Motif ID: REST.p3

Z-value: 0.722


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_577740900.601.1e-01Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 135 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_153141398 0.955 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chr15_-_72612247 0.451 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr17_+_30813928 0.449 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr15_-_72612497 0.448 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr3_+_193853937 0.424 HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_193853930 0.419 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr8_-_91094924 0.393 NM_004929
CALB1
calbindin 1, 28kDa
chr7_+_145813452 0.369 NM_014141
CNTNAP2
contactin associated protein-like 2
chr10_-_50970321 0.340 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr20_+_62328068 0.327 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_-_145559831 0.284 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr20_+_62328002 0.284 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr11_-_123524881 0.277 SCN3B
sodium channel, voltage-gated, type III, beta
chr2_+_46524448 0.262 NM_001430
EPAS1
endothelial PAS domain protein 1
chr17_-_3301703 0.238 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr17_-_3337134 0.233 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chrX_-_153141284 0.230 L1CAM
L1 cell adhesion molecule
chr20_-_62284701 0.220 NM_015894
STMN3
stathmin-like 3
chr9_+_135457974 0.199 NM_020064
BARHL1
BarH-like homeobox 1
chr14_+_93389491 0.187 CHGA
chromogranin A (parathyroid secretory protein 1)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
58.04 8.00e-03 GO:0010155 regulation of proton transport
47.49 1.56e-02 GO:0032225 regulation of synaptic transmission, dopaminergic
40.19 2.68e-02 GO:0051954 positive regulation of amine transport
26.79 7.35e-03 GO:0050433 regulation of catecholamine secretion
23.54 1.12e-03 GO:0051952 regulation of amine transport
13.00 2.17e-02 GO:0030534 adult behavior
11.24 2.94e-04 GO:0051969 regulation of transmission of nerve impulse
10.18 6.29e-04 GO:0031644 regulation of neurological system process
9.77 1.83e-02 GO:0007611 learning or memory
9.34 2.37e-02 GO:0050804 regulation of synaptic transmission
8.94 3.03e-02 GO:0050890 cognition
6.99 4.90e-07 GO:0007268 synaptic transmission
6.62 3.20e-07 GO:0019226 transmission of nerve impulse
6.62 3.20e-07 GO:0035637 multicellular organismal signaling
6.06 3.15e-03 GO:0007610 behavior
5.19 1.71e-03 GO:0046903 secretion
5.08 3.73e-02 GO:0044057 regulation of system process
4.69 1.17e-02 GO:0055082 cellular chemical homeostasis
4.42 4.69e-02 GO:0006873 cellular ion homeostasis
4.07 8.68e-04 GO:0007267 cell-cell signaling

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
23.22 2.39e-05 GO:0030672 synaptic vesicle membrane
14.35 6.48e-05 GO:0030665 clathrin coated vesicle membrane
14.02 7.60e-05 GO:0008021 synaptic vesicle
10.61 5.00e-04 GO:0030662 coated vesicle membrane
8.66 4.60e-04 GO:0030136 clathrin-coated vesicle
7.26 1.06e-05 GO:0044456 synapse part
7.08 2.02e-03 GO:0030135 coated vesicle
7.07 2.41e-02 GO:0045211 postsynaptic membrane
6.76 2.58e-04 GO:0030659 cytoplasmic vesicle membrane
6.53 3.50e-04 GO:0012506 vesicle membrane
6.29 4.99e-06 GO:0045202 synapse
5.61 1.34e-03 GO:0044433 cytoplasmic vesicle part
4.34 3.52e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
4.26 4.58e-05 GO:0031988 membrane-bounded vesicle
4.10 4.06e-02 GO:0043005 neuron projection
4.08 8.24e-05 GO:0031410 cytoplasmic vesicle
3.95 1.29e-04 GO:0031982 vesicle
3.69 1.09e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
116.07 1.18e-02 GO:0001591 dopamine receptor activity, coupled via Gi/Go
87.06 2.36e-02 GO:0016933 extracellular-glycine-gated ion channel activity
87.06 2.36e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
69.65 3.91e-02 GO:0004952 dopamine receptor activity
69.65 3.91e-02 GO:0022824 transmitter-gated ion channel activity
69.65 3.91e-02 GO:0022835 transmitter-gated channel activity
40.19 6.08e-03 GO:0016594 glycine binding
22.23 3.26e-05 GO:0005231 excitatory extracellular ligand-gated ion channel activity
14.52 4.22e-04 GO:0005230 extracellular ligand-gated ion channel activity
8.50 9.09e-03 GO:0043176 amine binding
8.37 9.94e-03 GO:0015276 ligand-gated ion channel activity
8.37 9.94e-03 GO:0022834 ligand-gated channel activity
5.29 1.66e-02 GO:0005261 cation channel activity
5.22 6.92e-03 GO:0022836 gated channel activity
5.04 1.38e-03 GO:0005216 ion channel activity
4.96 1.59e-03 GO:0022838 substrate-specific channel activity
4.81 2.12e-03 GO:0015267 channel activity
4.80 2.17e-03 GO:0022803 passive transmembrane transporter activity
3.34 2.95e-02 GO:0005509 calcium ion binding
2.77 8.41e-03 GO:0005215 transporter activity