Motif ID: TLX2.p2

Z-value: 1.184


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_74740585-0.216.1e-01Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_120935893 1.497 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr12_+_13044493 1.402 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr12_+_13044352 1.309 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr18_+_29027731 1.303 NM_001944
DSG3
desmoglein 3
chr1_+_86889768 1.270 NM_006536
CLCA2
chloride channel accessory 2
chr20_-_14318200 1.026 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr1_-_153363544 1.023 NM_002964
S100A8
S100 calcium binding protein A8
chr18_-_28681885 1.013 NM_004949
NM_024422
DSC2

desmocollin 2

chr10_+_48255223 1.005 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr1_-_21059132 0.999 NM_001103160
NM_001103161
SH2D5

SH2 domain containing 5

chr12_-_8815266 0.968 MFAP5
microfibrillar associated protein 5
chr20_+_58251715 0.941 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr20_-_43883183 0.936 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr16_-_68269948 0.923 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr5_-_60140041 0.886 NM_001104558
NM_024930
ELOVL7

ELOVL fatty acid elongase 7

chr15_+_41136178 0.880 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_+_95286099 0.877 NM_152369
SLC44A3
solute carrier family 44, member 3
chr1_+_95286193 0.874 SLC44A3
solute carrier family 44, member 3
chr1_+_152486977 0.865 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr9_-_33447527 0.827 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr5_+_131409484 0.827 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chrX_+_105937067 0.825 NM_024539
RNF128
ring finger protein 128
chr22_-_39639967 0.814 PDGFB
platelet-derived growth factor beta polypeptide
chr16_-_31146992 0.784 PRSS8
protease, serine, 8
chr12_-_71031174 0.783 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr8_+_80523376 0.767 STMN2
stathmin-like 2
chr16_-_72206023 0.758 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr15_+_40509628 0.757 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr19_-_15090349 0.753 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr10_+_82173574 0.745 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr19_-_6720585 0.741 NM_000064
C3
complement component 3
chr1_+_152881022 0.709 NM_005547
IVL
involucrin
chr16_-_31147062 0.705 NM_002773
PRSS8
protease, serine, 8
chr8_+_86376130 0.700 NM_000067
CA2
carbonic anhydrase II
chr16_+_82068910 0.699 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82068958 0.695 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_1860718 0.690 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr2_+_102979096 0.687 NM_003855
IL18R1
interleukin 18 receptor 1
chr14_+_65171149 0.678 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_-_8815370 0.678 NM_003480
MFAP5
microfibrillar associated protein 5
chr8_+_80523304 0.672 STMN2
stathmin-like 2
chr14_+_65171243 0.671 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr18_+_61254533 0.669 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_-_160990862 0.662 F11R
F11 receptor
chr19_-_51512803 0.656 NM_012315
KLK9
kallikrein-related peptidase 9
chr12_+_56732658 0.654 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr16_+_82068830 0.650 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr8_-_142264157 0.650 SLC45A4
solute carrier family 45, member 4
chr8_+_120220554 0.648 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr1_+_151483861 0.633 NM_020770
CGN
cingulin
chr12_-_8815479 0.622 MFAP5
microfibrillar associated protein 5
chr2_+_17721983 0.614 VSNL1
visinin-like 1
chr5_+_36606456 0.605 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr1_-_160990971 0.581 NM_016946
F11R
F11 receptor
chr10_-_47173917 0.578 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr8_+_80523339 0.565 STMN2
stathmin-like 2
chr5_+_68710938 0.556 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr5_+_36606667 0.555 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_+_47746919 0.554 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr10_+_11865310 0.554 NM_153256
C10orf47
chromosome 10 open reading frame 47
chr11_+_117947785 0.550 TMPRSS4
transmembrane protease, serine 4
chr1_-_24469571 0.549 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr2_+_17721806 0.542 NM_003385
VSNL1
visinin-like 1
chr11_+_117947726 0.533 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr12_+_101188373 0.531 NM_178826
ANO4
anoctamin 4
chr6_+_54711568 0.528 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr1_+_156030965 0.526 NM_020387
RAB25
RAB25, member RAS oncogene family
chr4_-_36245893 0.526 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_24645811 0.526 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr1_+_153330329 0.526 NM_002965
S100A9
S100 calcium binding protein A9
chr13_+_97999289 0.520


chr16_-_72206348 0.515 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr1_-_6526150 0.514 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chrX_+_38420690 0.513 NM_004615
TSPAN7
tetraspanin 7
chr16_+_69139466 0.511 NM_001199280
HAS3
hyaluronan synthase 3
chr8_-_57232653 0.508 SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr2_+_27665232 0.505 NM_001168364
NM_173853
KRTCAP3

keratinocyte associated protein 3

chr20_-_50418946 0.499 NM_020436
SALL4
sal-like 4 (Drosophila)
chr6_+_31638727 0.492 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr11_-_62623212 0.491 SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
chr19_+_50084586 0.479 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr3_-_182880463 0.476 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr10_-_135090325 0.470 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chrX_-_73512376 0.463 FTX
FTX transcript, XIST regulator (non-protein coding)
chr11_+_69924407 0.458 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr4_+_41937368 0.458 TMEM33
transmembrane protein 33
chr6_+_84562984 0.454 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr2_+_61108775 0.451 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr1_+_2005083 0.446 NM_001033581
PRKCZ
protein kinase C, zeta
chr10_+_82213892 0.445 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr10_+_82214066 0.443 TSPAN14
tetraspanin 14
chr16_+_57406398 0.442 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr6_+_106546736 0.442 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr3_-_151034514 0.442 NM_023915
GPR87
G protein-coupled receptor 87
chr19_+_49838646 0.440 CD37
CD37 molecule
chr3_-_45187843 0.436 CDCP1
CUB domain containing protein 1
chr7_-_22539795 0.434 NM_001164460
NM_207342
STEAP1B

STEAP family member 1B

chr12_-_95611023 0.434 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr11_-_64901995 0.433 NM_032431
NM_172230
SYVN1

synovial apoptosis inhibitor 1, synoviolin

chr21_-_16437125 0.429 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr10_+_75673346 0.428 PLAU
plasminogen activator, urokinase
chr4_+_41937105 0.427 NM_018126
TMEM33
transmembrane protein 33
chr10_+_75670861 0.427 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr1_+_26872306 0.422 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_+_61108724 0.420 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr12_+_49372235 0.416 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr10_-_123353330 0.415 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr8_+_102504836 0.415 GRHL2
grainyhead-like 2 (Drosophila)
chr22_-_37584254 0.414 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr17_-_10741398 0.411 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr3_-_45187861 0.409 CDCP1
CUB domain containing protein 1
chr7_-_22396511 0.407 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr11_-_66488712 0.406 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr3_+_50192420 0.406 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr18_+_19749403 0.405 NM_005257
GATA6
GATA binding protein 6
chr3_+_121774208 0.403 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr11_+_12308446 0.401 NM_032867
MICALCL
MICAL C-terminal like
chr9_-_33465191 0.401 NOL6
nucleolar protein family 6 (RNA-associated)
chr11_+_20620945 0.400 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr1_+_26856259 0.400 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_-_64901943 0.399 SYVN1
synovial apoptosis inhibitor 1, synoviolin
chr7_-_80548322 0.397 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_+_77356252 0.392 NM_020859
SHROOM3
shroom family member 3
chr18_+_29078026 0.392 NM_001943
DSG2
desmoglein 2
chr14_-_61747956 0.391 TMEM30B
transmembrane protein 30B
chr1_+_26872342 0.391 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr3_-_48470715 0.391 NM_002673
PLXNB1
plexin B1
chr19_+_3880675 0.389 ATCAY
ataxia, cerebellar, Cayman type
chr11_-_88070840 0.389 CTSC
cathepsin C
chrY_-_2655478 0.389 NM_003140
SRY
sex determining region Y
chr5_-_140012730 0.388 CD14
CD14 molecule
chr17_-_26127474 0.387 NM_000625
NOS2
nitric oxide synthase 2, inducible
chr2_-_62733475 0.386 NM_198276
TMEM17
transmembrane protein 17
chr1_-_153029987 0.385 NM_005988
SPRR2A
small proline-rich protein 2A
chr19_+_55315065 0.383 NM_001080770
NM_001080772
NM_002255
KIR2DL4


killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4


chr17_-_26127395 0.382 NOS2
nitric oxide synthase 2, inducible
chr16_+_5121809 0.381 NM_019109
ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
chr9_+_35673852 0.381 NM_001216
CA9
carbonic anhydrase IX
chr2_+_169659099 0.381 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr11_+_72929302 0.380 NM_002564
NM_176072
P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr1_-_11042093 0.379 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr7_+_48128939 0.378 UPP1
uridine phosphorylase 1
chr1_-_85514128 0.378 MCOLN3
mucolipin 3
chr6_-_52109226 0.378 NM_052872
IL17F
interleukin 17F
chr2_+_61108702 0.374 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr6_-_149806025 0.374 ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_138428477 0.373 NM_022121
PERP
PERP, TP53 apoptosis effector
chr1_-_85358851 0.371 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr8_-_105601234 0.365 NM_001135703
NM_013437
LRP12

low density lipoprotein receptor-related protein 12

chr16_+_4845265 0.365 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr11_+_34642587 0.365 NM_001206615
NM_012153
EHF

ets homologous factor

chr12_+_69139958 0.362 SLC35E3
solute carrier family 35, member E3
chr3_-_78666943 0.362 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr19_+_49838700 0.361 CD37
CD37 molecule
chr3_+_50304989 0.353 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr7_-_20256942 0.353 NM_182762
MACC1
metastasis associated in colon cancer 1
chr8_-_127570710 0.351 NM_174911
FAM84B
family with sequence similarity 84, member B
chr19_+_676346 0.348 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr15_+_73976689 0.348 CD276
CD276 molecule
chr1_-_169599349 0.343 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr19_-_36342894 0.342 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr10_-_5446781 0.342 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr16_-_10674443 0.341 NM_001424
EMP2
epithelial membrane protein 2
chr8_+_26435590 0.338 DPYSL2
dihydropyrimidinase-like 2
chr12_+_32112286 0.337 NM_018169
C12orf35
chromosome 12 open reading frame 35
chr16_+_84853585 0.336 NM_031476
CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr1_-_203320185 0.334 FMOD
fibromodulin
chr17_+_48243364 0.334 NM_000023
NM_001135697
SGCA

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

chr3_+_50192847 0.333 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_49838673 0.333 NM_001040031
NM_001774
CD37

CD37 molecule

chr8_-_105601124 0.333 LRP12
low density lipoprotein receptor-related protein 12
chr3_+_121796695 0.331 NM_006889
NM_176892
CD86

CD86 molecule

chr10_+_75670915 0.331 PLAU
plasminogen activator, urokinase
chr11_+_113775517 0.329 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr19_-_55658310 0.328 TNNT1
troponin T type 1 (skeletal, slow)
chr1_+_16174358 0.328 NM_015001
SPEN
spen homolog, transcriptional regulator (Drosophila)
chr2_-_192015733 0.324 STAT4
signal transducer and activator of transcription 4
chr2_-_139537803 0.322 NM_007226
NXPH2
neurexophilin 2
chr8_+_133879202 0.322 NM_003235
TG
thyroglobulin
chr3_-_45187897 0.321 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr16_-_85784628 0.320 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr16_+_18995508 0.320 NM_001160364
TMC7
transmembrane channel-like 7
chr19_-_19774501 0.319 NM_020410
ATP13A1
ATPase type 13A1
chr2_+_204801453 0.319 NM_012092
ICOS
inducible T-cell co-stimulator
chr5_-_157002739 0.317 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr2_-_190445466 0.315 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr1_+_43996478 0.315 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr14_-_54423448 0.314 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr19_-_19774472 0.311 ATP13A1
ATPase type 13A1
chr10_+_24755459 0.311 KIAA1217
KIAA1217
chr17_+_47653474 0.310 NXPH3
neurexophilin 3
chr1_-_95538443 0.309 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr13_-_107187312 0.304 NM_004093
EFNB2
ephrin-B2
chr3_+_140770742 0.304 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr1_+_111772332 0.302 NM_001025199
CHI3L2
chitinase 3-like 2
chr10_-_116418056 0.300 NM_002313
ABLIM1
actin binding LIM protein 1
chr10_+_82214071 0.299 TSPAN14
tetraspanin 14
chr1_+_207495009 0.299 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr3_-_129612371 0.298 NM_001128224
TMCC1
transmembrane and coiled-coil domain family 1
chr2_+_32390902 0.297 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 3.45e-04 GO:0048731 system development
1.29 4.06e-04 GO:0048856 anatomical structure development
1.27 6.89e-04 GO:0007275 multicellular organismal development
1.49 7.19e-04 GO:0002376 immune system process
1.24 3.03e-03 GO:0032502 developmental process
1.96 1.58e-02 GO:0061061 muscle structure development
1.33 1.71e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 6.06e-10 GO:0031224 intrinsic to membrane
1.27 1.36e-09 GO:0016021 integral to membrane
1.22 2.32e-08 GO:0044425 membrane part
1.17 2.48e-06 GO:0016020 membrane
1.37 1.79e-05 GO:0044459 plasma membrane part
1.50 1.80e-05 GO:0031226 intrinsic to plasma membrane
1.50 2.28e-05 GO:0005887 integral to plasma membrane
1.88 2.24e-04 GO:0009986 cell surface
1.45 1.91e-03 GO:0005783 endoplasmic reticulum
1.36 2.75e-03 GO:0012505 endomembrane system
1.54 5.84e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.55 6.61e-03 GO:0005789 endoplasmic reticulum membrane
1.51 7.55e-03 GO:0044432 endoplasmic reticulum part
1.18 1.47e-02 GO:0005886 plasma membrane
1.04 2.05e-02 GO:0044464 cell part
1.04 2.11e-02 GO:0005623 cell
1.18 2.22e-02 GO:0071944 cell periphery
1.46 2.80e-02 GO:0005615 extracellular space
2.80 3.05e-02 GO:0016459 myosin complex
1.38 4.52e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.45 6.88e-03 GO:0005102 receptor binding
2.22 1.31e-02 GO:0046873 metal ion transmembrane transporter activity
2.50 3.42e-02 GO:0015081 sodium ion transmembrane transporter activity