Motif ID: SRY.p2

Z-value: 0.566


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRYchrY_-_26554780.883.6e-03Click!


Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_105845619 1.454 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr10_-_105845556 1.383 COL17A1
collagen, type XVII, alpha 1
chr12_-_28124915 1.149 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_+_26400503 1.146 NM_001199837
SNX10
sorting nexin 10
chr5_+_140247767 1.130 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr4_+_40198526 1.050 NM_004310
RHOH
ras homolog gene family, member H
chr12_-_8815266 1.005 MFAP5
microfibrillar associated protein 5
chr3_+_189507448 0.959 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr15_+_43885251 0.859 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr10_-_123356158 0.736 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr10_+_118187381 0.734 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_52886971 0.717 NM_005554
KRT6A
keratin 6A
chr18_+_61254533 0.706 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr11_-_16424391 0.702 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr7_+_106505696 0.642 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_+_155099935 0.580 EFNA1
ephrin-A1
chr18_+_29027731 0.572 NM_001944
DSG3
desmoglein 3
chr5_+_36606667 0.569 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_36606456 0.561 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr21_+_43619798 0.526 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr12_-_8815479 0.525 MFAP5
microfibrillar associated protein 5
chr8_+_32504250 0.519 NM_013959
NRG1
neuregulin 1
chr17_-_56492938 0.519 RNF43
ring finger protein 43
chr12_-_52845862 0.506 NM_005555
KRT6B
keratin 6B
chr7_-_83824216 0.486 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr8_-_15095791 0.464 NM_139167
SGCZ
sarcoglycan, zeta
chr2_-_165424993 0.457 GRB14
growth factor receptor-bound protein 14
chr12_-_8815370 0.445 NM_003480
MFAP5
microfibrillar associated protein 5
chr3_+_136676706 0.443 NM_144717
IL20RB
interleukin 20 receptor beta
chr10_-_116444374 0.442 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr11_+_34654010 0.441 NM_001206616
EHF
ets homologous factor
chr9_-_107690526 0.435 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr5_+_140220811 0.432 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr5_+_140186658 0.430 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr2_+_102979096 0.418 NM_003855
IL18R1
interleukin 18 receptor 1
chr8_-_57233240 0.415 NM_138969
SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr12_-_71031174 0.407 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr6_-_136788012 0.397 NM_001198615
MAP7
microtubule-associated protein 7
chr18_-_52988916 0.390 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr15_-_59665069 0.381 NM_004998
MYO1E
myosin IE
chr2_-_161056762 0.370 ITGB6
integrin, beta 6
chr15_+_40509628 0.366 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr10_-_5446781 0.363 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr1_-_93342706 0.363 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr12_-_95611023 0.360 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr12_+_41831484 0.354 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr7_-_41742666 0.353 NM_002192
INHBA
inhibin, beta A
chr6_+_13925423 0.350 NM_001165033
RNF182
ring finger protein 182
chr6_-_29012951 0.350 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chrX_-_15683153 0.339 NM_020665
TMEM27
transmembrane protein 27
chr3_+_121774208 0.333 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr6_-_155777036 0.331 NM_015718
NOX3
NADPH oxidase 3
chr1_+_2005424 0.329 NM_001242874
PRKCZ
protein kinase C, zeta
chr5_+_68800003 0.329 NM_001205255
OCLN
occludin
chr3_-_191048324 0.323 NM_198152
UTS2D
urotensin 2 domain containing
chr12_-_105322056 0.321 NM_032148
SLC41A2
solute carrier family 41, member 2
chr13_-_41240607 0.318 NM_002015
FOXO1
forkhead box O1
chr11_-_16497917 0.316 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr2_-_160472960 0.316 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr1_+_155100304 0.313 NM_004428
NM_182685
EFNA1

ephrin-A1

chr10_-_116444112 0.310 ABLIM1
actin binding LIM protein 1
chr11_+_113775517 0.309 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr2_-_31352489 0.306 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr3_+_122044010 0.305 NM_005213
CSTA
cystatin A (stefin A)
chrX_+_135614310 0.305 NM_016267
VGLL1
vestigial like 1 (Drosophila)
chr6_-_116381765 0.297 NM_002031
FRK
fyn-related kinase
chr1_-_12677347 0.297 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr11_+_6897855 0.295 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr2_-_100722259 0.295 AFF3
AF4/FMR2 family, member 3
chr11_+_10482677 0.293 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr17_-_56494889 0.293 RNF43
ring finger protein 43
chr8_+_95653340 0.289 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr2_-_113542970 0.288 NM_000575
IL1A
interleukin 1, alpha
chr18_-_53071225 0.288 NM_001243232
TCF4
transcription factor 4
chr4_+_77356252 0.287 NM_020859
SHROOM3
shroom family member 3
chr1_+_81771844 0.285 LPHN2
latrophilin 2
chr12_-_10151689 0.283 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr6_+_90276556 0.282 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr11_+_10476665 0.281 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr5_+_40841296 0.280 NM_032587
CARD6
caspase recruitment domain family, member 6
chr2_-_113594325 0.280 NM_000576
IL1B
interleukin 1, beta
chr20_+_9198036 0.270 NM_182797
PLCB4
phospholipase C, beta 4
chr10_+_111967302 0.269 NM_130439
MXI1
MAX interactor 1
chr12_+_105153258 0.269 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr15_+_41136622 0.267 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr8_+_95653399 0.260 ESRP1
epithelial splicing regulatory protein 1
chr7_-_16505292 0.258 NM_015464
SOSTDC1
sclerostin domain containing 1
chr5_+_140207562 0.254 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chrX_-_99891690 0.253 NM_003270
TSPAN6
tetraspanin 6
chr7_+_86273219 0.249 NM_000840
GRM3
glutamate receptor, metabotropic 3
chrX_-_117107700 0.249 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr1_+_183155173 0.247 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chrX_-_78623006 0.247 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr19_+_751108 0.245 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr3_+_142342265 0.244 NM_002670
PLS1
plastin 1
chrX_-_100914816 0.240 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr1_-_60392461 0.238 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr1_+_156254069 0.237 NM_032323
TMEM79
transmembrane protein 79
chr1_+_2005083 0.234 NM_001033581
PRKCZ
protein kinase C, zeta
chr20_+_9288446 0.234 NM_000933
PLCB4
phospholipase C, beta 4
chr12_+_13043955 0.233 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr9_-_23826062 0.233 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_-_11623829 0.231 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr8_-_86253863 0.230 NM_001164830
CA1
carbonic anhydrase I
chr18_+_47088400 0.229 NM_006033
LIPG
lipase, endothelial
chr8_-_134309448 0.229 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr8_+_95653272 0.228 ESRP1
epithelial splicing regulatory protein 1
chr6_-_111888520 0.228 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr21_+_43710190 0.227 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr16_+_57673206 0.226 NM_001145774
GPR56
G protein-coupled receptor 56
chr14_-_99737821 0.225 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr3_+_112931374 0.224 NM_033254
BOC
Boc homolog (mouse)
chr14_-_23652840 0.223 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr11_-_118135197 0.222 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr5_+_140235594 0.220 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr2_+_102608305 0.219 NM_004633
IL1R2
interleukin 1 receptor, type II
chr15_+_43985083 0.219 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr20_-_43883183 0.217 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr11_+_36317724 0.216 NM_001160167
PRR5L
proline rich 5 like
chr3_-_111314181 0.215 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr12_-_48963802 0.215 NM_002289
LALBA
lactalbumin, alpha-
chr13_-_75901897 0.212 TBC1D4
TBC1 domain family, member 4
chr8_+_103563847 0.211 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr3_+_130569368 0.210 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr5_+_145317297 0.209 SH3RF2
SH3 domain containing ring finger 2
chr16_+_69141442 0.208 NM_005329
HAS3
hyaluronan synthase 3
chr11_-_102668892 0.208 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr2_-_56151273 0.207 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr17_+_8924822 0.207 NM_004822
NTN1
netrin 1
chr10_-_123357503 0.205 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr6_-_47009992 0.205 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chrX_+_107288199 0.204 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr2_+_196521470 0.203 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr5_+_31799030 0.202 NM_178140
PDZD2
PDZ domain containing 2
chrX_-_32430370 0.201 NM_004011
NM_004012
DMD

dystrophin

chr4_+_86699858 0.200 ARHGAP24
Rho GTPase activating protein 24
chr5_-_158634641 0.200 NM_001199382
RNF145
ring finger protein 145
chr9_+_22446783 0.199 NM_022160
DMRTA1
DMRT-like family A1
chr11_+_5410606 0.196 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr18_-_53177999 0.196 NM_001243231
TCF4
transcription factor 4
chr4_+_88896838 0.195 SPP1
secreted phosphoprotein 1
chr10_-_123353330 0.194 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr2_+_27665232 0.193 NM_001168364
NM_173853
KRTCAP3

keratinocyte associated protein 3

chr14_+_23842017 0.193 NM_172314
NM_022789
IL25

interleukin 25

chr1_+_152956563 0.192 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr5_+_147582338 0.192 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr20_+_58251715 0.192 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr4_+_86699846 0.191 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr6_+_13925097 0.190 NM_001165032
NM_152737
RNF182

ring finger protein 182

chr4_-_10023094 0.190 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr8_-_80993009 0.189 NM_001025252
TPD52
tumor protein D52
chrX_-_117119282 0.188 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr6_-_28555066 0.188 NM_052923
SCAND3
SCAN domain containing 3
chr6_+_139456240 0.186 NM_016217
HECA
headcase homolog (Drosophila)
chr19_-_11564568 0.186 ELAVL3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr1_+_156252725 0.186 TMEM79
transmembrane protein 79
chr1_-_207095198 0.184 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr4_+_89299874 0.183 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chrX_-_24690740 0.182 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_+_32851469 0.182 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr17_+_27573874 0.182 NM_005208
CRYBA1
crystallin, beta A1
chrX_+_91090459 0.181 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr4_-_164534656 0.181 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr14_-_23652818 0.180 SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr11_-_102668822 0.180 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr1_-_60392324 0.179 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr8_-_125580745 0.179 MTSS1
metastasis suppressor 1
chr10_-_103874661 0.179 NM_003893
LDB1
LIM domain binding 1
chr6_+_13924676 0.179 NM_001165034
RNF182
ring finger protein 182
chr10_-_62332666 0.179 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr10_+_111985628 0.175 NM_005962
MXI1
MAX interactor 1
chr2_+_86668270 0.174 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr4_-_105416050 0.173 CXXC4
CXXC finger protein 4
chr15_-_59665053 0.173 MYO1E
myosin IE
chr11_-_115375065 0.173 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr20_-_18038520 0.173 NM_021220
OVOL2
ovo-like 2 (Drosophila)
chr17_-_34122547 0.173 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr1_+_153003677 0.172 NM_003125
SPRR1B
small proline-rich protein 1B
chr12_+_20848288 0.171 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr1_-_117210301 0.170 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr7_+_69064316 0.168 AUTS2
autism susceptibility candidate 2
chr5_+_121465214 0.168 NM_207317
ZNF474
zinc finger protein 474
chr1_+_62208091 0.168 NM_176877
INADL
InaD-like (Drosophila)
chr18_-_13915534 0.167 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr6_-_136847743 0.167 NM_001198614
NM_001198618
NM_001198619
MAP7


microtubule-associated protein 7


chrY_-_2655478 0.166 NM_003140
SRY
sex determining region Y
chr2_+_86668428 0.165 KDM3A
lysine (K)-specific demethylase 3A
chr1_+_66458389 0.165 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr14_-_61748510 0.164 NM_001017970
TMEM30B
transmembrane protein 30B
chr13_-_48987017 0.164 LPAR6
lysophosphatidic acid receptor 6
chr4_+_140587086 0.164 MGST2
microsomal glutathione S-transferase 2
chr7_+_39017608 0.162 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr4_-_90759446 0.161 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr6_-_136847609 0.161 MAP7
microtubule-associated protein 7
chr6_-_49604524 0.160 NM_000324
RHAG
Rh-associated glycoprotein
chr6_+_84562984 0.160 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr10_+_90424145 0.158 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr4_+_140586921 0.158 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chrX_-_31526414 0.154 NM_004014
DMD
dystrophin
chrX_-_138914384 0.152 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 5.57e-05 GO:0007275 multicellular organismal development
1.23 7.85e-05 GO:0032502 developmental process
1.17 4.92e-04 GO:0032501 multicellular organismal process
1.24 6.05e-04 GO:0048856 anatomical structure development
1.36 1.53e-03 GO:0007399 nervous system development
1.24 2.09e-03 GO:0048731 system development
1.27 7.62e-03 GO:0048869 cellular developmental process
1.27 1.46e-02 GO:0030154 cell differentiation
1.31 3.17e-02 GO:0009653 anatomical structure morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 3.82e-02 GO:0031224 intrinsic to membrane
1.12 4.16e-02 GO:0016021 integral to membrane

Nothing significant found in function category.