Motif ID: TCF4_dimer.p2

Z-value: 2.149


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_532570330.393.4e-01Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_39382878 2.726 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr9_-_97401588 2.019 FBP1
fructose-1,6-bisphosphatase 1
chr15_+_74218962 1.997 LOXL1
lysyl oxidase-like 1
chr11_-_694842 1.766 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr6_+_124125068 1.609 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr11_-_63933493 1.475 NM_014067
MACROD1
MACRO domain containing 1
chrX_-_107018889 1.328 TSC22D3
TSC22 domain family, member 3
chr1_+_89990396 1.297 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chr9_-_97401746 1.294 FBP1
fructose-1,6-bisphosphatase 1
chr15_+_74218786 1.282 NM_005576
LOXL1
lysyl oxidase-like 1
chr15_+_74218794 1.259 LOXL1
lysyl oxidase-like 1
chr9_-_97401833 1.160 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr10_-_21462987 1.137 NEBL
nebulette
chr9_-_131940538 1.127 NM_203434
IER5L
immediate early response 5-like
chr11_-_63933204 1.115 MACROD1
MACRO domain containing 1
chr3_-_87040246 1.107 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr3_-_178789535 1.100 ZMAT3
zinc finger, matrin-type 3
chr16_-_28550324 1.087 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr3_-_178789597 1.078 NM_022470
NM_152240
ZMAT3

zinc finger, matrin-type 3

chr21_+_27011588 1.072 NM_021219
JAM2
junctional adhesion molecule 2
chr11_-_695010 1.067 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr5_+_176237435 1.065 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr17_+_39394269 1.042 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr19_-_18391440 1.024


chr8_+_72756218 0.985 LOC100132891
uncharacterized LOC100132891
chr6_-_139695349 0.984 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr8_+_72756335 0.968


chr10_-_21463019 0.965 NM_001173484
NM_213569
NEBL

nebulette

chr14_-_34419957 0.960 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr11_+_65779461 0.918 NM_001323
CST6
cystatin E/M
chr17_-_53800074 0.904 NM_018286
TMEM100
transmembrane protein 100
chr4_+_41258941 0.903 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr8_+_37654833 0.902 GPR124
G protein-coupled receptor 124
chr1_-_144931707 0.898 PDE4DIP
phosphodiesterase 4D interacting protein
chr11_-_695069 0.894 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr10_+_111967302 0.890 NM_130439
MXI1
MAX interactor 1
chrX_-_107019001 0.878 NM_198057
TSC22D3
TSC22 domain family, member 3
chr17_-_21156577 0.878 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr1_-_3528058 0.873 NM_001409
MEGF6
multiple EGF-like-domains 6
chr9_-_35689799 0.861 TPM2
tropomyosin 2 (beta)
chr16_-_28550227 0.854 NUPR1
nuclear protein, transcriptional regulator, 1
chr9_+_133320093 0.849 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr17_+_39261640 0.844 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr9_-_131940481 0.830 IER5L
immediate early response 5-like
chr4_+_134073180 0.802 PCDH10
protocadherin 10
chr1_-_23885916 0.795 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr8_-_93029864 0.793 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_-_71959109 0.789 NM_001190807
NM_001914
NM_148923
CYB5A


cytochrome b5 type A (microsomal)


chr6_-_46459010 0.784 NM_001251974
RCAN2
regulator of calcineurin 2
chr6_-_46293404 0.784 RCAN2
regulator of calcineurin 2
chr9_-_35689902 0.773 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr17_-_19648771 0.773 NM_001135168
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_19648924 0.766 NM_001135167
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr18_-_52626636 0.763 NM_025214
CCDC68
coiled-coil domain containing 68
chr1_-_32707198 0.750 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr5_+_169532900 0.749 NM_012188
NM_144769
FOXI1

forkhead box I1

chr20_+_43029973 0.747 HNF4A
hepatocyte nuclear factor 4, alpha
chr4_+_113970784 0.743 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr17_+_40811261 0.741 NM_016437
TUBG2
tubulin, gamma 2
chrX_-_135863502 0.714 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_-_57522469 0.709 NM_001145459
NM_139211
HOPX

HOP homeobox

chr4_-_41216455 0.695 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr11_-_2018703 0.694 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr9_+_17578952 0.691 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chrX_-_154114431 0.691 NM_019863
F8
coagulation factor VIII, procoagulant component
chr11_-_2018334 0.685 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr6_+_72892371 0.675 RIMS1
regulating synaptic membrane exocytosis 1
chr11_-_2018446 0.675 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr6_-_88854989 0.674 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr15_+_74218811 0.674 LOXL1
lysyl oxidase-like 1
chr21_+_30517897 0.670 C21orf7
chromosome 21 open reading frame 7
chr8_+_104383701 0.661 CTHRC1
collagen triple helix repeat containing 1
chr1_-_33168356 0.660 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr11_-_2018568 0.652 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr6_-_139695784 0.651 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr17_+_38230678 0.649 THRA
thyroid hormone receptor, alpha
chr11_-_2019007 0.648 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr15_-_40545109 0.646 NM_001039905
C15orf56
chromosome 15 open reading frame 56
chr1_-_27339326 0.645 NM_052943
FAM46B
family with sequence similarity 46, member B
chr11_+_113930430 0.644 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr16_+_4385141 0.635 GLIS2
GLIS family zinc finger 2
chr2_-_27294491 0.630 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr3_-_18480203 0.629 NM_001131010
SATB1
SATB homeobox 1
chr6_-_139695739 0.622 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr1_+_145562305 0.622 ANKRD35
ankyrin repeat domain 35
chr6_-_88875766 0.622 NM_001160226
NM_001160258
NM_001160259
NM_016083
CNR1



cannabinoid receptor 1 (brain)



chr8_+_104383785 0.615 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr7_+_94023872 0.612 NM_000089
COL1A2
collagen, type I, alpha 2
chr9_+_90112754 0.606 NM_004938
DAPK1
death-associated protein kinase 1
chr10_-_103347882 0.597 POLL
polymerase (DNA directed), lambda
chr17_-_66596736 0.592 FAM20A
family with sequence similarity 20, member A
chr8_-_72756384 0.591 MSC
musculin
chr10_+_31607419 0.589 ZEB1
zinc finger E-box binding homeobox 1
chr10_+_99258615 0.587 NM_024954
UBTD1
ubiquitin domain containing 1
chr16_-_30107492 0.587 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr3_-_195310770 0.581 APOD
apolipoprotein D
chr17_-_8702438 0.579 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr4_-_175443601 0.578 HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr1_+_6094342 0.571 NM_001199860
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr10_-_28591844 0.569 MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr6_+_36646489 0.565 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr7_+_94024201 0.563 COL1A2
collagen, type I, alpha 2
chr7_+_12726910 0.561 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr5_+_156693051 0.561 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr8_+_17433941 0.558 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr1_-_108507474 0.556 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr4_-_100242487 0.552 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr19_-_12886263 0.551 HOOK2
hook homolog 2 (Drosophila)
chr5_+_76248679 0.551 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr4_-_186733372 0.548 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr3_-_195310985 0.547 NM_001647
APOD
apolipoprotein D
chr14_+_105781180 0.545 PACS2
phosphofurin acidic cluster sorting protein 2
chr4_-_140005344 0.544 ELF2
E74-like factor 2 (ets domain transcription factor)
chr11_+_113931228 0.536 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr6_-_35696359 0.530 NM_001145775
FKBP5
FK506 binding protein 5
chr16_+_1031807 0.527 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chrX_+_9754465 0.524 NM_001649
SHROOM2
shroom family member 2
chr11_+_1886394 0.524 NM_001242932
LSP1
lymphocyte-specific protein 1
chr5_-_176936834 0.521 DOK3
docking protein 3
chr16_+_1032063 0.521 SOX8
SRY (sex determining region Y)-box 8
chr17_-_53809444 0.520 NM_001099640
TMEM100
transmembrane protein 100
chr17_+_1665233 0.519 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_31608097 0.518 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr6_+_72596699 0.515 RIMS1
regulating synaptic membrane exocytosis 1
chr19_+_6135650 0.513 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr12_-_33049664 0.512 NM_001005242
NM_004572
PKP2

plakophilin 2

chr5_-_176936857 0.512 NM_024872
DOK3
docking protein 3
chr8_+_37654406 0.510 GPR124
G protein-coupled receptor 124
chr6_-_53530505 0.508 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr14_+_105190533 0.507 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr19_+_18668571 0.506 NM_001171948
NM_001171949
NM_024069
KXD1


KxDL motif containing 1


chr16_+_85646923 0.506 NM_014615
KIAA0182
KIAA0182
chr17_+_1665281 0.503 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_111789600 0.493 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr5_+_95066628 0.493 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr12_-_91505215 0.491 LUM
lumican
chr20_-_44485953 0.487 NM_005469
ACOT8
acyl-CoA thioesterase 8
chrX_-_13956530 0.486 GPM6B
glycoprotein M6B
chr16_-_4987056 0.485 NM_002705
PPL
periplakin
chr5_+_148520985 0.484 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr17_+_1665306 0.483 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr5_+_126626455 0.481 NM_032446
MEGF10
multiple EGF-like-domains 10
chr2_-_220436267 0.479 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr3_-_99833348 0.478 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr5_+_139028483 0.478 CXXC5
CXXC finger protein 5
chr5_+_139027868 0.477 CXXC5
CXXC finger protein 5
chr2_-_80530943 0.475 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr12_-_91505541 0.474 NM_002345
LUM
lumican
chr20_-_34025955 0.472 NM_000557
GDF5
growth differentiation factor 5
chr17_+_7452374 0.469 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr19_+_36359346 0.468 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr1_+_53527822 0.467 NM_001199081
PODN
podocan
chr2_+_210288668 0.466 NM_001039538
MAP2
microtubule-associated protein 2
chr9_+_34990715 0.466 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr5_+_139027955 0.460 CXXC5
CXXC finger protein 5
chr2_-_220436010 0.460 OBSL1
obscurin-like 1
chr3_+_49059490 0.457 NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr13_-_70682458 0.456 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chrX_+_16964730 0.454 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr6_+_132891460 0.453 NM_175067
TAAR6
trace amine associated receptor 6
chr5_+_32711729 0.452 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr17_+_40440481 0.451 STAT5A
signal transducer and activator of transcription 5A
chr13_+_28194846 0.451 NM_001206559
POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr5_+_139028025 0.451 NM_016463
CXXC5
CXXC finger protein 5
chr12_-_52914080 0.451 NM_000424
KRT5
keratin 5
chr4_+_114214102 0.450 ANK2
ankyrin 2, neuronal
chr3_+_49059046 0.450 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr10_-_103347978 0.446 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr12_-_124457099 0.446 NM_025140
CCDC92
coiled-coil domain containing 92
chr11_+_111789658 0.444 C11orf52
chromosome 11 open reading frame 52
chr11_-_111957417 0.444 NM_012459
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr8_+_22436641 0.443 PDLIM2
PDZ and LIM domain 2 (mystique)
chr3_+_184056304 0.442 FAM131A
family with sequence similarity 131, member A
chr5_+_145718586 0.440 NM_002700
POU4F3
POU class 4 homeobox 3
chr3_-_49459870 0.440 AMT
aminomethyltransferase
chr2_-_211179765 0.440 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr13_-_114018201 0.439 GRTP1
growth hormone regulated TBC protein 1
chr13_+_78271820 0.436 NM_001242868
SLAIN1
SLAIN motif family, member 1
chr5_+_139027907 0.435 CXXC5
CXXC finger protein 5
chr3_-_165555167 0.435 BCHE
butyrylcholinesterase
chrX_+_102470003 0.434 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr14_+_105780903 0.433 PACS2
phosphofurin acidic cluster sorting protein 2
chr10_+_103348040 0.433 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr11_-_35547144 0.428 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr17_-_42345434 0.428 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr11_+_73358593 0.427 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr7_-_122526410 0.426 CADPS2
Ca++-dependent secretion activator 2
chr17_+_67410825 0.426 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr15_-_80216004 0.426 ST20
suppressor of tumorigenicity 20
chr9_+_36136710 0.424 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr12_-_108733075 0.423 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr16_-_89043215 0.422 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr3_-_187463227 0.422 BCL6
B-cell CLL/lymphoma 6
chr11_+_66790189 0.422 NM_001177880
SYT12
synaptotagmin XII
chr19_-_14316980 0.420 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr2_-_219925237 0.418 NM_002181
IHH
Indian hedgehog
chrX_-_13956445 0.417


chr16_+_21695749 0.415 NM_001161683
OTOA
otoancorin
chr19_+_56158953 0.413 NM_013301
CCDC106
coiled-coil domain containing 106
chr6_+_42928464 0.412 NM_018960
GNMT
glycine N-methyltransferase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 6.33e-05 GO:0050794 regulation of cellular process
1.08 3.51e-04 GO:0065007 biological regulation
1.05 4.64e-04 GO:0009987 cellular process
1.25 5.31e-04 GO:0035556 intracellular signal transduction
1.08 5.64e-04 GO:0050789 regulation of biological process
1.19 6.04e-04 GO:0048523 negative regulation of cellular process
1.22 6.12e-04 GO:0023051 regulation of signaling
1.24 1.04e-03 GO:0009966 regulation of signal transduction
1.18 1.07e-03 GO:0048519 negative regulation of biological process
2.31 1.83e-03 GO:0032313 regulation of Rab GTPase activity
2.31 1.83e-03 GO:0032483 regulation of Rab protein signal transduction
1.51 3.91e-03 GO:0031329 regulation of cellular catabolic process
1.12 4.06e-03 GO:0051716 cellular response to stimulus
1.47 7.84e-03 GO:0009894 regulation of catabolic process
1.14 1.27e-02 GO:0048731 system development
1.18 2.02e-02 GO:0048583 regulation of response to stimulus
1.14 2.14e-02 GO:0048518 positive regulation of biological process
1.12 2.53e-02 GO:0080090 regulation of primary metabolic process
1.15 2.79e-02 GO:0048522 positive regulation of cellular process
1.12 3.55e-02 GO:0007165 signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 1.08e-13 GO:0005737 cytoplasm
1.08 1.98e-13 GO:0005622 intracellular
1.07 6.51e-12 GO:0044424 intracellular part
1.10 1.58e-05 GO:0044444 cytoplasmic part
1.20 3.53e-05 GO:0005829 cytosol
1.39 1.54e-03 GO:0031966 mitochondrial membrane
1.36 6.00e-03 GO:0005740 mitochondrial envelope
1.40 1.50e-02 GO:0019866 organelle inner membrane
1.05 2.11e-02 GO:0043229 intracellular organelle
1.41 2.12e-02 GO:0005743 mitochondrial inner membrane
1.05 2.49e-02 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 2.33e-12 GO:0005515 protein binding
1.05 2.65e-06 GO:0005488 binding
2.27 8.73e-04 GO:0005097 Rab GTPase activator activity
1.24 9.15e-03 GO:0030528 transcription regulator activity