• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: ZBTB6.p2

Z-value: 1.473

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_-_52914080	4.243	NM_000424	KRT5	keratin 5
chr12_-_52845862	4.089	NM_005555	KRT6B	keratin 6B
chr1_+_43996478	3.812	NM_002840 NM_130440	PTPRF	protein tyrosine phosphatase, receptor type, F
chr17_+_54671059	2.783	NM_005450	NOG	noggin
chr12_-_52886971	2.625	NM_005554	KRT6A	keratin 6A
chr5_-_149682447	2.266	NM_001012301	ARSI	arylsulfatase family, member I
chr12_+_53342842	2.085	NM_000224	KRT18	keratin 18
chr12_+_53342899	1.637		KRT18	keratin 18
chr19_-_36001336	1.576	NM_001126059	DMKN	dermokine
chr4_+_1795004	1.524	NM_000142 NM_001163213 NM_022965	FGFR3	fibroblast growth factor receptor 3
chr16_+_22825481	1.261		HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr19_-_15090349	1.245		SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr1_+_158150678	1.239		CD1D	CD1d molecule
chr20_+_6748744	1.226	NM_001200	BMP2	bone morphogenetic protein 2
chr16_+_22825806	1.171	NM_006043	HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_-_242687997	1.163	NM_152666	PLD5	phospholipase D family, member 5
chr1_+_26856259	1.151		RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_+_104512975	1.134	NM_001100117	RIMS2	regulating synaptic membrane exocytosis 2
chr5_-_141257943	1.101	NM_002587 NM_032420	PCDH1	protocadherin 1
chr5_+_140220811	1.098	NM_018911 NM_031856	PCDHA8	protocadherin alpha 8
chr10_+_23983674	1.085	NM_001098500	KIAA1217	KIAA1217
chr6_+_150464156	1.061	NM_030949	PPP1R14C	protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr3_-_189838673	1.057		LEPREL1	leprecan-like 1
chr4_+_30722445	1.021		PCDH7	protocadherin 7
chr1_+_26856252	0.961		RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_26856240	0.940	NM_002953	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr9_-_139948448	0.937	NM_001246 NM_203468	ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2
chr5_+_52776479	0.923		FST	follistatin
chr19_+_38755422	0.894		SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr6_-_136847609	0.880		MAP7	microtubule-associated protein 7
chr3_-_190040192	0.877	NM_021101	CLDN1	claudin 1
chr22_+_40390935	0.869	NM_138435	FAM83F	family with sequence similarity 83, member F
chr17_+_48610045	0.860	NM_017957	EPN3	epsin 3
chr1_-_205290756	0.855	NM_030952	NUAK2	NUAK family, SNF1-like kinase, 2
chr11_-_79151694	0.832	NM_001098816	ODZ4	odz, odd Oz/ten-m homolog 4 (Drosophila)
chr5_+_52776408	0.827		FST	follistatin
chr10_+_75673346	0.806		PLAU	plasminogen activator, urokinase
chr3_-_189838907	0.801	NM_018192	LEPREL1	leprecan-like 1
chr22_+_33197744	0.779		TIMP3	TIMP metallopeptidase inhibitor 3
chr16_+_69141442	0.767	NM_005329	HAS3	hyaluronan synthase 3
chr10_-_103879933	0.762	NM_001113407	LDB1	LIM domain binding 1
chr1_+_109792640	0.761	NM_001408	CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr18_-_47721165	0.747	NM_001080467	MYO5B	myosin VB
chr22_+_33197678	0.731		TIMP3	TIMP metallopeptidase inhibitor 3
chr15_+_45422130	0.729	NM_017434 NM_175940	DUOX1	dual oxidase 1
chr17_+_48610077	0.715		EPN3	epsin 3
chr2_+_220492286	0.710	NM_005070 NM_201574	SLC4A3	solute carrier family 4, anion exchanger, member 3
chr2_+_85360373	0.707	NM_031283	TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)
chr18_-_28622624	0.696	NM_001941 NM_024423	DSC3	desmocollin 3
chr11_+_111411232	0.690	NM_178834	LAYN	layilin
chr11_+_111411419	0.690		LAYN	layilin
chr6_+_30850693	0.688		DDR1	discoidin domain receptor tyrosine kinase 1
chr6_+_37137882	0.677	NM_001243186 NM_002648	PIM1	pim-1 oncogene
chr10_+_48255223	0.656	NM_001040084 NM_001098845	ANXA8L2 ANXA8 ANXA8L1	annexin A8-like 2 annexin A8 annexin A8-like 1
chr17_+_47572592	0.643	NM_002507	NGFR	nerve growth factor receptor
chr7_+_26191732	0.634	NM_004289	NFE2L3	nuclear factor (erythroid-derived 2)-like 3
chr3_-_13921617	0.630	NM_004625	WNT7A	wingless-type MMTV integration site family, member 7A
chr12_+_53342654	0.623	NM_199187	KRT18	keratin 18
chr1_-_6662681	0.622		KLHL21	kelch-like 21 (Drosophila)
chr10_+_47746919	0.622	NM_001630	ANXA8L2 ANXA8	annexin A8-like 2 annexin A8
chr20_+_58152563	0.621	NM_001199505	PHACTR3	phosphatase and actin regulator 3
chr1_+_15250578	0.618	NM_001018000	KAZN	kazrin, periplakin interacting protein
chr18_+_29078026	0.614	NM_001943	DSG2	desmoglein 2
chr19_+_45312294	0.613	NM_001013257 NM_005581	BCAM	basal cell adhesion molecule (Lutheran blood group)
chr17_+_9548853	0.611	NM_153210	USP43	ubiquitin specific peptidase 43
chrX_+_17393537	0.609	NM_198270	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr11_+_63753827	0.605		OTUB1	OTU domain, ubiquitin aldehyde binding 1
chr6_-_107435635	0.594	NM_001080450	BEND3	BEN domain containing 3
chr11_+_10476665	0.585	NM_001025389	AMPD3	adenosine monophosphate deaminase 3
chr6_-_136788012	0.584	NM_001198615	MAP7	microtubule-associated protein 7
chr6_+_1312674	0.584	NM_033260	FOXQ1	forkhead box Q1
chr17_-_41910439	0.578	NM_001932	MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr19_-_55658310	0.572		TNNT1	troponin T type 1 (skeletal, slow)
chr1_+_13910251	0.567	NM_006474 NM_198389	PDPN	podoplanin
chr1_+_156252725	0.561		TMEM79	transmembrane protein 79
chr12_-_28124915	0.557	NM_002820 NM_198965	PTHLH	parathyroid hormone-like hormone
chr2_-_20425166	0.557	NM_001006946	SDC1	syndecan 1
chrX_+_152954965	0.556	NM_001142806	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr21_+_46825001	0.552	NM_130445	COL18A1	collagen, type XVIII, alpha 1
chr10_-_14646407	0.539		FAM107B	family with sequence similarity 107, member B
chr7_+_26331611	0.538		SNX10	sorting nexin 10
chr3_+_140770412	0.518		SPSB4	splA/ryanodine receptor domain and SOCS box containing 4
chr19_+_54376975	0.517		MYADM	myeloid-associated differentiation marker
chr9_-_104249333	0.516	NM_032342	C9orf125	chromosome 9 open reading frame 125
chr11_+_1861431	0.515	NM_001145841	TNNI2	troponin I type 2 (skeletal, fast)
chr19_+_41223282	0.504		ITPKC	inositol-trisphosphate 3-kinase C
chr4_+_30721865	0.503	NM_032456 NM_001173523 NM_002589 NM_032457	PCDH7	protocadherin 7
chr6_+_43043944	0.498	NM_002821 NM_152880 NM_152881 NM_152882	PTK7	PTK7 protein tyrosine kinase 7
chr7_-_98030165	0.488		BAIAP2L1	BAI1-associated protein 2-like 1
chr3_+_10857867	0.483	NM_014229	SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr3_-_48470715	0.481	NM_002673	PLXNB1	plexin B1
chr1_-_109940497	0.473	NM_002959	SORT1	sortilin 1
chr11_+_33563772	0.472	NM_012194	C11orf41	chromosome 11 open reading frame 41
chr20_+_58251715	0.470	NM_001199506	PHACTR3	phosphatase and actin regulator 3
chr10_+_120789227	0.470	NM_199461	NANOS1	nanos homolog 1 (Drosophila)
chr15_+_40545348	0.469		PAK6	p21 protein (Cdc42/Rac)-activated kinase 6
chr17_-_34122547	0.463	NM_001032278 NM_024302	MMP28	matrix metallopeptidase 28
chr5_+_140180782	0.462	NM_018906 NM_031497	PCDHA3	protocadherin alpha 3
chr6_+_14118002	0.460		CD83	CD83 molecule
chr10_-_105614952	0.455	NM_014631	SH3PXD2A	SH3 and PX domains 2A
chr20_+_13202417	0.455	NM_080826	ISM1	isthmin 1 homolog (zebrafish)
chr8_+_98656494	0.451		MTDH	metadherin
chr18_-_24128499	0.450	NM_001142730	KCTD1	potassium channel tetramerisation domain containing 1
chr5_+_140346053	0.447		PCDHAC2	protocadherin alpha subfamily C, 2
chr12_+_104850641	0.445	NM_001173982 NM_018413	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11
chr11_+_45944155	0.443		GYLTL1B	glycosyltransferase-like 1B
chr8_+_98656428	0.442		MTDH	metadherin
chr3_-_52090090	0.442	NM_001947	DUSP7	dual specificity phosphatase 7
chr6_-_13486986	0.440		GFOD1	glucose-fructose oxidoreductase domain containing 1
chr10_-_14646237	0.439		FAM107B	family with sequence similarity 107, member B
chr2_-_235405692	0.436	NM_005737	ARL4C	ADP-ribosylation factor-like 4C
chr1_+_1981902	0.432	NM_002744	PRKCZ	protein kinase C, zeta
chr7_+_26331493	0.432	NM_001199835 NM_013322	SNX10	sorting nexin 10
chr3_+_140950671	0.428	NM_001037172 NM_152282	ACPL2	acid phosphatase-like 2
chr6_+_21593963	0.427	NM_003107	SOX4	SRY (sex determining region Y)-box 4
chr16_+_3014216	0.422	NM_001253725 NM_001253726 NM_024507 NM_172229	KREMEN2	kringle containing transmembrane protein 2
chr10_+_129705299	0.421	NM_006504	PTPRE	protein tyrosine phosphatase, receptor type, E
chr14_-_38064440	0.418	NM_004496	FOXA1	forkhead box A1
chr15_+_40531236	0.417		PAK6	p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_117452359	0.413	NM_020440	PTGFRN	prostaglandin F2 receptor negative regulator
chr6_-_53409897	0.410	NM_001197115 NM_001498	GCLC	glutamate-cysteine ligase, catalytic subunit
chr1_-_115053677	0.404		TRIM33	tripartite motif containing 33
chr10_-_125853102	0.402		CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr9_-_117150217	0.401		AKNA	AT-hook transcription factor
chr6_+_30881981	0.398	NM_001167733 NM_020442 NM_001167734	VARS2	valyl-tRNA synthetase 2, mitochondrial (putative)
chr1_-_48462561	0.396	NM_001194986	LOC388630	UPF0632 protein A
chr1_+_60280462	0.393	NM_015888	HOOK1	hook homolog 1 (Drosophila)
chr12_-_6484389	0.393	NM_001159576	SCNN1A	sodium channel, nonvoltage-gated 1 alpha
chr16_+_3096681	0.389	NM_022468	MMP25	matrix metallopeptidase 25
chr4_-_122302112	0.389	NM_198179	QRFPR	pyroglutamylated RFamide peptide receptor
chr12_-_52867521	0.388	NM_173086	KRT6C	keratin 6C
chr1_+_45965855	0.387	NM_015506	MMACHC	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr7_+_144052432	0.385	NM_005435	ARHGEF5	Rho guanine nucleotide exchange factor (GEF) 5
chr2_-_20424627	0.385	NM_002997	SDC1	syndecan 1
chr4_+_30722191	0.383		PCDH7	protocadherin 7
chr1_+_15480213	0.380	NM_001136218 NM_018022	TMEM51	transmembrane protein 51
chr17_+_7608413	0.380	NM_001406	EFNB3	ephrin-B3
chr1_-_223537400	0.379	NM_001037175 NM_017982	SUSD4	sushi domain containing 4
chr4_-_139163222	0.377	NM_014331	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr22_-_46933066	0.376	NM_014246	CELSR1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr1_-_41131323	0.376	NM_014747	RIMS3	regulating synaptic membrane exocytosis 3
chr17_-_34079896	0.375	NM_139285	GAS2L2	growth arrest-specific 2 like 2
chr22_+_23522743	0.375		BCR	breakpoint cluster region
chr5_+_140213968	0.375	NM_018910 NM_031852	PCDHA7	protocadherin alpha 7
chr6_-_30712294	0.374	NM_003897	IER3	immediate early response 3
chr11_+_130029663	0.373	NM_021978	ST14	suppression of tumorigenicity 14 (colon carcinoma)
chr3_-_116164321	0.371		LSAMP	limbic system-associated membrane protein
chr1_+_15272414	0.371	NM_001017999	KAZN	kazrin, periplakin interacting protein
chr4_-_74486100	0.369	NM_177532 NM_201431	RASSF6	Ras association (RalGDS/AF-6) domain family member 6
chr1_+_14925177	0.369	NM_015209 NM_201628	KAZN	kazrin, periplakin interacting protein
chr1_+_95582827	0.368	NM_152487	TMEM56	transmembrane protein 56
chr4_+_41258909	0.367		UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr19_+_41699076	0.365	NM_030622	CYP2S1	cytochrome P450, family 2, subfamily S, polypeptide 1
chr10_-_6019454	0.364	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chr8_-_66753968	0.364	NM_001242318	PDE7A	phosphodiesterase 7A
chr4_+_41258895	0.362	NM_004181	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr17_-_73874056	0.361		TRIM47	tripartite motif containing 47
chr12_+_56473808	0.359	NM_001982 NM_001005915	ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr17_+_16120465	0.356	NM_004278	PIGL	phosphatidylinositol glycan anchor biosynthesis, class L
chr16_+_68679198	0.350		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr1_+_40627031	0.349	NM_012421	RLF	rearranged L-myc fusion
chr12_+_50898744	0.349	NM_173602	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr3_+_6902812	0.348		GRM7	glutamate receptor, metabotropic 7
chr1_-_19282773	0.347	NM_001136265	IFFO2	intermediate filament family orphan 2
chr22_-_39639967	0.347		PDGFB	platelet-derived growth factor beta polypeptide
chr20_+_1874779	0.346	NM_001040022	SIRPA	signal-regulatory protein alpha
chr1_-_153588789	0.346	NM_020672	S100A14	S100 calcium binding protein A14
chr14_-_91526912	0.345	NM_004755 NM_182398	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr11_-_115375065	0.343	NM_001098517 NM_014333	CADM1	cell adhesion molecule 1
chr11_+_63753902	0.343		OTUB1	OTU domain, ubiquitin aldehyde binding 1
chr22_+_45064323	0.342	NM_001017528 NM_001017529	PRR5	proline rich 5 (renal)
chr6_-_13487772	0.340	NM_001242629 NM_018988	GFOD1	glucose-fructose oxidoreductase domain containing 1
chr5_+_175298604	0.337		CPLX2	complexin 2
chr1_+_32042122	0.337		TINAGL1	tubulointerstitial nephritis antigen-like 1
chr3_+_140770742	0.335	NM_080862	SPSB4	splA/ryanodine receptor domain and SOCS box containing 4
chr12_+_49688908	0.332	NM_006262	PRPH	peripherin
chr6_-_97285058	0.331	NM_001143957 NM_030784	GPR63	G protein-coupled receptor 63
chr5_+_140345746	0.330	NM_018899	PCDHAC2	protocadherin alpha subfamily C, 2
chr1_+_15256295	0.330	NM_001018001	KAZN	kazrin, periplakin interacting protein
chr11_-_125366048	0.328	NM_005103 NM_022549	FEZ1	fasciculation and elongation protein zeta 1 (zygin I)
chr14_-_94855120	0.327	NM_000295	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_-_98741605	0.327		SMURF1	SMAD specific E3 ubiquitin protein ligase 1
chr10_-_47173917	0.327	NM_001040084 NM_001098845	ANXA8L2 ANXA8 ANXA8L1	annexin A8-like 2 annexin A8 annexin A8-like 1
chr15_-_75017710	0.324	NM_000499	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1
chr8_+_61591358	0.323		CHD7	chromodomain helicase DNA binding protein 7
chr1_+_32042085	0.323	NM_001204414 NM_022164	TINAGL1	tubulointerstitial nephritis antigen-like 1
chr19_+_38755238	0.323		SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr4_+_41258941	0.320		UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr17_-_76128487	0.319	NM_007267	TMC6	transmembrane channel-like 6
chr15_-_83378488	0.319	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr2_+_148602050	0.318		ACVR2A	activin A receptor, type IIA
chr1_+_156030965	0.318	NM_020387	RAB25	RAB25, member RAS oncogene family
chr17_-_4642638	0.317		CXCL16	chemokine (C-X-C motif) ligand 16
chr20_-_44539542	0.314		PLTP	phospholipid transfer protein
chr1_+_40627055	0.314		RLF	rearranged L-myc fusion
chr5_+_52776263	0.313	NM_006350 NM_013409	FST	follistatin
chr18_+_55888838	0.313		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_55711746	0.313		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_86564044	0.313	NM_002890	RASA1	RAS p21 protein activator (GTPase activating protein) 1
chr4_+_106816627	0.311		NPNT	nephronectin

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.12	2.58e-10	GO:0009987	cellular process
1.39	1.32e-06	GO:0006464	protein modification process
1.37	4.33e-06	GO:0043412	macromolecule modification
1.24	8.36e-06	GO:0023052	signaling
1.29	8.63e-05	GO:0044267	cellular protein metabolic process
1.23	2.35e-04	GO:0007165	signal transduction
1.53	6.62e-04	GO:0006468	protein phosphorylation
1.24	1.09e-03	GO:0019538	protein metabolic process
1.42	3.25e-03	GO:0006793	phosphorus metabolic process
1.42	3.25e-03	GO:0006796	phosphate metabolic process
1.33	5.73e-03	GO:0007399	nervous system development
1.17	5.74e-03	GO:0044260	cellular macromolecule metabolic process
1.16	6.43e-03	GO:0043170	macromolecule metabolic process
1.29	8.66e-03	GO:0007166	cell surface receptor linked signaling pathway
1.42	2.63e-02	GO:0016310	phosphorylation
1.10	3.21e-02	GO:0065007	biological regulation
1.18	4.82e-02	GO:0051179	localization

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.37	1.53e-08	GO:0044459	plasma membrane part
1.18	1.55e-08	GO:0044425	membrane part
1.15	4.48e-08	GO:0016020	membrane
1.19	3.32e-07	GO:0031224	intrinsic to membrane
1.19	3.58e-07	GO:0016021	integral to membrane
1.44	1.55e-06	GO:0031226	intrinsic to plasma membrane
1.44	3.19e-06	GO:0005887	integral to plasma membrane
1.65	2.03e-03	GO:0009986	cell surface
1.15	1.41e-02	GO:0005886	plasma membrane
1.15	2.13e-02	GO:0071944	cell periphery
2.19	3.39e-02	GO:0042470	melanosome
2.19	3.39e-02	GO:0048770	pigment granule
1.53	3.61e-02	GO:0045202	synapse
3.75	4.56e-02	GO:0044304	main axon

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.15	7.12e-07	GO:0005515	protein binding
1.44	1.02e-03	GO:0022891	substrate-specific transmembrane transporter activity
1.50	4.07e-03	GO:0004672	protein kinase activity
1.70	6.78e-03	GO:0022836	gated channel activity
1.39	6.83e-03	GO:0022857	transmembrane transporter activity
1.89	9.65e-03	GO:0005244	voltage-gated ion channel activity
1.89	9.65e-03	GO:0022832	voltage-gated channel activity
1.42	1.52e-02	GO:0016773	phosphotransferase activity, alcohol group as acceptor
5.84	1.97e-02	GO:0003756	protein disulfide isomerase activity
5.84	1.97e-02	GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups
5.84	1.97e-02	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds
1.47	2.64e-02	GO:0008324	cation transmembrane transporter activity
2.32	3.16e-02	GO:0005275	amine transmembrane transporter activity
1.56	3.53e-02	GO:0005216	ion channel activity
1.39	4.32e-02	GO:0015075	ion transmembrane transporter activity
1.25	4.40e-02	GO:0016740	transferase activity
1.26	4.61e-02	GO:0032559	adenyl ribonucleotide binding
1.33	4.67e-02	GO:0022892	substrate-specific transporter activity
1.26	4.89e-02	GO:0030554	adenyl nucleotide binding