Motif ID: POU5F1.p2

Z-value: 0.989


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_311346140.762.7e-02Click!


Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_33357725 0.989 NM_000109
DMD
dystrophin
chr1_-_23885916 0.876 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr10_-_98031154 0.876 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_+_67410825 0.869 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr6_+_26124372 0.818 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr2_+_233734993 0.744 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr1_+_27668462 0.733 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr1_+_27668499 0.730 SYTL1
synaptotagmin-like 1
chr16_-_48269087 0.711 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr1_-_108231122 0.694 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr18_-_53089722 0.657 NM_001243233
TCF4
transcription factor 4
chr19_-_44124013 0.653 NM_182498
ZNF428
zinc finger protein 428
chr10_-_116286661 0.626 NM_006720
ABLIM1
actin binding LIM protein 1
chr1_+_15272414 0.618 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr7_+_129008044 0.559 AHCYL2
adenosylhomocysteinase-like 2
chrX_+_80457559 0.553 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr19_+_6135650 0.547 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chrX_-_31526414 0.546 NM_004014
DMD
dystrophin
chr13_+_97874704 0.494 MBNL2
muscleblind-like 2 (Drosophila)
chr19_-_44123732 0.482 ZNF428
zinc finger protein 428
chr4_-_186733372 0.466 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_-_23886284 0.464 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr13_+_97928196 0.452 MBNL2
muscleblind-like 2 (Drosophila)
chr20_+_17207680 0.449 PCSK2
proprotein convertase subtilisin/kexin type 2
chr12_+_7942025 0.435 NANOG
Nanog homeobox
chr9_-_124990706 0.418 NM_001242333
LHX6
LIM homeobox 6
chr20_+_17207669 0.410 PCSK2
proprotein convertase subtilisin/kexin type 2
chr19_-_50143350 0.406 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chrX_-_24665225 0.399 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_+_175036993 0.396 NM_022093
TNN
tenascin N
chr9_-_3223007 0.392


chr19_-_36004553 0.391 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chrX_+_80457597 0.385 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_-_153363544 0.381 NM_002964
S100A8
S100 calcium binding protein A8
chr21_-_32201926 0.381 NM_181606
KRTAP7-1
keratin associated protein 7-1 (gene/pseudogene)
chr4_+_134070443 0.379 NM_020815
NM_032961
PCDH10

protocadherin 10

chr5_-_175964223 0.377 NM_014901
RNF44
ring finger protein 44
chr13_-_70682458 0.375 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr11_-_94964209 0.373 NM_144665
SESN3
sestrin 3
chrX_-_106960268 0.367 NM_004089
TSC22D3
TSC22 domain family, member 3
chr12_-_95945226 0.366 NM_032147
USP44
ubiquitin specific peptidase 44
chrX_-_24665454 0.366 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr4_-_90759446 0.364 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr12_+_113344738 0.354 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr17_-_7307413 0.348 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 readthrough
chromosome 17 open reading frame 61
chr3_+_158787040 0.348 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr1_-_149859465 0.344 NM_175065
HIST2H2AB
HIST2H2BE
histone cluster 2, H2ab
histone cluster 2, H2be
chrX_+_80457302 0.344 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr17_+_9729380 0.340 NM_004246
GLP2R
glucagon-like peptide 2 receptor
chr2_-_193059249 0.338 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr13_+_97928414 0.335 MBNL2
muscleblind-like 2 (Drosophila)
chr7_-_141673572 0.329 NM_176817
TAS2R38
taste receptor, type 2, member 38
chr12_-_31479120 0.329 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr5_-_36301999 0.327 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr3_-_18480203 0.323 NM_001131010
SATB1
SATB homeobox 1
chr1_+_61542928 0.322 NM_001145511
NFIA
nuclear factor I/A
chr1_+_244214552 0.321 NM_205768
ZNF238
zinc finger protein 238
chr4_+_81106423 0.320 NM_020226
PRDM8
PR domain containing 8
chr11_+_5653484 0.320 NM_130390
TRIM34
tripartite motif containing 34
chr1_+_6052357 0.316 NM_001199861
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr4_-_153303663 0.316 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_+_167298382 0.315 POU2F1
POU class 2 homeobox 1
chr11_+_58939960 0.315 DTX4
deltex homolog 4 (Drosophila)
chr9_-_124990949 0.314 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr15_-_83474805 0.313 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr12_-_31479084 0.312 FAM60A
family with sequence similarity 60, member A
chr1_+_167298280 0.304 NM_001198783
POU2F1
POU class 2 homeobox 1
chr16_-_28550227 0.303 NUPR1
nuclear protein, transcriptional regulator, 1
chr1_+_24840800 0.301 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr3_-_57234279 0.296 NM_003865
HESX1
HESX homeobox 1
chr1_-_228645517 0.292 NM_033445
HIST3H2A
histone cluster 3, H2a
chr1_-_154832187 0.292 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr16_-_79634610 0.291 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr17_-_38256548 0.290 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr16_-_28550324 0.290 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr17_-_34257730 0.290 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr1_+_244214576 0.290 ZNF238
zinc finger protein 238
chr17_-_8063946 0.288 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr12_-_31479038 0.288 FAM60A
family with sequence similarity 60, member A
chr10_-_116286570 0.287 ABLIM1
actin binding LIM protein 1
chr1_+_153003677 0.287 NM_003125
SPRR1B
small proline-rich protein 1B
chr2_-_119605758 0.287 NM_001426
EN1
engrailed homeobox 1
chr9_-_124989755 0.285 NM_001242334
LHX6
LIM homeobox 6
chrX_-_106960028 0.283 TSC22D3
TSC22 domain family, member 3
chr6_+_26251826 0.280 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr3_-_126327397 0.280 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr15_+_80364902 0.279 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr6_-_27114577 0.278 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr8_+_95653340 0.278 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr16_-_30107492 0.278 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr14_-_22005035 0.276 NM_005407
SALL2
sal-like 2 (Drosophila)
chr12_-_16757944 0.276 LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_+_123793894 0.276 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr8_+_123793988 0.274 ZHX2
zinc fingers and homeoboxes 2
chr8_+_123794043 0.273 ZHX2
zinc fingers and homeoboxes 2
chr9_-_140196702 0.269 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr7_-_56101830 0.268 PSPH
phosphoserine phosphatase
chr8_+_86099909 0.267 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr6_-_138820580 0.267


chr6_+_163984574 0.266 QKI
QKI, KH domain containing, RNA binding
chr6_-_143266283 0.264 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr12_-_7245006 0.263 NM_001733
C1R
complement component 1, r subcomponent
chr17_-_41739261 0.261 NM_001040002
MEOX1
mesenchyme homeobox 1
chr7_+_129007942 0.260 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr18_+_29027731 0.259 NM_001944
DSG3
desmoglein 3
chr1_-_149399159 0.259 NM_001024599
HIST2H2BF
histone cluster 2, H2bf
chr1_+_174417211 0.257 NM_005684
GPR52
G protein-coupled receptor 52
chr15_+_40532034 0.256 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr15_+_60296420 0.256 NM_012182
FOXB1
forkhead box B1
chr12_-_6772252 0.255 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr12_-_52886971 0.252 NM_005554
KRT6A
keratin 6A
chr12_-_7245048 0.251 C1R
complement component 1, r subcomponent
chr9_-_117160748 0.251 AKNA
AT-hook transcription factor
chr15_+_25101697 0.251 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_-_94586678 0.250 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr7_-_41742666 0.250 NM_002192
INHBA
inhibin, beta A
chr1_+_6052758 0.249 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr8_+_66582107 0.248 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr1_-_149858114 0.245 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr1_+_220863627 0.244 NM_024709
C1orf115
chromosome 1 open reading frame 115
chr1_+_6052699 0.242 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr1_+_164528914 0.242 PBX1
pre-B-cell leukemia homeobox 1
chr4_-_153273683 0.242 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr9_+_135854097 0.242 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr3_+_189507448 0.241 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr19_+_17858504 0.240 NM_001161357
NM_001161358
FCHO1

FCH domain only 1

chr2_+_17721806 0.240 NM_003385
VSNL1
visinin-like 1
chr4_-_159094163 0.239 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr1_-_149783910 0.238 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chrX_+_22050920 0.236 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr6_+_26183957 0.234 NM_003523
HIST1H2BE
histone cluster 1, H2be
chr10_+_49609641 0.234 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr8_+_95653399 0.233 ESRP1
epithelial splicing regulatory protein 1
chr6_-_27100528 0.233 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr1_+_84767288 0.231 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr11_-_85430117 0.230 NM_206929
SYTL2
synaptotagmin-like 2
chrX_-_109683457 0.229 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_-_31380507 0.229 NM_022728
NEUROD6
neurogenic differentiation 6
chr6_+_27215479 0.225 NM_005865
PRSS16
protease, serine, 16 (thymus)
chr17_+_38219040 0.225 NM_001190918
NM_003250
NM_199334
THRA


thyroid hormone receptor, alpha


chr6_+_43139201 0.224 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr15_+_29033259 0.224 LOC100289656
Dexi homolog (mouse) pseudogene
chr19_+_17337012 0.224 NM_024578
OCEL1
occludin/ELL domain containing 1
chr1_+_84864214 0.223 NM_021233
DNASE2B
deoxyribonuclease II beta
chr1_+_236558715 0.222 NM_080738
EDARADD
EDAR-associated death domain
chr6_-_26124130 0.221 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr2_+_17721983 0.220 VSNL1
visinin-like 1
chr6_-_42419782 0.218 NM_033502
TRERF1
transcriptional regulating factor 1
chr11_-_85437457 0.217 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr4_-_159093523 0.216 FAM198B
family with sequence similarity 198, member B
chr10_+_124145584 0.216 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr3_+_151591428 0.215 NM_033050
SUCNR1
succinate receptor 1
chr6_-_155777036 0.215 NM_015718
NOX3
NADPH oxidase 3
chr3_+_127641901 0.213 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr17_-_47841517 0.212 NM_030802
FAM117A
family with sequence similarity 117, member A
chr1_+_6094342 0.211 NM_001199860
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr13_+_97874540 0.210 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr12_+_120740123 0.210 NM_012240
SIRT4
sirtuin 4
chr20_+_361938 0.210 TRIB3
tribbles homolog 3 (Drosophila)
chr1_+_212782103 0.209 ATF3
activating transcription factor 3
chr4_-_159093717 0.209 NM_016613
FAM198B
family with sequence similarity 198, member B
chr17_-_47841468 0.208 FAM117A
family with sequence similarity 117, member A
chr3_+_46395224 0.206 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr12_+_7053180 0.204 NM_138425
C12orf57
chromosome 12 open reading frame 57
chr1_-_108507474 0.204 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr22_-_38714088 0.203 NM_001894
CSNK1E
casein kinase 1, epsilon
chrX_-_33229428 0.202 NM_004006
DMD
dystrophin
chr18_-_52988916 0.201 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr1_+_235491752 0.201 NM_001037277
GGPS1
geranylgeranyl diphosphate synthase 1
chr17_-_39675078 0.200 NM_002275
KRT15
keratin 15
chr20_+_17207596 0.199 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr11_-_31832784 0.199 PAX6
paired box 6
chrX_+_69674914 0.198 NM_001166278
DLG3
discs, large homolog 3 (Drosophila)
chr14_-_21572789 0.196 NM_001102454
ZNF219
zinc finger protein 219
chr1_+_61547388 0.195 NM_001145512
NFIA
nuclear factor I/A
chr1_-_19217384 0.194 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr20_-_7921068 0.194 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr22_+_38035718 0.194 SH3BP1
SH3-domain binding protein 1
chr18_+_61575203 0.194 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr12_+_113344811 0.193 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_-_153348057 0.193 NM_005621
S100A12
S100 calcium binding protein A12
chr14_-_21567069 0.193 NM_001101672
ZNF219
zinc finger protein 219
chr6_+_37137882 0.191 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr16_-_4323000 0.191 NM_003223
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chrX_-_32430370 0.188 NM_004011
NM_004012
DMD

dystrophin

chr7_-_27183225 0.188 NM_019102
HOXA5
homeobox A5
chr4_-_110723334 0.187 NM_000204
CFI
complement factor I
chr6_+_21593963 0.186 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr17_+_7554415 0.186 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr6_+_27114860 0.186 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chrX_-_80457440 0.185 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chrX_+_15525430 0.183 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr1_+_33722158 0.183 NM_152493
ZNF362
zinc finger protein 362
chr2_-_161056573 0.182 NM_000888
ITGB6
integrin, beta 6
chr10_-_64578926 0.182 NM_001136178
EGR2
early growth response 2
chr1_+_192778168 0.182 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr2_+_68961912 0.182 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr7_-_150945731 0.182 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr6_+_35265654 0.181 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr12_-_16760935 0.181 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 9.36e-13 GO:0032502 developmental process
1.45 1.20e-11 GO:0048856 anatomical structure development
1.24 1.25e-11 GO:0050789 regulation of biological process
1.43 1.60e-11 GO:0007275 multicellular organismal development
1.25 2.63e-11 GO:0050794 regulation of cellular process
1.48 2.76e-11 GO:0048731 system development
1.22 5.35e-11 GO:0065007 biological regulation
1.41 6.38e-10 GO:0060255 regulation of macromolecule metabolic process
1.38 2.81e-09 GO:0080090 regulation of primary metabolic process
1.55 5.69e-09 GO:0048513 organ development
1.46 9.30e-09 GO:0010468 regulation of gene expression
1.48 2.38e-08 GO:0051252 regulation of RNA metabolic process
1.49 4.21e-08 GO:0006355 regulation of transcription, DNA-dependent
1.13 5.18e-08 GO:0009987 cellular process
1.35 1.19e-07 GO:0031323 regulation of cellular metabolic process
1.44 1.24e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.75 1.35e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.32 1.78e-07 GO:0019222 regulation of metabolic process
1.41 3.41e-07 GO:0031326 regulation of cellular biosynthetic process
1.78 4.03e-07 GO:0006351 transcription, DNA-dependent
1.40 4.77e-07 GO:0009889 regulation of biosynthetic process
1.42 8.19e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.40 9.08e-07 GO:0048518 positive regulation of biological process
1.25 9.87e-07 GO:0032501 multicellular organismal process
1.71 1.49e-06 GO:0032774 RNA biosynthetic process
1.86 2.74e-06 GO:0010628 positive regulation of gene expression
1.54 6.53e-06 GO:0007399 nervous system development
1.37 1.22e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.85 1.63e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.43 1.77e-05 GO:0030154 cell differentiation
1.36 2.10e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.20 2.34e-05 GO:0050896 response to stimulus
1.29 2.85e-05 GO:0023052 signaling
1.42 3.12e-05 GO:0048869 cellular developmental process
1.58 3.87e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.55 6.91e-05 GO:0002376 immune system process
1.37 7.30e-05 GO:0048522 positive regulation of cellular process
2.67 1.05e-04 GO:0009952 anterior/posterior pattern formation
1.26 1.19e-04 GO:0051716 cellular response to stimulus
2.80 1.23e-04 GO:0006333 chromatin assembly or disassembly
3.23 1.45e-04 GO:0006334 nucleosome assembly
1.92 1.53e-04 GO:0006325 chromatin organization
1.39 1.74e-04 GO:0048523 negative regulation of cellular process
1.91 1.86e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.52 2.07e-04 GO:0009893 positive regulation of metabolic process
1.79 2.30e-04 GO:0009887 organ morphogenesis
1.75 2.50e-04 GO:0051254 positive regulation of RNA metabolic process
1.84 2.75e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.83 3.16e-04 GO:0051253 negative regulation of RNA metabolic process
3.03 3.59e-04 GO:0034728 nucleosome organization
3.07 4.67e-04 GO:0031497 chromatin assembly
2.27 6.07e-04 GO:0003002 regionalization
1.71 6.26e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.28 6.85e-04 GO:0007165 signal transduction
1.74 9.78e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.66 1.06e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 1.14e-03 GO:0031325 positive regulation of cellular metabolic process
1.96 1.16e-03 GO:0009792 embryo development ending in birth or egg hatching
2.22 1.17e-03 GO:0030097 hemopoiesis
1.44 1.24e-03 GO:0009653 anatomical structure morphogenesis
1.65 1.58e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.68 1.62e-03 GO:0009890 negative regulation of biosynthetic process
1.95 1.75e-03 GO:0043009 chordate embryonic development
3.18 2.03e-03 GO:0048706 embryonic skeletal system development
1.72 2.16e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.72 2.28e-03 GO:0010629 negative regulation of gene expression
1.62 2.39e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.33 2.54e-03 GO:0048519 negative regulation of biological process
2.76 2.75e-03 GO:0071824 protein-DNA complex subunit organization
2.81 3.05e-03 GO:0065004 protein-DNA complex assembly
1.65 4.53e-03 GO:0009790 embryo development
1.67 4.70e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
2.07 4.75e-03 GO:0048534 hemopoietic or lymphoid organ development
1.68 4.86e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.57 6.08e-03 GO:0031328 positive regulation of cellular biosynthetic process
2.14 7.28e-03 GO:0048568 embryonic organ development
3.90 7.53e-03 GO:0048663 neuron fate commitment
2.00 7.54e-03 GO:0002520 immune system development
1.56 7.67e-03 GO:0009891 positive regulation of biosynthetic process
2.59 9.64e-03 GO:0033673 negative regulation of kinase activity
1.66 1.11e-02 GO:0051276 chromosome organization
2.40 1.13e-02 GO:0071103 DNA conformation change
2.52 1.16e-02 GO:0006323 DNA packaging
1.94 1.25e-02 GO:0001501 skeletal system development
1.60 1.81e-02 GO:0030182 neuron differentiation
1.91 2.02e-02 GO:0051093 negative regulation of developmental process
1.57 2.40e-02 GO:2000026 regulation of multicellular organismal development
2.11 2.40e-02 GO:0045786 negative regulation of cell cycle
1.34 2.47e-02 GO:0048583 regulation of response to stimulus
2.45 3.00e-02 GO:0051348 negative regulation of transferase activity
1.50 3.03e-02 GO:0022008 neurogenesis
1.50 3.03e-02 GO:0050793 regulation of developmental process
2.53 3.52e-02 GO:0006469 negative regulation of protein kinase activity
2.30 3.66e-02 GO:0048562 embryonic organ morphogenesis
1.81 4.07e-02 GO:0048598 embryonic morphogenesis
1.85 4.12e-02 GO:0007389 pattern specification process
1.55 4.93e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.25 3.48e-08 GO:0005634 nucleus
4.00 6.05e-06 GO:0000786 nucleosome
2.24 8.84e-05 GO:0000785 chromatin
1.09 2.00e-04 GO:0005622 intracellular
1.09 4.58e-04 GO:0044424 intracellular part
2.77 2.16e-03 GO:0032993 protein-DNA complex
11.43 2.35e-02 GO:0070382 exocytic vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.03 1.45e-16 GO:0001071 nucleic acid binding transcription factor activity
2.03 1.45e-16 GO:0003700 sequence-specific DNA binding transcription factor activity
2.21 9.10e-15 GO:0043565 sequence-specific DNA binding
1.92 1.13e-13 GO:0030528 transcription regulator activity
1.12 6.49e-10 GO:0005488 binding
1.21 9.01e-10 GO:0005515 protein binding
1.43 1.12e-07 GO:0003677 DNA binding
1.27 2.26e-04 GO:0003676 nucleic acid binding
1.91 4.43e-03 GO:0016564 transcription repressor activity
1.86 9.29e-03 GO:0016563 transcription activator activity