Motif ID: TFAP2B.p2

Z-value: 1.709


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_507864380.482.3e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_231175971 1.429 NM_198552
 FAM89A
family with sequence similarity 89, member A
chr2_+_47596447 1.339 EPCAM
epithelial cell adhesion molecule
chrX_+_152953751 1.146 NM_001142805
NM_005629
 SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr6_-_99797530 1.099 NM_032511
 C6orf168
chromosome 6 open reading frame 168
chr2_+_47596286 1.092 NM_002354
 EPCAM
epithelial cell adhesion molecule
chr15_+_80987609 1.026 NM_021214
 FAM108C1
family with sequence similarity 108, member C1
chr22_+_45098091 1.008 NM_181334
 PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr14_-_105634708 0.999 JAG2
jagged 2
chr4_+_1795004 0.989 NM_000142
NM_001163213
NM_022965
 FGFR3


fibroblast growth factor receptor 3


chr22_-_43583132 0.987 NM_015140
 TTLL12
tubulin tyrosine ligase-like family, member 12
chr22_+_51113069 0.888 NM_001080420
 SHANK3
SH3 and multiple ankyrin repeat domains 3
chr9_-_100954883 0.861 NM_052820
 CORO2A
coronin, actin binding protein, 2A
chr17_+_30813928 0.806 NM_003885
 CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr2_+_75061234 0.802 HK2
hexokinase 2
chr7_+_4722091 0.798 FOXK1
forkhead box K1
chr17_+_9548853 0.764 NM_153210
 USP43
ubiquitin specific peptidase 43
chr13_-_99229037 0.763 STK24
serine/threonine kinase 24
chr6_+_4776826 0.748 CDYL
chromodomain protein, Y-like
chr6_+_71998476 0.743 NM_024576
 OGFRL1
opioid growth factor receptor-like 1
chr6_+_71998508 0.743 OGFRL1
opioid growth factor receptor-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 176 entries
enrichment   p-value GO term description
3.11 2.03e-02 GO:0060071 Wnt receptor signaling pathway, planar cell polarity pathway
3.11 2.03e-02 GO:0090175 regulation of establishment of planar polarity
1.72 2.02e-04 GO:0016055 Wnt receptor signaling pathway
1.68 2.54e-07 GO:0048011 nerve growth factor receptor signaling pathway
1.68 2.01e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.60 1.22e-06 GO:0051101 regulation of DNA binding
1.59 1.27e-02 GO:0060562 epithelial tube morphogenesis
1.58 1.11e-07 GO:0051098 regulation of binding
1.58 2.51e-05 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
1.58 2.70e-02 GO:0051099 positive regulation of binding
1.56 4.13e-05 GO:0090046 regulation of transcription regulator activity
1.55 1.26e-02 GO:0030900 forebrain development
1.52 2.02e-02 GO:0035239 tube morphogenesis
1.48 1.01e-03 GO:0032446 protein modification by small protein conjugation
1.48 5.59e-03 GO:0003002 regionalization
1.48 1.71e-02 GO:0045786 negative regulation of cell cycle
1.47 2.85e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.47 3.52e-03 GO:0016567 protein ubiquitination
1.45 4.02e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.43 7.84e-09 GO:0007167 enzyme linked receptor protein signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.79 1.49e-02 GO:0030427 site of polarized growth
1.75 4.81e-02 GO:0030426 growth cone
1.50 4.96e-02 GO:0000151 ubiquitin ligase complex
1.32 3.02e-03 GO:0000139 Golgi membrane
1.30 1.18e-03 GO:0044431 Golgi apparatus part
1.29 1.16e-06 GO:0005794 Golgi apparatus
1.28 5.81e-04 GO:0044451 nucleoplasm part
1.25 8.75e-13 GO:0044428 nuclear part
1.25 5.61e-10 GO:0031981 nuclear lumen
1.25 6.55e-07 GO:0005654 nucleoplasm
1.24 8.99e-08 GO:0012505 endomembrane system
1.21 5.72e-09 GO:0070013 intracellular organelle lumen
1.21 6.53e-08 GO:0005829 cytosol
1.20 1.52e-08 GO:0031974 membrane-enclosed lumen
1.20 2.70e-08 GO:0043233 organelle lumen
1.20 4.14e-02 GO:0042995 cell projection
1.17 3.68e-20 GO:0005634 nucleus
1.17 8.48e-05 GO:0031090 organelle membrane
1.15 3.18e-32 GO:0043227 membrane-bounded organelle
1.15 6.93e-30 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
1.55 4.64e-07 GO:0008134 transcription factor binding
1.55 3.13e-04 GO:0010843 promoter binding
1.52 7.89e-04 GO:0000975 regulatory region DNA binding
1.52 7.89e-04 GO:0001067 regulatory region nucleic acid binding
1.52 7.89e-04 GO:0044212 transcription regulatory region DNA binding
1.50 3.60e-02 GO:0004721 phosphoprotein phosphatase activity
1.49 7.59e-06 GO:0016563 transcription activator activity
1.45 6.42e-03 GO:0019787 small conjugating protein ligase activity
1.44 3.47e-04 GO:0016564 transcription repressor activity
1.43 2.13e-02 GO:0004842 ubiquitin-protein ligase activity
1.41 1.39e-05 GO:0019904 protein domain specific binding
1.41 1.18e-02 GO:0016881 acid-amino acid ligase activity
1.40 5.67e-05 GO:0004674 protein serine/threonine kinase activity
1.40 3.57e-02 GO:0016791 phosphatase activity
1.39 7.17e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.36 4.96e-06 GO:0004672 protein kinase activity
1.35 6.40e-08 GO:0016301 kinase activity
1.35 7.56e-07 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.33 3.83e-06 GO:0019899 enzyme binding
1.32 3.15e-02 GO:0003712 transcription cofactor activity