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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for AR_NR3C2

Z-value: 0.15

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 AR
NR3C2
ENSG00000151623.10 NR3C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg19_v2_chrX_+_66764375_667644650.413.1e-01Click!
NR3C2hg19_v2_chr4_-_149365827_149365870-0.078.6e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_19290117 1.15 ENST00000497081.2
 MFAP4
 microfibrillar-associated protein 4
chr17_-_19290483 1.10 ENST00000395592.2
ENST00000299610.4
 MFAP4
 microfibrillar-associated protein 4
chr19_-_14945933 0.87 ENST00000322301.3
 OR7A5
 olfactory receptor, family 7, subfamily A, member 5
chr3_-_58563094 0.72 ENST00000464064.1
 FAM107A
 family with sequence similarity 107, member A
chr10_+_60759378 0.71 ENST00000432535.1
 LINC00844
 long intergenic non-protein coding RNA 844
chr12_+_53443680 0.49 ENST00000314250.6
ENST00000451358.1
 TENC1
 tensin like C1 domain containing phosphatase (tensin 2)
chr12_+_53443963 0.49 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
 TENC1
 tensin like C1 domain containing phosphatase (tensin 2)
chr16_+_56666563 0.37 ENST00000570233.1
 MT1M
 metallothionein 1M
chr1_+_22979676 0.28 ENST00000432749.2
ENST00000314933.6
 C1QB
 complement component 1, q subcomponent, B chain
chr1_-_1149506 0.27 ENST00000379236.3
 TNFRSF4
 tumor necrosis factor receptor superfamily, member 4
chr15_+_31658349 0.26 ENST00000558844.1
 KLF13
 Kruppel-like factor 13
chr8_+_91013676 0.26 ENST00000519410.1
ENST00000522161.1
ENST00000517761.1
ENST00000520227.1
 DECR1
 2,4-dienoyl CoA reductase 1, mitochondrial
chr19_+_35630926 0.25 ENST00000588081.1
ENST00000589121.1
 FXYD1
 FXYD domain containing ion transport regulator 1
chr20_+_15177480 0.24 ENST00000402914.1
 MACROD2
 MACRO domain containing 2
chr14_+_105190514 0.23 ENST00000330877.2
 ADSSL1
 adenylosuccinate synthase like 1
chr19_+_35630628 0.22 ENST00000588715.1
ENST00000588607.1
 FXYD1
 FXYD domain containing ion transport regulator 1
chr22_+_23046750 0.22 ENST00000390307.2
 IGLV3-22
 immunoglobulin lambda variable 3-22 (gene/pseudogene)
chr16_+_56716336 0.20 ENST00000394485.4
ENST00000562939.1
 MT1X
 metallothionein 1X
chr8_+_91013577 0.20 ENST00000220764.2
 DECR1
 2,4-dienoyl CoA reductase 1, mitochondrial
chr5_-_141392538 0.20 ENST00000503794.1
ENST00000510194.1
ENST00000504424.1
ENST00000513454.1
ENST00000458112.2
ENST00000542860.1
ENST00000503229.1
ENST00000500692.2
ENST00000311337.6
ENST00000504139.1
ENST00000505689.1
 GNPDA1
 glucosamine-6-phosphate deaminase 1
chr7_+_94285637 0.20 ENST00000482108.1
ENST00000488574.1
 PEG10
 paternally expressed 10
chr16_+_67207838 0.18 ENST00000566871.1
ENST00000268605.7
 NOL3
 nucleolar protein 3 (apoptosis repressor with CARD domain)
chr16_+_67207872 0.18 ENST00000563258.1
ENST00000568146.1
 NOL3
 nucleolar protein 3 (apoptosis repressor with CARD domain)
chr1_+_22979474 0.17 ENST00000509305.1
 C1QB
 complement component 1, q subcomponent, B chain
chr19_+_35630344 0.17 ENST00000455515.2
 FXYD1
 FXYD domain containing ion transport regulator 1
chr9_+_131683174 0.16 ENST00000372592.3
ENST00000428610.1
 PHYHD1
 phytanoyl-CoA dioxygenase domain containing 1
chr22_+_30477000 0.16 ENST00000403975.1
 HORMAD2
 HORMA domain containing 2
chr1_+_112162381 0.14 ENST00000433097.1
ENST00000369709.3
ENST00000436150.2
 RAP1A
 RAP1A, member of RAS oncogene family
chr12_-_56615693 0.13 ENST00000394013.2
ENST00000345093.4
ENST00000551711.1
ENST00000552656.1
 RNF41
 ring finger protein 41
chrY_-_16098393 0.13 ENST00000250825.4
 VCY
 variable charge, Y-linked
chr8_-_72756667 0.12 ENST00000325509.4
 MSC
 musculin
chr3_-_15382875 0.12 ENST00000408919.3
 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
chr8_-_49833978 0.12 ENST00000020945.1
 SNAI2
 snail family zinc finger 2
chr17_+_41323204 0.12 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
 NBR1
 neighbor of BRCA1 gene 1
chrY_+_16168097 0.12 ENST00000250823.4
 VCY1B
 variable charge, Y-linked 1B
chr16_+_56659687 0.12 ENST00000568293.1
ENST00000330439.6
 MT1E
 metallothionein 1E
chr3_-_119396193 0.12 ENST00000484810.1
ENST00000497116.1
ENST00000261070.2
 COX17
 COX17 cytochrome c oxidase copper chaperone
chr11_+_48002076 0.12 ENST00000418331.2
ENST00000440289.2
 PTPRJ
 protein tyrosine phosphatase, receptor type, J
chr14_-_106845789 0.12 ENST00000390617.2
 IGHV3-35
 immunoglobulin heavy variable 3-35 (non-functional)
chr16_-_4852915 0.11 ENST00000322048.7
 ROGDI
 rogdi homolog (Drosophila)
chr8_-_49834299 0.11 ENST00000396822.1
 SNAI2
 snail family zinc finger 2
chr12_+_66582919 0.11 ENST00000545837.1
ENST00000457197.2
 IRAK3
 interleukin-1 receptor-associated kinase 3
chr4_-_69817481 0.11 ENST00000251566.4
 UGT2A3
 UDP glucuronosyltransferase 2 family, polypeptide A3
chr14_-_24616426 0.11 ENST00000216802.5
 PSME2
 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_+_51318513 0.10 ENST00000332160.4
 METTL7A
 methyltransferase like 7A
chr18_-_48346130 0.10 ENST00000592966.1
 MRO
 maestro
chr2_+_242577027 0.10 ENST00000402096.1
ENST00000404914.3
 ATG4B
 autophagy related 4B, cysteine peptidase
chr17_-_61996136 0.10 ENST00000342364.4
 GH1
 growth hormone 1
chr11_-_114271139 0.09 ENST00000325636.4
 C11orf71
 chromosome 11 open reading frame 71
chr22_+_18632666 0.09 ENST00000215794.7
 USP18
 ubiquitin specific peptidase 18
chr11_-_236326 0.09 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
 SIRT3
 sirtuin 3
chr2_-_231825668 0.09 ENST00000392039.2
 GPR55
 G protein-coupled receptor 55
chr13_+_114462193 0.09 ENST00000375353.3
 TMEM255B
 transmembrane protein 255B
chr1_+_1846519 0.08 ENST00000378604.3
 CALML6
 calmodulin-like 6
chr17_+_37824217 0.08 ENST00000394246.1
 PNMT
 phenylethanolamine N-methyltransferase
chr18_-_48346415 0.08 ENST00000431965.2
ENST00000436348.2
 MRO
 maestro
chr17_-_61996160 0.08 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
 GH1
 growth hormone 1
chr14_-_106866934 0.08 ENST00000390618.2
 IGHV3-38
 immunoglobulin heavy variable 3-38 (non-functional)
chr8_+_62200509 0.08 ENST00000519846.1
ENST00000518592.1
ENST00000325897.4
 CLVS1
 clavesin 1
chr9_-_35563896 0.07 ENST00000399742.2
 FAM166B
 family with sequence similarity 166, member B
chr19_+_58570605 0.07 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
 ZNF135
 zinc finger protein 135
chr1_-_49242553 0.07 ENST00000371833.3
 BEND5
 BEN domain containing 5
chr12_+_52203789 0.07 ENST00000599343.1
 AC068987.1
 HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881
chr5_-_173043591 0.07 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
 BOD1
 biorientation of chromosomes in cell division 1
chr4_-_8442438 0.07 ENST00000356406.5
ENST00000413009.2
 ACOX3
 acyl-CoA oxidase 3, pristanoyl
chr18_+_56530136 0.07 ENST00000591083.1
 ZNF532
 zinc finger protein 532
chr17_-_6459802 0.07 ENST00000262483.8
 PITPNM3
 PITPNM family member 3
chr4_-_135122903 0.07 ENST00000421491.3
ENST00000529122.2
 PABPC4L
 poly(A) binding protein, cytoplasmic 4-like
chrX_+_8433376 0.07 ENST00000440654.2
ENST00000381029.4
 VCX3B
 variable charge, X-linked 3B
chr8_+_24298597 0.06 ENST00000380789.1
 ADAM7
 ADAM metallopeptidase domain 7
chr6_+_127898312 0.06 ENST00000329722.7
 C6orf58
 chromosome 6 open reading frame 58
chr17_-_61996192 0.06 ENST00000392824.4
 CSHL1
 chorionic somatomammotropin hormone-like 1
chr19_+_56187987 0.06 ENST00000411543.2
 EPN1
 epsin 1
chr1_+_61547405 0.06 ENST00000371189.4
 NFIA
 nuclear factor I/A
chr8_+_24298531 0.06 ENST00000175238.6
 ADAM7
 ADAM metallopeptidase domain 7
chr16_-_66584059 0.06 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
 TK2
 thymidine kinase 2, mitochondrial
chr6_-_26235206 0.06 ENST00000244534.5
 HIST1H1D
 histone cluster 1, H1d
chr18_-_48346298 0.06 ENST00000398439.3
 MRO
 maestro
chr1_+_76262552 0.06 ENST00000263187.3
 MSH4
 mutS homolog 4
chr19_+_8117881 0.05 ENST00000390669.3
 CCL25
 chemokine (C-C motif) ligand 25
chr19_+_54704610 0.05 ENST00000302907.4
 RPS9
 ribosomal protein S9
chr15_+_65204075 0.05 ENST00000380230.3
ENST00000357698.3
ENST00000395720.1
ENST00000496660.1
ENST00000319580.8
 ANKDD1A
 ankyrin repeat and death domain containing 1A
chr12_-_122241812 0.05 ENST00000538335.1
 AC084018.1
 AC084018.1
chr19_+_8117636 0.05 ENST00000253451.4
ENST00000315626.4
 CCL25
 chemokine (C-C motif) ligand 25
chr9_-_40792063 0.05 ENST00000377626.3
ENST00000441795.1
ENST00000602553.1
 ZNF658
 zinc finger protein 658
chrX_+_8432871 0.04 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
 VCX3B
 variable charge, X-linked 3B
chr14_-_106692191 0.04 ENST00000390607.2
 IGHV3-21
 immunoglobulin heavy variable 3-21
chr17_-_16472483 0.04 ENST00000395824.1
ENST00000448349.2
ENST00000395825.3
 ZNF287
 zinc finger protein 287
chr11_-_75380165 0.04 ENST00000304771.3
 MAP6
 microtubule-associated protein 6
chr4_-_186347099 0.04 ENST00000505357.1
ENST00000264689.6
 UFSP2
 UFM1-specific peptidase 2
chr14_-_106552755 0.04 ENST00000390600.2
 IGHV3-9
 immunoglobulin heavy variable 3-9
chr11_+_114270752 0.04 ENST00000540163.1
 RBM7
 RNA binding motif protein 7
chr4_+_37892682 0.04 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
 TBC1D1
 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr15_-_20193370 0.04 ENST00000558565.2
 IGHV3OR15-7
 immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr11_+_114271251 0.04 ENST00000375490.5
 RBM7
 RNA binding motif protein 7
chr20_+_45947246 0.04 ENST00000599904.1
 AL031666.2
 HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr12_-_11002063 0.03 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
 PRR4
 proline rich 4 (lacrimal)
chr11_+_103907308 0.03 ENST00000302259.3
 DDI1
 DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr3_+_13521665 0.03 ENST00000295757.3
ENST00000402259.1
ENST00000402271.1
ENST00000446613.2
ENST00000404548.1
ENST00000404040.1
 HDAC11
 histone deacetylase 11
chr11_+_114271314 0.03 ENST00000541475.1
 RBM7
 RNA binding motif protein 7
chr11_-_506739 0.03 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
 RNH1
 ribonuclease/angiogenin inhibitor 1
chr2_-_73298802 0.03 ENST00000411783.1
ENST00000410065.1
ENST00000442582.1
ENST00000272433.2
 SFXN5
 sideroflexin 5
chr14_-_106668095 0.03 ENST00000390606.2
 IGHV3-20
 immunoglobulin heavy variable 3-20
chr16_+_25703274 0.03 ENST00000331351.5
 HS3ST4
 heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chrX_+_153029633 0.03 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
 PLXNB3
 plexin B3
chr6_-_111927062 0.03 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chr6_-_52774464 0.02 ENST00000370968.1
ENST00000211122.3
 GSTA3
 glutathione S-transferase alpha 3
chr18_+_45778672 0.02 ENST00000600091.1
 AC091150.1
 HCG1818186; Uncharacterized protein
chr1_+_93811438 0.02 ENST00000370272.4
ENST00000370267.1
 DR1
 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr19_-_42916499 0.02 ENST00000601189.1
ENST00000599211.1
 LIPE
 lipase, hormone-sensitive
chr2_-_109605663 0.02 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
 EDAR
 ectodysplasin A receptor
chr17_+_38333263 0.02 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
 RAPGEFL1
 Rap guanine nucleotide exchange factor (GEF)-like 1
chr17_-_3794021 0.02 ENST00000381769.2
 CAMKK1
 calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr2_+_238395803 0.02 ENST00000264605.3
 MLPH
 melanophilin
chr14_-_107211459 0.02 ENST00000390636.2
 IGHV3-73
 immunoglobulin heavy variable 3-73
chr18_+_7754957 0.02 ENST00000400053.4
 PTPRM
 protein tyrosine phosphatase, receptor type, M
chr16_+_56672571 0.02 ENST00000290705.8
 MT1A
 metallothionein 1A
chr3_+_169490606 0.02 ENST00000349841.5
 MYNN
 myoneurin
chr2_+_238395879 0.01 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
 MLPH
 melanophilin
chr16_-_67978016 0.01 ENST00000264005.5
 LCAT
 lecithin-cholesterol acyltransferase
chr3_+_169491171 0.01 ENST00000356716.4
 MYNN
 myoneurin
chr3_+_169490834 0.01 ENST00000392733.1
 MYNN
 myoneurin
chr2_+_242577097 0.01 ENST00000419606.1
ENST00000474739.2
ENST00000396411.3
ENST00000425239.1
ENST00000400771.3
ENST00000430617.2
 ATG4B
 autophagy related 4B, cysteine peptidase
chr7_+_94139105 0.01 ENST00000297273.4
 CASD1
 CAS1 domain containing 1
chr5_-_179499086 0.01 ENST00000261947.4
 RNF130
 ring finger protein 130
chr22_+_19939026 0.00 ENST00000406520.3
 COMT
 catechol-O-methyltransferase
chr3_-_24207039 0.00 ENST00000280696.5
 THRB
 thyroid hormone receptor, beta
chr12_-_10251603 0.00 ENST00000457018.2
 CLEC1A
 C-type lectin domain family 1, member A
chr22_+_24030321 0.00 ENST00000401461.1
 RGL4
 ral guanine nucleotide dissociation stimulator-like 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.4 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.1 0.6 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.1 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.7 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.2 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.1 GO:0042414 epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418)
0.0 0.2 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.3 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.0 0.1 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.1 GO:1901525 negative regulation of macromitophagy(GO:1901525)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0071953 elastic fiber(GO:0071953)
0.1 0.4 GO:0005602 complement component C1 complex(GO:0005602)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0005713 recombination nodule(GO:0005713)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.2 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.4 GO:0035877 death effector domain binding(GO:0035877)
0.0 0.1 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.1 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0031386 protein tag(GO:0031386)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis