Motif ID: UAAGACU

Z-value: 0.660


Mature miRNA associated with seed UAAGACU:

NamemiRBase Accession
hsa-miR-499-5p MIMAT0002870



Activity profile for motif UAAGACU.

activity profile for motif UAAGACU


Sorted Z-values histogram for motif UAAGACU

Sorted Z-values for motif UAAGACU



Network of associatons between targets according to the STRING database.



First level regulatory network of UAAGACU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_95066628 1.154 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr14_-_61115906 0.929 NM_005982
SIX1
SIX homeobox 1
chr6_+_72926462 0.881 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_72922513 0.851 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr6_+_72926144 0.807 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_73076431 0.749 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_158526698 0.715 NM_024007
EBF1
early B-cell factor 1
chr18_-_25757351 0.595 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr3_-_18466759 0.547 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr3_-_18480203 0.520 NM_001131010
SATB1
SATB homeobox 1
chr1_+_145438437 0.510 NM_006472
TXNIP
thioredoxin interacting protein
chr11_+_19734821 0.472 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr7_+_90338711 0.447 NM_012395
CDK14
cyclin-dependent kinase 14
chr1_-_92351613 0.446 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr1_-_92371558 0.445 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr11_+_19372270 0.443 NM_001111018
NAV2
neuron navigator 2
chr8_+_16884745 0.432 NM_181723
EFHA2
EF-hand domain family, member A2
chr11_-_70935807 0.375 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr11_-_70507911 0.374 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr6_+_72596648 0.371 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_126366439 0.360 NM_178450
MARCH3
membrane-associated ring finger (C3HC4) 3
chrX_+_9754465 0.329 NM_001649
SHROOM2
shroom family member 2
chr5_+_176237435 0.321 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr15_+_63481713 0.309 NM_016530
RAB8B
RAB8B, member RAS oncogene family
chr8_+_38585703 0.294 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chrX_-_154114431 0.286 NM_019863
F8
coagulation factor VIII, procoagulant component
chr19_-_3700466 0.280 NM_001195733
NM_012398
PIP5K1C

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

chr15_-_49338496 0.278 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr8_+_38644721 0.274 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chrX_-_154250769 0.268 NM_000132
F8
coagulation factor VIII, procoagulant component
chr2_-_214016332 0.267 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr5_-_10761344 0.264 NM_004394
DAP
death-associated protein
chr5_-_114880536 0.259 NM_020177
FEM1C
fem-1 homolog c (C. elegans)
chr2_-_145277879 0.249 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr9_-_72374855 0.248 NM_001099666
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr14_-_73453651 0.238 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr7_+_102073953 0.229 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr14_-_73493744 0.220 NM_021260
ZFYVE1
zinc finger, FYVE domain containing 1
chr1_+_26606212 0.218 NM_031286
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr11_+_111848008 0.218 NM_033425
DIXDC1
DIX domain containing 1
chr16_-_4897265 0.216 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr12_+_15699277 0.210 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr5_-_58334936 0.201 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr1_-_225840660 0.194 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr6_-_52860076 0.190 NM_001512
GSTA4
glutathione S-transferase alpha 4
chr6_+_36646455 0.184 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr9_+_96793046 0.181 NM_177995
NM_001253830
PTPDC1

protein tyrosine phosphatase domain containing 1

chr1_+_154300275 0.177 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr12_+_15475190 0.176 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr15_-_48470453 0.176 NM_016132
MYEF2
myelin expression factor 2
chr16_-_80837878 0.176 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr12_+_32654976 0.174 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_+_29322802 0.173 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr9_+_96846710 0.170 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr5_-_59783885 0.167 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_145611018 0.162 NM_014455
RNF115
ring finger protein 115
chrX_-_34675366 0.161 NM_031442
TMEM47
transmembrane protein 47
chr13_-_107220444 0.161 NM_018011
ARGLU1
arginine and glutamate rich 1
chr6_+_3118861 0.158 NM_004332
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr2_-_214015053 0.158 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr11_+_111807857 0.157 NM_001037954
DIXDC1
DIX domain containing 1
chr13_+_49549953 0.155 NM_001079673
FNDC3A
fibronectin type III domain containing 3A
chr15_-_45815001 0.155 NM_013309
SLC30A4
solute carrier family 30 (zinc transporter), member 4
chr5_+_60628085 0.153 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr14_+_105780751 0.151 NM_001100913
NM_015197
PACS2

phosphofurin acidic cluster sorting protein 2

chr16_+_53088791 0.151 NM_025134
CHD9
chromodomain helicase DNA binding protein 9
chrX_-_114468604 0.150 NM_001243963
NM_020871
LRCH2

leucine-rich repeats and calponin homology (CH) domain containing 2

chr10_-_74385887 0.149 NM_001195518
NM_006077
MICU1

mitochondrial calcium uptake 1

chr2_+_204192915 0.148 NM_005759
ABI2
abl-interactor 2
chr16_+_54965110 0.148 NM_001252197
NM_005853
IRX5

iroquois homeobox 5

chr2_-_128100673 0.144 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr8_-_23712297 0.141 NM_003155
STC1
stanniocalcin 1
chr6_+_36644236 0.138 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr4_+_123747815 0.137 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr7_-_120498128 0.137 NM_012338
TSPAN12
tetraspanin 12
chr9_+_82186846 0.137 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_-_74283693 0.137 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr1_+_97187174 0.134 NM_021190
PTBP2
polypyrimidine tract binding protein 2
chr5_+_161277391 0.133 NM_001127647
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_+_58677489 0.128 NM_003620
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr5_+_161274939 0.127 NM_001127644
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr3_-_15382874 0.127 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chrX_+_30671456 0.126 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr3_-_141868208 0.123 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr12_-_92539614 0.123 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr5_+_161275541 0.123 NM_001127645
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_-_59189620 0.123 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_90679115 0.122 NM_020801
ARRDC3
arrestin domain containing 3
chr5_-_58295758 0.122 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_141719188 0.121 NM_001178140
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_-_76478737 0.116 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr19_-_7293876 0.115 NM_000208
NM_001079817
INSR

insulin receptor

chr5_+_161277702 0.115 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_+_161275897 0.113 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_+_161274684 0.112 NM_001127643
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_-_58652671 0.111 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_62502410 0.109 NM_004396
DDX5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr17_-_62050200 0.108 NM_000334
SCN4A
sodium channel, voltage-gated, type IV, alpha subunit
chr7_+_138916230 0.105 NM_173569
UBN2
ubinuclein 2
chr3_-_15374082 0.105 NM_004844
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr12_+_99038918 0.105 NM_001160
NM_013229
NM_181861
NM_181868
NM_181869
APAF1




apoptotic peptidase activating factor 1




chr5_+_122110737 0.102 NM_003100
SNX2
sorting nexin 2
chr13_+_100258886 0.101 NM_206808
CLYBL
citrate lyase beta like
chr5_-_59064437 0.101 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58571916 0.100 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_-_29120571 0.097 NM_015254
KIF13B
kinesin family member 13B
chr6_+_126102278 0.092 NM_001199619
NM_001199620
NCOA7

nuclear receptor coactivator 7

chr4_+_56212381 0.092 NM_024592
SRD5A3
steroid 5 alpha-reductase 3
chr13_+_49684388 0.092 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr8_+_79428335 0.090 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr3_-_37034609 0.090 NM_014805
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr3_-_141747434 0.087 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr19_+_37997840 0.086 NM_001013659
ZNF793
zinc finger protein 793
chr12_-_95942570 0.086 NM_001042403
USP44
ubiquitin specific peptidase 44
chr9_+_91003238 0.081 NM_006717
SPIN1
spindlin 1
chr3_-_124774735 0.080 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr18_-_57364643 0.079 NM_133459
CCBE1
collagen and calcium binding EGF domains 1
chr1_-_151414641 0.079 NM_207171
POGZ
pogo transposable element with ZNF domain
chr17_-_8534008 0.079 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr5_-_131132715 0.079 NM_001008738
NM_133372
FNIP1

folliculin interacting protein 1

chr12_-_49582800 0.076 NM_006009
TUBA1A
tubulin, alpha 1a
chr13_+_50571137 0.076 NM_001007278
NM_005798
NM_052811
NM_213590
TRIM13



tripartite motif containing 13



chr20_-_32274154 0.074 NM_005225
E2F1
E2F transcription factor 1
chr15_+_57210823 0.071 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr2_+_228029280 0.070 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr7_-_30029904 0.070 NM_001145514
SCRN1
secernin 1
chr22_+_30279064 0.070 NM_021090
NM_153050
NM_153051
MTMR3


myotubularin related protein 3


chr6_+_39760772 0.070 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr14_-_50698090 0.068 NM_006939
SOS2
son of sevenless homolog 2 (Drosophila)
chr1_-_70820363 0.068 NM_030816
ANKRD13C
ankyrin repeat domain 13C
chr14_+_90863302 0.067 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr1_-_108231122 0.065 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr22_+_21213248 0.064 NM_004782
SNAP29
synaptosomal-associated protein, 29kDa
chr7_-_30029284 0.063 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr6_+_39760148 0.063 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_+_126111782 0.061 NM_001122842
NM_001199621
NM_181782
NCOA7


nuclear receptor coactivator 7


chr5_-_58882274 0.061 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_95945226 0.059 NM_032147
USP44
ubiquitin specific peptidase 44
chr6_+_126240369 0.054 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr8_+_48920969 0.053 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr4_+_25235651 0.052 NM_018323
PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chr5_-_36151953 0.052 NM_001007527
LMBRD2
LMBR1 domain containing 2
chr13_-_74707913 0.052 NM_007249
KLF12
Kruppel-like factor 12
chr5_+_112043188 0.051 NM_001127511
APC
adenomatous polyposis coli
chr14_+_53196852 0.051 NM_001130701
NM_145251
STYX

serine/threonine/tyrosine interacting protein

chr1_-_21113160 0.045 NM_016287
HP1BP3
heterochromatin protein 1, binding protein 3
chr3_+_186501360 0.044 NM_001967
EIF4A2
eukaryotic translation initiation factor 4A2
chr9_-_127952037 0.044 NM_001123355
NM_001123369
NM_002721
PPP6C


protein phosphatase 6, catalytic subunit


chr5_+_161274196 0.043 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr11_-_118047336 0.043 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr6_+_163835668 0.042 NM_006775
NM_206853
NM_206854
NM_206855
QKI



QKI, KH domain containing, RNA binding



chr5_-_107006585 0.042 NM_001962
EFNA5
ephrin-A5
chr11_-_10829519 0.041 NM_001172705
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr14_+_103801160 0.041 NM_183004
EIF5
eukaryotic translation initiation factor 5
chr1_+_19923457 0.040 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr3_-_15563160 0.040 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr16_-_69166492 0.039 NM_001039690
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr7_-_106301329 0.036 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr10_-_7453412 0.036 NM_001029880
SFMBT2
Scm-like with four mbt domains 2
chr17_-_46178559 0.036 NM_006807
CBX1
chromobox homolog 1
chrX_-_112084006 0.036 NM_133265
AMOT
angiomotin
chr21_+_34697197 0.035 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chrX_-_112066353 0.035 NM_001113490
AMOT
angiomotin
chr10_-_7451198 0.034 NM_001018039
SFMBT2
Scm-like with four mbt domains 2
chr1_-_108507474 0.034 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr7_+_107531585 0.034 NM_000108
DLD
dihydrolipoamide dehydrogenase
chr8_+_85095501 0.033 NM_173848
RALYL
RALY RNA binding protein-like
chr9_-_19786886 0.033 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr3_-_15540378 0.033 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr12_+_68042493 0.032 NM_003583
NM_006482
DYRK2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

chr16_-_69166062 0.032 NM_001040146
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr17_+_26369617 0.030 NM_016231
NLK
nemo-like kinase
chr8_+_85095452 0.029 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr1_-_151431892 0.029 NM_001194937
NM_001194938
NM_015100
NM_145796
POGZ



pogo transposable element with ZNF domain



chr2_-_86564632 0.029 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr3_-_71774407 0.028 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr7_-_23053732 0.028 NM_032581
FAM126A
family with sequence similarity 126, member A
chr4_+_103790125 0.027 NM_001008388
CISD2
CDGSH iron sulfur domain 2
chr10_+_112631552 0.027 NM_001199492
NM_014456
NM_145341
PDCD4


programmed cell death 4 (neoplastic transformation inhibitor)


chr17_-_36762105 0.027 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr2_+_69969105 0.027 NM_001153
ANXA4
annexin A4
chr15_+_57511616 0.027 NM_207040
TCF12
transcription factor 12
chrX_-_24045302 0.026 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr12_-_99288502 0.026 NM_001204065
NM_001204079
NM_001204080
NM_001204081
ANKS1B



ankyrin repeat and sterile alpha motif domain containing 1B



chr13_-_110438896 0.026 NM_003749
IRS2
insulin receptor substrate 2
chr7_+_114055048 0.026 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr4_+_159690176 0.026 NM_020840
FNIP2
folliculin interacting protein 2
chr3_+_89156673 0.024 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr11_+_111944967 0.023 NM_001082969
NM_001082970
NM_018195
C11orf57


chromosome 11 open reading frame 57


chr17_-_60142598 0.023 NM_005121
MED13
mediator complex subunit 13
chrX_+_48398048 0.022 NM_002536
TBC1D25
TBC1 domain family, member 25
chr1_+_110543548 0.020 NM_001242674
AHCYL1
adenosylhomocysteinase-like 1
chr9_-_123476578 0.020 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr15_-_64648359 0.018 NM_022048
CSNK1G1
casein kinase 1, gamma 1
chr2_+_226265601 0.018 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr7_+_107384278 0.017 NM_024814
CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr5_+_112073555 0.016 NM_000038
NM_001127510
APC

adenomatous polyposis coli

chr11_+_11862955 0.016 NM_017944
USP47
ubiquitin specific peptidase 47
chr1_-_154832187 0.012 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr10_+_94050858 0.012 NM_017824
MARCH5
membrane-associated ring finger (C3HC4) 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 7.62e-03 GO:0050794 regulation of cellular process
1.41 8.96e-03 GO:0065007 biological regulation
5.77 9.38e-03 GO:0043408 regulation of MAPKKK cascade
1.26 1.01e-02 GO:0009987 cellular process
18.96 4.93e-02 GO:0051865 protein autoubiquitination

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.69 2.52e-03 GO:0030027 lamellipodium
1.34 8.44e-03 GO:0005737 cytoplasm
2.95 1.80e-02 GO:0030054 cell junction
1.22 1.98e-02 GO:0044424 intracellular part
13.04 3.75e-02 GO:0005913 cell-cell adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.20 1.31e-04 GO:0019904 protein domain specific binding
2.80 9.70e-03 GO:0019899 enzyme binding
4.50 1.60e-02 GO:0019900 kinase binding
104.25 1.77e-02 GO:0031405 lipoic acid binding
1.37 2.29e-02 GO:0005515 protein binding