Motif ID: PRRX1,2.p2

Z-value: 1.263


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX1chr1_+_1706333120.801.8e-02Click!
PRRX2chr9_+_132427919-0.531.7e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_38172862 4.095 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr9_-_95186559 3.996 NM_005014
OMD
osteomodulin
chr5_+_71502700 3.822 MAP1B
microtubule-associated protein 1B
chr2_+_189839132 3.447 COL3A1
collagen, type III, alpha 1
chr12_-_91576805 3.387 NM_001920
DCN
decorin
chr10_+_69869249 3.086 NM_032578
MYPN
myopalladin
chr5_-_75919051 3.045 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr14_-_92413738 2.807 FBLN5
fibulin 5
chr12_-_91576579 2.684 DCN
decorin
chr2_+_189839078 2.564 NM_000090
COL3A1
collagen, type III, alpha 1
chr6_-_46293628 2.524 NM_005822
RCAN2
regulator of calcineurin 2
chr6_+_72926144 2.414 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr2_+_210444364 2.227 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr13_+_102104941 2.204 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_-_207082626 2.142 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr2_+_189839113 2.113 COL3A1
collagen, type III, alpha 1
chr8_-_120651019 2.047 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr5_-_111312522 2.043 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr5_+_67586466 2.019 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr16_+_53133063 1.979 CHD9
chromodomain helicase DNA binding protein 9
chr17_-_66951381 1.859 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr2_+_210444154 1.831 MAP2
microtubule-associated protein 2
chr3_+_69812620 1.825 NM_001184967
MITF
microphthalmia-associated transcription factor
chr10_-_21186530 1.741 NM_006393
NEBL
nebulette
chr4_-_138453564 1.662 PCDH18
protocadherin 18
chr1_+_215178884 1.652 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr3_+_69812961 1.611 NM_006722
MITF
microphthalmia-associated transcription factor
chr2_+_152214105 1.605 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_-_92777657 1.582 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_-_114790221 1.548 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr6_+_136172802 1.493 NM_018945
PDE7B
phosphodiesterase 7B
chr13_-_34250899 1.470 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_-_117747017 1.452 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr7_-_14025826 1.443 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_+_95066628 1.436 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr8_+_17396285 1.405 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chrX_+_85517970 1.393 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr14_+_101295409 1.385 MEG3
maternally expressed 3 (non-protein coding)
chr1_-_57045214 1.359 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_114478117 1.355 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr2_-_145277568 1.353 ZEB2
zinc finger E-box binding homeobox 2
chr4_-_138453628 1.350 NM_019035
PCDH18
protocadherin 18
chr1_-_57045129 1.331 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_188419049 1.324 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_-_195310770 1.319 APOD
apolipoprotein D
chr6_-_46293404 1.263 RCAN2
regulator of calcineurin 2
chr1_-_57045235 1.250 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_163038934 1.220 NM_001113381
RGS4
regulator of G-protein signaling 4
chr3_+_148447966 1.212 NM_032049
AGTR1
angiotensin II receptor, type 1
chr5_+_59784004 1.205 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr11_-_27742224 1.200 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr12_-_91505215 1.180 LUM
lumican
chr1_-_232651227 1.168 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_+_163038395 1.168 NM_001102445
RGS4
regulator of G-protein signaling 4
chr2_-_224467095 1.165 SCG2
secretogranin II
chr3_-_114102488 1.151 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr8_-_108510094 1.149 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr1_-_57044980 1.148 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_140602914 1.131 NM_018934
PCDHB14
protocadherin beta 14
chr17_-_67138013 1.104 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_-_18480203 1.089 NM_001131010
SATB1
SATB homeobox 1
chr12_-_10605928 1.083 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr2_-_224467049 1.066 SCG2
secretogranin II
chr2_-_163099877 1.052 NM_004460
FAP
fibroblast activation protein, alpha
chr9_-_95166827 1.042 NM_014057
NM_033014
OGN

osteoglycin

chr6_+_73076431 1.041 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr5_+_71403040 1.006 NM_005909
MAP1B
microtubule-associated protein 1B
chr4_+_71108304 0.983 NM_005212
CSN3
casein kappa
chr14_-_61115906 0.977 NM_005982
SIX1
SIX homeobox 1
chr18_+_6834431 0.971 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr15_+_100173182 0.956 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr9_-_95298251 0.951 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr11_+_5710816 0.918 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr12_-_56106061 0.917 NM_001144997
ITGA7
integrin, alpha 7
chr6_+_72926462 0.917 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_91505541 0.904 NM_002345
LUM
lumican
chr3_-_195310985 0.893 NM_001647
APOD
apolipoprotein D
chrX_-_142723921 0.889 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr17_-_67240955 0.885 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr9_-_95244750 0.884 NM_001193335
NM_017680
ASPN

asporin

chr17_+_48821106 0.874 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr2_-_145275086 0.874 ZEB2
zinc finger E-box binding homeobox 2
chr9_-_95244634 0.862 ASPN
asporin
chr2_-_175462428 0.853 WIPF1
WAS/WASL interacting protein family, member 1
chr3_+_12392993 0.851 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr8_+_77593506 0.851 NM_024721
ZFHX4
zinc finger homeobox 4
chr3_-_151987332 0.838 LOC401093
uncharacterized LOC401093
chr2_-_224467142 0.827 NM_003469
SCG2
secretogranin II
chr3_+_69985750 0.822 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr1_+_74701070 0.821 NM_015978
TNNI3K
TNNI3 interacting kinase
chr6_+_155538096 0.812 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr8_+_77593522 0.803 ZFHX4
zinc finger homeobox 4
chr5_+_178450775 0.801 NM_001136116
ZNF879
zinc finger protein 879
chr16_-_51185150 0.797 NM_002968
SALL1
sal-like 1 (Drosophila)
chr1_+_59775749 0.787 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr5_-_168271852 0.785


chr3_+_69915374 0.781 NM_198177
MITF
microphthalmia-associated transcription factor
chr3_-_112358510 0.780 CCDC80
coiled-coil domain containing 80
chr20_-_34025955 0.771 NM_000557
GDF5
growth differentiation factor 5
chr11_+_5710926 0.770 TRIM22
tripartite motif containing 22
chr9_+_120466607 0.764 TLR4
toll-like receptor 4
chr15_+_93443559 0.764 CHD2
chromodomain helicase DNA binding protein 2
chr2_-_200325200 0.758 SATB2
SATB homeobox 2
chr4_+_55095263 0.758 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_-_112359547 0.755 CCDC80
coiled-coil domain containing 80
chr10_+_31610063 0.754 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr1_+_183774214 0.753 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr3_-_112358758 0.748 CCDC80
coiled-coil domain containing 80
chr8_-_122653493 0.747 NM_005328
HAS2
hyaluronan synthase 2
chr4_+_74347461 0.741 NM_001133
AFM
afamin
chr13_-_44203608 0.738 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr12_-_47219734 0.729 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chrX_-_154250769 0.721 NM_000132
F8
coagulation factor VIII, procoagulant component
chr4_-_100242487 0.720 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr12_-_10588543 0.708 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr2_+_121554866 0.703 NM_005270
GLI2
GLI family zinc finger 2
chr2_-_99279935 0.702 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr2_+_128175989 0.696 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr11_-_27741192 0.687 NM_001143807
BDNF
brain-derived neurotrophic factor
chr4_+_77953942 0.685 SEPT11
septin 11
chr5_+_140529619 0.683 NM_018939
PCDHB6
protocadherin beta 6
chr2_-_200329810 0.681 NM_001172517
SATB2
SATB homeobox 2
chr4_+_160188997 0.680 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chrX_+_7137471 0.673 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr9_+_79115548 0.673 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chrX_+_22050920 0.669 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr9_+_97521930 0.664 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr10_+_83637442 0.664 NM_001165973
NRG3
neuregulin 3
chr3_-_112359565 0.658 CCDC80
coiled-coil domain containing 80
chr2_+_24807345 0.649 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr3_-_151058439 0.642 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr8_-_93111915 0.634 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_-_3011944 0.631 NM_014646
LPIN2
lipin 2
chr7_+_90339146 0.630 CDK14
cyclin-dependent kinase 14
chr7_+_148287656 0.628 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr12_+_15699277 0.628 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr3_-_187463227 0.626 BCL6
B-cell CLL/lymphoma 6
chr2_+_109204777 0.626 LIMS1
LIM and senescent cell antigen-like domains 1
chr12_-_7656285 0.625 NM_004244
NM_203416
CD163

CD163 molecule

chr6_+_132891460 0.623 NM_175067
TAAR6
trace amine associated receptor 6
chr6_+_39760138 0.623


chr9_-_20622476 0.621 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_-_100712248 0.618 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr10_-_32667543 0.617 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr9_+_120466625 0.615 TLR4
toll-like receptor 4
chr3_-_112359251 0.615 CCDC80
coiled-coil domain containing 80
chr17_-_39623476 0.613 NM_002278
KRT32
keratin 32
chr2_-_158300517 0.613 NM_004288
CYTIP
cytohesin 1 interacting protein
chr12_-_10573041 0.611 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr11_-_58611979 0.608 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr12_+_18414473 0.608 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr3_-_112359277 0.600 CCDC80
coiled-coil domain containing 80
chr5_+_115898218 0.599


chr13_-_33780142 0.596 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr5_-_159827042 0.592 NM_022090
C5orf54
chromosome 5 open reading frame 54
chr5_+_140624916 0.591 PCDHB15
protocadherin beta 15
chr11_+_65266980 0.590


chr19_+_30863318 0.589 NM_014717
ZNF536
zinc finger protein 536
chr6_-_85473898 0.586 NM_001080508
TBX18
T-box 18
chr8_-_12973752 0.584 NM_001164271
DLC1
deleted in liver cancer 1
chr3_+_180320955 0.583 TTC14
tetratricopeptide repeat domain 14
chr5_-_14871555 0.582 NM_054027
ANKH
ankylosis, progressive homolog (mouse)
chr3_+_157154579 0.581 NM_002852
PTX3
pentraxin 3, long
chr5_+_140782367 0.574 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr13_+_76334796 0.574 NM_015842
LMO7
LIM domain 7
chr6_+_144612872 0.573 NM_007124
UTRN
utrophin
chr12_+_54422193 0.571 NM_004503
HOXC6
homeobox C6
chr13_+_24144402 0.571 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr2_-_145277879 0.571 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr2_-_211018294 0.569 C2orf67
chromosome 2 open reading frame 67
chr1_+_162602198 0.568 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr10_-_49812996 0.561 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr3_+_20081523 0.560 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr5_+_140771482 0.560 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr13_+_99058147 0.560


chr1_+_162602308 0.560 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_+_196621007 0.559 NM_000186
NM_001014975
CFH

complement factor H

chr20_-_45976626 0.558 ZMYND8
zinc finger, MYND-type containing 8
chr3_+_148415657 0.557 NM_000685
NM_004835
NM_009585
NM_031850
AGTR1



angiotensin II receptor, type 1



chr6_+_155411422 0.557 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr16_+_86612114 0.554 NM_005250
FOXL1
forkhead box L1
chr5_-_39394423 0.552 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_+_78356710 0.550 RNF213
ring finger protein 213
chr18_-_65182507 0.549 DSEL
dermatan sulfate epimerase-like
chr8_-_72268720 0.549 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr10_-_70066594 0.549 PBLD
phenazine biosynthesis-like protein domain containing
chr14_+_88471467 0.547 NM_003608
GPR65
G protein-coupled receptor 65
chr1_-_163113938 0.544 RGS5
regulator of G-protein signaling 5
chr3_-_151102536 0.543 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr10_+_63808968 0.542 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_+_120105656 0.541 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr9_-_123812535 0.541 NM_001735
C5
complement component 5
chr3_-_187452669 0.540 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr20_+_43029973 0.538 HNF4A
hepatocyte nuclear factor 4, alpha
chr12_-_71551564 0.537 TSPAN8
tetraspanin 8
chrX_+_80457302 0.536 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr12_-_29937691 0.535 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr7_+_129932973 0.533 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chrX_-_135749436 0.529 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr8_-_38326351 0.528 NM_001174063
NM_001174064
NM_015850
NM_023105
NM_023106
NM_023110
FGFR1





fibroblast growth factor receptor 1






Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 2.33e-02 GO:0048519 negative regulation of biological process
1.10 2.40e-02 GO:0050794 regulation of cellular process
1.09 4.55e-02 GO:0050789 regulation of biological process
1.41 4.79e-02 GO:0010629 negative regulation of gene expression
1.08 4.99e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 4.08e-03 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.06 8.39e-04 GO:0005488 binding
1.09 4.44e-03 GO:0005515 protein binding
1.54 5.81e-03 GO:0003712 transcription cofactor activity
1.53 6.56e-03 GO:0000988 protein binding transcription factor activity
1.53 6.56e-03 GO:0000989 transcription factor binding transcription factor activity
1.37 2.40e-02 GO:0005509 calcium ion binding