Motif ID: SOX{8,9,10}.p2

Z-value: 1.165


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_383805380.658.0e-02Click!
SOX9chr17_+_701171540.512.0e-01Click!
SOX8chr16_+_1032063,
chr16_+_1031807
-0.502.1e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_8815266 2.539 MFAP5
microfibrillar associated protein 5
chr10_-_105845619 1.994 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr12_-_52886971 1.947 NM_005554
KRT6A
keratin 6A
chr18_-_74728677 1.878 MBP
myelin basic protein
chr10_-_105845556 1.862 COL17A1
collagen, type XVII, alpha 1
chr12_-_8815370 1.830 NM_003480
MFAP5
microfibrillar associated protein 5
chr1_+_209602164 1.620 NM_001104548
MIR205HG
MIR205 host gene (non-protein coding)
chr15_+_41136622 1.578 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr20_+_58179601 1.448 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr10_-_123356158 1.270 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr12_-_8815479 1.268 MFAP5
microfibrillar associated protein 5
chr2_-_161056762 1.264 ITGB6
integrin, beta 6
chr1_+_153003677 1.238 NM_003125
SPRR1B
small proline-rich protein 1B
chr10_-_103874661 1.127 NM_003893
LDB1
LIM domain binding 1
chr15_+_41136178 1.111 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr11_-_16424391 1.103 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr5_-_176836488 0.996 F12
coagulation factor XII (Hageman factor)
chr5_+_140213968 0.981 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr8_+_95653340 0.973 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr17_-_39942937 0.973 NM_002230
NM_021991
JUP

junction plakoglobin

chr1_-_117210301 0.950 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr3_+_189507448 0.928 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr7_+_69064316 0.919 AUTS2
autism susceptibility candidate 2
chr2_-_31352489 0.902 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr8_+_95653399 0.876 ESRP1
epithelial splicing regulatory protein 1
chr16_+_69141442 0.872 NM_005329
HAS3
hyaluronan synthase 3
chr7_+_16793320 0.850 NM_014399
TSPAN13
tetraspanin 13
chr12_-_95611023 0.846 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr5_-_176836535 0.831 NM_000505
F12
coagulation factor XII (Hageman factor)
chr1_+_35220647 0.819 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr1_-_221915426 0.805 DUSP10
dual specificity phosphatase 10
chr2_+_220492286 0.800 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr7_+_26191732 0.788 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr3_+_189349215 0.765 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chrX_-_24690740 0.755 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_-_240322692 0.749 HDAC4
histone deacetylase 4
chr11_+_34654010 0.746 NM_001206616
EHF
ets homologous factor
chrX_+_68048792 0.746 NM_004429
EFNB1
ephrin-B1
chr1_-_12677347 0.741 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_-_221915393 0.740 DUSP10
dual specificity phosphatase 10
chr1_-_153363544 0.740 NM_002964
S100A8
S100 calcium binding protein A8
chr8_-_21988518 0.739 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr1_+_160370363 0.715 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr18_+_11751470 0.714 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr1_-_221915458 0.708 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr4_-_15939949 0.696 FGFBP1
fibroblast growth factor binding protein 1
chr3_+_111717585 0.695 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr2_-_161056573 0.670 NM_000888
ITGB6
integrin, beta 6
chr8_+_102504661 0.666 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr1_+_26503973 0.659 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr1_-_205290756 0.650 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr1_+_156119734 0.646 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_-_6767417 0.644 NM_005490
SH2D3A
SH2 domain containing 3A
chr6_-_2840683 0.641 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr13_+_113656076 0.634 MCF2L
MCF.2 cell line derived transforming sequence-like
chr18_+_19749403 0.626 NM_005257
GATA6
GATA binding protein 6
chrX_+_105937067 0.621 NM_024539
RNF128
ring finger protein 128
chr8_+_95653272 0.615 ESRP1
epithelial splicing regulatory protein 1
chr19_-_55660557 0.611 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr12_-_24103953 0.610 SOX5
SRY (sex determining region Y)-box 5
chr8_-_80993009 0.596 NM_001025252
TPD52
tumor protein D52
chr16_+_838645 0.589 CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr16_+_838610 0.579 NM_022092
CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr16_+_838634 0.576 CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr11_+_1860232 0.574 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr15_-_72490109 0.572 NM_001012642
GRAMD2
GRAM domain containing 2
chr11_-_79151694 0.570 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr6_-_13487772 0.564 NM_001242629
NM_018988
GFOD1

glucose-fructose oxidoreductase domain containing 1

chr7_-_41742666 0.564 NM_002192
INHBA
inhibin, beta A
chr9_-_124989755 0.560 NM_001242334
LHX6
LIM homeobox 6
chr9_-_140196702 0.552 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr20_+_62795773 0.551 MYT1
myelin transcription factor 1
chr11_+_60691911 0.546 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr9_-_136024522 0.546 NM_001042368
RALGDS
ral guanine nucleotide dissociation stimulator
chrX_+_152954965 0.543 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr14_+_24641204 0.543 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr17_-_37764165 0.530 NM_006160
NEUROD2
neurogenic differentiation 2
chr7_-_139876718 0.530 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr6_+_90276556 0.509 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr9_-_126030792 0.501 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chrX_-_15683153 0.492 NM_020665
TMEM27
transmembrane protein 27
chr14_+_24641084 0.489 REC8
REC8 homolog (yeast)
chr4_-_103265818 0.480 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_-_39743085 0.479 NM_000526
KRT14
keratin 14
chrX_+_82763268 0.475 NM_000307
POU3F4
POU class 3 homeobox 4
chr5_-_16936290 0.471 MYO10
myosin X
chr12_-_31479120 0.469 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr12_-_71003622 0.468 NM_001206971
NM_001206972
NM_002837
PTPRB


protein tyrosine phosphatase, receptor type, B


chr11_+_128563772 0.464 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr19_+_45394459 0.461 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr12_-_31479084 0.461 FAM60A
family with sequence similarity 60, member A
chr8_-_119123804 0.461 NM_000127
EXT1
exostosin 1
chr17_-_39684585 0.455 NM_002276
KRT19
keratin 19
chr3_-_123339178 0.451 MYLK
myosin light chain kinase
chr9_-_126030854 0.448 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr15_-_73661141 0.447 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr1_+_33231227 0.447 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr10_-_14646237 0.445 FAM107B
family with sequence similarity 107, member B
chr19_-_49658645 0.441 NM_002152
HRC
histidine rich calcium binding protein
chr7_+_20370324 0.436 ITGB8
integrin, beta 8
chr8_+_102504836 0.433 GRHL2
grainyhead-like 2 (Drosophila)
chr3_-_139258531 0.430 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr9_+_124461365 0.429 DAB2IP
DAB2 interacting protein
chr2_-_60780404 0.420 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr21_+_43710190 0.418 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr12_-_31479038 0.414 FAM60A
family with sequence similarity 60, member A
chr19_+_35606731 0.414 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chrX_+_49126326 0.410 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr1_-_6479880 0.409 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr3_+_136537860 0.409 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr6_-_107435635 0.408 NM_001080450
BEND3
BEN domain containing 3
chr16_-_30934437 0.407 FBXL19-AS1
FBXL19 antisense RNA 1 (non-protein coding)
chr17_-_39684499 0.407 KRT19
keratin 19
chr1_-_43424536 0.406 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr5_+_148206155 0.405 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr8_-_125580745 0.404 MTSS1
metastasis suppressor 1
chr5_-_175964223 0.403 NM_014901
RNF44
ring finger protein 44
chr20_+_20348744 0.400 NM_002196
INSM1
insulinoma-associated 1
chr1_+_202183282 0.397 NM_001017404
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr22_+_38035718 0.395 SH3BP1
SH3-domain binding protein 1
chr18_+_55888799 0.395 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_-_31526414 0.394 NM_004014
DMD
dystrophin
chr22_-_46933066 0.392 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr15_+_40650411 0.391 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr1_-_32801606 0.391 NM_023009
MARCKSL1
MARCKS-like 1
chr2_+_102314162 0.391 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr11_+_128563993 0.390 FLI1
Friend leukemia virus integration 1
chr3_-_48470715 0.389 NM_002673
PLXNB1
plexin B1
chr17_+_42422665 0.387 GRN
granulin
chr10_+_24498088 0.386 KIAA1217
KIAA1217
chr22_+_33197744 0.386 TIMP3
TIMP metallopeptidase inhibitor 3
chr18_+_55888838 0.385 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_-_78809658 0.385 NM_004272
HOMER1
homer homolog 1 (Drosophila)
chr17_+_54230835 0.383 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr14_+_23305913 0.382 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr7_+_73245192 0.381 NM_001305
CLDN4
claudin 4
chrX_+_65384078 0.380 NM_001130860
NM_014799
HEPH

hephaestin

chr10_+_24755459 0.379 KIAA1217
KIAA1217
chr10_+_74653338 0.377 NM_152635
OIT3
oncoprotein induced transcript 3
chr15_-_34659245 0.375 NM_153613
LPCAT4
lysophosphatidylcholine acyltransferase 4
chr13_-_75901897 0.375 TBC1D4
TBC1 domain family, member 4
chr22_+_33197678 0.375 TIMP3
TIMP metallopeptidase inhibitor 3
chr14_-_71275732 0.374 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr17_+_42422627 0.373 GRN
granulin
chr3_+_51422691 0.372 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr3_+_111718006 0.371 NM_001008273
TAGLN3
transgelin 3
chr2_-_238499317 0.370 RAB17
RAB17, member RAS oncogene family
chr1_+_200860619 0.370 NM_018265
C1orf106
chromosome 1 open reading frame 106
chr8_+_82192717 0.370 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr3_+_111261039 0.369 CD96
CD96 molecule
chr17_+_57232859 0.366 NM_018304
PRR11
proline rich 11
chr21_+_18885104 0.366 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr19_+_45504686 0.366 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr1_-_217311095 0.365 NM_001134285
ESRRG
estrogen-related receptor gamma
chr10_+_24497719 0.365 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr1_-_43424324 0.365 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr11_+_128563973 0.363 FLI1
Friend leukemia virus integration 1
chr18_-_78005230 0.356 NM_032510
PARD6G
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr1_-_6545521 0.355 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr6_-_42419782 0.354 NM_033502
TRERF1
transcriptional regulating factor 1
chr14_+_23305907 0.353 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr2_+_70142152 0.352 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr12_-_54779482 0.350 ZNF385A
zinc finger protein 385A
chrX_-_117107700 0.346 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr3_-_123339423 0.344 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr14_+_23305792 0.343 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr9_+_4792833 0.337 NM_005772
RCL1
RNA terminal phosphate cyclase-like 1
chr7_+_77167351 0.336 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr12_-_91452130 0.335 NM_007035
KERA
keratocan
chr19_+_45394522 0.332 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr16_-_58663734 0.332 CNOT1
CCR4-NOT transcription complex, subunit 1
chr2_-_75796847 0.331 NM_032181
FAM176A
family with sequence similarity 176, member A
chr12_-_24103842 0.331 SOX5
SRY (sex determining region Y)-box 5
chrX_-_24665454 0.329 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr3_+_14444083 0.327 NM_001134367
NM_001134368
NM_003043
SLC6A6


solute carrier family 6 (neurotransmitter transporter, taurine), member 6


chr1_+_33231260 0.326 KIAA1522
KIAA1522
chr3_+_51422716 0.325 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr9_+_4792876 0.325 RCL1
RNA terminal phosphate cyclase-like 1
chr16_+_56817367 0.324 NM_001242796
NUP93
nucleoporin 93kDa
chr12_+_49372235 0.324 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr6_+_50681256 0.323 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr5_-_16936371 0.322 NM_012334
MYO10
myosin X
chr14_+_23305816 0.321 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr8_+_104831415 0.318 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr6_+_14117486 0.317 NM_001251901
CD83
CD83 molecule
chr17_-_46507599 0.316 SKAP1
src kinase associated phosphoprotein 1
chr11_+_6897855 0.316 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr1_+_43766565 0.313 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr18_-_24128499 0.312 NM_001142730
KCTD1
potassium channel tetramerisation domain containing 1
chr1_-_16539103 0.311 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr16_+_56815703 0.309 NM_001242795
NUP93
nucleoporin 93kDa
chr6_+_100054649 0.308 NM_021620
PRDM13
PR domain containing 13
chr16_+_57673206 0.308 NM_001145774
GPR56
G protein-coupled receptor 56
chr18_-_13915534 0.307 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chrX_-_110654373 0.306 NM_000555
DCX
doublecortin
chr19_+_45394569 0.306 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_40254510 0.305 BMP8B
bone morphogenetic protein 8b
chr4_+_40198526 0.305 NM_004310
RHOH
ras homolog gene family, member H
chr12_-_18243052 0.303 NM_024730
RERGL
RERG/RAS-like
chr4_-_110723334 0.301 NM_000204
CFI
complement factor I

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 9.08e-10 GO:0007275 multicellular organismal development
1.36 1.07e-09 GO:0032502 developmental process
1.37 8.18e-08 GO:0048856 anatomical structure development
1.40 8.32e-08 GO:0048731 system development
1.50 2.98e-05 GO:0007399 nervous system development
1.41 4.14e-05 GO:0030154 cell differentiation
1.40 7.73e-05 GO:0048869 cellular developmental process
1.29 7.90e-05 GO:0071840 cellular component organization or biogenesis
1.30 8.00e-05 GO:0016043 cellular component organization
1.10 3.82e-04 GO:0009987 cellular process
1.33 5.01e-04 GO:0071842 cellular component organization at cellular level
1.20 7.91e-04 GO:0032501 multicellular organismal process
1.31 9.83e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.38 1.59e-03 GO:0048513 organ development
1.62 3.03e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.64 4.55e-03 GO:0010628 positive regulation of gene expression
1.48 1.05e-02 GO:0022607 cellular component assembly
1.53 1.57e-02 GO:0009888 tissue development
1.37 1.60e-02 GO:0006996 organelle organization
1.62 2.07e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.56 2.46e-02 GO:2000026 regulation of multicellular organismal development
1.52 2.78e-02 GO:0009891 positive regulation of biosynthetic process
1.43 3.26e-02 GO:0044085 cellular component biogenesis
1.51 4.35e-02 GO:0051128 regulation of cellular component organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 3.43e-04 GO:0044428 nuclear part
1.36 5.90e-04 GO:0031981 nuclear lumen
1.16 4.70e-03 GO:0005634 nucleus
1.29 4.94e-03 GO:0043233 organelle lumen
1.39 5.96e-03 GO:0005654 nucleoplasm
1.27 1.14e-02 GO:0031974 membrane-enclosed lumen
1.27 1.69e-02 GO:0070013 intracellular organelle lumen
4.89 3.86e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.27 1.49e-02 GO:0003677 DNA binding
1.07 2.33e-02 GO:0005488 binding
1.12 3.46e-02 GO:0005515 protein binding