Motif ID: TFAP2{A,C}.p2

Z-value: 0.784


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10412606,
chr6_-_10415438
0.714.9e-02Click!
TFAP2Cchr20_+_552043070.294.9e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_152953751 0.834 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr7_-_44365019 0.807 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr16_+_22825806 0.770 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_68679198 0.767 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr22_+_45098091 0.666 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr2_+_18059923 0.611 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr16_+_68679229 0.588 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr9_-_140196702 0.504 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr8_+_86376130 0.504 NM_000067
CA2
carbonic anhydrase II
chr8_+_61591358 0.487 CHD7
chromodomain helicase DNA binding protein 7
chr8_+_104512975 0.485 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr6_-_4079390 0.476 NM_173563
C6orf146
chromosome 6 open reading frame 146
chr17_+_9548853 0.461 NM_153210
USP43
ubiquitin specific peptidase 43
chr18_-_74207145 0.445 NM_014643
ZNF516
zinc finger protein 516
chr18_+_33877630 0.441 NM_025135
FHOD3
formin homology 2 domain containing 3
chr1_+_233463513 0.428 NM_032435
KIAA1804
mixed lineage kinase 4
chr2_+_85360373 0.427 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr8_-_127570710 0.403 NM_174911
FAM84B
family with sequence similarity 84, member B
chr22_+_45098046 0.400 NM_181333
PRR5
proline rich 5 (renal)
chr22_+_40390935 0.395 NM_138435
FAM83F
family with sequence similarity 83, member F
chr2_-_165477818 0.392 GRB14
growth factor receptor-bound protein 14
chr13_+_37005966 0.385 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr1_+_117452359 0.384 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr16_-_68269948 0.377 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr3_+_50192847 0.374 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr12_+_104850762 0.371 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr11_+_10472223 0.360 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr17_-_7197896 0.352 YBX2
Y box binding protein 2
chr6_+_36098261 0.349 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr2_-_165477986 0.348 GRB14
growth factor receptor-bound protein 14
chr17_-_7197811 0.337 YBX2
Y box binding protein 2
chr17_-_7197866 0.333 NM_015982
YBX2
Y box binding protein 2
chr7_-_139876718 0.331 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr1_-_6321034 0.330 NM_207370
GPR153
G protein-coupled receptor 153
chr1_-_32801606 0.327 NM_023009
MARCKSL1
MARCKS-like 1
chr12_+_104850750 0.326 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_+_122459791 0.326 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr1_+_109792640 0.325 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr12_+_104850784 0.323 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr8_-_80679897 0.323 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr7_+_150783771 0.322 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr8_-_127570465 0.322 FAM84B
family with sequence similarity 84, member B
chr20_+_1875825 0.321 NM_001040023
SIRPA
signal-regulatory protein alpha
chr4_+_79472851 0.321 ANXA3
annexin A3
chr17_+_8924822 0.320 NM_004822
NTN1
netrin 1
chr13_-_95364248 0.316 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr9_-_124990949 0.316 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr10_+_82214071 0.313 TSPAN14
tetraspanin 14
chr6_+_41606193 0.307 NM_005586
MDFI
MyoD family inhibitor
chr9_-_124990706 0.307 NM_001242333
LHX6
LIM homeobox 6
chr16_+_22825481 0.307 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr12_+_70759974 0.305 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr18_-_48723689 0.305 MEX3C
mex-3 homolog C (C. elegans)
chr20_-_46414636 0.303 NM_018837
SULF2
sulfatase 2
chr12_+_133067156 0.299 NM_001142641
FBRSL1
fibrosin-like 1
chr1_+_234040547 0.298 NM_173508
SLC35F3
solute carrier family 35, member F3
chr20_+_6748744 0.296 NM_001200
BMP2
bone morphogenetic protein 2
chr5_+_140346053 0.296 PCDHAC2
protocadherin alpha subfamily C, 2
chr19_-_38746978 0.293 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_95582827 0.293 NM_152487
TMEM56
transmembrane protein 56
chr18_+_21452981 0.289 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr6_+_43139201 0.289 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr8_+_28351694 0.287 NM_017412
NM_145866
FZD3

frizzled family receptor 3

chr16_-_402617 0.285 NM_003502
NM_181050
AXIN1

axin 1

chr17_+_54671059 0.285 NM_005450
NOG
noggin
chr22_-_46933066 0.283 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr7_-_994008 0.282 ADAP1
ArfGAP with dual PH domains 1
chr8_-_48650683 0.281 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr3_-_195635879 0.280 NM_005781
TNK2
tyrosine kinase, non-receptor, 2
chr10_+_82214074 0.279 TSPAN14
tetraspanin 14
chr16_-_85784628 0.279 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr2_+_173292344 0.279 ITGA6
integrin, alpha 6
chr14_-_21566497 0.278 ZNF219
zinc finger protein 219
chr18_-_28681885 0.278 NM_004949
NM_024422
DSC2

desmocollin 2

chr9_-_112260529 0.277 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr15_+_41136178 0.275 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr6_+_43738757 0.274 VEGFA
vascular endothelial growth factor A
chr2_+_173292306 0.268 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr1_-_19282773 0.268 NM_001136265
IFFO2
intermediate filament family orphan 2
chr2_-_235405692 0.266 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr6_+_157099873 0.264 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr1_+_205473768 0.264 CDK18
cyclin-dependent kinase 18
chr19_+_45312294 0.263 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr14_+_65171243 0.261 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr10_-_118501981 0.260 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr12_+_104850986 0.260 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr3_+_51428720 0.259 RBM15B
RNA binding motif protein 15B
chr11_+_58939539 0.258 NM_015177
DTX4
deltex homolog 4 (Drosophila)
chr4_+_1795004 0.258 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr21_+_18885296 0.258 CXADR
coxsackie virus and adenovirus receptor
chr12_+_104850641 0.255 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr10_+_82213892 0.255 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr9_+_101569933 0.254 NM_024642
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
chr10_-_123357503 0.252 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr3_-_38691118 0.252 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr5_+_140346289 0.251 NM_031883
PCDHAC2
protocadherin alpha subfamily C, 2
chr20_+_20348744 0.249 NM_002196
INSM1
insulinoma-associated 1
chr17_-_73874634 0.248 NM_033452
TRIM47
tripartite motif containing 47
chr2_+_47596286 0.246 NM_002354
EPCAM
epithelial cell adhesion molecule
chr6_+_7541892 0.245 DSP
desmoplakin
chr8_+_56792392 0.245 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr19_-_49865638 0.243 NM_003598
TEAD2
TEA domain family member 2
chr1_-_27286875 0.243 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr10_+_23728197 0.240 NM_001145373
OTUD1
OTU domain containing 1
chr4_-_25864430 0.240 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr3_+_113666544 0.240 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr1_-_154531083 0.239 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr7_+_26191732 0.238 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr9_-_96717544 0.238 NM_021570
BARX1
BARX homeobox 1
chr17_-_41623652 0.237 NM_001079675
ETV4
ets variant 4
chr9_+_116638544 0.237 NM_133374
ZNF618
zinc finger protein 618
chr11_+_69924407 0.236 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr12_-_12715244 0.236 NM_030640
DUSP16
dual specificity phosphatase 16
chr10_+_82168206 0.235 NM_001243780
NM_001243781
NM_032333
C10orf58


chromosome 10 open reading frame 58


chr6_-_99797530 0.235 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr3_-_185542807 0.234 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr13_+_25946084 0.234 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr10_+_82214066 0.233 TSPAN14
tetraspanin 14
chr16_+_81478774 0.233 NM_198390
CMIP
c-Maf inducing protein
chr1_-_6545521 0.233 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_33430285 0.233 NM_001127361
NM_153341
RNF19B

ring finger protein 19B

chr12_-_31477080 0.233 FAM60A
family with sequence similarity 60, member A
chr15_+_81293286 0.228 NM_022566
MESDC1
mesoderm development candidate 1
chr14_-_105634708 0.228 JAG2
jagged 2
chr17_-_73874056 0.228 TRIM47
tripartite motif containing 47
chr1_+_160370363 0.227 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr6_+_43738177 0.225 VEGFA
vascular endothelial growth factor A
chr1_+_183155393 0.225 LAMC2
laminin, gamma 2
chr14_+_105886253 0.224 MTA1
metastasis associated 1
chr13_+_37006408 0.224 NM_001111045
NM_003914
CCNA1

cyclin A1

chr20_+_1874779 0.221 NM_001040022
SIRPA
signal-regulatory protein alpha
chr15_+_68871285 0.221 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr8_-_144947433 0.219 NM_031308
EPPK1
epiplakin 1
chr6_+_135502477 0.219 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr11_+_45944155 0.218 GYLTL1B
glycosyltransferase-like 1B
chr1_-_25256364 0.218 RUNX3
runt-related transcription factor 3
chr17_-_74497406 0.217 NM_024599
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr12_+_53342842 0.217 NM_000224
KRT18
keratin 18
chr7_-_98030426 0.216 NM_018842
BAIAP2L1
BAI1-associated protein 2-like 1
chr12_+_2904289 0.216 FKBP4
FK506 binding protein 4, 59kDa
chr14_-_21566728 0.215 NM_016423
ZNF219
zinc finger protein 219
chr10_-_103874661 0.214 NM_003893
LDB1
LIM domain binding 1
chr18_-_24129084 0.214 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr8_+_56792399 0.213 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr11_-_17035948 0.212 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr14_-_23834841 0.208 NM_005864
NM_032459
EFS

embryonal Fyn-associated substrate

chr2_+_220492286 0.208 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr6_+_135502445 0.208 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chrX_-_3631654 0.208 NM_005044
PRKX
protein kinase, X-linked
chr11_-_119234628 0.207 USP2
ubiquitin specific peptidase 2
chr19_+_39279849 0.203 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr4_+_79472741 0.203 NM_005139
ANXA3
annexin A3
chr5_+_56111379 0.203 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr1_-_201368617 0.202 NM_005558
LAD1
ladinin 1
chr21_+_18885104 0.202 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr18_+_19749403 0.201 NM_005257
GATA6
GATA binding protein 6
chr17_-_39780762 0.201 NM_000422
KRT17
keratin 17
chr12_-_91573264 0.200 NM_133503
DCN
decorin
chr1_+_955468 0.200 NM_198576
AGRN
agrin
chr11_+_58939960 0.200 DTX4
deltex homolog 4 (Drosophila)
chr6_-_143266283 0.199 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr12_-_124018428 0.199 RILPL1
Rab interacting lysosomal protein-like 1
chr9_+_137218324 0.199 RXRA
retinoid X receptor, alpha
chr9_-_23821477 0.198 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr15_+_101420004 0.198 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr5_-_16617085 0.196 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr6_-_3456734 0.195 NM_015482
SLC22A23
solute carrier family 22, member 23
chr13_-_20806533 0.195 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr15_+_101420032 0.195 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr1_-_25256767 0.195 NM_004350
RUNX3
runt-related transcription factor 3
chr13_-_76055872 0.195 NM_014832
TBC1D4
TBC1 domain family, member 4
chr1_+_205473683 0.194 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr5_-_60140041 0.194 NM_001104558
NM_024930
ELOVL7

ELOVL fatty acid elongase 7

chr9_+_130548326 0.193 CDK9
cyclin-dependent kinase 9
chr6_+_17281773 0.193 NM_001143942
RBM24
RNA binding motif protein 24
chr1_-_57045129 0.191 PPAP2B
phosphatidic acid phosphatase type 2B
chr7_+_150811719 0.190 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr3_-_13921617 0.190 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr3_-_189838673 0.190 LEPREL1
leprecan-like 1
chr11_+_65554566 0.190 OVOL1
ovo-like 1(Drosophila)
chr22_+_51113069 0.190 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr8_-_75233461 0.190 NM_020647
JPH1
junctophilin 1
chr2_-_165478357 0.190 NM_004490
GRB14
growth factor receptor-bound protein 14
chr5_-_176831385 0.189 F12
coagulation factor XII (Hageman factor)
chr11_+_65554504 0.188 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr1_+_26856252 0.188 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_+_61591239 0.188 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr14_+_67999915 0.187 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr20_+_1875534 0.186 SIRPA
signal-regulatory protein alpha
chr17_-_27916602 0.185 NM_001085454
NM_014030
GIT1

G protein-coupled receptor kinase interacting ArfGAP 1

chr7_-_129251465 0.185


chr20_+_1875382 0.184 NM_080792
SIRPA
signal-regulatory protein alpha
chr1_-_48462561 0.184 NM_001194986
LOC388630
UPF0632 protein A
chr15_+_80987609 0.183 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr1_+_40420781 0.182 NM_001136493
NM_032793
MFSD2A

major facilitator superfamily domain containing 2A

chr22_+_38035718 0.181 SH3BP1
SH3-domain binding protein 1
chr1_+_26856240 0.181 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_71905947 0.181 TYSND1
trypsin domain containing 1
chr16_-_57318452 0.181 PLLP
plasmolipin
chr4_-_22517339 0.181 NM_145290
GPR125
G protein-coupled receptor 125

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.35e-28 GO:0009987 cellular process
1.18 7.04e-23 GO:0044260 cellular macromolecule metabolic process
1.14 1.73e-20 GO:0044237 cellular metabolic process
1.15 1.86e-17 GO:0043170 macromolecule metabolic process
1.12 7.46e-17 GO:0050794 regulation of cellular process
1.10 1.81e-16 GO:0065007 biological regulation
1.11 2.09e-16 GO:0050789 regulation of biological process
1.12 2.47e-16 GO:0044238 primary metabolic process
1.11 1.96e-15 GO:0008152 metabolic process
1.26 2.92e-15 GO:0006464 protein modification process
1.21 5.17e-15 GO:0044267 cellular protein metabolic process
1.24 3.05e-14 GO:0043412 macromolecule modification
1.16 3.24e-11 GO:0016043 cellular component organization
1.15 1.03e-10 GO:0071840 cellular component organization or biogenesis
1.17 2.53e-10 GO:0019538 protein metabolic process
1.17 1.72e-09 GO:0071842 cellular component organization at cellular level
1.15 2.18e-09 GO:0006807 nitrogen compound metabolic process
1.14 2.40e-09 GO:0031323 regulation of cellular metabolic process
1.13 2.61e-09 GO:0019222 regulation of metabolic process
1.17 5.21e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.15 5.67e-09 GO:0034641 cellular nitrogen compound metabolic process
1.14 9.00e-09 GO:0060255 regulation of macromolecule metabolic process
1.14 1.04e-08 GO:0080090 regulation of primary metabolic process
1.16 3.70e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 9.19e-08 GO:0006996 organelle organization
1.18 1.68e-07 GO:0048523 negative regulation of cellular process
1.25 1.33e-06 GO:0007049 cell cycle
1.12 2.02e-06 GO:0051179 localization
1.16 2.04e-06 GO:0048519 negative regulation of biological process
1.15 2.91e-06 GO:0048522 positive regulation of cellular process
1.29 4.81e-06 GO:0006468 protein phosphorylation
1.24 4.83e-06 GO:0006793 phosphorus metabolic process
1.24 4.83e-06 GO:0006796 phosphate metabolic process
1.25 6.27e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.16 9.17e-06 GO:0090304 nucleic acid metabolic process
1.25 9.33e-06 GO:0031324 negative regulation of cellular metabolic process
1.24 9.45e-06 GO:0009892 negative regulation of metabolic process
1.14 1.21e-05 GO:0048518 positive regulation of biological process
1.15 1.98e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.14 2.53e-05 GO:0010468 regulation of gene expression
1.29 2.58e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.31 2.96e-05 GO:0000278 mitotic cell cycle
1.14 4.49e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.27 5.41e-05 GO:0009890 negative regulation of biosynthetic process
1.13 8.06e-05 GO:0009889 regulation of biosynthetic process
1.13 8.96e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.13 9.66e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.27 1.40e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.24 1.56e-04 GO:0016310 phosphorylation
1.28 1.81e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.31 1.83e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.13 2.44e-04 GO:0031326 regulation of cellular biosynthetic process
1.12 2.46e-04 GO:0051234 establishment of localization
1.41 3.46e-04 GO:0032446 protein modification by small protein conjugation
1.27 3.78e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.14 4.27e-04 GO:0051252 regulation of RNA metabolic process
1.16 4.44e-04 GO:0016070 RNA metabolic process
1.21 4.77e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.12 6.14e-04 GO:0006810 transport
1.26 6.35e-04 GO:0009719 response to endogenous stimulus
1.23 7.16e-04 GO:0022402 cell cycle process
1.10 8.31e-04 GO:0023052 signaling
1.17 8.49e-04 GO:0009966 regulation of signal transduction
1.16 8.77e-04 GO:0023051 regulation of signaling
1.20 1.15e-03 GO:0032268 regulation of cellular protein metabolic process
1.22 1.37e-03 GO:0016265 death
1.22 1.48e-03 GO:0008219 cell death
1.15 1.95e-03 GO:0010467 gene expression
1.10 2.02e-03 GO:0007165 signal transduction
1.13 2.11e-03 GO:0006355 regulation of transcription, DNA-dependent
1.19 2.13e-03 GO:0051246 regulation of protein metabolic process
1.33 2.14e-03 GO:0016568 chromatin modification
1.35 2.35e-03 GO:0070647 protein modification by small protein conjugation or removal
1.24 2.71e-03 GO:0022403 cell cycle phase
1.21 2.78e-03 GO:0048468 cell development
1.26 2.80e-03 GO:0009725 response to hormone stimulus
1.26 2.80e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.34 3.29e-03 GO:0071495 cellular response to endogenous stimulus
1.17 3.30e-03 GO:0051641 cellular localization
1.16 3.88e-03 GO:0007399 nervous system development
1.09 5.00e-03 GO:0032502 developmental process
1.38 5.91e-03 GO:0016567 protein ubiquitination
1.24 7.18e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.26 7.78e-03 GO:0016071 mRNA metabolic process
1.26 8.51e-03 GO:0051253 negative regulation of RNA metabolic process
1.10 1.16e-02 GO:0048856 anatomical structure development
1.23 1.26e-02 GO:0009790 embryo development
1.25 1.60e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.25 1.67e-02 GO:0044265 cellular macromolecule catabolic process
1.09 1.74e-02 GO:0007275 multicellular organismal development
1.08 1.77e-02 GO:0051716 cellular response to stimulus
1.33 1.90e-02 GO:0032870 cellular response to hormone stimulus
1.23 2.47e-02 GO:0009057 macromolecule catabolic process
1.16 2.49e-02 GO:0033036 macromolecule localization
1.21 2.52e-02 GO:0012501 programmed cell death
1.11 2.65e-02 GO:0044249 cellular biosynthetic process
1.23 2.70e-02 GO:0010629 negative regulation of gene expression
1.17 2.79e-02 GO:0044248 cellular catabolic process
1.21 3.06e-02 GO:0006915 apoptosis
1.12 4.25e-02 GO:0048869 cellular developmental process
1.41 4.74e-02 GO:0016569 covalent chromatin modification
1.17 4.79e-02 GO:0008104 protein localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 4.73e-38 GO:0005622 intracellular
1.09 4.11e-37 GO:0044424 intracellular part
1.12 2.17e-31 GO:0043227 membrane-bounded organelle
1.12 3.63e-31 GO:0043231 intracellular membrane-bounded organelle
1.10 1.58e-28 GO:0043226 organelle
1.10 1.94e-28 GO:0043229 intracellular organelle
1.12 4.40e-27 GO:0005737 cytoplasm
1.15 3.77e-22 GO:0005634 nucleus
1.13 4.24e-18 GO:0044444 cytoplasmic part
1.21 7.57e-13 GO:0044428 nuclear part
1.11 3.46e-12 GO:0044446 intracellular organelle part
1.11 5.13e-12 GO:0044422 organelle part
1.03 1.49e-10 GO:0044464 cell part
1.03 1.69e-10 GO:0005623 cell
1.19 9.29e-10 GO:0005829 cytosol
1.20 4.76e-09 GO:0031981 nuclear lumen
1.17 2.21e-08 GO:0031974 membrane-enclosed lumen
1.17 4.78e-08 GO:0070013 intracellular organelle lumen
1.16 5.21e-08 GO:0043233 organelle lumen
1.21 4.37e-07 GO:0005654 nucleoplasm
1.15 3.04e-04 GO:0012505 endomembrane system
1.22 1.19e-03 GO:0044451 nucleoplasm part
1.43 2.34e-03 GO:0030424 axon
1.36 3.40e-03 GO:0005635 nuclear envelope
1.18 4.37e-03 GO:0005794 Golgi apparatus
1.12 5.26e-03 GO:0031090 organelle membrane
1.20 9.13e-03 GO:0031967 organelle envelope
1.65 1.41e-02 GO:0030426 growth cone
1.20 1.45e-02 GO:0031975 envelope
1.64 1.52e-02 GO:0030427 site of polarized growth
1.26 1.67e-02 GO:0043005 neuron projection
1.27 2.89e-02 GO:0048471 perinuclear region of cytoplasm
1.09 4.35e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 7.38e-45 GO:0005515 protein binding
1.09 1.54e-34 GO:0005488 binding
1.32 8.71e-09 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.29 3.63e-08 GO:0016301 kinase activity
1.16 5.44e-08 GO:0000166 nucleotide binding
1.38 1.81e-07 GO:0004674 protein serine/threonine kinase activity
1.31 1.48e-06 GO:0004672 protein kinase activity
1.25 2.04e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.27 2.12e-06 GO:0019899 enzyme binding
1.15 1.85e-04 GO:0017076 purine nucleotide binding
1.16 1.97e-04 GO:0030554 adenyl nucleotide binding
1.14 2.91e-04 GO:0032553 ribonucleotide binding
1.14 2.91e-04 GO:0032555 purine ribonucleotide binding
1.16 3.06e-04 GO:0032559 adenyl ribonucleotide binding
1.14 3.29e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.37 3.69e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.39 3.82e-04 GO:0016881 acid-amino acid ligase activity
1.10 4.60e-04 GO:0003676 nucleic acid binding
1.16 6.14e-04 GO:0005524 ATP binding
1.29 8.98e-04 GO:0019904 protein domain specific binding
1.22 1.42e-03 GO:0042802 identical protein binding
1.18 2.30e-03 GO:0030528 transcription regulator activity
1.14 3.38e-03 GO:0016740 transferase activity
1.20 5.06e-03 GO:0003723 RNA binding
1.37 5.20e-03 GO:0019787 small conjugating protein ligase activity
1.11 1.06e-02 GO:0003677 DNA binding
1.32 1.28e-02 GO:0008134 transcription factor binding
1.21 1.29e-02 GO:0046983 protein dimerization activity
1.36 1.57e-02 GO:0004842 ubiquitin-protein ligase activity
1.29 4.10e-02 GO:0016563 transcription activator activity