Motif ID: TFAP4.p2

Z-value: 1.352


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_4323000,
chr16_-_4322695
-0.831.0e-02Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_57044980 2.270 PPAP2B
phosphatidic acid phosphatase type 2B
chr11_-_35547144 2.255 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr1_+_159175048 2.017 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr1_-_57045129 1.879 PPAP2B
phosphatidic acid phosphatase type 2B
chr8_+_97506020 1.861 SDC2
syndecan 2
chr14_-_92414004 1.622 NM_006329
FBLN5
fibulin 5
chr8_+_104383785 1.547 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr8_+_97505895 1.525 SDC2
syndecan 2
chr7_+_100199881 1.519 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr14_-_92413738 1.517 FBLN5
fibulin 5
chr6_+_124125068 1.472 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr8_+_97506141 1.454 SDC2
syndecan 2
chr16_+_53133063 1.436 CHD9
chromodomain helicase DNA binding protein 9
chr12_+_56075418 1.394 METTL7B
methyltransferase like 7B
chr12_+_56075329 1.387 NM_152637
METTL7B
methyltransferase like 7B
chr8_+_104383701 1.372 CTHRC1
collagen triple helix repeat containing 1
chr1_-_57045214 1.355 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_78354199 1.338 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr8_+_97506071 1.149 SDC2
syndecan 2
chr12_+_90102639 1.136 LOC338758
uncharacterized LOC338758
chr11_+_113930296 1.056 ZBTB16
zinc finger and BTB domain containing 16
chr11_+_113930430 1.048 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr5_+_92920592 1.038 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr5_+_40680042 1.034 PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr6_-_154831652 1.000 CNKSR3
CNKSR family member 3
chr6_-_154831788 0.993 CNKSR3
CNKSR family member 3
chr12_-_108733075 0.989 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr8_+_37654833 0.976 GPR124
G protein-coupled receptor 124
chrX_+_16964730 0.966 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr14_-_52535945 0.948 NM_007361
NID2
nidogen 2 (osteonidogen)
chr14_-_52535711 0.917 NID2
nidogen 2 (osteonidogen)
chr8_+_97506478 0.914 SDC2
syndecan 2
chr14_-_52535737 0.892 NID2
nidogen 2 (osteonidogen)
chr8_+_17433941 0.887 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr5_+_40680021 0.886 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr8_+_37654757 0.881 GPR124
G protein-coupled receptor 124
chr22_-_21905372 0.857 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr7_-_45960738 0.837 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr11_+_67777788 0.834 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr8_-_13134028 0.832 DLC1
deleted in liver cancer 1
chr19_+_12863406 0.818 NM_017682
BEST2
bestrophin 2
chr11_+_67777795 0.817 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr1_+_155829259 0.794 NM_152280
SYT11
synaptotagmin XI
chr5_-_136834887 0.776 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr5_-_180688095 0.770 NM_032765
TRIM52
tripartite motif containing 52
chr5_+_131630065 0.766 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr6_-_35696359 0.763 NM_001145775
FKBP5
FK506 binding protein 5
chr8_+_97505876 0.762 NM_002998
SDC2
syndecan 2
chr5_-_111093792 0.752 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr9_+_90112419 0.743 DAPK1
death-associated protein kinase 1
chrX_-_106960028 0.716 TSC22D3
TSC22 domain family, member 3
chr11_+_15136483 0.716 NM_001042536
INSC
inscuteable homolog (Drosophila)
chr17_-_76921076 0.712 TIMP2
TIMP metallopeptidase inhibitor 2
chr20_+_33292117 0.703 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr17_-_76921205 0.703 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_201708940 0.701 NM_001167738
NAV1
neuron navigator 1
chr14_-_60337350 0.697 NM_021136
RTN1
reticulon 1
chr8_+_37654395 0.692 NM_032777
GPR124
G protein-coupled receptor 124
chr8_+_37654406 0.691 GPR124
G protein-coupled receptor 124
chr5_+_156693051 0.691 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr22_+_21738039 0.686 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr16_+_69599869 0.682 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_-_72748491 0.663


chr6_-_154831704 0.651 NM_173515
CNKSR3
CNKSR family member 3
chr16_+_69600110 0.638 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr13_+_76210449 0.625 LMO7
LIM domain 7
chr17_+_81037504 0.620 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr6_+_72596699 0.617 RIMS1
regulating synaptic membrane exocytosis 1
chr17_-_76921453 0.610 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr2_-_233352530 0.607 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr1_+_51434231 0.593 NM_001262
CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr12_-_54812936 0.593 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr13_+_96329398 0.579 DNAJC3
DnaJ (Hsp40) homolog, subfamily C, member 3
chr5_+_95066628 0.575 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr3_-_9811583 0.571 CAMK1
calcium/calmodulin-dependent protein kinase I
chr19_+_14544100 0.571 NM_002741
PKN1
protein kinase N1
chrX_+_80457597 0.568 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr6_+_72596648 0.565 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr21_+_37507209 0.565 NM_001236
CBR3
carbonyl reductase 3
chr16_-_3355374 0.561 NM_033208
TIGD7
tigger transposable element derived 7
chr4_+_4861371 0.559 NM_002448
MSX1
msh homeobox 1
chr16_+_89642111 0.555 NM_014427
NM_153636
CPNE7

copine VII

chr17_+_78194090 0.553 NM_001166347
NM_001166348
NM_001166349
NM_173626
SLC26A11



solute carrier family 26, member 11



chr22_+_45898690 0.544 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr11_+_133938965 0.541 JAM3
junctional adhesion molecule 3
chr8_-_23712297 0.537 NM_003155
STC1
stanniocalcin 1
chr5_-_176739291 0.532 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr6_+_108882104 0.525 FOXO3
forkhead box O3
chr6_-_132722564 0.520 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr3_-_9811623 0.516 CAMK1
calcium/calmodulin-dependent protein kinase I
chr12_-_54813010 0.510 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr9_-_120177326 0.507 ASTN2
astrotactin 2
chr4_+_81187741 0.504 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr19_+_56915382 0.502 NM_001159860
ZNF583
zinc finger protein 583
chr1_+_51434375 0.497 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr3_-_9811628 0.494 NM_003656
CAMK1
calcium/calmodulin-dependent protein kinase I
chr9_-_120177307 0.491 NM_014010
ASTN2
astrotactin 2
chr16_+_67311412 0.491 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr11_-_2018703 0.485 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_-_32403975 0.485 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr9_+_90112754 0.483 NM_004938
DAPK1
death-associated protein kinase 1
chr9_+_36136710 0.482 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr11_+_43963809 0.481 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr19_+_39786964 0.479 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr12_-_54813002 0.472 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_+_13349716 0.469 EMP1
epithelial membrane protein 1
chr3_+_142838596 0.468 NM_004267
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr17_-_19648771 0.467 NM_001135168
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chrX_-_106959597 0.463 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr12_-_104234968 0.460 NM_001031701
NT5DC3
5'-nucleotidase domain containing 3
chr5_+_137774632 0.460 NM_016606
REEP2
receptor accessory protein 2
chr12_+_113860146 0.457 NM_138432
SDSL
serine dehydratase-like
chr3_-_195306274 0.457 APOD
apolipoprotein D
chr17_-_53800074 0.457 NM_018286
TMEM100
transmembrane protein 100
chr20_+_33146500 0.450 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr18_-_65183922 0.446 NM_032160
DSEL
dermatan sulfate epimerase-like
chr5_-_176738831 0.443 MXD3
MAX dimerization protein 3
chr14_+_21538339 0.442 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chrX_-_77395108 0.440 NM_015975
TAF9B
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr15_-_43910959 0.438 NM_153700
STRC
stereocilin
chr1_+_51434447 0.435 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr4_+_77870944 0.433 SEPT11
septin 11
chr7_+_17338182 0.433 NM_001621
AHR
aryl hydrocarbon receptor
chrX_+_54835492 0.431 NM_201222
MAGED2
melanoma antigen family D, 2
chr1_+_90098643 0.430 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr8_+_72756218 0.430 LOC100132891
uncharacterized LOC100132891
chr8_+_17354562 0.429 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr11_-_2018568 0.429 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_-_39694891 0.428 NM_001080468
SYCN
syncollin
chr1_+_201709051 0.428 NAV1
neuron navigator 1
chr6_-_132272311 0.427 NM_001901
CTGF
connective tissue growth factor
chr17_+_79860071 0.427 NM_148896
NPB
neuropeptide B
chrX_-_154114431 0.425 NM_019863
F8
coagulation factor VIII, procoagulant component
chr16_+_2802683 0.423 SRRM2
serine/arginine repetitive matrix 2
chr5_+_172068188 0.420 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr4_+_77870864 0.420 NM_018243
SEPT11
septin 11
chr6_-_15663098 0.418 DTNBP1
dystrobrevin binding protein 1
chr8_+_72756335 0.416


chr4_-_2263706 0.414 NM_006454
MXD4
MAX dimerization protein 4
chr1_+_110210643 0.411 NM_000848
NM_001142368
GSTM2

glutathione S-transferase mu 2 (muscle)

chr12_-_104234783 0.410 NT5DC3
5'-nucleotidase domain containing 3
chr1_+_78956727 0.405 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr17_+_80186886 0.405 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr10_-_21462987 0.398 NEBL
nebulette
chr5_-_121412805 0.397 NM_001178102
LOX
lysyl oxidase
chr2_-_207082626 0.396 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr1_+_180123906 0.395 NM_001004128
NM_002826
QSOX1

quiescin Q6 sulfhydryl oxidase 1

chr21_-_28217692 0.393 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr6_-_167571315 0.392 NM_005299
GPR31
G protein-coupled receptor 31
chr4_-_156787377 0.390 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr19_+_36359346 0.388 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr15_-_37393364 0.386 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr15_-_48937068 0.385 FBN1
fibrillin 1
chr1_-_182360181 0.384 GLUL
glutamate-ammonia ligase
chr1_+_180124031 0.383 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr3_+_49449638 0.381 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr1_+_180123975 0.380 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr7_-_50861114 0.376 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr6_-_167040506 0.376 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr7_+_94023872 0.376 NM_000089
COL1A2
collagen, type I, alpha 2
chr5_+_137774897 0.374 REEP2
receptor accessory protein 2
chrX_-_99986496 0.372 NM_001174068
NM_080737
SYTL4

synaptotagmin-like 4

chr6_+_84743250 0.371 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr6_-_167275997 0.368 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr7_+_100728719 0.366 NM_030961
TRIM56
tripartite motif containing 56
chrX_+_80457302 0.365 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_+_178063237 0.365 RASAL2
RAS protein activator like 2
chr6_-_153452383 0.363 NM_012419
RGS17
regulator of G-protein signaling 17
chr6_-_167040659 0.363 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_2263808 0.358 MXD4
MAX dimerization protein 4
chr1_+_22351984 0.356 LINC00339
long intergenic non-protein coding RNA 339
chr15_+_63569748 0.354 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr1_+_62902735 0.353 USP1
ubiquitin specific peptidase 1
chr11_+_76777926 0.352 NM_004055
CAPN5
calpain 5
chrX_+_80457559 0.351 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_-_156828665 0.351 NM_014215
INSRR
insulin receptor-related receptor
chr21_-_28217272 0.351 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_-_2018446 0.350 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_+_180124023 0.349 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr1_+_180124013 0.348 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr17_+_61851512 0.348


chr1_-_43232728 0.348 NM_001146289
NM_001243246
NM_022356
LEPRE1


leucine proline-enriched proteoglycan (leprecan) 1


chr10_+_93170086 0.347 NM_173497
NM_182765
HECTD2

HECT domain containing 2

chr4_+_186317892 0.347 ANKRD37
ankyrin repeat domain 37
chr16_+_88493878 0.344 NM_001127464
ZNF469
zinc finger protein 469
chr2_-_96657538 0.340 ANKRD36C
ankyrin repeat domain 36C
chr4_+_15005364 0.338 CPEB2
cytoplasmic polyadenylation element binding protein 2
chr17_+_14204326 0.337 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chrX_-_153979161 0.337 NM_001081573
NM_080612
GAB3

GRB2-associated binding protein 3

chr5_+_180688174 0.336


chr11_+_60635014 0.336 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr10_-_93392744 0.335 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr2_+_65216526 0.334 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr10_-_3827205 0.334 KLF6
Kruppel-like factor 6
chr10_-_44070008 0.334 NM_001099282
NM_001099283
NM_001099284
ZNF239


zinc finger protein 239


chr6_+_108882068 0.333 NM_001455
FOXO3
forkhead box O3
chr16_-_31106049 0.332 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr1_+_210406194 0.331 NM_019605
SERTAD4
SERTA domain containing 4
chr12_+_1738411 0.327 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr9_+_4490193 0.324 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 3.91e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 7.18e-04 GO:0000267 cell fraction
1.34 2.17e-03 GO:0005783 endoplasmic reticulum
2.16 4.15e-03 GO:0019717 synaptosome
1.09 7.79e-03 GO:0005737 cytoplasm
1.35 1.68e-02 GO:0005626 insoluble fraction
1.35 2.07e-02 GO:0005624 membrane fraction
1.41 2.26e-02 GO:0030054 cell junction
1.35 4.07e-02 GO:0044432 endoplasmic reticulum part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 2.27e-03 GO:0005515 protein binding
1.06 1.52e-02 GO:0005488 binding