Motif ID: STAT2,4,6.p2

Z-value: 0.586


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT4chr2_-_192015934,
chr2_-_192016293,
chr2_-_192015706
-0.601.2e-01Click!
STAT2chr12_-_56753916-0.285.0e-01Click!
STAT6chr12_-_575051760.206.3e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_71502700 0.303 MAP1B
microtubule-associated protein 1B
chr11_-_133715368 0.251 NM_174927
SPATA19
spermatogenesis associated 19
chr3_-_112564789 0.201 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr9_-_89562103 0.181 NM_002048
GAS1
growth arrest-specific 1
chr4_+_41258895 0.170 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr4_+_41258909 0.166 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_-_31845818 0.163 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr4_+_41258941 0.158 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr14_+_24779356 0.151 NM_001164692
NM_019839
LTB4R2

leukotriene B4 receptor 2

chr2_-_38303265 0.138 CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr12_-_42877785 0.137 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr1_+_186798031 0.135 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr8_+_30601666 0.135 NM_005671
UBXN8
UBX domain protein 8
chr2_+_33701320 0.131 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_42877743 0.130 PRICKLE1
prickle homolog 1 (Drosophila)
chr5_+_57878901 0.129 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr5_-_138210992 0.124 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr4_+_55095263 0.123 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr15_+_33010174 0.120 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr3_+_14166552 0.118 TMEM43
transmembrane protein 43
chr11_-_102826433 0.116 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr3_+_14166543 0.115 TMEM43
transmembrane protein 43
chr3_+_14166582 0.113 TMEM43
transmembrane protein 43
chr5_-_138211054 0.113 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr1_-_153931077 0.110 CRTC2
CREB regulated transcription coactivator 2
chr3_+_14166439 0.110 NM_024334
TMEM43
transmembrane protein 43
chr21_+_26934440 0.109 MIR155HG
MIR155 host gene (non-protein coding)
chr11_+_130318457 0.108 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr19_+_57050299 0.103 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr3_+_14166632 0.101 TMEM43
transmembrane protein 43
chr8_+_32405727 0.100 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr16_+_2802634 0.099 SRRM2
serine/arginine repetitive matrix 2
chr2_+_27301434 0.099 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr11_-_86383653 0.099 NM_001161586
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr1_+_36690038 0.098 THRAP3
thyroid hormone receptor associated protein 3
chr9_+_127420690 0.094 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr16_+_2802656 0.091 SRRM2
serine/arginine repetitive matrix 2
chr16_+_2802605 0.089 SRRM2
serine/arginine repetitive matrix 2
chr16_+_2802683 0.087 SRRM2
serine/arginine repetitive matrix 2
chr8_-_120651019 0.087 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr4_+_30722445 0.087 PCDH7
protocadherin 7
chr1_+_155853546 0.086 SYT11
synaptotagmin XI
chr16_+_2802673 0.081 SRRM2
serine/arginine repetitive matrix 2
chr10_-_101841593 0.080 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr8_-_110661007 0.080 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr2_+_27301693 0.079 EMILIN1
elastin microfibril interfacer 1
chr2_-_220083699 0.078 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr9_-_117880411 0.078 NM_002160
TNC
tenascin C
chr6_+_43399488 0.078 NM_033450
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr10_-_90611675 0.076 NM_144590
ANKRD22
ankyrin repeat domain 22
chr17_+_68165660 0.076 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr7_-_134001502 0.076 SLC35B4
solute carrier family 35, member B4
chr17_-_1619473 0.076 MIR22HG
MIR22 host gene (non-protein coding)
chr2_-_38303307 0.075 NM_000104
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr9_-_130517552 0.075 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr16_+_2802708 0.074 SRRM2
serine/arginine repetitive matrix 2
chr7_-_97601654 0.074


chr16_+_27413482 0.074 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr2_-_74756823 0.073 AUP1
ancient ubiquitous protein 1
chr12_+_1929432 0.073 NM_001039029
NM_001163925
NM_001163926
LRTM2


leucine-rich repeats and transmembrane domains 2


chr2_-_145277568 0.073 ZEB2
zinc finger E-box binding homeobox 2
chr11_-_116663106 0.073 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr19_-_12997956 0.072 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr12_+_60083125 0.071 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr2_-_74756838 0.070 AUP1
ancient ubiquitous protein 1
chr7_+_80275634 0.070 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr14_+_78870092 0.070 NM_004796
NRXN3
neurexin 3
chr12_+_133656984 0.069 NM_003440
ZNF140
zinc finger protein 140
chr2_+_189157551 0.068 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr3_+_110790460 0.068 NM_001243286
NM_015480
PVRL3

poliovirus receptor-related 3

chrX_+_44703248 0.067 NM_022076
DUSP21
dual specificity phosphatase 21
chr7_-_134001749 0.066 NM_032826
SLC35B4
solute carrier family 35, member B4
chr1_-_184006828 0.066 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chrM_+_6138 0.066


chr5_-_149792370 0.064 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr2_-_74756755 0.063 AUP1
ancient ubiquitous protein 1
chr12_-_46384208 0.063 SCAF11
SR-related CTD-associated factor 11
chr5_+_33440801 0.063 NM_152295
TARS
threonyl-tRNA synthetase
chr6_+_31638727 0.063 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr5_+_131630065 0.063 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr7_-_150020661 0.062 NM_001164458
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr12_-_117537090 0.062 NM_001168325
NM_017899
TESC

tescalcin

chr2_-_166060552 0.062 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr2_-_74756824 0.061 AUP1
ancient ubiquitous protein 1
chr2_+_197504277 0.061 NM_001080539
CCDC150
coiled-coil domain containing 150
chr2_-_74756815 0.061 AUP1
ancient ubiquitous protein 1
chr2_-_167232464 0.059 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr1_+_32645322 0.059 NM_175852
TXLNA
taxilin alpha
chrX_+_99899388 0.059 SRPX2
sushi-repeat containing protein, X-linked 2
chr1_+_34632483 0.059 NM_032884
C1orf94
chromosome 1 open reading frame 94
chr8_+_75896707 0.059 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr19_-_49339913 0.058 NM_016246
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chrX_+_100663205 0.058 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr18_-_7117757 0.057 NM_005559
LAMA1
laminin, alpha 1
chr1_+_174844655 0.057 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chrX_+_135067573 0.057 NM_001177651
NM_001042537
NM_006359
SLC9A6


solute carrier family 9 (sodium/hydrogen exchanger), member 6


chr12_-_57146081 0.057 NM_000946
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr17_-_8274852 0.057 NM_213597
KRBA2
KRAB-A domain containing 2
chr17_-_26697224 0.056 VTN
vitronectin
chr9_+_131683173 0.056 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr18_-_56296188 0.056 NM_052947
ALPK2
alpha-kinase 2
chr2_-_31361591 0.055 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr19_-_12845539 0.055 C19orf43
chromosome 19 open reading frame 43
chr1_-_153930911 0.055 CRTC2
CREB regulated transcription coactivator 2
chr19_+_50192440 0.055 C19orf76
chromosome 19 open reading frame 76
chr19_+_50191920 0.055 NM_001101340
C19orf76
chromosome 19 open reading frame 76
chr2_+_172864803 0.054 NM_199227
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr17_-_27053119 0.054 NM_138463
TLCD1
TLC domain containing 1
chr2_-_178937472 0.054 NM_016953
PDE11A
phosphodiesterase 11A
chr11_+_65271145 0.054


chr12_-_110434028 0.054 GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chrX_+_119495939 0.053 NM_001142447
NM_012069
ATP1B4

ATPase, Na+/K+ transporting, beta 4 polypeptide

chr12_-_11214892 0.053 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr14_-_96000962 0.053 SNHG10
small nucleolar RNA host gene 10 (non-protein coding)
chr17_+_32582295 0.053 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr12_-_8380193 0.053 NM_018088
FAM90A1
family with sequence similarity 90, member A1
chr2_+_177016112 0.053 NM_014621
HOXD4
homeobox D4
chr19_+_55344130 0.053 NM_012314
KIR2DS4
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
chr12_-_93964636 0.053


chr16_-_28550227 0.052 NUPR1
nuclear protein, transcriptional regulator, 1
chr3_-_186079776 0.052 NM_001080744
NM_001080745
NM_001346
DGKG


diacylglycerol kinase, gamma 90kDa


chr6_+_155538096 0.052 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr14_-_100841656 0.052 WARS
tryptophanyl-tRNA synthetase
chr14_-_100841793 0.052 WARS
tryptophanyl-tRNA synthetase
chr15_+_71184781 0.052 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr9_+_103791030 0.052 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr7_-_14025826 0.051 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr22_-_36019363 0.051 NM_203377
MB
myoglobin
chr11_+_10326618 0.051 NM_001124
ADM
adrenomedullin
chr16_+_70207927 0.051 NM_173619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr1_+_90098643 0.051 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr2_+_166150340 0.051 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr17_-_53800074 0.051 NM_018286
TMEM100
transmembrane protein 100
chrX_+_135067634 0.051 SLC9A6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr1_-_54304107 0.051 NM_001168551
NM_018087
TMEM48

transmembrane protein 48

chr1_-_153931096 0.051 NM_181715
CRTC2
CREB regulated transcription coactivator 2
chr5_-_111092918 0.051 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr15_+_62682682 0.051 TLN2
talin 2
chr14_+_38678594 0.051 SSTR1
somatostatin receptor 1
chr9_+_131684561 0.050 NM_001100877
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr17_-_76356153 0.050 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr10_-_12085022 0.050 NM_080599
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr10_-_121356527 0.050 NM_001033925
NM_003252
TIAL1

TIA1 cytotoxic granule-associated RNA binding protein-like 1

chr5_-_55290601 0.050 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr14_+_32798478 0.050 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr9_-_110251308 0.050 KLF4
Kruppel-like factor 4 (gut)
chr8_+_36641841 0.050 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr22_+_20067732 0.050 NM_001190326
NM_022720
DGCR8

DiGeorge syndrome critical region gene 8

chrX_-_34150427 0.050 NM_203408
FAM47A
family with sequence similarity 47, member A
chr12_-_11150473 0.049 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr7_+_120629444 0.049 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chrX_+_152770083 0.049 BGN
biglycan
chr19_-_49339667 0.049 HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr16_+_69984625 0.049 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr1_-_54303933 0.049 TMEM48
transmembrane protein 48
chr11_+_6866882 0.048 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr2_+_177016337 0.048


chr4_+_41937105 0.048 NM_018126
TMEM33
transmembrane protein 33
chr8_+_77593522 0.048 ZFHX4
zinc finger homeobox 4
chr5_+_143550395 0.048 NM_020768
KCTD16
potassium channel tetramerisation domain containing 16
chr17_-_26697310 0.048 VTN
vitronectin
chr19_-_44439410 0.048 NM_003425
ZNF45
zinc finger protein 45
chr8_+_32579350 0.048 NM_001159996
NRG1
neuregulin 1
chr3_+_159706622 0.047 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr12_-_46662779 0.047 SLC38A1
solute carrier family 38, member 1
chrX_-_110039285 0.047 NM_001143981
NM_001143982
NM_001143983
CHRDL1


chordin-like 1


chr5_+_55062712 0.047 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr16_-_28550324 0.047 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr14_-_35344852 0.047 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr4_+_114214102 0.046 ANK2
ankyrin 2, neuronal
chrX_+_69509878 0.046 NM_012310
KIF4A
kinesin family member 4A
chr10_+_92631697 0.046 NM_001104546
NM_006413
RPP30

ribonuclease P/MRP 30kDa subunit

chr6_-_137113624 0.046 NM_005923
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr5_-_177423242 0.045 NM_006261
PROP1
PROP paired-like homeobox 1
chr8_+_77593506 0.045 NM_024721
ZFHX4
zinc finger homeobox 4
chr1_-_53163985 0.045 SELRC1
Sel1 repeat containing 1
chr9_-_110251754 0.045 KLF4
Kruppel-like factor 4 (gut)
chr1_-_53164014 0.045 SELRC1
Sel1 repeat containing 1
chr11_-_27681195 0.045 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr11_-_104893894 0.044 NM_001136109
NM_001136110
NM_001136112
NM_004347
CASP5



caspase 5, apoptosis-related cysteine peptidase



chr3_+_130612806 0.044 NM_001199179
NM_001001485
NM_001199183
NM_001199184
NM_001199185
NM_014382
NM_001001486
NM_001001487
ATP2C1







ATPase, Ca++ transporting, type 2C, member 1







chr1_+_26737306 0.044 LIN28A
lin-28 homolog A (C. elegans)
chr12_-_122985396 0.044 ZCCHC8
zinc finger, CCHC domain containing 8
chr13_+_115079943 0.044 NM_001164144
NM_001164145
NM_032436
CHAMP1


chromosome alignment maintaining phosphoprotein 1


chr19_+_57791281 0.044 ZNF460
zinc finger protein 460
chr8_+_124084936 0.043 WDR67
WD repeat domain 67
chr12_+_133657478 0.043 ZNF140
zinc finger protein 140
chr2_+_17935379 0.043 NM_001130009
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr12_-_11286842 0.043 NM_001097643
TAS2R30
taste receptor, type 2, member 30
chr2_-_74756973 0.043 NM_181575
AUP1
ancient ubiquitous protein 1
chr3_+_154797644 0.043 NM_007287
MME
membrane metallo-endopeptidase
chr1_+_63833324 0.043 ALG6
asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
chr9_-_86571652 0.043 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr11_+_118754474 0.043 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr19_-_49250023 0.043 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr5_-_149792276 0.043 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr5_+_55149149 0.043 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr15_-_50411405 0.043 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr19_+_11200124 0.043 LDLR
low density lipoprotein receptor
chr1_+_63833260 0.042 NM_013339
ALG6
asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.87e-04 GO:0009987 cellular process
1.33 8.78e-03 GO:0007399 nervous system development
1.63 9.77e-03 GO:0048812 neuron projection morphogenesis
1.64 1.32e-02 GO:0007409 axonogenesis
1.57 1.70e-02 GO:0032990 cell part morphogenesis
1.57 2.07e-02 GO:0048858 cell projection morphogenesis
1.42 2.93e-02 GO:0040011 locomotion
1.60 3.00e-02 GO:0048667 cell morphogenesis involved in neuron differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 2.25e-04 GO:0012505 endomembrane system
1.80 4.52e-03 GO:0005635 nuclear envelope
1.78 9.11e-03 GO:0016323 basolateral plasma membrane
1.22 3.06e-02 GO:0044428 nuclear part
2.06 4.62e-02 GO:0030055 cell-substrate junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 3.93e-04 GO:0005515 protein binding
1.07 6.90e-04 GO:0005488 binding
2.35 1.35e-03 GO:0019955 cytokine binding
2.75 1.20e-02 GO:0004896 cytokine receptor activity