Motif ID: RREB1.p2

Z-value: 1.754


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_7108864-0.686.5e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_114018201 1.227 GRTP1
growth hormone regulated TBC protein 1
chr6_-_46459010 1.019 NM_001251974
 RCAN2
regulator of calcineurin 2
chr21_-_44495894 0.939 NM_000071
 CBS
cystathionine-beta-synthase
chr21_+_27011766 0.931 JAM2
junctional adhesion molecule 2
chr13_-_114018365 0.908 NM_024719
 GRTP1
growth hormone regulated TBC protein 1
chr21_+_27012067 0.796 JAM2
junctional adhesion molecule 2
chr10_+_111969988 0.784 NM_001008541
 MXI1
MAX interactor 1
chr19_+_3366575 0.704 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr1_-_184006491 0.693 GLT25D2
glycosyltransferase 25 domain containing 2
chr9_+_130922471 0.641 NM_024112
 C9orf16
chromosome 9 open reading frame 16
chrX_+_66763868 0.639 NM_000044
 AR
androgen receptor
chrX_+_102585113 0.616 NM_152278
 TCEAL7
transcription elongation factor A (SII)-like 7
chr21_+_44073650 0.611 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
 PDE9A



















phosphodiesterase 9A



















chr21_-_44496423 0.606 NM_001178008
NM_001178009
 CBS

cystathionine-beta-synthase

chr21_+_27011588 0.596 NM_021219
 JAM2
junctional adhesion molecule 2
chr11_-_2019007 0.550 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr21_-_47604300 0.530 C21orf56
chromosome 21 open reading frame 56
chr21_-_47604360 0.529 NM_001142854
NM_032261
 C21orf56

chromosome 21 open reading frame 56

chr21_-_47604340 0.526 C21orf56
chromosome 21 open reading frame 56
chr11_-_2018703 0.510 H19
H19, imprinted maternally expressed transcript (non-protein coding)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 89 entries
enrichment   p-value GO term description
1.88 1.08e-04 GO:0071375 cellular response to peptide hormone stimulus
1.88 1.71e-02 GO:0046039 GTP metabolic process
1.79 2.48e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.67 2.43e-03 GO:0032870 cellular response to hormone stimulus
1.66 1.11e-03 GO:0071495 cellular response to endogenous stimulus
1.65 1.37e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.64 2.09e-03 GO:0043434 response to peptide hormone stimulus
1.60 9.42e-06 GO:0051253 negative regulation of RNA metabolic process
1.59 2.84e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.59 1.67e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.56 3.19e-06 GO:0051254 positive regulation of RNA metabolic process
1.56 9.80e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.55 3.90e-06 GO:0010628 positive regulation of gene expression
1.53 5.44e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.53 1.19e-04 GO:0010629 negative regulation of gene expression
1.52 1.42e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.52 1.84e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 2.95e-03 GO:0019226 transmission of nerve impulse
1.52 2.95e-03 GO:0035637 multicellular organismal signaling
1.51 3.25e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.29 5.33e-07 GO:0005829 cytosol
1.24 7.85e-18 GO:0005634 nucleus
1.12 1.24e-08 GO:0043227 membrane-bounded organelle
1.12 3.08e-08 GO:0005737 cytoplasm
1.11 2.42e-15 GO:0044424 intracellular part
1.11 4.36e-09 GO:0043226 organelle
1.11 4.59e-09 GO:0043229 intracellular organelle
1.11 1.81e-08 GO:0043231 intracellular membrane-bounded organelle
1.10 2.30e-15 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
1.98 4.34e-04 GO:0003714 transcription corepressor activity
1.71 2.45e-12 GO:0043565 sequence-specific DNA binding
1.61 5.77e-14 GO:0001071 nucleic acid binding transcription factor activity
1.61 5.77e-14 GO:0003700 sequence-specific DNA binding transcription factor activity
1.60 2.51e-02 GO:0003702 RNA polymerase II transcription factor activity
1.50 1.62e-02 GO:0003712 transcription cofactor activity
1.50 1.82e-02 GO:0000988 protein binding transcription factor activity
1.50 1.82e-02 GO:0000989 transcription factor binding transcription factor activity
1.48 7.78e-06 GO:0019899 enzyme binding
1.47 5.33e-08 GO:0030528 transcription regulator activity
1.24 5.07e-05 GO:0003677 DNA binding
1.20 7.33e-20 GO:0005515 protein binding
1.16 6.92e-03 GO:0003676 nucleic acid binding
1.09 8.96e-13 GO:0005488 binding