Motif ID: SREBF1,2.p2

Z-value: 1.209


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF2chr22_+_42229105-0.639.7e-02Click!
SREBF1chr17_-_17740288-0.147.4e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_183605207 2.656 NM_015149
 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr5_-_150537306 2.269 ANXA6
annexin A6
chr19_+_49458151 2.138 BAX
BCL2-associated X protein
chr5_-_150537261 2.067 ANXA6
annexin A6
chr19_+_49458031 2.060 NM_004324
NM_138761
NM_138763
NM_138764
 BAX



BCL2-associated X protein



chr19_+_49458129 2.006 BAX
BCL2-associated X protein
chr10_-_93392857 1.984 NM_005398
 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr5_-_172198160 1.979 NM_004417
 DUSP1
dual specificity phosphatase 1
chrX_+_55744049 1.953 NM_006064
NM_016656
 RRAGB

Ras-related GTP binding B

chr22_+_35777087 1.870 HMOX1
heme oxygenase (decycling) 1
chr12_+_56109832 1.859 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 readthrough
biogenesis of lysosomal organelles complex-1, subunit 1
chr19_+_14544100 1.707 NM_002741
 PKN1
protein kinase N1
chr15_+_44084039 1.648 NM_001018108
NM_001199875
NM_001199876
 SERF2


small EDRK-rich factor 2


chr5_-_150537335 1.552 NM_001155
 ANXA6
annexin A6
chr22_+_35695872 1.527 TOM1
target of myb1 (chicken)
chr12_-_63328663 1.494 NM_020700
 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr13_-_33859835 1.471 NM_178006
 STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_+_14544216 1.448 PKN1
protein kinase N1
chr1_-_31845818 1.371 NM_004102
 FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr19_-_36545298 1.335 THAP8
THAP domain containing 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
8.50 1.00e-02 GO:0032008 positive regulation of TOR signaling cascade
7.29 5.34e-04 GO:0032006 regulation of TOR signaling cascade
5.34 6.02e-03 GO:0015682 ferric iron transport
5.34 6.02e-03 GO:0033572 transferrin transport
4.86 4.61e-02 GO:0015988 energy coupled proton transport, against electrochemical gradient
4.86 4.61e-02 GO:0015991 ATP hydrolysis coupled proton transport
4.25 6.19e-03 GO:0007033 vacuole organization
4.13 8.40e-04 GO:0006818 hydrogen transport
4.02 2.75e-03 GO:0015992 proton transport
1.65 8.40e-03 GO:0033554 cellular response to stress
1.63 2.34e-03 GO:0032774 RNA biosynthetic process
1.59 3.18e-02 GO:0006351 transcription, DNA-dependent
1.43 1.45e-02 GO:0034645 cellular macromolecule biosynthetic process
1.41 2.74e-02 GO:0009059 macromolecule biosynthetic process
1.38 4.80e-02 GO:0010467 gene expression
1.33 2.79e-02 GO:0044249 cellular biosynthetic process
1.32 1.31e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 4.43e-03 GO:0034641 cellular nitrogen compound metabolic process
1.31 4.73e-02 GO:0009058 biosynthetic process
1.30 3.55e-03 GO:0006807 nitrogen compound metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
6.56 1.13e-03 GO:0033176 proton-transporting V-type ATPase complex
4.41 1.52e-03 GO:0016469 proton-transporting two-sector ATPase complex
3.38 3.40e-02 GO:0016605 PML body
3.23 6.06e-07 GO:0005774 vacuolar membrane
3.18 5.36e-07 GO:0044437 vacuolar part
2.81 3.55e-03 GO:0005765 lysosomal membrane
2.79 1.86e-10 GO:0005773 vacuole
2.65 1.78e-03 GO:0005769 early endosome
2.40 3.00e-05 GO:0000323 lytic vacuole
2.40 3.00e-05 GO:0005764 lysosome
2.10 8.45e-06 GO:0005768 endosome
1.72 3.64e-02 GO:0005740 mitochondrial envelope
1.59 2.18e-02 GO:0031975 envelope
1.57 3.71e-02 GO:0031967 organelle envelope
1.44 1.17e-02 GO:0005654 nucleoplasm
1.36 3.03e-03 GO:0005829 cytosol
1.36 3.52e-03 GO:0031090 organelle membrane
1.35 1.39e-03 GO:0031974 membrane-enclosed lumen
1.35 2.04e-03 GO:0070013 intracellular organelle lumen
1.35 2.08e-02 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
2.85 1.65e-02 GO:0015078 hydrogen ion transmembrane transporter activity
1.20 3.15e-06 GO:0005515 protein binding
1.11 2.77e-05 GO:0005488 binding