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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for EVX2

Z-value: 0.83

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 EVX2

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EVX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_111718036 0.52 ENST00000455401.2
 TAGLN3
 transgelin 3
chr3_+_111717600 0.51 ENST00000273368.4
 TAGLN3
 transgelin 3
chr3_+_111718173 0.50 ENST00000494932.1
 TAGLN3
 transgelin 3
chr11_-_115375107 0.50 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1
 cell adhesion molecule 1
chr1_+_28261492 0.47 ENST00000373894.3
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr3_+_111717511 0.46 ENST00000478951.1
ENST00000393917.2
 TAGLN3
 transgelin 3
chr1_+_28261621 0.45 ENST00000549094.1
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr11_+_65554493 0.32 ENST00000335987.3
 OVOL1
 ovo-like zinc finger 1
chr17_-_27418537 0.32 ENST00000408971.2
 TIAF1
 TGFB1-induced anti-apoptotic factor 1
chr1_+_28261533 0.25 ENST00000411604.1
ENST00000373888.4
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr4_+_144354644 0.23 ENST00000512843.1
 GAB1
 GRB2-associated binding protein 1
chr20_-_50418972 0.21 ENST00000395997.3
 SALL4
 spalt-like transcription factor 4
chr20_-_50418947 0.21 ENST00000371539.3
 SALL4
 spalt-like transcription factor 4
chr20_-_50419055 0.19 ENST00000217086.4
 SALL4
 spalt-like transcription factor 4
chr18_-_33709268 0.12 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6
 solute carrier family 39 (zinc transporter), member 6
chr1_+_160160346 0.11 ENST00000368078.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_160160283 0.10 ENST00000368079.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr6_-_111927062 0.09 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chr19_+_11071546 0.09 ENST00000358026.2
 SMARCA4
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr4_-_41884582 0.07 ENST00000499082.2
 LINC00682
 long intergenic non-protein coding RNA 682
chr6_-_111927449 0.06 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
 TRAF3IP2
 TRAF3 interacting protein 2
chr12_+_28410128 0.03 ENST00000381259.1
ENST00000381256.1
 CCDC91
 coiled-coil domain containing 91
chr4_-_41884620 0.03 ENST00000504870.1
 LINC00682
 long intergenic non-protein coding RNA 682
chr20_+_30467600 0.02 ENST00000375934.4
ENST00000375922.4
 TTLL9
 tubulin tyrosine ligase-like family, member 9
chr15_-_55562479 0.01 ENST00000564609.1
 RAB27A
 RAB27A, member RAS oncogene family
chr5_-_96478466 0.00 ENST00000274382.4
 LIX1
 Lix1 homolog (chicken)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.3 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 1.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0014802 terminal cisterna(GO:0014802)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions