Motif ID: SMAD1..7,9.p2

Z-value: 1.720


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD4chr18_+_48556600-0.953.1e-04Click!
SMAD5chr5_+_135468538-0.911.9e-03Click!
SMAD1chr4_+_1464027040.686.3e-02Click!
SMAD2chr18_-_45457454-0.571.4e-01Click!
SMAD6chr15_+_669954140.403.2e-01Click!
SMAD7chr18_-_464691180.334.2e-01Click!
SMAD3chr15_+_67358161-0.294.9e-01Click!
SMAD9chr13_-_374943700.118.0e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_35607218 2.628 FXYD3
FXYD domain containing ion transport regulator 3
chr19_-_35992798 2.100 NM_001035516
DMKN
dermokine
chr8_+_32504250 2.075 NM_013959
NRG1
neuregulin 1
chr19_+_751108 1.797 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr22_+_38035683 1.747 NM_018957
SH3BP1
SH3-domain binding protein 1
chr1_+_15272414 1.641 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr16_+_57662301 1.621 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr15_+_41136178 1.588 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_-_160990862 1.561 F11R
F11 receptor
chr1_-_160990971 1.543 NM_016946
F11R
F11 receptor
chr11_+_66824308 1.464 RHOD
ras homolog gene family, member D
chr16_+_22825481 1.454 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr12_-_52867521 1.444 NM_173086
KRT6C
keratin 6C
chr1_+_183155173 1.441 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr18_-_47376156 1.403 MYO5B
myosin VB
chr2_-_110874142 1.389 NM_005434
MALL
mal, T-cell differentiation protein-like
chr22_+_40390935 1.360 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_+_109792640 1.356 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr11_+_130029663 1.356 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr8_-_8239188 1.348 NM_001080826
SGK223
homolog of rat pragma of Rnd2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
7.05 1.87e-03 GO:0048880 sensory system development
7.05 1.87e-03 GO:0048892 lateral line nerve development
7.05 1.87e-03 GO:0048895 lateral line nerve glial cell differentiation
7.05 1.87e-03 GO:0048925 lateral line system development
7.05 1.87e-03 GO:0048937 lateral line nerve glial cell development
7.05 1.87e-03 GO:0050935 iridophore differentiation
6.94 1.32e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
5.95 4.52e-03 GO:0090184 positive regulation of kidney development
5.82 3.91e-04 GO:0048484 enteric nervous system development
5.77 2.70e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
4.14 2.06e-02 GO:0090183 regulation of kidney development
3.82 2.63e-02 GO:0048483 autonomic nervous system development
3.53 8.80e-03 GO:0021675 nerve development
3.50 2.04e-02 GO:0014032 neural crest cell development
2.31 2.50e-02 GO:0061138 morphogenesis of a branching epithelium
1.83 6.11e-04 GO:0051240 positive regulation of multicellular organismal process
1.65 1.67e-02 GO:0016477 cell migration
1.36 1.13e-02 GO:0051239 regulation of multicellular organismal process
1.34 9.44e-03 GO:0007399 nervous system development
1.27 3.11e-07 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.44 3.88e-02 GO:0030054 cell junction
1.41 8.79e-05 GO:0005887 integral to plasma membrane
1.38 3.56e-04 GO:0031226 intrinsic to plasma membrane
1.33 3.42e-06 GO:0044459 plasma membrane part
1.21 1.47e-05 GO:0071944 cell periphery
1.21 2.26e-05 GO:0005886 plasma membrane
1.17 1.13e-09 GO:0016020 membrane
1.17 6.85e-05 GO:0016021 integral to membrane
1.17 8.76e-05 GO:0031224 intrinsic to membrane
1.16 1.12e-05 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.11 1.31e-02 GO:0005515 protein binding