Motif ID: SOX17.p2

Z-value: 1.049


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX17chr8_+_55370494-0.676.8e-02Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_81398416 0.547 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr2_+_70142236 0.394 MXD1
MAX dimerization protein 1
chr12_-_24103953 0.379 SOX5
SRY (sex determining region Y)-box 5
chr2_+_70142303 0.377 MXD1
MAX dimerization protein 1
chr2_+_75061234 0.370 HK2
hexokinase 2
chr5_-_64777703 0.325 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr3_+_31574119 0.324 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr7_-_131241321 0.314 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr7_+_69064316 0.271 AUTS2
autism susceptibility candidate 2
chr17_+_26646120 0.266 NM_014573
TMEM97
transmembrane protein 97
chr8_+_26435590 0.241 DPYSL2
dihydropyrimidinase-like 2
chr5_+_139781395 0.239 NM_020690
NM_001197030
NM_017747
NM_017978
NM_024668
ANKHD1-EIF4EBP3
ANKHD1



ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1



chr5_+_139781450 0.234 ANKHD1-EIF4EBP3
ANKHD1
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr7_+_121513158 0.232 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr16_+_838634 0.223 CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr5_+_139781472 0.222 ANKHD1-EIF4EBP3
ANKHD1
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr16_+_838610 0.222 NM_022092
CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr16_-_30934437 0.221 FBXL19-AS1
FBXL19 antisense RNA 1 (non-protein coding)
chr20_-_17662704 0.217 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr20_+_18794369 0.217 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr19_+_13906207 0.214 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr5_+_108084638 0.213 FER
fer (fps/fes related) tyrosine kinase
chr16_+_838645 0.213 CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr5_+_139781424 0.210 ANKHD1
ankyrin repeat and KH domain containing 1
chr7_+_116660291 0.209 ST7
suppression of tumorigenicity 7
chr14_+_103800492 0.208 NM_001969
EIF5
eukaryotic translation initiation factor 5
chr19_+_45394459 0.206 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr5_+_102465256 0.203 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr20_-_17662828 0.202 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr13_-_31040035 0.198 NM_002128
HMGB1
high mobility group box 1
chr4_-_80994309 0.187 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr15_+_40886217 0.186 CASC5
cancer susceptibility candidate 5
chr17_-_79196702 0.185 NM_001009811
NM_014984
AZI1

5-azacytidine induced 1

chrX_+_78003205 0.184 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr7_+_116660263 0.180 ST7
suppression of tumorigenicity 7
chr3_-_20227618 0.179 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
NM_001199251
NM_001199252
NM_001199253
NM_001199254
NM_001199255
NM_001199256
NM_001199257
SGOL1












shugoshin-like 1 (S. pombe)












chr3_+_51422716 0.179 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr11_-_67141647 0.178 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr1_-_8931634 0.176 NM_001201483
ENO1
enolase 1, (alpha)
chr2_+_172950207 0.175 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr20_-_56285576 0.174 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr2_-_97405775 0.172 LMAN2L
lectin, mannose-binding 2-like
chr12_+_108909049 0.168 NM_007076
FICD
FIC domain containing
chr3_-_48601200 0.168 NM_033199
UCN2
urocortin 2
chr4_-_80993713 0.167 ANTXR2
anthrax toxin receptor 2
chr5_+_148206155 0.167 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr2_+_169757749 0.165 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr2_-_97405799 0.164 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr16_+_56817367 0.162 NM_001242796
NUP93
nucleoporin 93kDa
chr19_+_3880675 0.160 ATCAY
ataxia, cerebellar, Cayman type
chr6_-_108279307 0.160 SEC63
SEC63 homolog (S. cerevisiae)
chr3_+_51422691 0.160 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr20_+_37554954 0.159 NM_030919
FAM83D
family with sequence similarity 83, member D
chr6_+_12290528 0.158 NM_001168319
NM_001955
EDN1

endothelin 1

chrX_+_151999605 0.156 NSDHL
NAD(P) dependent steroid dehydrogenase-like
chr13_-_31039966 0.153 HMGB1
high mobility group box 1
chrX_+_48367346 0.150 NM_022825
NM_203473
PORCN

porcupine homolog (Drosophila)

chr1_-_16161279 0.150


chr5_+_140474198 0.149 NM_018936
PCDHB2
protocadherin beta 2
chr1_+_45805877 0.148 TOE1
target of EGR1, member 1 (nuclear)
chr7_-_111846384 0.146 NM_014705
DOCK4
dedicator of cytokinesis 4
chr5_+_68462948 0.146 CCNB1
cyclin B1
chr17_-_61777478 0.146 NM_030576
LIMD2
LIM domain containing 2
chr11_-_4599049 0.146 NM_144663
C11orf40
chromosome 11 open reading frame 40
chr17_-_8113862 0.145 NM_004217
AURKB
aurora kinase B
chr14_+_103800534 0.143 EIF5
eukaryotic translation initiation factor 5
chr3_+_67048726 0.142 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr11_+_560868 0.142 NM_001143993
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr2_-_61765394 0.141 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr9_-_128003634 0.141 NM_005347
HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr22_+_38142245 0.140 TRIOBP
TRIO and F-actin binding protein
chr20_+_42086533 0.139 SRSF6
serine/arginine-rich splicing factor 6
chr19_+_45394522 0.139 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_179262936 0.139 SOAT1
sterol O-acyltransferase 1
chr3_-_149510609 0.139 NM_001144960
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr1_+_27719151 0.138 NM_005281
GPR3
G protein-coupled receptor 3
chr4_+_75310852 0.137 NM_001657
AREG
amphiregulin
chr17_-_49124128 0.137 NM_001251971
SPAG9
sperm associated antigen 9
chr7_+_89843133 0.135 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr11_-_133715368 0.134 NM_174927
SPATA19
spermatogenesis associated 19
chr1_+_43824598 0.133 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr13_-_31736031 0.132 NM_006644
HSPH1
heat shock 105kDa/110kDa protein 1
chr14_-_106926393 0.132 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_45805783 0.132 TOE1
target of EGR1, member 1 (nuclear)
chr20_+_37555055 0.131 FAM83D
family with sequence similarity 83, member D
chr3_+_157154579 0.129 NM_002852
PTX3
pentraxin 3, long
chr7_+_150690838 0.129 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chrX_+_151999565 0.128 NSDHL
NAD(P) dependent steroid dehydrogenase-like
chrX_+_151999510 0.127 NM_001129765
NM_015922
NSDHL

NAD(P) dependent steroid dehydrogenase-like

chr5_+_68462985 0.127 CCNB1
cyclin B1
chr2_+_197504277 0.127 NM_001080539
CCDC150
coiled-coil domain containing 150
chr1_-_197115566 0.126 NM_001206846
NM_018136
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr14_+_85996512 0.126 FLRT2
fibronectin leucine rich transmembrane protein 2
chrX_-_47931000 0.125 NM_001190255
ZNF630
zinc finger protein 630
chr1_+_45805669 0.124 TOE1
target of EGR1, member 1 (nuclear)
chr14_+_85996454 0.124 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr9_+_134000939 0.124 NM_005085
NUP214
nucleoporin 214kDa
chr6_+_25754926 0.123 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr6_-_139613114 0.123 NM_153235
TXLNB
taxilin beta
chr2_-_61765345 0.123 XPO1
exportin 1 (CRM1 homolog, yeast)
chr11_+_33563772 0.121 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr6_-_108279212 0.120 SEC63
SEC63 homolog (S. cerevisiae)
chr12_-_122985471 0.119 NM_017612
ZCCHC8
zinc finger, CCHC domain containing 8
chr19_+_50031232 0.119 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr3_-_137851123 0.118 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr2_-_220094354 0.118 NM_001077198
NM_024085
ATG9A

ATG9 autophagy related 9 homolog A (S. cerevisiae)

chr5_+_176875325 0.118 NM_001174102
PRR7
proline rich 7 (synaptic)
chr2_-_61765367 0.118 XPO1
exportin 1 (CRM1 homolog, yeast)
chr15_+_90118740 0.117 NM_152259
C15orf42
chromosome 15 open reading frame 42
chr4_+_2061238 0.117 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr16_-_2264776 0.116 NM_001042371
PGP
phosphoglycolate phosphatase
chr3_-_9439122 0.115 LOC440944
uncharacterized LOC440944
chr1_+_179262960 0.115 SOAT1
sterol O-acyltransferase 1
chr6_+_80714389 0.115 TTK
TTK protein kinase
chr9_+_130159383 0.115 NM_014580
SLC2A8
solute carrier family 2 (facilitated glucose transporter), member 8
chr14_+_23938902 0.114 NGDN
neuroguidin, EIF4E binding protein
chr17_-_38210611 0.114 MED24
mediator complex subunit 24
chr20_-_13971256 0.113 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr6_-_53213586 0.113 ELOVL5
ELOVL fatty acid elongase 5
chr11_+_128563772 0.112 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr12_-_6960406 0.111 NM_031299
CDCA3
cell division cycle associated 3
chr1_+_46713385 0.111 RAD54L
RAD54-like (S. cerevisiae)
chr3_+_45927995 0.111 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr1_+_201709051 0.110 NAV1
neuron navigator 1
chr17_-_48262900 0.110 COL1A1
collagen, type I, alpha 1
chr2_+_73612821 0.110 NM_015120
ALMS1
Alstrom syndrome 1
chr17_+_57232859 0.109 NM_018304
PRR11
proline rich 11
chr1_+_45805341 0.109 NM_025077
TOE1
target of EGR1, member 1 (nuclear)
chr5_+_145826866 0.109 NM_001040006
NM_006706
TCERG1

transcription elongation regulator 1

chr9_-_128003348 0.108 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr1_+_46713359 0.108 NM_001142548
NM_003579
RAD54L

RAD54-like (S. cerevisiae)

chr11_-_28129687 0.107 KIF18A
kinesin family member 18A
chr11_-_28129646 0.106 KIF18A
kinesin family member 18A
chr5_-_16936371 0.105 NM_012334
MYO10
myosin X
chr2_-_174767282 0.105


chr9_-_74383301 0.104 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr1_-_33815498 0.104 NM_004427
PHC2
polyhomeotic homolog 2 (Drosophila)
chr4_+_55523906 0.104 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr15_+_39873276 0.104 NM_003246
THBS1
thrombospondin 1
chr11_-_28129701 0.104 NM_031217
KIF18A
kinesin family member 18A
chr2_+_153191830 0.104 FMNL2
formin-like 2
chr7_-_92463211 0.103 NM_001259
CDK6
cyclin-dependent kinase 6
chr14_+_103800678 0.103 EIF5
eukaryotic translation initiation factor 5
chr9_-_128003615 0.103 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr8_-_82024277 0.102 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr14_+_103800548 0.102 EIF5
eukaryotic translation initiation factor 5
chr9_-_99180661 0.102 NM_153695
ZNF367
zinc finger protein 367
chr2_+_10262694 0.102 NM_001165931
RRM2
ribonucleotide reductase M2
chr9_+_140135738 0.101 TUBB4B
tubulin, beta 4B class IVb
chr2_+_10262853 0.101 NM_001034
RRM2
ribonucleotide reductase M2
chr5_+_112312427 0.101 DCP2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr1_-_53018721 0.101 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr3_+_5229430 0.101 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr15_+_40886442 0.100 NM_144508
NM_170589
CASC5

cancer susceptibility candidate 5

chr14_-_35344450 0.100 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr14_-_107218786 0.100 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr21_-_16437125 0.100 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr2_+_54683276 0.100 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr6_-_108395939 0.100 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr4_-_80994183 0.099


chr14_-_60097223 0.099 RTN1
reticulon 1
chr6_-_62995852 0.098 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr5_-_137548982 0.098 CDC23
cell division cycle 23 homolog (S. cerevisiae)
chr3_+_1134619 0.098 NM_014461
CNTN6
contactin 6
chr1_+_45792544 0.098 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr12_-_52585686 0.097 NM_001081492
NM_182507
KRT80

keratin 80

chr19_+_4247049 0.097 NM_018074
CCDC94
coiled-coil domain containing 94
chr5_-_24645084 0.097 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr7_-_25164902 0.097 NM_018947
CYCS
cytochrome c, somatic
chr3_-_192635933 0.097 NM_178496
MB21D2
Mab-21 domain containing 2
chrX_+_70443055 0.096 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr18_+_31158540 0.096 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr14_-_35344080 0.096 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr20_-_590909 0.095 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr9_-_35828728 0.094 NM_001012446
C9orf128
chromosome 9 open reading frame 128
chr9_+_140135698 0.094 NM_006088
TUBB4B
tubulin, beta 4B class IVb
chr17_+_38444130 0.094 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr11_+_13690151 0.094 NM_032228
FAR1
fatty acyl CoA reductase 1
chr12_-_75905382 0.093 KRR1
KRR1, small subunit (SSU) processome component, homolog (yeast)
chr22_+_26825220 0.092 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr3_+_5229357 0.092 NM_014674
EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr17_-_61777467 0.092 LIMD2
LIM domain containing 2
chr15_+_77223942 0.092 NM_002902
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr15_+_89164522 0.092 NM_022767
AEN
apoptosis enhancing nuclease
chr20_+_207898 0.092 NM_080831
DEFB129
defensin, beta 129
chr5_-_77805930 0.091 LHFPL2
lipoma HMGIC fusion partner-like 2
chr11_-_67141008 0.091 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr8_-_117023 0.091 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr1_-_43424324 0.091 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr17_+_38444134 0.090 NM_001254
CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr9_+_140135742 0.090 TUBB4B
tubulin, beta 4B class IVb
chr12_-_45270071 0.090 NELL2
NEL-like 2 (chicken)
chr11_-_46867788 0.090 CKAP5
cytoskeleton associated protein 5
chr1_+_46713433 0.090 RAD54L
RAD54-like (S. cerevisiae)
chr16_-_81253974 0.090 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr6_-_108279320 0.090 SEC63
SEC63 homolog (S. cerevisiae)
chr13_-_31735718 0.089 HSPH1
heat shock 105kDa/110kDa protein 1
chr15_+_40650411 0.089 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr4_+_154387450 0.089 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr16_+_56815703 0.089 NM_001242795
NUP93
nucleoporin 93kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 1.58e-07 GO:0009987 cellular process
1.46 2.30e-04 GO:0044085 cellular component biogenesis
1.49 2.36e-04 GO:0022607 cellular component assembly
1.28 3.61e-04 GO:0071842 cellular component organization at cellular level
1.28 3.71e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.24 8.00e-04 GO:0016043 cellular component organization
1.20 9.81e-04 GO:0044260 cellular macromolecule metabolic process
1.22 1.70e-03 GO:0071840 cellular component organization or biogenesis
1.20 1.07e-02 GO:0032502 developmental process
1.28 1.14e-02 GO:0030154 cell differentiation
1.49 1.64e-02 GO:0071844 cellular component assembly at cellular level
1.51 1.81e-02 GO:0022403 cell cycle phase
1.56 2.18e-02 GO:0000278 mitotic cell cycle
2.24 2.44e-02 GO:0051789 response to protein stimulus
1.27 2.70e-02 GO:0048869 cellular developmental process
1.31 2.73e-02 GO:0006996 organelle organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 1.93e-08 GO:0043233 organelle lumen
1.37 6.21e-08 GO:0031974 membrane-enclosed lumen
1.37 8.61e-08 GO:0070013 intracellular organelle lumen
1.36 5.89e-07 GO:0044428 nuclear part
1.40 6.62e-07 GO:0031981 nuclear lumen
1.19 1.01e-06 GO:0005634 nucleus
1.11 1.35e-06 GO:0043226 organelle
1.45 4.32e-06 GO:0005654 nucleoplasm
1.11 4.48e-06 GO:0043229 intracellular organelle
1.08 2.85e-05 GO:0044424 intracellular part
1.17 5.35e-05 GO:0044422 organelle part
1.17 9.02e-05 GO:0044446 intracellular organelle part
1.10 3.61e-04 GO:0043227 membrane-bounded organelle
1.10 4.55e-04 GO:0043231 intracellular membrane-bounded organelle
2.52 7.36e-04 GO:0005788 endoplasmic reticulum lumen
1.97 8.47e-04 GO:0016604 nuclear body
1.51 9.98e-04 GO:0044451 nucleoplasm part
1.07 1.16e-03 GO:0005622 intracellular
1.43 1.80e-02 GO:0044432 endoplasmic reticulum part
1.03 4.67e-02 GO:0044464 cell part
1.03 4.81e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 6.11e-07 GO:0005515 protein binding
1.08 4.44e-06 GO:0005488 binding
6.03 1.97e-02 GO:0051787 misfolded protein binding
1.67 2.75e-02 GO:0003779 actin binding
1.18 3.80e-02 GO:0003676 nucleic acid binding