Motif ID: ZIC1..3.p2

Z-value: 1.059


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_147127151-0.686.5e-02Click!
ZIC2chr13_+_100633977,
chr13_+_100634257		-0.581.3e-01Click!
ZIC3chrX_+_1366483130.472.4e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_168727715 1.464 NM_003062
 SLIT3
slit homolog 3 (Drosophila)
chr2_+_217498205 1.393 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr2_+_217498082 1.240 NM_000597
 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr11_-_111782447 1.038 NM_001885
 CRYAB
crystallin, alpha B
chr14_+_101292483 1.008


chr5_+_71403040 0.995 NM_005909
 MAP1B
microtubule-associated protein 1B
chr7_-_150946031 0.994 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_-_150602020 0.910 ENSA
endosulfine alpha
chrX_-_15872921 0.807 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr17_-_5404304 0.779 NM_001162371
 LOC728392
uncharacterized LOC728392
chr9_+_90112419 0.730 DAPK1
death-associated protein kinase 1
chrX_-_15872905 0.726


chr19_+_56159400 0.719 CCDC106
coiled-coil domain containing 106
chrX_-_51812249 0.699 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
 MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr1_-_150602047 0.688 ENSA
endosulfine alpha
chr1_-_150602089 0.674 NM_004436
NM_207042
NM_207043
NM_207044
NM_207168
 ENSA




endosulfine alpha




chr10_-_90712510 0.674 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_170633312 0.670 NM_006902
NM_022716
 PRRX1

paired related homeobox 1

chr11_-_65640199 0.659 NM_016938
 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr10_+_8097350 0.653 GATA3
GATA binding protein 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 71 entries
enrichment   p-value GO term description
3.44 1.45e-02 GO:0051149 positive regulation of muscle cell differentiation
1.77 5.80e-03 GO:0016568 chromatin modification
1.75 3.70e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.75 3.27e-02 GO:0060284 regulation of cell development
1.74 2.21e-03 GO:0007409 axonogenesis
1.73 7.75e-03 GO:0007264 small GTPase mediated signal transduction
1.72 2.47e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.69 5.06e-03 GO:0048812 neuron projection morphogenesis
1.68 5.27e-04 GO:0051253 negative regulation of RNA metabolic process
1.67 2.89e-03 GO:0000904 cell morphogenesis involved in differentiation
1.65 2.59e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.65 6.37e-03 GO:0031175 neuron projection development
1.61 1.57e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.60 2.79e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.60 2.42e-02 GO:0048858 cell projection morphogenesis
1.59 3.42e-02 GO:0032990 cell part morphogenesis
1.57 1.58e-02 GO:0048666 neuron development
1.56 1.41e-02 GO:0010629 negative regulation of gene expression
1.55 4.83e-03 GO:0030182 neuron differentiation
1.54 4.34e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
1.92 4.24e-02 GO:0030136 clathrin-coated vesicle
1.71 3.53e-02 GO:0012506 vesicle membrane
1.51 1.31e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.50 8.39e-04 GO:0031410 cytoplasmic vesicle
1.48 3.34e-03 GO:0031988 membrane-bounded vesicle
1.47 2.77e-03 GO:0031982 vesicle
1.46 1.03e-02 GO:0044451 nucleoplasm part
1.38 6.53e-04 GO:0005654 nucleoplasm
1.25 1.54e-02 GO:0005829 cytosol
1.23 1.34e-03 GO:0043234 protein complex
1.19 6.33e-06 GO:0005634 nucleus
1.18 1.23e-02 GO:0032991 macromolecular complex
1.15 1.58e-07 GO:0005737 cytoplasm
1.12 9.03e-13 GO:0005622 intracellular
1.12 2.04e-11 GO:0044424 intracellular part
1.12 3.25e-07 GO:0043229 intracellular organelle
1.12 4.19e-07 GO:0043226 organelle
1.12 8.23e-06 GO:0043231 intracellular membrane-bounded organelle
1.12 8.34e-06 GO:0043227 membrane-bounded organelle
1.12 2.27e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.02 3.74e-02 GO:0003714 transcription corepressor activity
1.80 3.18e-03 GO:0008134 transcription factor binding
1.75 8.88e-04 GO:0003712 transcription cofactor activity
1.74 9.89e-04 GO:0000988 protein binding transcription factor activity
1.74 9.89e-04 GO:0000989 transcription factor binding transcription factor activity
1.67 3.35e-02 GO:0016563 transcription activator activity
1.43 1.57e-03 GO:0001071 nucleic acid binding transcription factor activity
1.43 1.57e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.39 9.82e-03 GO:0030528 transcription regulator activity
1.23 4.82e-15 GO:0005515 protein binding
1.11 7.71e-11 GO:0005488 binding