Motif ID: RXRG_dimer.p3

Z-value: 0.839


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PPARGchr3_+_12329332,
chr3_+_12392993,
chr3_+_12330336
0.944.4e-04Click!
NR1H2chr19_+_508796810.658.4e-02Click!
RXRBchr6_-_331683690.492.2e-01Click!
RXRAchr9_+_137218324-0.383.6e-01Click!
RXRGchr1_-_1654144990.285.0e-01Click!
PPARAchr22_+_46546690-0.275.2e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_92918924 1.222 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr12_-_6665220 0.934 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr19_+_50016500 0.800 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_50016490 0.795 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_+_30524662 0.770 PRR3
proline rich 3
chr6_+_31623668 0.690 NM_019101
APOM
apolipoprotein M
chr6_+_31623688 0.688 APOM
apolipoprotein M
chr2_-_178257380 0.581 LOC100130691
uncharacterized LOC100130691
chr11_+_118868841 0.543 NM_198489
CCDC84
coiled-coil domain containing 84
chr2_+_109065665 0.532 GCC2
GRIP and coiled-coil domain containing 2
chr11_+_118868861 0.524 CCDC84
coiled-coil domain containing 84
chr19_+_50016435 0.522 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_28113598 0.518 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_109237679 0.494 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_28113612 0.493 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr17_-_8198124 0.491 NM_201520
SLC25A35
solute carrier family 25, member 35
chr20_-_44485953 0.485 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr2_+_109065576 0.485 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr10_-_21814610 0.454 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr7_+_143079925 0.439 ZYX
zyxin
chr1_+_78354199 0.428 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr2_+_28113655 0.420 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr7_+_143079354 0.395 ZYX
zyxin
chr19_+_50016606 0.386 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_28113481 0.381 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr2_-_219432955 0.375 NM_020935
USP37
ubiquitin specific peptidase 37
chr16_+_4714709 0.372 MGRN1
mahogunin, ring finger 1
chr1_+_145727665 0.360 NM_001201325
NM_001201326
NM_002614
PDZK1


PDZ domain containing 1


chr2_+_162016926 0.359 NM_001199135
TANK
TRAF family member-associated NFKB activator
chr7_-_65447233 0.358 NM_000181
GUSB
glucuronidase, beta
chr19_+_10197023 0.349 C19orf66
chromosome 19 open reading frame 66
chr1_-_155881163 0.348 NM_006912
RIT1
Ras-like without CAAX 1
chr1_+_145727712 0.342 PDZK1
PDZ domain containing 1
chr20_+_37590969 0.341 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr14_+_101295409 0.339 MEG3
maternally expressed 3 (non-protein coding)
chr19_+_10196972 0.334 C19orf66
chromosome 19 open reading frame 66
chr13_+_100741268 0.327 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr5_+_118965253 0.323 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr20_+_30945988 0.320 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr3_-_49314281 0.319 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr16_-_87970107 0.316 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr7_-_65447162 0.309 GUSB
glucuronidase, beta
chr7_-_65447206 0.304 GUSB
glucuronidase, beta
chr20_+_36661849 0.301 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr7_-_65447187 0.300 GUSB
glucuronidase, beta
chr12_-_54121203 0.295 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr2_-_28113211 0.290 NM_022128
RBKS
ribokinase
chr1_-_43855473 0.284 NM_052877
NM_201542
MED8

mediator complex subunit 8

chr19_+_6372805 0.273 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr9_+_115142395 0.272 HSDL2
hydroxysteroid dehydrogenase like 2
chr19_+_6372720 0.267 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr6_+_30594607 0.267 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr8_+_22423170 0.260 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr11_+_86013252 0.260 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr9_+_115142188 0.260 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr3_-_48936227 0.259 NM_000387
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr20_-_20033005 0.255 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr1_+_101491401 0.251


chr4_+_159593233 0.233 NM_004453
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr5_+_172484353 0.233 C5orf41
chromosome 5 open reading frame 41
chr1_-_160312959 0.222


chr2_-_207024103 0.221 NM_001199981
NM_001199982
NM_001199983
NM_005006
NDUFS1



NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)



chr1_-_226374400 0.218 ACBD3
acyl-CoA binding domain containing 3
chr17_-_8198605 0.215 SLC25A35
solute carrier family 25, member 35
chr2_-_19558371 0.209 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr2_+_207024330 0.207 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr20_+_44486219 0.207 NM_080752
ZSWIM3
zinc finger, SWIM-type containing 3
chr2_+_207024614 0.206 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr3_-_49449400 0.206 RHOA
ras homolog gene family, member A
chr3_-_150690785 0.196 NM_001195794
NM_174878
CLRN1

clarin 1

chr1_+_61547625 0.195 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr15_-_100273540 0.195 LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr2_+_120125141 0.194 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr22_+_30163351 0.193 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr1_-_160313056 0.189 COPA
coatomer protein complex, subunit alpha
chr1_-_160313029 0.184 COPA
coatomer protein complex, subunit alpha
chr21_+_45432202 0.182 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr19_+_6372443 0.177 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr1_-_43855448 0.177 MED8
mediator complex subunit 8
chr14_+_50087400 0.176 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr3_-_49449393 0.175 RHOA
ras homolog gene family, member A
chr2_+_178257371 0.173 NM_003659
AGPS
alkylglycerone phosphate synthase
chr6_-_31926628 0.172 NM_002904
RDBP
RD RNA binding protein
chr19_+_16308664 0.167 NM_001130524
NM_032493
AP1M1

adaptor-related protein complex 1, mu 1 subunit

chr22_-_44893179 0.159 LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr1_-_76397975 0.157 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr2_-_27603249 0.157 NM_001201459
ZNF513
zinc finger protein 513
chr18_+_54318561 0.155 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr2_+_120124828 0.154 NM_001178017
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr3_-_49449423 0.154 RHOA
ras homolog gene family, member A
chr2_+_207024317 0.152 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr19_+_2328628 0.150 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr19_+_54606141 0.148 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr20_-_36661822 0.147 NM_014657
TTI1
TELO2 interacting protein 1
chr3_-_49449357 0.142 RHOA
ras homolog gene family, member A
chr12_+_69202796 0.142 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr18_+_47340328 0.141


chr1_+_43855549 0.140 NM_015284
SZT2
seizure threshold 2 homolog (mouse)
chr2_+_219283809 0.139 NM_007127
VIL1
villin 1
chr3_-_49449409 0.139 RHOA
ras homolog gene family, member A
chr7_-_100844192 0.138 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr5_-_176981537 0.137 NM_001190946
FAM193B
family with sequence similarity 193, member B
chr7_+_120628722 0.137 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr2_+_178257488 0.134 AGPS
alkylglycerone phosphate synthase
chr1_+_45274153 0.132 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr1_-_55089068 0.130 NM_176782
FAM151A
family with sequence similarity 151, member A
chr4_-_4543690 0.130 STX18
syntaxin 18
chr2_-_24307179 0.129 NM_001206802
TP53I3
tumor protein p53 inducible protein 3
chr3_-_49449525 0.128 NM_001664
RHOA
ras homolog gene family, member A
chr22_+_47158517 0.127 NM_014346
TBC1D22A
TBC1 domain family, member 22A
chr19_+_33622997 0.127 NM_173479
WDR88
WD repeat domain 88
chrX_-_18372777 0.127 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr20_+_42187705 0.126 SGK2
serum/glucocorticoid regulated kinase 2
chr4_+_109541721 0.123 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr20_-_34542205 0.120 SCAND1
SCAN domain containing 1
chr2_-_220034706 0.119 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr1_-_155881063 0.117 RIT1
Ras-like without CAAX 1
chr17_+_7123246 0.116 ACADVL
acyl-CoA dehydrogenase, very long chain
chr2_+_138721807 0.112 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr1_-_161039413 0.111 ARHGAP30
Rho GTPase activating protein 30
chr3_-_50605062 0.111 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr3_+_46539484 0.107 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr1_-_111970354 0.105 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr8_-_71316006 0.103 NM_006540
NCOA2
nuclear receptor coactivator 2
chr19_+_2328679 0.103 SPPL2B
signal peptide peptidase-like 2B
chr5_+_42548314 0.102 NM_001242403
GHR
growth hormone receptor
chr15_-_100273620 0.100 NM_152449
LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr20_+_36662138 0.100 RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr12_+_67663147 0.100 CAND1
cullin-associated and neddylation-dissociated 1
chr5_+_1801493 0.099 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr1_-_173886401 0.097 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr17_+_73996986 0.096 NM_001258
CDK3
cyclin-dependent kinase 3
chr22_+_50585483 0.096 NM_001164106
MOV10L1
Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
chr12_+_107168336 0.095 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr1_-_79472360 0.094 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr3_+_139654001 0.093 NM_022131
CLSTN2
calsyntenin 2
chr15_+_96873845 0.092 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chrX_-_64254592 0.091 NM_001178032
NM_001243804
ZC4H2

zinc finger, C4H2 domain containing

chr17_-_7123368 0.090 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr2_-_176046120 0.089 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr16_-_30596808 0.086 NM_152458
ZNF785
zinc finger protein 785
chr17_-_1395950 0.084 NM_001080779
MYO1C
myosin IC
chr20_+_43160435 0.084 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr1_+_151138497 0.084 NM_001204856
NM_024041
SCNM1

sodium channel modifier 1

chr19_-_39390168 0.082 NM_012237
NM_001193286
NM_030593
SIRT2


sirtuin 2


chr8_+_96037186 0.081 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr9_+_104296120 0.078 NM_019592
RNF20
ring finger protein 20
chr11_+_116700620 0.077 NM_000040
APOC3
apolipoprotein C-III
chr12_+_56624500 0.077 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr1_+_160313061 0.076 NM_015331
NCSTN
nicastrin
chr13_+_21714684 0.073 SAP18
Sin3A-associated protein, 18kDa
chr12_+_14538232 0.073 ATF7IP
activating transcription factor 7 interacting protein
chr22_+_24115035 0.072 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr10_-_119805673 0.072 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr17_-_45973142 0.072


chr1_-_154946830 0.072 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr20_-_34542385 0.071 NM_033630
SCAND1
SCAN domain containing 1
chr8_+_144816287 0.070 LOC100128338
uncharacterized LOC100128338
chr19_+_44100734 0.070 NM_001145347
ZNF576
zinc finger protein 576
chr5_-_32444729 0.069 ZFR
zinc finger RNA binding protein
chr1_-_226374401 0.068 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr16_-_3493489 0.068 NM_152457
ZNF597
zinc finger protein 597
chr19_-_38806381 0.067 NM_001039671
NM_001145461
NM_001145462
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr5_-_42811959 0.066 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr22_-_24059436 0.065


chr9_+_91933384 0.063 NM_024077
SECISBP2
SECIS binding protein 2
chr19_+_36239445 0.063 LIN37
lin-37 homolog (C. elegans)
chr3_-_52312257 0.063 WDR82
WD repeat domain 82
chr17_+_3377346 0.061 NM_001128085
ASPA
aspartoacylase
chr22_+_51021454 0.060 LOC100144603
uncharacterized transcript
chr7_-_72936538 0.059 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr22_-_41864656 0.059 NM_032758
PHF5A
PHD finger protein 5A
chr7_-_74489572 0.056 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr22_-_24059502 0.056 GUSBP11
glucuronidase, beta pseudogene 11
chr19_-_38806546 0.054 NM_001039672
NM_001039673
NM_001145463
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr1_+_44679111 0.054 NM_001034023
NM_001034024
NM_019100
DMAP1


DNA methyltransferase 1 associated protein 1


chr13_+_21714709 0.053 SAP18
Sin3A-associated protein, 18kDa
chr19_-_10679328 0.052 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr17_+_26800657 0.051 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr2_-_73460326 0.051 NM_032319
PRADC1
protease-associated domain containing 1
chr12_+_51818592 0.051 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr7_-_25164902 0.051 NM_018947
CYCS
cytochrome c, somatic
chr16_-_30546145 0.050 NM_023931
ZNF747
zinc finger protein 747
chr10_+_119806334 0.050 CASC2
cancer susceptibility candidate 2 (non-protein coding)
chr1_-_193075186 0.050 NM_001243399
NM_016066
GLRX2

glutaredoxin 2

chr7_+_128349111 0.050 FAM71F1
family with sequence similarity 71, member F1
chr12_+_67663060 0.050 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr4_-_4543747 0.049 NM_016930
STX18
syntaxin 18
chr20_+_54967572 0.049 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_-_154946801 0.048 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr19_+_36239261 0.047 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr1_-_50489489 0.047 AGBL4
ATP/GTP binding protein-like 4
chr3_-_14988939 0.046 LOC100505641
uncharacterized LOC100505641
chr11_-_66206260 0.045 NM_016050
NM_170738
NM_170739
MRPL11


mitochondrial ribosomal protein L11


chr1_-_101491308 0.045 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr6_-_30523933 0.044 GNL1
guanine nucleotide binding protein-like 1
chr7_-_74306672 0.044 STAG3L2
stromal antigen 3-like 2
chr19_-_41196419 0.043 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr19_+_2328685 0.043 SPPL2B
signal peptide peptidase-like 2B
chr22_-_19166276 0.043 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.71 9.69e-03 GO:0005743 mitochondrial inner membrane
3.40 2.32e-02 GO:0019866 organelle inner membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
22.63 4.69e-03 GO:0000062 fatty-acyl-CoA binding
9.10 1.01e-02 GO:0033293 monocarboxylic acid binding