Motif ID: SPIB.p2

Z-value: 0.962


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_509221940.482.3e-01Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_207205996 0.871 NM_001083924
NM_023938
 C1orf116

chromosome 1 open reading frame 116

chr12_+_4382882 0.641 NM_001759
 CCND2
cyclin D2
chr2_+_113885137 0.626 NM_173842
 IL1RN
interleukin 1 receptor antagonist
chr1_+_186798031 0.550 NM_024420
 PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_-_189840225 0.510 NM_001134418
 LEPREL1
leprecan-like 1
chr2_+_113885145 0.508 IL1RN
interleukin 1 receptor antagonist
chr4_+_40198526 0.502 NM_004310
 RHOH
ras homolog gene family, member H
chr6_-_47009992 0.484 NM_025048
NM_153840
 GPR110

G protein-coupled receptor 110

chr18_-_53068755 0.452 TCF4
transcription factor 4
chr2_+_47596286 0.420 NM_002354
 EPCAM
epithelial cell adhesion molecule
chr12_-_6745087 0.381 NM_020400
 LPAR5
lysophosphatidic acid receptor 5
chr8_-_144810691 0.376 FAM83H
family with sequence similarity 83, member H
chr3_-_12800739 0.362 NM_018306
 TMEM40
transmembrane protein 40
chr1_-_183560010 0.356 NM_001127651
 NCF2
neutrophil cytosolic factor 2
chr1_-_161008710 0.350 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr1_-_161008733 0.336 NM_001113205
NM_001113206
NM_001113207
 TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr19_-_49243836 0.322 NM_017805
 RASIP1
Ras interacting protein 1
chr17_-_56492938 0.321 RNF43
ring finger protein 43
chr1_+_160370363 0.320 NM_020335
 VANGL2
vang-like 2 (van gogh, Drosophila)
chr1_-_183559669 0.319 NM_000433
NM_001190789
NM_001190794
 NCF2


neutrophil cytosolic factor 2



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
2.09 5.15e-03 GO:0019080 viral genome expression
2.09 5.15e-03 GO:0019083 viral transcription
2.02 1.50e-02 GO:0006415 translational termination
1.95 1.24e-02 GO:0006414 translational elongation
1.80 1.32e-02 GO:0050870 positive regulation of T cell activation
1.75 3.63e-02 GO:0031016 pancreas development
1.72 1.20e-02 GO:0051251 positive regulation of lymphocyte activation
1.56 5.28e-03 GO:0006412 translation
1.55 4.04e-10 GO:0006955 immune response
1.52 3.49e-03 GO:0045087 innate immune response
1.48 2.66e-03 GO:0002684 positive regulation of immune system process
1.46 1.19e-03 GO:0001775 cell activation
1.45 2.06e-11 GO:0002376 immune system process
1.43 2.35e-02 GO:0050776 regulation of immune response
1.37 3.22e-03 GO:0002682 regulation of immune system process
1.35 1.75e-03 GO:0006952 defense response
1.31 5.01e-03 GO:0032774 RNA biosynthetic process
1.29 2.83e-02 GO:0009611 response to wounding
1.26 3.78e-05 GO:0010467 gene expression
1.25 8.28e-05 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
2.10 2.51e-03 GO:0022626 cytosolic ribosome
1.68 2.15e-03 GO:0005840 ribosome
1.65 2.72e-02 GO:0044445 cytosolic part
1.37 9.32e-03 GO:0030529 ribonucleoprotein complex
1.25 2.68e-03 GO:0005887 integral to plasma membrane
1.23 7.78e-03 GO:0031226 intrinsic to plasma membrane
1.22 1.64e-05 GO:0044459 plasma membrane part
1.06 4.04e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
3.51 4.47e-02 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
1.11 2.23e-06 GO:0005515 protein binding
1.05 6.81e-03 GO:0005488 binding