_72504643 0.036 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr12_-_8219001 0.036 C3AR1
complement component 3a receptor 1
chr1_+_52082545 0.036 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr1_+_196788860 0.035 NM_002113
CFHR1
complement factor H-related 1
chr9_+_131683173 0.035 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr10_-_5060191 0.035 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr9_-_77643179 0.035 C9orf41
chromosome 9 open reading frame 41
chr3_-_123339178 0.034 MYLK
myosin light chain kinase
chr9_-_124921981 0.034 NDUFA8
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chr2_-_100722259 0.033 AFF3
AF4/FMR2 family, member 3
chr8_-_93111915 0.033 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_16759939 0.033 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_100316530 0.032 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr6_-_125623071 0.032 HDDC2
HD domain containing 2
chr7_-_83270746 0.032 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_-_8218930 0.032 NM_004054
C3AR1
complement component 3a receptor 1
chr9_+_125795787 0.032 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr3_+_130569368 0.032 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr9_-_124922049 0.032 NM_014222
NDUFA8
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chr1_+_241815579 0.031 NM_144625
WDR64
WD repeat domain 64
chr4_+_89300110 0.031 HERC6
hect domain and RLD 6
chr11_+_64358281 0.031 NM_144585
NM_153378
SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.02 6.62e-03 GO:0006955 immune response
1.73 1.41e-02 GO:0002376 immune system process
2.82 3.30e-02 GO:0032101 regulation of response to external stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 3.73e-04 GO:0005886 plasma membrane
1.36 6.23e-04 GO:0071944 cell periphery
1.49 9.09e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.37 2.98e-03 GO:0004867 serine-type endopeptidase inhibitor activity
2.24 7.19e-03 GO:0008289 lipid binding