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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for DDIT3

Z-value: 0.32

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DDIT3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_579143040.088.6e-01Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_-_92413353 0.34 ENST00000556154.1
 FBLN5
 fibulin 5
chr3_+_157154578 0.31 ENST00000295927.3
 PTX3
 pentraxin 3, long
chr14_-_92413727 0.28 ENST00000267620.10
 FBLN5
 fibulin 5
chr7_-_56101826 0.23 ENST00000421626.1
 PSPH
 phosphoserine phosphatase
chr3_+_12392971 0.18 ENST00000287820.6
 PPARG
 peroxisome proliferator-activated receptor gamma
chr9_+_80912059 0.18 ENST00000347159.2
ENST00000376588.3
 PSAT1
 phosphoserine aminotransferase 1
chr8_-_93029865 0.16 ENST00000422361.2
 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr20_+_54987305 0.16 ENST00000371336.3
ENST00000434344.1
 CASS4
 Cas scaffolding protein family member 4
chr8_-_93029520 0.14 ENST00000521553.1
 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr20_+_54987168 0.14 ENST00000360314.3
 CASS4
 Cas scaffolding protein family member 4
chr15_+_41245160 0.13 ENST00000444189.2
ENST00000446533.3
 CHAC1
 ChaC, cation transport regulator homolog 1 (E. coli)
chr4_-_119274121 0.13 ENST00000296498.3
 PRSS12
 protease, serine, 12 (neurotrypsin, motopsin)
chr12_-_25101920 0.12 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr11_+_20044096 0.11 ENST00000533917.1
 NAV2
 neuron navigator 2
chr12_-_25102252 0.10 ENST00000261192.7
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr8_+_27629459 0.10 ENST00000523566.1
 ESCO2
 establishment of sister chromatid cohesion N-acetyltransferase 2
chr7_-_130598059 0.08 ENST00000432045.2
 MIR29B1
 microRNA 29a
chr4_-_99578789 0.08 ENST00000511651.1
ENST00000505184.1
 TSPAN5
 tetraspanin 5
chr6_+_31895254 0.08 ENST00000299367.5
ENST00000442278.2
 C2
 complement component 2
chr19_-_6604094 0.08 ENST00000597430.2
 CD70
 CD70 molecule
chr1_-_20250110 0.07 ENST00000375116.3
 PLA2G2E
 phospholipase A2, group IIE
chr2_-_63815628 0.07 ENST00000409562.3
 WDPCP
 WD repeat containing planar cell polarity effector
chr3_+_44840679 0.07 ENST00000425755.1
 KIF15
 kinesin family member 15
chr2_+_227700652 0.07 ENST00000341329.3
ENST00000392062.2
ENST00000437454.1
ENST00000443477.1
ENST00000423616.1
ENST00000448992.1
 RHBDD1
 rhomboid domain containing 1
chr19_+_12917364 0.06 ENST00000221486.4
 RNASEH2A
 ribonuclease H2, subunit A
chr8_-_18744528 0.06 ENST00000523619.1
 PSD3
 pleckstrin and Sec7 domain containing 3
chr5_-_178017355 0.06 ENST00000390654.3
 COL23A1
 collagen, type XXIII, alpha 1
chr12_-_12491608 0.06 ENST00000545735.1
 MANSC1
 MANSC domain containing 1
chr5_+_72143988 0.06 ENST00000506351.2
 TNPO1
 transportin 1
chr11_-_33913708 0.06 ENST00000257818.2
 LMO2
 LIM domain only 2 (rhombotin-like 1)
chr8_+_24151620 0.06 ENST00000437154.2
 ADAM28
 ADAM metallopeptidase domain 28
chr1_-_112032284 0.05 ENST00000414219.1
 ADORA3
 adenosine A3 receptor
chr15_-_83837983 0.05 ENST00000562702.1
 HDGFRP3
 Hepatoma-derived growth factor-related protein 3
chr20_-_31592113 0.05 ENST00000420875.1
ENST00000375519.2
ENST00000375523.3
ENST00000356173.3
 SUN5
 Sad1 and UNC84 domain containing 5
chr4_+_157997273 0.05 ENST00000541722.1
ENST00000512619.1
 GLRB
 glycine receptor, beta
chr4_+_157997209 0.05 ENST00000264428.4
 GLRB
 glycine receptor, beta
chr2_-_43453734 0.05 ENST00000282388.3
 ZFP36L2
 ZFP36 ring finger protein-like 2
chr17_-_77813186 0.05 ENST00000448310.1
ENST00000269397.4
 CBX4
 chromobox homolog 4
chr9_+_112542572 0.05 ENST00000374530.3
 PALM2-AKAP2
 PALM2-AKAP2 readthrough
chr1_-_114447683 0.05 ENST00000256658.4
ENST00000369564.1
 AP4B1
 adaptor-related protein complex 4, beta 1 subunit
chr2_+_169757750 0.05 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2
 glucose-6-phosphatase, catalytic, 2
chr2_+_113825547 0.04 ENST00000341010.2
ENST00000337569.3
 IL1F10
 interleukin 1 family, member 10 (theta)
chr1_+_114447763 0.04 ENST00000369563.3
 DCLRE1B
 DNA cross-link repair 1B
chr13_-_24007815 0.04 ENST00000382298.3
 SACS
 spastic ataxia of Charlevoix-Saguenay (sacsin)
chr11_+_47279504 0.04 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
 NR1H3
 nuclear receptor subfamily 1, group H, member 3
chr4_+_6784401 0.04 ENST00000425103.1
ENST00000307659.5
 KIAA0232
 KIAA0232
chr1_+_154229547 0.04 ENST00000428595.1
 UBAP2L
 ubiquitin associated protein 2-like
chr2_-_40680578 0.04 ENST00000455476.1
 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_174844645 0.04 ENST00000486220.1
 RABGAP1L
 RAB GTPase activating protein 1-like
chr1_-_114447412 0.04 ENST00000369567.1
ENST00000369566.3
 AP4B1
 adaptor-related protein complex 4, beta 1 subunit
chr1_+_40840320 0.04 ENST00000372708.1
 SMAP2
 small ArfGAP2
chr8_+_24151553 0.04 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
 ADAM28
 ADAM metallopeptidase domain 28
chr22_-_27456361 0.04 ENST00000453934.1
 CTA-992D9.6
 CTA-992D9.6
chr15_+_59730348 0.04 ENST00000288228.5
ENST00000559628.1
ENST00000557914.1
ENST00000560474.1
 FAM81A
 family with sequence similarity 81, member A
chr1_+_33546714 0.04 ENST00000294517.6
ENST00000358680.3
ENST00000373443.3
ENST00000398167.1
 ADC
 arginine decarboxylase
chr11_-_10315741 0.03 ENST00000256190.8
 SBF2
 SET binding factor 2
chr5_+_112074029 0.03 ENST00000512211.2
 APC
 adenomatous polyposis coli
chr10_-_17659234 0.03 ENST00000466335.1
 PTPLA
 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr9_+_110045537 0.03 ENST00000358015.3
 RAD23B
 RAD23 homolog B (S. cerevisiae)
chr12_+_57857475 0.03 ENST00000528467.1
 GLI1
 GLI family zinc finger 1
chr8_-_11058847 0.03 ENST00000297303.4
ENST00000416569.2
 XKR6
 XK, Kell blood group complex subunit-related family, member 6
chr12_-_63328817 0.03 ENST00000228705.6
 PPM1H
 protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr15_+_85923856 0.02 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
 AKAP13
 A kinase (PRKA) anchor protein 13
chrX_+_9431324 0.02 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X
 transducin (beta)-like 1X-linked
chr16_-_70323422 0.02 ENST00000261772.8
 AARS
 alanyl-tRNA synthetase
chr10_-_17659357 0.02 ENST00000326961.6
ENST00000361271.3
 PTPLA
 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr2_-_63815860 0.02 ENST00000272321.7
ENST00000431065.1
 WDPCP
 WD repeat containing planar cell polarity effector
chr2_-_161350305 0.02 ENST00000348849.3
 RBMS1
 RNA binding motif, single stranded interacting protein 1
chr14_+_22265444 0.02 ENST00000390430.2
 TRAV8-1
 T cell receptor alpha variable 8-1
chr17_+_30594823 0.02 ENST00000536287.1
 RHBDL3
 rhomboid, veinlet-like 3 (Drosophila)
chr9_-_95055956 0.02 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
 IARS
 isoleucyl-tRNA synthetase
chr10_-_92681033 0.02 ENST00000371697.3
 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
chr15_-_64126084 0.02 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
 HERC1
 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr22_+_17956618 0.02 ENST00000262608.8
 CECR2
 cat eye syndrome chromosome region, candidate 2
chr14_+_32798462 0.02 ENST00000280979.4
 AKAP6
 A kinase (PRKA) anchor protein 6
chr19_+_10736183 0.02 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
 SLC44A2
 solute carrier family 44 (choline transporter), member 2
chr11_+_34073269 0.02 ENST00000389645.3
 CAPRIN1
 cell cycle associated protein 1
chr10_+_12391481 0.02 ENST00000378847.3
 CAMK1D
 calcium/calmodulin-dependent protein kinase ID
chr9_-_95056010 0.02 ENST00000443024.2
 IARS
 isoleucyl-tRNA synthetase
chr11_+_62495997 0.02 ENST00000316461.4
 TTC9C
 tetratricopeptide repeat domain 9C
chrX_-_138724994 0.02 ENST00000536274.1
 MCF2
 MCF.2 cell line derived transforming sequence
chr5_+_118812237 0.02 ENST00000513628.1
 HSD17B4
 hydroxysteroid (17-beta) dehydrogenase 4
chr14_+_32798547 0.02 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6
 A kinase (PRKA) anchor protein 6
chr9_+_112542591 0.01 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
 PALM2
PALM2-AKAP2
AKAP2
 paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr19_+_33865218 0.01 ENST00000585933.2
 CEBPG
 CCAAT/enhancer binding protein (C/EBP), gamma
chr19_+_41497178 0.01 ENST00000324071.4
 CYP2B6
 cytochrome P450, family 2, subfamily B, polypeptide 6
chr19_+_49258775 0.01 ENST00000593756.1
 FGF21
 fibroblast growth factor 21
chr5_+_118812294 0.01 ENST00000509514.1
 HSD17B4
 hydroxysteroid (17-beta) dehydrogenase 4
chr7_+_99006232 0.01 ENST00000403633.2
 BUD31
 BUD31 homolog (S. cerevisiae)
chr14_+_21387491 0.01 ENST00000258817.2
 RP11-84C10.2
 RP11-84C10.2
chr10_+_102756800 0.01 ENST00000370223.3
 LZTS2
 leucine zipper, putative tumor suppressor 2
chr1_-_161277210 0.01 ENST00000491222.2
 MPZ
 myelin protein zero
chr3_-_148939835 0.01 ENST00000264613.6
 CP
 ceruloplasmin (ferroxidase)
chr10_+_60028818 0.01 ENST00000333926.5
 CISD1
 CDGSH iron sulfur domain 1
chr6_+_151187074 0.01 ENST00000367308.4
 MTHFD1L
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr20_+_24929866 0.01 ENST00000480798.1
ENST00000376835.2
 CST7
 cystatin F (leukocystatin)
chrX_-_100129128 0.01 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
 NOX1
 NADPH oxidase 1
chr2_-_216300784 0.01 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1
 fibronectin 1
chr16_-_18908196 0.01 ENST00000565324.1
ENST00000561947.1
 SMG1
 SMG1 phosphatidylinositol 3-kinase-related kinase
chr22_-_30901637 0.01 ENST00000381982.3
ENST00000255858.7
ENST00000540456.1
ENST00000392772.2
 SEC14L4
 SEC14-like 4 (S. cerevisiae)
chr8_+_118147498 0.01 ENST00000519688.1
ENST00000456015.2
 SLC30A8
 solute carrier family 30 (zinc transporter), member 8
chr7_-_138363824 0.01 ENST00000419765.3
 SVOPL
 SVOP-like
chr2_-_179672142 0.01 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
 TTN
 titin
chr4_+_111397216 0.00 ENST00000265162.5
 ENPEP
 glutamyl aminopeptidase (aminopeptidase A)
chr17_-_34257771 0.00 ENST00000394529.3
ENST00000293273.6
 RDM1
 RAD52 motif 1
chrX_-_138724677 0.00 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
 MCF2
 MCF.2 cell line derived transforming sequence
chrX_-_40506766 0.00 ENST00000378421.1
ENST00000440784.2
ENST00000327877.5
ENST00000378426.1
ENST00000378418.2
 CXorf38
 chromosome X open reading frame 38
chr11_-_8680383 0.00 ENST00000299550.6
 TRIM66
 tripartite motif containing 66
chr5_-_137878887 0.00 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
 ETF1
 eukaryotic translation termination factor 1
chr11_+_34073195 0.00 ENST00000341394.4
 CAPRIN1
 cell cycle associated protein 1
chr1_-_44820880 0.00 ENST00000372257.2
ENST00000457571.1
ENST00000452396.1
 ERI3
 ERI1 exoribonuclease family member 3
chr5_+_145583107 0.00 ENST00000506502.1
 RBM27
 RNA binding motif protein 27
chr2_+_63816087 0.00 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
 MDH1
 malate dehydrogenase 1, NAD (soluble)
chr17_-_34257731 0.00 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
 RDM1
 RAD52 motif 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.2 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0090521 regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.0 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.0 GO:0031860 telomeric 3' overhang formation(GO:0031860)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0071953 elastic fiber(GO:0071953)
0.0 0.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)