Motif ID: TBX4,5.p2

Z-value: 0.858


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX5chr12_-_114846191-0.373.7e-01Click!
TBX4chr17_+_59533806-0.186.7e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_95078713 0.566 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chrX_-_142723921 0.479 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr6_+_72596699 0.474 RIMS1
regulating synaptic membrane exocytosis 1
chr5_+_71403040 0.443 NM_005909
MAP1B
microtubule-associated protein 1B
chr12_-_91576579 0.429 DCN
decorin
chr1_+_38022514 0.427 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr7_-_150973819 0.401 NM_001003802
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_-_694842 0.399 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr15_-_93631751 0.389 NM_001166287
RGMA
RGM domain family, member A
chr12_-_91576805 0.387 NM_001920
DCN
decorin
chr6_+_132129195 0.357 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr6_+_31623668 0.337 NM_019101
APOM
apolipoprotein M
chr1_-_3528058 0.329 NM_001409
MEGF6
multiple EGF-like-domains 6
chr4_-_8160435 0.323 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr10_-_93392744 0.313 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr10_-_93392857 0.299 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr11_-_63381485 0.269 PLA2G16
phospholipase A2, group XVI
chr5_+_76248679 0.262 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr12_+_90103470 0.257 LOC338758
uncharacterized LOC338758
chr6_+_72596648 0.256 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_6756597 0.249 ACRBP
acrosin binding protein
chr12_+_90102639 0.248 LOC338758
uncharacterized LOC338758
chr11_-_63381840 0.247 PLA2G16
phospholipase A2, group XVI
chr2_+_128176019 0.243 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr11_-_695010 0.235 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr6_+_132129154 0.234 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr1_+_90024271 0.232 NM_015350
LRRC8B
leucine rich repeat containing 8 family, member B
chr12_+_56075329 0.232 NM_152637
METTL7B
methyltransferase like 7B
chr11_-_695069 0.229 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr6_+_31623688 0.226 APOM
apolipoprotein M
chr3_-_49726081 0.216 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr10_+_31608097 0.214 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr2_-_175869910 0.211 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr1_+_45274153 0.211 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr22_+_27053392 0.206 MIAT
myocardial infarction associated transcript (non-protein coding)
chr12_+_7169192 0.204


chr7_+_70597788 0.203 NM_022479
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr21_+_38445562 0.199 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr19_+_46367517 0.197 NM_004497
FOXA3
forkhead box A3
chr9_-_73736513 0.196 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr9_-_123837410 0.190 C5
complement component 5
chr8_-_22550057 0.189 NM_001199881
EGR3
early growth response 3
chr1_-_201915715 0.188 NM_012134
LMOD1
leiomodin 1 (smooth muscle)
chr3_+_169755733 0.187 NM_014373
GPR160
G protein-coupled receptor 160
chr19_-_11565612 0.184


chr8_-_124553253 0.183 FBXO32
F-box protein 32
chr6_+_84222252 0.181 PRSS35
protease, serine, 35
chr3_+_169755782 0.178 GPR160
G protein-coupled receptor 160
chr1_-_201915467 0.177 LMOD1
leiomodin 1 (smooth muscle)
chr10_+_70320044 0.176 NM_030625
TET1
tet methylcytosine dioxygenase 1
chr2_+_71295685 0.176 NAGK
N-acetylglucosamine kinase
chr6_+_124125068 0.175 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr13_+_31287614 0.175 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr11_+_66790815 0.175 NM_177963
SYT12
synaptotagmin XII
chr19_+_9435370 0.171 NM_001202425
ZNF559-ZNF177
ZNF559-ZNF177 readthrough
chr12_+_56661026 0.170 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr12_+_56075418 0.169 METTL7B
methyltransferase like 7B
chr8_-_124553448 0.168 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr3_+_12329332 0.168 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr20_+_33146500 0.165 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr6_-_13295817 0.164 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr21_+_37507209 0.164 NM_001236
CBR3
carbonyl reductase 3
chr11_-_118550354 0.163 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chr5_+_82767492 0.162 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr1_-_33168356 0.161 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr11_+_1889902 0.160 NM_001013253
LSP1
lymphocyte-specific protein 1
chr19_-_44405934 0.160 LOC100505715
uncharacterized LOC100505715
chr7_+_141463896 0.158 NM_016943
TAS2R3
taste receptor, type 2, member 3
chr5_-_66492574 0.157 NM_005582
CD180
CD180 molecule
chr8_-_22549901 0.155 NM_001199880
EGR3
early growth response 3
chr8_-_142377364 0.154 NM_005293
GPR20
G protein-coupled receptor 20
chr10_+_31607419 0.154 ZEB1
zinc finger E-box binding homeobox 1
chr2_-_133427624 0.153 LYPD1
LY6/PLAUR domain containing 1
chr20_+_13976014 0.152 NM_080676
MACROD2
MACRO domain containing 2
chr3_-_158390266 0.152 NM_020169
LXN
latexin
chr13_-_34250899 0.151 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr22_-_29075708 0.150 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr14_-_61115906 0.150 NM_005982
SIX1
SIX homeobox 1
chrX_+_149531439 0.146 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr12_+_51818592 0.144 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr12_+_131438451 0.144 NM_198827
GPR133
G protein-coupled receptor 133
chr12_+_79258794 0.144 SYT1
synaptotagmin I
chr11_+_118478305 0.141 NM_001144758
NM_001144759
PHLDB1

pleckstrin homology-like domain, family B, member 1

chr17_+_34431219 0.141 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr11_+_73358593 0.140 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr2_-_188419049 0.138 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_-_8279984 0.136 KRBA2
KRAB-A domain containing 2
chr11_+_2920910 0.136 NM_183233
SLC22A18
solute carrier family 22, member 18
chr12_+_53817638 0.135 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr12_-_58026612 0.135 B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr12_-_6579754 0.132 NM_014231
NM_016830
NM_199245
VAMP1


vesicle-associated membrane protein 1 (synaptobrevin 1)


chr3_+_52279742 0.132 NM_144641
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr6_+_35182182 0.129 NM_152753
SCUBE3
signal peptide, CUB domain, EGF-like 3
chr6_+_42928464 0.128 NM_018960
GNMT
glycine N-methyltransferase
chr17_+_42299282 0.126


chr10_+_135160843 0.125 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr17_-_61950997 0.125 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr2_+_27799388 0.124 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr19_+_35521591 0.123 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr12_+_56109832 0.123 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 readthrough
biogenesis of lysosomal organelles complex-1, subunit 1
chr5_+_139027955 0.122 CXXC5
CXXC finger protein 5
chr4_-_8073711 0.122 ABLIM2
actin binding LIM protein family, member 2
chr4_+_671710 0.122 NM_002477
MYL5
myosin, light chain 5, regulatory
chr7_+_44788453 0.121 NM_031449
ZMIZ2
zinc finger, MIZ-type containing 2
chr16_+_28889808 0.121 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr7_+_80231503 0.120 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr4_-_186733372 0.120 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr15_-_90294359 0.120 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr9_-_20622476 0.119 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_+_43638000 0.118 NM_001167965
NM_001195831
NM_152498
WDR65


WD repeat domain 65


chr7_-_1499107 0.117 NM_182924
MICALL2
MICAL-like 2
chr7_+_29234111 0.117 NM_004067
CHN2
chimerin (chimaerin) 2
chr12_+_51818669 0.116 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr1_+_159141376 0.116 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chrX_+_153672449 0.116 NM_004699
FAM50A
family with sequence similarity 50, member A
chr15_-_93632161 0.116 NM_020211
RGMA
RGM domain family, member A
chr17_-_45973142 0.115


chr12_+_1738411 0.115 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr9_+_36036900 0.115 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr11_+_65779461 0.114 NM_001323
CST6
cystatin E/M
chr4_+_81118639 0.113 NM_001099403
PRDM8
PR domain containing 8
chr15_-_77197743 0.113 SCAPER
S-phase cyclin A-associated protein in the ER
chr2_-_188419185 0.113 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr14_+_51026853 0.113 ATL1
atlastin GTPase 1
chr2_-_56150862 0.112 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr5_+_42549657 0.111 NM_001242404
GHR
growth hormone receptor
chr17_+_180995 0.111 NM_001242780
LOC100506388
uncharacterized LOC100506388
chr17_+_58755158 0.110 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr2_+_121103670 0.110 NM_002193
INHBB
inhibin, beta B
chr20_+_62492565 0.110 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr18_+_47340328 0.110


chr11_+_1886394 0.109 NM_001242932
LSP1
lymphocyte-specific protein 1
chrX_+_153672490 0.109 FAM50A
family with sequence similarity 50, member A
chr17_-_15165860 0.109 PMP22
peripheral myelin protein 22
chr17_-_15165873 0.108 NM_153321
PMP22
peripheral myelin protein 22
chr19_+_49838673 0.108 NM_001040031
NM_001774
CD37

CD37 molecule

chr19_-_58220535 0.107 NM_001085384
ZNF154
zinc finger protein 154
chr17_-_15165800 0.107 PMP22
peripheral myelin protein 22
chr10_-_81205091 0.106 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr2_+_219536719 0.106 NM_001243313
NM_015690
STK36

serine/threonine kinase 36

chr3_+_138067969 0.106 NM_001252090
MRAS
muscle RAS oncogene homolog
chr5_+_140571903 0.106 NM_018930
PCDHB10
protocadherin beta 10
chr10_+_135192694 0.105 NM_152911
NM_207127
NM_207128
PAOX


polyamine oxidase (exo-N4-amino)


chr11_+_67776016 0.105 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr3_+_134514300 0.104 EPHB1
EPH receptor B1
chr6_+_84743250 0.103 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr6_-_38607635 0.103 BTBD9
BTB (POZ) domain containing 9
chr6_+_31543340 0.103 NM_000594
TNF
tumor necrosis factor
chr2_-_145090038 0.103 NM_001164629
GTDC1
glycosyltransferase-like domain containing 1
chr7_-_150974179 0.102 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr15_+_83776323 0.102 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr11_-_104034685 0.101 PDGFD
platelet derived growth factor D
chr1_-_177939347 0.101 SEC16B
SEC16 homolog B (S. cerevisiae)
chr19_+_49838646 0.101 CD37
CD37 molecule
chr10_-_25012168 0.100 ARHGAP21
Rho GTPase activating protein 21
chr12_+_54378929 0.100 NM_017409
HOXC10
homeobox C10
chr2_+_169921298 0.100 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_+_140718353 0.100 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr19_+_49838734 0.100 CD37
CD37 molecule
chr1_-_26232890 0.099 NM_001145454
NM_005563
STMN1

stathmin 1

chr2_-_230135954 0.099 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr17_+_39968961 0.098 NM_021939
FKBP10
FK506 binding protein 10, 65 kDa
chr1_+_192778168 0.098 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr3_+_138067444 0.098 NM_001085049
NM_001252093
MRAS

muscle RAS oncogene homolog

chr17_+_67410825 0.098 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr4_-_159092509 0.097 FAM198B
family with sequence similarity 198, member B
chr2_-_145090028 0.097 GTDC1
glycosyltransferase-like domain containing 1
chr12_-_63328663 0.097 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_+_51318743 0.097 METTL7A
methyltransferase like 7A
chr1_-_241520467 0.096 NM_002924
RGS7
regulator of G-protein signaling 7
chr9_-_20622433 0.096 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_+_178062955 0.096 RASAL2
RAS protein activator like 2
chr19_-_36247917 0.095 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr12_+_65672682 0.095 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr12_-_96184510 0.095 NM_021229
NTN4
netrin 4
chr22_+_50528307 0.095 NM_001164104
NM_018995
MOV10L1

Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)

chr19_-_58238895 0.094 NM_024833
ZNF671
zinc finger protein 671
chr6_+_35181721 0.093 SCUBE3
signal peptide, CUB domain, EGF-like 3
chr14_+_51026742 0.093 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr2_+_30369749 0.092 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr12_+_65672422 0.091 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr3_-_48594209 0.091 NM_004567
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr5_-_1445510 0.091 NM_001044
SLC6A3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
chr17_+_4675175 0.091 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr2_+_113672769 0.091 NM_173205
IL37
interleukin 37
chr9_-_95186559 0.091 NM_005014
OMD
osteomodulin
chr15_+_79575145 0.091 NM_001146341
ANKRD34C
ankyrin repeat domain 34C
chr16_+_85646923 0.091 NM_014615
KIAA0182
KIAA0182
chrX_+_102470003 0.091 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr22_-_32341298 0.090 NM_015372
C22orf24
chromosome 22 open reading frame 24
chr7_-_1498961 0.090 MICALL2
MICAL-like 2
chr12_+_79257772 0.090 NM_001135805
SYT1
synaptotagmin I
chr17_+_19281726 0.090 NM_002749
NM_139034
MAPK7

mitogen-activated protein kinase 7

chr17_-_8059637 0.089 PER1
period homolog 1 (Drosophila)
chr6_-_27440459 0.088 NM_007149
ZNF184
zinc finger protein 184
chr2_+_30369800 0.088 YPEL5
yippee-like 5 (Drosophila)
chr3_-_8811263 0.088 NM_000916
OXTR
oxytocin receptor
chr13_+_93879011 0.088 NM_005708
GPC6
glypican 6
chr7_-_150675236 0.088 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr10_-_13544944 0.087 NM_001100912
NM_152751
BEND7

BEN domain containing 7


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.97 4.89e-03 GO:0007507 heart development
2.53 7.19e-03 GO:0003007 heart morphogenesis
1.86 9.97e-03 GO:0061061 muscle structure development
2.97 1.45e-02 GO:0048738 cardiac muscle tissue development
2.20 2.88e-02 GO:0060537 muscle tissue development
2.26 2.99e-02 GO:0014706 striated muscle tissue development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.30 2.17e-02 GO:0005242 inward rectifier potassium channel activity