Motif ID: ZEB1.p2

Z-value: 4.054


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_31608097-0.974.0e-05Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_38755097 15.853 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_38755422 15.789 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755238 15.626 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr7_+_26331493 12.220 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr16_+_68771192 12.137 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_60280462 11.993 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr2_+_47596286 11.511 NM_002354
EPCAM
epithelial cell adhesion molecule
chr16_+_68771214 11.368 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr2_+_47596447 11.179 EPCAM
epithelial cell adhesion molecule
chr11_+_32851469 11.138 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr19_+_35739519 11.048 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr19_+_35739778 10.721 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_95653272 10.320 ESRP1
epithelial splicing regulatory protein 1
chr1_+_1981902 10.224 NM_002744
PRKCZ
protein kinase C, zeta
chr14_-_61747956 9.987 TMEM30B
transmembrane protein 30B
chr19_+_6464259 9.648 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr7_+_26331611 9.263 SNX10
sorting nexin 10
chr19_+_35739282 8.769 LSR
lipolysis stimulated lipoprotein receptor
chr22_+_40390935 8.204 NM_138435
FAM83F
family with sequence similarity 83, member F
chr8_+_120220554 7.974 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr19_+_35739838 7.823 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_68679229 7.073 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr7_-_22396511 7.009 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr9_-_126030792 6.701 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr18_+_33877630 6.486 NM_025135
FHOD3
formin homology 2 domain containing 3
chr5_+_68788387 6.382 NM_001205254
OCLN
occludin
chr2_+_223289285 6.169 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr2_+_223289212 6.111 SGPP2
sphingosine-1-phosphate phosphatase 2
chr1_-_27286875 6.031 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr16_+_68771304 5.977 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_-_209979388 5.718 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr4_-_36245893 5.685 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_167718485 5.510 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr9_-_126030854 5.320 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr6_+_36098261 5.226 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr4_+_75310852 5.196 NM_001657
AREG
amphiregulin
chr6_+_7541837 5.146 DSP
desmoplakin
chr8_+_86376130 5.090 NM_000067
CA2
carbonic anhydrase II
chr6_+_7541863 5.071 NM_001008844
NM_004415
DSP

desmoplakin

chr2_+_17721806 4.985 NM_003385
VSNL1
visinin-like 1
chr17_-_7165788 4.922 CLDN7
claudin 7
chr7_+_148036528 4.917 CNTNAP2
contactin associated protein-like 2
chr21_-_42219038 4.886 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr19_+_7702020 4.830 STXBP2
syntaxin binding protein 2
chr17_-_39942937 4.772 NM_002230
NM_021991
JUP

junction plakoglobin

chr13_+_25946084 4.761 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr8_-_127570465 4.751 FAM84B
family with sequence similarity 84, member B
chr2_+_163200582 4.730 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr11_+_69924407 4.709 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr17_-_31203889 4.688 NM_015194
MYO1D
myosin ID
chr6_+_7541892 4.618 DSP
desmoplakin
chr4_+_75480628 4.606 NM_001657
AREG
amphiregulin
chr2_+_17721983 4.598 VSNL1
visinin-like 1
chr16_-_68269948 4.569 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr18_-_47721165 4.481 NM_001080467
MYO5B
myosin VB
chr13_-_20806533 4.471 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr17_-_31204071 4.455 MYO1D
myosin ID
chr19_-_51487070 4.447 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr1_+_62208091 4.434 NM_176877
INADL
InaD-like (Drosophila)
chr15_+_40545348 4.412 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr8_-_75233461 4.406 NM_020647
JPH1
junctophilin 1
chr14_-_61748510 4.280 NM_001017970
TMEM30B
transmembrane protein 30B
chr2_+_163200623 4.271 GCA
grancalcin, EF-hand calcium binding protein
chr15_-_44487237 4.256 NM_032892
FRMD5
FERM domain containing 5
chr17_-_7166263 4.214 NM_001185023
NM_001307
CLDN7

claudin 7

chr14_-_105635114 4.140 NM_002226
NM_145159
JAG2

jagged 2

chr4_+_40198526 4.113 NM_004310
RHOH
ras homolog gene family, member H
chr14_-_105634708 4.109 JAG2
jagged 2
chr1_-_159915382 4.089 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr19_+_7702010 4.068 STXBP2
syntaxin binding protein 2
chr2_-_165477818 4.017 GRB14
growth factor receptor-bound protein 14
chr4_+_89300110 3.994 HERC6
hect domain and RLD 6
chr16_+_68679198 3.960 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr1_+_95582827 3.950 NM_152487
TMEM56
transmembrane protein 56
chr11_-_125366048 3.939 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr11_-_17035948 3.896 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr3_-_189838673 3.875 LEPREL1
leprecan-like 1
chr15_-_44487468 3.858 FRMD5
FERM domain containing 5
chr2_-_165477986 3.850 GRB14
growth factor receptor-bound protein 14
chr1_-_160990971 3.755 NM_016946
F11R
F11 receptor
chr4_+_89299980 3.710 HERC6
hect domain and RLD 6
chr8_+_95653340 3.706 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr8_+_95653399 3.682 ESRP1
epithelial splicing regulatory protein 1
chr11_+_72929392 3.673 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr20_-_6103562 3.669 FERMT1
fermitin family member 1
chr6_-_136871542 3.614 MAP7
microtubule-associated protein 7
chr2_-_122042767 3.608 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr11_+_72929302 3.589 NM_002564
NM_176072
P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr11_+_45944155 3.589 GYLTL1B
glycosyltransferase-like 1B
chr19_+_7701976 3.582 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr1_-_160990862 3.581 F11R
F11 receptor
chr14_+_65171243 3.568 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr21_-_42218587 3.433 DSCAM
Down syndrome cell adhesion molecule
chr11_+_1860232 3.414 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr17_+_73521744 3.388 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr12_+_56473808 3.370 NM_001982
NM_001005915
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr4_+_79472741 3.235 NM_005139
ANXA3
annexin A3
chr19_-_35992798 3.133 NM_001035516
DMKN
dermokine
chr6_+_150464156 3.080 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr11_-_66139064 3.065 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr7_+_16793320 3.050 NM_014399
TSPAN13
tetraspanin 13
chr19_-_51522953 3.009 NM_145888
KLK10
kallikrein-related peptidase 10
chr11_-_88070840 2.966 CTSC
cathepsin C
chr12_-_52914080 2.937 NM_000424
KRT5
keratin 5
chr18_+_47088400 2.936 NM_006033
LIPG
lipase, endothelial
chr5_+_68710938 2.910 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr1_+_183155393 2.871 LAMC2
laminin, gamma 2
chr1_+_183155361 2.841 LAMC2
laminin, gamma 2
chr19_-_51523272 2.830 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr1_+_183155173 2.816 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr19_-_36001336 2.806 NM_001126059
DMKN
dermokine
chr4_+_155665150 2.791 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr1_+_46646199 2.775 TSPAN1
tetraspanin 1
chr2_-_216878314 2.733 NM_018000
MREG
melanoregulin
chr21_+_43933983 2.712 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr2_-_46384 2.692 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr18_+_29078026 2.691 NM_001943
DSG2
desmoglein 2
chr8_+_28351694 2.688 NM_017412
NM_145866
FZD3

frizzled family receptor 3

chr1_+_95286193 2.620 SLC44A3
solute carrier family 44, member 3
chr17_+_54671059 2.579 NM_005450
NOG
noggin
chr1_+_24645811 2.560 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr19_+_7660698 2.546 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr1_+_95285900 2.529 NM_001114106
SLC44A3
solute carrier family 44, member 3
chr8_-_494834 2.529 C8orf42
chromosome 8 open reading frame 42
chr17_+_73717515 2.527 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr14_+_65171149 2.527 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_+_152954965 2.489 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr15_-_52587851 2.472 NM_018728
MYO5C
myosin VC
chr20_+_61273786 2.458 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr17_+_73717596 2.403 ITGB4
integrin, beta 4
chr17_+_73717556 2.375 ITGB4
integrin, beta 4
chr3_-_45187843 2.374 CDCP1
CUB domain containing protein 1
chr10_+_71211215 2.362 NM_012339
TSPAN15
tetraspanin 15
chr3_-_189838907 2.353 NM_018192
LEPREL1
leprecan-like 1
chr20_+_61273823 2.337 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr11_-_88070905 2.334 NM_001114173
NM_001814
NM_148170
CTSC


cathepsin C


chr22_+_29876180 2.310 NM_021076
NEFH
neurofilament, heavy polypeptide
chr7_-_139762339 2.306 PARP12
poly (ADP-ribose) polymerase family, member 12
chr3_+_47021146 2.305 NM_015175
NBEAL2
neurobeachin-like 2
chr1_+_44064509 2.304 PTPRF
protein tyrosine phosphatase, receptor type, F
chr1_+_24645914 2.302 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr11_+_130029663 2.286 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr4_+_85504056 2.283 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr11_+_75479766 2.273 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr3_+_113666544 2.271 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr4_+_89299874 2.250 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr4_-_53617565 2.237 ERVMER34-1
endogenous retrovirus group MER34, member 1
chr1_+_109792640 2.218 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr1_+_35247838 2.215 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr11_+_130029712 2.211 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr11_-_108464344 2.201 NM_015065
EXPH5
exophilin 5
chr14_-_67878859 2.193 PLEK2
pleckstrin 2
chr3_-_45187861 2.182 CDCP1
CUB domain containing protein 1
chr11_+_130029773 2.182 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr3_-_56835829 2.181 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr21_-_43187197 2.180 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_+_203097427 2.177 ADORA1
adenosine A1 receptor
chr12_-_48298765 2.153 NM_000376
NM_001017535
NM_001017536
VDR


vitamin D (1,25- dihydroxyvitamin D3) receptor


chr8_+_32405727 2.148 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr14_-_67878770 2.146 NM_016445
PLEK2
pleckstrin 2
chr11_+_130029699 2.143 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr11_-_441956 2.138 ANO9
anoctamin 9
chr11_+_59522801 2.135 STX3
syntaxin 3
chr19_-_6767417 2.130 NM_005490
SH2D3A
SH2 domain containing 3A
chr7_-_44365019 2.121 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr11_-_119234628 2.115 USP2
ubiquitin specific peptidase 2
chr4_-_53617781 2.105 NM_001242690
NM_024534
ERVMER34-1

endogenous retrovirus group MER34, member 1

chr2_-_237416091 2.101 NM_024726
IQCA1
IQ motif containing with AAA domain 1
chr8_+_102504836 2.091 GRHL2
grainyhead-like 2 (Drosophila)
chr8_+_102504661 2.076 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr19_+_45281125 2.074 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr11_-_441995 2.038 NM_001012302
ANO9
anoctamin 9
chr18_+_59992519 2.036 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr1_+_151483861 2.031 NM_020770
CGN
cingulin
chr12_+_56473944 2.031 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr1_-_41131323 2.027 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr16_+_71660063 2.027 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr5_+_31639424 2.018 PDZD2
PDZ domain containing 2
chr19_+_35607218 2.014 FXYD3
FXYD domain containing ion transport regulator 3
chr1_+_234349995 2.008 SLC35F3
solute carrier family 35, member F3
chr1_+_234040547 1.999 NM_173508
SLC35F3
solute carrier family 35, member F3
chr3_-_48470715 1.998 NM_002673
PLXNB1
plexin B1
chr8_-_144654921 1.994 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr20_-_6103860 1.980 FERMT1
fermitin family member 1
chr6_-_13486382 1.975 NM_001242628
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr12_-_51785192 1.964 NM_007210
GALNT6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr17_-_43510279 1.964 NM_174919
ARHGAP27
Rho GTPase activating protein 27
chr11_-_72504643 1.960 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr8_-_144815888 1.960 NM_198488
FAM83H
family with sequence similarity 83, member H
chr15_+_41136622 1.958 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr3_-_190040192 1.947 NM_021101
CLDN1
claudin 1
chr6_+_143382030 1.941 AIG1
androgen-induced 1
chr12_+_7282963 1.937 NM_014718
CLSTN3
calsyntenin 3
chr12_-_28122884 1.915 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr3_-_45187897 1.899 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr17_-_39684499 1.887 KRT19
keratin 19
chr15_+_40531236 1.875 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr12_-_52886971 1.874 NM_005554
KRT6A
keratin 6A
chr12_+_50017340 1.873 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr22_+_45148437 1.866 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.81e-05 GO:0009987 cellular process
1.18 5.33e-04 GO:0023052 signaling
1.18 6.06e-03 GO:0007165 signal transduction
1.15 1.83e-02 GO:0051716 cellular response to stimulus
2.15 3.88e-02 GO:0045216 cell-cell junction organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 7.06e-08 GO:0005737 cytoplasm
1.07 6.94e-06 GO:0005622 intracellular
1.31 2.66e-05 GO:0012505 endomembrane system
1.26 4.89e-05 GO:0031090 organelle membrane
1.13 6.38e-05 GO:0044444 cytoplasmic part
1.07 1.18e-04 GO:0044424 intracellular part
1.10 7.28e-04 GO:0016020 membrane
1.08 2.58e-03 GO:0043231 intracellular membrane-bounded organelle
1.04 2.78e-03 GO:0044464 cell part
1.08 2.86e-03 GO:0043227 membrane-bounded organelle
1.04 2.92e-03 GO:0005623 cell
1.31 4.52e-03 GO:0005783 endoplasmic reticulum
1.73 6.88e-03 GO:0005911 cell-cell junction
1.11 9.10e-03 GO:0044446 intracellular organelle part
1.11 2.90e-02 GO:0044422 organelle part
1.07 3.68e-02 GO:0043229 intracellular organelle
1.06 4.16e-02 GO:0043226 organelle
1.34 4.33e-02 GO:0031967 organelle envelope
1.34 4.79e-02 GO:0005789 endoplasmic reticulum membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.54e-05 GO:0005515 protein binding
1.25 6.02e-04 GO:0017076 purine nucleotide binding
1.25 6.21e-04 GO:0032553 ribonucleotide binding
1.25 6.21e-04 GO:0032555 purine ribonucleotide binding
1.25 9.96e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.26 1.18e-03 GO:0016740 transferase activity
1.19 1.69e-02 GO:0000166 nucleotide binding
1.11 2.22e-02 GO:0003824 catalytic activity
2.10 2.30e-02 GO:0015294 solute:cation symporter activity
1.24 2.80e-02 GO:0005524 ATP binding
1.24 2.95e-02 GO:0032559 adenyl ribonucleotide binding
1.23 3.43e-02 GO:0030554 adenyl nucleotide binding
2.09 4.83e-02 GO:0005275 amine transmembrane transporter activity